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Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds

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Personen und Körperschaften: Inuki, Shinsuke (VerfasserIn)
Titel: Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds/ by Shinsuke Inuki
Format: E-Book
Sprache: Englisch
veröffentlicht:
Tokyo Springer Tokyo 2012
Gesamtaufnahme: Springer Theses
SpringerLink
Schlagwörter:
Bioorganic chemistry
Catalysis
Chemistry
Quelle: Verbunddaten SWB
Zugangsinformationen: Elektronischer Volltext - Campuslizenz
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505 8 0 |a Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds; Supervisors' Foreword; Acknowledgments; Contents; 1 Introduction; Abstract; References; Part ITotal Synthesis of Pachastrissamine (Jaspine B); 2 Total Synthesis through Palladium-Catalyzed Bis-Cyclization of Bromoallenes; Abstract; 2.1…Experimental Section; 2.1.1 General Methods; 2.1.2 tert-Butyl (R)-4-[(R)-3-Bromopropa-1,2-dienyl]-2, 2-dimethyloxazolidine-3-carboxylate (12a); 2.1.3 N-[(2R,4R)-5-Bromo-1-hydroxypenta-3,4-dien-2-yl] benzamide (9a) 
505 8 0 |a 2.1.4 (3aS,6aS)-6-Methylene-2-phenyl-3a,4,6,6a -tetrahydrofuro[3,4-d]oxazole (8)2.1.5 (R)-N-[5-(Methoxymethyl)-2,3-dihydrofuran-3-yl] benzamide (13a); 2.1.6 (R)-N-{5-[(2,2,2-Trifluoroethoxy)methyl] -2,3-dihydrofuran-3-yl}benzamide (13b); 2.1.7 N-(5-Methylfuran-3-yl)benzamide (14); 2.1.8 tert-Butyl (R)-4-[(S)-3-Bromopropa-1,2-dienyl]-2, 2-dimethyloxazolidine-3-carboxylate (12b); 2.1.9 N-[(2R,4S)-5-Bromo-1-hydroxypenta -3,4-dien-2-yl]benzamide (9b); 2.1.10 [(3aS,6S,6aS)-2-Phenyl-3a,4,6,6a-tetrahydrofuro [3,4-d]oxazol-6-yl]methanol (15) 
505 8 0 |a 2.1.11 (3aS,6S,6aS)-2-Phenyl-6-tetradecyl-3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (16)2.1.12 (3aS,6S,6aS)-2-Phenyl-6-(3-phenylpropyl) -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17a); 2.1.13 (3aS,6S,6aS)-6-Ethyl-2-phenyl-3a,4,6, 6a-tetrahydrofuro[3,4-d]oxazole (17b); 2.1.14 (3aS,6S,6aS)-6-Isobutyl-2-phenyl-3a,4,6, 6a-tetrahydrofuro[3,4-d]oxazole (17c); 2.1.15 (3aS,6S,6aS)-6-(2-Methylallyl)-2-phenyl -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17d); 2.1.16 (1S,4S,7S)-5-(4-Phenylhepta-1,6-dien-4-yl) -2-oxa-5-azabicyclo[2.2.1]heptan-7-ol (18) 
505 8 0 |a 2.1.17 (3aS,6S,6aS)-6-(But-3-enyl)-2-phenyl -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17e)References; 3 Total Synthesis through Palladium-Catalyzed Bis-Cyclization of Propargyl Chlorides and Carbonates; Abstract; 3.1…Experimental Section; 3.1.1 General Methods; 3.1.2 tert-Butyl (S)-4-[(S)-1-Hydroxyhexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-6); 3.1.3 tert-Butyl (S)-4-[(R)-1-Hydroxyhexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-6); 3.1.4 tert-Butyl (S)-4-[(S)-1-(Methoxycarbonyloxy)hexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-7) 
505 8 0 |a 3.1.5 tert-Butyl (S)-4-[(R)-1-(Methoxycarbonyloxy)hexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-7)3.1.6 (2S,3S)-2-Benzamido-1-hydroxyoctadec-4-yn-3-yl Methyl Carbonate (syn-8); 3.1.7 (2S,3R)-2-Benzamido-1-hydroxyoctadec-4-yn-3-yl Methyl Carbonate (anti-8); 3.1.8 tert-Butyl (S)-4-[(R)-1-Chlorohexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-9); 3.1.9 tert-Butyl (S)-4-[(S)-1-Chlorohexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-9); 3.1.10 N-[(2S,3R)-3-Chloro-1-hydroxyoctadec-4-yn-2-yl]benzamide (syn-12) 
505 8 0 |a 3.1.11 N-[(2S,3S)-3-Chloro-1-hydroxyoctadec-4-yn-2-yl]benzamide (anti-12) 
520 |a The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26 per cent overall yield in seven steps), lysergic acid (4.0 per cent overall yield in fifteen steps), lysergol (3.6 per cent overall yield in fifteen steps) and isolysergol (8.2 per cent overall yield in eleven steps) have been achieved. These are 
520 |a The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26 per cent overall yield in seven steps), lysergic acid (4.0 per cent overall yield in fifteen steps), lysergol (3.6 per cent overall yield in fifteen steps) and isolysergol (8.2 per cent overall yield in eleven steps) have been achieved. These are 
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650 0 |a Catalysis 
650 0 |a Chemistry 
650 0 |a Chemistry 
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author Inuki, Shinsuke
author_facet Inuki, Shinsuke
author_role aut
author_sort Inuki, Shinsuke
author_variant s i si
callnumber-first Q - Science
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callnumber-raw QD241-441, QD181.S1 .I889 2012
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contents Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds; Supervisors' Foreword; Acknowledgments; Contents; 1 Introduction; Abstract; References; Part ITotal Synthesis of Pachastrissamine (Jaspine B); 2 Total Synthesis through Palladium-Catalyzed Bis-Cyclization of Bromoallenes; Abstract; 2.1…Experimental Section; 2.1.1 General Methods; 2.1.2 tert-Butyl (R)-4-[(R)-3-Bromopropa-1,2-dienyl]-2, 2-dimethyloxazolidine-3-carboxylate (12a); 2.1.3 N-[(2R,4R)-5-Bromo-1-hydroxypenta-3,4-dien-2-yl] benzamide (9a), 2.1.4 (3aS,6aS)-6-Methylene-2-phenyl-3a,4,6,6a -tetrahydrofuro[3,4-d]oxazole (8)2.1.5 (R)-N-[5-(Methoxymethyl)-2,3-dihydrofuran-3-yl] benzamide (13a); 2.1.6 (R)-N-{5-[(2,2,2-Trifluoroethoxy)methyl] -2,3-dihydrofuran-3-yl}benzamide (13b); 2.1.7 N-(5-Methylfuran-3-yl)benzamide (14); 2.1.8 tert-Butyl (R)-4-[(S)-3-Bromopropa-1,2-dienyl]-2, 2-dimethyloxazolidine-3-carboxylate (12b); 2.1.9 N-[(2R,4S)-5-Bromo-1-hydroxypenta -3,4-dien-2-yl]benzamide (9b); 2.1.10 [(3aS,6S,6aS)-2-Phenyl-3a,4,6,6a-tetrahydrofuro [3,4-d]oxazol-6-yl]methanol (15), 2.1.11 (3aS,6S,6aS)-2-Phenyl-6-tetradecyl-3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (16)2.1.12 (3aS,6S,6aS)-2-Phenyl-6-(3-phenylpropyl) -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17a); 2.1.13 (3aS,6S,6aS)-6-Ethyl-2-phenyl-3a,4,6, 6a-tetrahydrofuro[3,4-d]oxazole (17b); 2.1.14 (3aS,6S,6aS)-6-Isobutyl-2-phenyl-3a,4,6, 6a-tetrahydrofuro[3,4-d]oxazole (17c); 2.1.15 (3aS,6S,6aS)-6-(2-Methylallyl)-2-phenyl -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17d); 2.1.16 (1S,4S,7S)-5-(4-Phenylhepta-1,6-dien-4-yl) -2-oxa-5-azabicyclo[2.2.1]heptan-7-ol (18), 2.1.17 (3aS,6S,6aS)-6-(But-3-enyl)-2-phenyl -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17e)References; 3 Total Synthesis through Palladium-Catalyzed Bis-Cyclization of Propargyl Chlorides and Carbonates; Abstract; 3.1…Experimental Section; 3.1.1 General Methods; 3.1.2 tert-Butyl (S)-4-[(S)-1-Hydroxyhexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-6); 3.1.3 tert-Butyl (S)-4-[(R)-1-Hydroxyhexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-6); 3.1.4 tert-Butyl (S)-4-[(S)-1-(Methoxycarbonyloxy)hexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-7), 3.1.5 tert-Butyl (S)-4-[(R)-1-(Methoxycarbonyloxy)hexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-7)3.1.6 (2S,3S)-2-Benzamido-1-hydroxyoctadec-4-yn-3-yl Methyl Carbonate (syn-8); 3.1.7 (2S,3R)-2-Benzamido-1-hydroxyoctadec-4-yn-3-yl Methyl Carbonate (anti-8); 3.1.8 tert-Butyl (S)-4-[(R)-1-Chlorohexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-9); 3.1.9 tert-Butyl (S)-4-[(S)-1-Chlorohexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-9); 3.1.10 N-[(2S,3R)-3-Chloro-1-hydroxyoctadec-4-yn-2-yl]benzamide (syn-12), 3.1.11 N-[(2S,3S)-3-Chloro-1-hydroxyoctadec-4-yn-2-yl]benzamide (anti-12), The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26 per cent overall yield in seven steps), lysergic acid (4.0 per cent overall yield in fifteen steps), lysergol (3.6 per cent overall yield in fifteen steps) and isolysergol (8.2 per cent overall yield in eleven steps) have been achieved. These are
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spelling Inuki, Shinsuke aut, Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds by Shinsuke Inuki, Tokyo Springer Tokyo 2012, Online-Ressource (XVI, 106p. 66 illus, digital), Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Springer Theses, SpringerLink Bücher, Description based upon print version of record, Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds; Supervisors' Foreword; Acknowledgments; Contents; 1 Introduction; Abstract; References; Part ITotal Synthesis of Pachastrissamine (Jaspine B); 2 Total Synthesis through Palladium-Catalyzed Bis-Cyclization of Bromoallenes; Abstract; 2.1…Experimental Section; 2.1.1 General Methods; 2.1.2 tert-Butyl (R)-4-[(R)-3-Bromopropa-1,2-dienyl]-2, 2-dimethyloxazolidine-3-carboxylate (12a); 2.1.3 N-[(2R,4R)-5-Bromo-1-hydroxypenta-3,4-dien-2-yl] benzamide (9a), 2.1.4 (3aS,6aS)-6-Methylene-2-phenyl-3a,4,6,6a -tetrahydrofuro[3,4-d]oxazole (8)2.1.5 (R)-N-[5-(Methoxymethyl)-2,3-dihydrofuran-3-yl] benzamide (13a); 2.1.6 (R)-N-{5-[(2,2,2-Trifluoroethoxy)methyl] -2,3-dihydrofuran-3-yl}benzamide (13b); 2.1.7 N-(5-Methylfuran-3-yl)benzamide (14); 2.1.8 tert-Butyl (R)-4-[(S)-3-Bromopropa-1,2-dienyl]-2, 2-dimethyloxazolidine-3-carboxylate (12b); 2.1.9 N-[(2R,4S)-5-Bromo-1-hydroxypenta -3,4-dien-2-yl]benzamide (9b); 2.1.10 [(3aS,6S,6aS)-2-Phenyl-3a,4,6,6a-tetrahydrofuro [3,4-d]oxazol-6-yl]methanol (15), 2.1.11 (3aS,6S,6aS)-2-Phenyl-6-tetradecyl-3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (16)2.1.12 (3aS,6S,6aS)-2-Phenyl-6-(3-phenylpropyl) -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17a); 2.1.13 (3aS,6S,6aS)-6-Ethyl-2-phenyl-3a,4,6, 6a-tetrahydrofuro[3,4-d]oxazole (17b); 2.1.14 (3aS,6S,6aS)-6-Isobutyl-2-phenyl-3a,4,6, 6a-tetrahydrofuro[3,4-d]oxazole (17c); 2.1.15 (3aS,6S,6aS)-6-(2-Methylallyl)-2-phenyl -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17d); 2.1.16 (1S,4S,7S)-5-(4-Phenylhepta-1,6-dien-4-yl) -2-oxa-5-azabicyclo[2.2.1]heptan-7-ol (18), 2.1.17 (3aS,6S,6aS)-6-(But-3-enyl)-2-phenyl -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17e)References; 3 Total Synthesis through Palladium-Catalyzed Bis-Cyclization of Propargyl Chlorides and Carbonates; Abstract; 3.1…Experimental Section; 3.1.1 General Methods; 3.1.2 tert-Butyl (S)-4-[(S)-1-Hydroxyhexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-6); 3.1.3 tert-Butyl (S)-4-[(R)-1-Hydroxyhexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-6); 3.1.4 tert-Butyl (S)-4-[(S)-1-(Methoxycarbonyloxy)hexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-7), 3.1.5 tert-Butyl (S)-4-[(R)-1-(Methoxycarbonyloxy)hexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-7)3.1.6 (2S,3S)-2-Benzamido-1-hydroxyoctadec-4-yn-3-yl Methyl Carbonate (syn-8); 3.1.7 (2S,3R)-2-Benzamido-1-hydroxyoctadec-4-yn-3-yl Methyl Carbonate (anti-8); 3.1.8 tert-Butyl (S)-4-[(R)-1-Chlorohexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-9); 3.1.9 tert-Butyl (S)-4-[(S)-1-Chlorohexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-9); 3.1.10 N-[(2S,3R)-3-Chloro-1-hydroxyoctadec-4-yn-2-yl]benzamide (syn-12), 3.1.11 N-[(2S,3S)-3-Chloro-1-hydroxyoctadec-4-yn-2-yl]benzamide (anti-12), The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26 per cent overall yield in seven steps), lysergic acid (4.0 per cent overall yield in fifteen steps), lysergol (3.6 per cent overall yield in fifteen steps) and isolysergol (8.2 per cent overall yield in eleven steps) have been achieved. These are, Bioorganic chemistry, Catalysis, Chemistry, 9784431540427, Buchausg. u.d.T. 978-4-431-54042-7, https://doi.org/10.1007/978-4-431-54043-4 Verlag Volltext, http://dx.doi.org/10.1007/978-4-431-54043-4 Resolving-System lizenzpflichtig Volltext, https://swbplus.bsz-bw.de/bsz355115832cov.jpg V:DE-576 X:springer image/jpeg 20150513103910 Cover, (DE-627)67592670X, http://dx.doi.org/10.1007/978-4-431-54043-4 DE-Ch1, DE-Ch1 epn:3342282819 2011-12-16T14:45:47Z, DE-105 epn:3342282835 2018-03-13T10:54:12Z, http://dx.doi.org/10.1007/978-4-431-54043-4 Zum Online-Dokument DE-Zi4, DE-Zi4 epn:3342282851 2012-11-10T04:11:46Z, http://dx.doi.org/10.1007/978-4-431-54043-4 DE-520, DE-520 epn:3342282878 2011-12-16T14:45:47Z
spellingShingle Inuki, Shinsuke, Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds, Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds; Supervisors' Foreword; Acknowledgments; Contents; 1 Introduction; Abstract; References; Part ITotal Synthesis of Pachastrissamine (Jaspine B); 2 Total Synthesis through Palladium-Catalyzed Bis-Cyclization of Bromoallenes; Abstract; 2.1…Experimental Section; 2.1.1 General Methods; 2.1.2 tert-Butyl (R)-4-[(R)-3-Bromopropa-1,2-dienyl]-2, 2-dimethyloxazolidine-3-carboxylate (12a); 2.1.3 N-[(2R,4R)-5-Bromo-1-hydroxypenta-3,4-dien-2-yl] benzamide (9a), 2.1.4 (3aS,6aS)-6-Methylene-2-phenyl-3a,4,6,6a -tetrahydrofuro[3,4-d]oxazole (8)2.1.5 (R)-N-[5-(Methoxymethyl)-2,3-dihydrofuran-3-yl] benzamide (13a); 2.1.6 (R)-N-{5-[(2,2,2-Trifluoroethoxy)methyl] -2,3-dihydrofuran-3-yl}benzamide (13b); 2.1.7 N-(5-Methylfuran-3-yl)benzamide (14); 2.1.8 tert-Butyl (R)-4-[(S)-3-Bromopropa-1,2-dienyl]-2, 2-dimethyloxazolidine-3-carboxylate (12b); 2.1.9 N-[(2R,4S)-5-Bromo-1-hydroxypenta -3,4-dien-2-yl]benzamide (9b); 2.1.10 [(3aS,6S,6aS)-2-Phenyl-3a,4,6,6a-tetrahydrofuro [3,4-d]oxazol-6-yl]methanol (15), 2.1.11 (3aS,6S,6aS)-2-Phenyl-6-tetradecyl-3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (16)2.1.12 (3aS,6S,6aS)-2-Phenyl-6-(3-phenylpropyl) -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17a); 2.1.13 (3aS,6S,6aS)-6-Ethyl-2-phenyl-3a,4,6, 6a-tetrahydrofuro[3,4-d]oxazole (17b); 2.1.14 (3aS,6S,6aS)-6-Isobutyl-2-phenyl-3a,4,6, 6a-tetrahydrofuro[3,4-d]oxazole (17c); 2.1.15 (3aS,6S,6aS)-6-(2-Methylallyl)-2-phenyl -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17d); 2.1.16 (1S,4S,7S)-5-(4-Phenylhepta-1,6-dien-4-yl) -2-oxa-5-azabicyclo[2.2.1]heptan-7-ol (18), 2.1.17 (3aS,6S,6aS)-6-(But-3-enyl)-2-phenyl -3a,4,6,6a-tetrahydrofuro[3,4-d]oxazole (17e)References; 3 Total Synthesis through Palladium-Catalyzed Bis-Cyclization of Propargyl Chlorides and Carbonates; Abstract; 3.1…Experimental Section; 3.1.1 General Methods; 3.1.2 tert-Butyl (S)-4-[(S)-1-Hydroxyhexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-6); 3.1.3 tert-Butyl (S)-4-[(R)-1-Hydroxyhexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-6); 3.1.4 tert-Butyl (S)-4-[(S)-1-(Methoxycarbonyloxy)hexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-7), 3.1.5 tert-Butyl (S)-4-[(R)-1-(Methoxycarbonyloxy)hexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-7)3.1.6 (2S,3S)-2-Benzamido-1-hydroxyoctadec-4-yn-3-yl Methyl Carbonate (syn-8); 3.1.7 (2S,3R)-2-Benzamido-1-hydroxyoctadec-4-yn-3-yl Methyl Carbonate (anti-8); 3.1.8 tert-Butyl (S)-4-[(R)-1-Chlorohexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (syn-9); 3.1.9 tert-Butyl (S)-4-[(S)-1-Chlorohexadec-2-yn-1-yl]-2,2-dimethyloxazolidine-3-carboxylate (anti-9); 3.1.10 N-[(2S,3R)-3-Chloro-1-hydroxyoctadec-4-yn-2-yl]benzamide (syn-12), 3.1.11 N-[(2S,3S)-3-Chloro-1-hydroxyoctadec-4-yn-2-yl]benzamide (anti-12), The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26 per cent overall yield in seven steps), lysergic acid (4.0 per cent overall yield in fifteen steps), lysergol (3.6 per cent overall yield in fifteen steps) and isolysergol (8.2 per cent overall yield in eleven steps) have been achieved. These are, Bioorganic chemistry, Catalysis, Chemistry
swb_id_str 355115832
title Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
title_auth Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
title_full Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds by Shinsuke Inuki
title_fullStr Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds by Shinsuke Inuki
title_full_unstemmed Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds by Shinsuke Inuki
title_short Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
title_sort total synthesis of bioactive natural products by palladium-catalyzed domino cyclization of allenes and related compounds
title_unstemmed Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
topic Bioorganic chemistry, Catalysis, Chemistry
topic_facet Bioorganic chemistry, Catalysis, Chemistry
url https://doi.org/10.1007/978-4-431-54043-4, http://dx.doi.org/10.1007/978-4-431-54043-4, https://swbplus.bsz-bw.de/bsz355115832cov.jpg
work_keys_str_mv AT inukishinsuke totalsynthesisofbioactivenaturalproductsbypalladiumcatalyzeddominocyclizationofallenesandrelatedcompounds