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Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum
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| Zeitschriftentitel: | Natural Product Communications |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Natural Product Communications, 14, 2019, 7, S. 1934578X1986393 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
|
| Schlagwörter: |
| author_facet |
Lima, Rafaely N. Ribeiro, Adauto S. Santiago, Gilvandete M.P. Costa, Cinara O. d´S. Soares, Milena B. Bezerra, Daniel P. Shanmugam, Saravanan Freitas, Lisiane dos S. Alves, Pericles B. Lima, Rafaely N. Ribeiro, Adauto S. Santiago, Gilvandete M.P. Costa, Cinara O. d´S. Soares, Milena B. Bezerra, Daniel P. Shanmugam, Saravanan Freitas, Lisiane dos S. Alves, Pericles B. |
|---|---|
| author |
Lima, Rafaely N. Ribeiro, Adauto S. Santiago, Gilvandete M.P. Costa, Cinara O. d´S. Soares, Milena B. Bezerra, Daniel P. Shanmugam, Saravanan Freitas, Lisiane dos S. Alves, Pericles B. |
| spellingShingle |
Lima, Rafaely N. Ribeiro, Adauto S. Santiago, Gilvandete M.P. Costa, Cinara O. d´S. Soares, Milena B. Bezerra, Daniel P. Shanmugam, Saravanan Freitas, Lisiane dos S. Alves, Pericles B. Natural Product Communications Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine |
| author_sort |
lima, rafaely n. |
| spelling |
Lima, Rafaely N. Ribeiro, Adauto S. Santiago, Gilvandete M.P. Costa, Cinara O. d´S. Soares, Milena B. Bezerra, Daniel P. Shanmugam, Saravanan Freitas, Lisiane dos S. Alves, Pericles B. 1934-578X 1555-9475 SAGE Publications Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine http://dx.doi.org/10.1177/1934578x19863932 <jats:p>The chemical constituents of essential oils extracted by hydrodistillation from Piper klotzschianum, P. hispidum, and P. arboreum, collected from the remaining Atlantic forest in Sergipe State, were characterized and submitted to cytotoxic and larvicidal activity assays. The major constituents identified (stems, fresh, and dried leaves) were ( E)-caryophyllene (16.8%) and bicyclogermacrene (21.6%). Germacrene D (22.8%) was identified only in P. klotzschianum and P. hispidum. A high percentage of β-pinene (27.2%) and α-pinene (7.2%) were present in P. klotzschianum stems and δ-3-carene in the fresh and dried leaves of P. hispidum (17.4% and 19.1%, respectively). Piper klotzschianum showed the best cytotoxic activity, inhibiting human hepatocellular carcinoma (27.3 µg/mL), human promyelocytic leukemia (33.8 µg/mL), and murine melanoma (37.9 µg/mL) cell lines. Larvicidal activity was also tested and the essential oil from the dried leaves of P. klotzschianum was the most potent against Aedes aegypti larvae, with an LC<jats:sub>50</jats:sub>value of 122.4 µg/mL.</jats:p> Antitumor and<i>Aedes aegypti</i>Larvicidal Activities of Essential Oils From<i>Piper klotzschianum</i>,<i>P. hispidum</i>, and<i>P. arboreum</i> Natural Product Communications |
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| title |
Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_unstemmed |
Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_full |
Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_fullStr |
Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_full_unstemmed |
Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_short |
Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_sort |
antitumor and<i>aedes aegypti</i>larvicidal activities of essential oils from<i>piper klotzschianum</i>,<i>p. hispidum</i>, and<i>p. arboreum</i> |
| topic |
Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine |
| url |
http://dx.doi.org/10.1177/1934578x19863932 |
| publishDate |
2019 |
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<jats:p>The chemical constituents of essential oils extracted by hydrodistillation from Piper klotzschianum, P. hispidum, and P. arboreum, collected from the remaining Atlantic forest in Sergipe State, were characterized and submitted to cytotoxic and larvicidal activity assays. The major constituents identified (stems, fresh, and dried leaves) were ( E)-caryophyllene (16.8%) and bicyclogermacrene (21.6%). Germacrene D (22.8%) was identified only in P. klotzschianum and P. hispidum. A high percentage of β-pinene (27.2%) and α-pinene (7.2%) were present in P. klotzschianum stems and δ-3-carene in the fresh and dried leaves of P. hispidum (17.4% and 19.1%, respectively). Piper klotzschianum showed the best cytotoxic activity, inhibiting human hepatocellular carcinoma (27.3 µg/mL), human promyelocytic leukemia (33.8 µg/mL), and murine melanoma (37.9 µg/mL) cell lines. Larvicidal activity was also tested and the essential oil from the dried leaves of P. klotzschianum was the most potent against Aedes aegypti larvae, with an LC<jats:sub>50</jats:sub>value of 122.4 µg/mL.</jats:p> |
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| author | Lima, Rafaely N., Ribeiro, Adauto S., Santiago, Gilvandete M.P., Costa, Cinara O. d´S., Soares, Milena B., Bezerra, Daniel P., Shanmugam, Saravanan, Freitas, Lisiane dos S., Alves, Pericles B. |
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| description | <jats:p>The chemical constituents of essential oils extracted by hydrodistillation from Piper klotzschianum, P. hispidum, and P. arboreum, collected from the remaining Atlantic forest in Sergipe State, were characterized and submitted to cytotoxic and larvicidal activity assays. The major constituents identified (stems, fresh, and dried leaves) were ( E)-caryophyllene (16.8%) and bicyclogermacrene (21.6%). Germacrene D (22.8%) was identified only in P. klotzschianum and P. hispidum. A high percentage of β-pinene (27.2%) and α-pinene (7.2%) were present in P. klotzschianum stems and δ-3-carene in the fresh and dried leaves of P. hispidum (17.4% and 19.1%, respectively). Piper klotzschianum showed the best cytotoxic activity, inhibiting human hepatocellular carcinoma (27.3 µg/mL), human promyelocytic leukemia (33.8 µg/mL), and murine melanoma (37.9 µg/mL) cell lines. Larvicidal activity was also tested and the essential oil from the dried leaves of P. klotzschianum was the most potent against Aedes aegypti larvae, with an LC<jats:sub>50</jats:sub>value of 122.4 µg/mL.</jats:p> |
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| spelling | Lima, Rafaely N. Ribeiro, Adauto S. Santiago, Gilvandete M.P. Costa, Cinara O. d´S. Soares, Milena B. Bezerra, Daniel P. Shanmugam, Saravanan Freitas, Lisiane dos S. Alves, Pericles B. 1934-578X 1555-9475 SAGE Publications Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine http://dx.doi.org/10.1177/1934578x19863932 <jats:p>The chemical constituents of essential oils extracted by hydrodistillation from Piper klotzschianum, P. hispidum, and P. arboreum, collected from the remaining Atlantic forest in Sergipe State, were characterized and submitted to cytotoxic and larvicidal activity assays. The major constituents identified (stems, fresh, and dried leaves) were ( E)-caryophyllene (16.8%) and bicyclogermacrene (21.6%). Germacrene D (22.8%) was identified only in P. klotzschianum and P. hispidum. A high percentage of β-pinene (27.2%) and α-pinene (7.2%) were present in P. klotzschianum stems and δ-3-carene in the fresh and dried leaves of P. hispidum (17.4% and 19.1%, respectively). Piper klotzschianum showed the best cytotoxic activity, inhibiting human hepatocellular carcinoma (27.3 µg/mL), human promyelocytic leukemia (33.8 µg/mL), and murine melanoma (37.9 µg/mL) cell lines. Larvicidal activity was also tested and the essential oil from the dried leaves of P. klotzschianum was the most potent against Aedes aegypti larvae, with an LC<jats:sub>50</jats:sub>value of 122.4 µg/mL.</jats:p> Antitumor and<i>Aedes aegypti</i>Larvicidal Activities of Essential Oils From<i>Piper klotzschianum</i>,<i>P. hispidum</i>, and<i>P. arboreum</i> Natural Product Communications |
| spellingShingle | Lima, Rafaely N., Ribeiro, Adauto S., Santiago, Gilvandete M.P., Costa, Cinara O. d´S., Soares, Milena B., Bezerra, Daniel P., Shanmugam, Saravanan, Freitas, Lisiane dos S., Alves, Pericles B., Natural Product Communications, Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum, Complementary and alternative medicine, Plant Science, Drug Discovery, Pharmacology, General Medicine |
| title | Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_full | Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_fullStr | Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_full_unstemmed | Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_short | Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| title_sort | antitumor and<i>aedes aegypti</i>larvicidal activities of essential oils from<i>piper klotzschianum</i>,<i>p. hispidum</i>, and<i>p. arboreum</i> |
| title_unstemmed | Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum |
| topic | Complementary and alternative medicine, Plant Science, Drug Discovery, Pharmacology, General Medicine |
| url | http://dx.doi.org/10.1177/1934578x19863932 |