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Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
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| Titel: | Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds/ by Shinsuke Inuki |
| Format: | E-Book |
| Sprache: | Englisch |
| veröffentlicht: |
Tokyo
Springer Tokyo
2012
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| Gesamtaufnahme: |
Springer Theses SpringerLink |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB |
| Zugangsinformationen: | Elektronischer Volltext - Campuslizenz |
| Zusammenfassung: |
The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26 per cent overall yield in seven steps), lysergic acid (4.0 per cent overall yield in fifteen steps), lysergol (3.6 per cent overall yield in fifteen steps) and isolysergol (8.2 per cent overall yield in eleven steps) have been achieved. These are The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26 per cent overall yield in seven steps), lysergic acid (4.0 per cent overall yield in fifteen steps), lysergol (3.6 per cent overall yield in fifteen steps) and isolysergol (8.2 per cent overall yield in eleven steps) have been achieved. These are |
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| Beschreibung: | Description based upon print version of record |
| Umfang: | Online-Ressource (XVI, 106p. 66 illus, digital) |
| ISBN: |
9784431540434
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| DOI: | 10.1007/978-4-431-54043-4 |