%0 Electronic Article %A Lima, Rafaely N. and Ribeiro, Adauto S. and Santiago, Gilvandete M.P. and Costa, Cinara O. d´S. and Soares, Milena B. and Bezerra, Daniel P. and Shanmugam, Saravanan and Freitas, Lisiane dos S. and Alves, Pericles B. %I SAGE Publications %D 2019 %D 2019 %G English %@ 1934-578X %@ 1555-9475 %~ Hochschule Zittau / Görlitz, Hochschulbibliothek %T Antitumor andAedes aegyptiLarvicidal Activities of Essential Oils FromPiper klotzschianum,P. hispidum, andP. arboreum %V 14 %J Natural Product Communications %V 14 %N 7 %P 1934578X1986393 %U http://dx.doi.org/10.1177/1934578x19863932 %X The chemical constituents of essential oils extracted by hydrodistillation from Piper klotzschianum, P. hispidum, and P. arboreum, collected from the remaining Atlantic forest in Sergipe State, were characterized and submitted to cytotoxic and larvicidal activity assays. The major constituents identified (stems, fresh, and dried leaves) were ( E)-caryophyllene (16.8%) and bicyclogermacrene (21.6%). Germacrene D (22.8%) was identified only in P. klotzschianum and P. hispidum. A high percentage of β-pinene (27.2%) and α-pinene (7.2%) were present in P. klotzschianum stems and δ-3-carene in the fresh and dried leaves of P. hispidum (17.4% and 19.1%, respectively). Piper klotzschianum showed the best cytotoxic activity, inhibiting human hepatocellular carcinoma (27.3 µg/mL), human promyelocytic leukemia (33.8 µg/mL), and murine melanoma (37.9 µg/mL) cell lines. Larvicidal activity was also tested and the essential oil from the dried leaves of P. klotzschianum was the most potent against Aedes aegypti larvae, with an LC50value of 122.4 µg/mL. %Z https://katalog.hszg.de/Record/ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8xOTM0NTc4eDE5ODYzOTMy %U https://katalog.hszg.de/Record/ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8xOTM0NTc4eDE5ODYzOTMy