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Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas
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| Zeitschriftentitel: | Technology in Cancer Research & Treatment |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Technology in Cancer Research & Treatment, 13, 2014, 1, S. 11-19 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Zorlu, F. Gultekin, M. Cengiz, M. Yildiz, F. Akyol, F. Gurkaynak, M. Ozyigit, G. Zorlu, F. Gultekin, M. Cengiz, M. Yildiz, F. Akyol, F. Gurkaynak, M. Ozyigit, G. |
|---|---|
| author |
Zorlu, F. Gultekin, M. Cengiz, M. Yildiz, F. Akyol, F. Gurkaynak, M. Ozyigit, G. |
| spellingShingle |
Zorlu, F. Gultekin, M. Cengiz, M. Yildiz, F. Akyol, F. Gurkaynak, M. Ozyigit, G. Technology in Cancer Research & Treatment Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas Cancer Research Oncology |
| author_sort |
zorlu, f. |
| spelling |
Zorlu, F. Gultekin, M. Cengiz, M. Yildiz, F. Akyol, F. Gurkaynak, M. Ozyigit, G. 1533-0346 1533-0338 SAGE Publications Cancer Research Oncology http://dx.doi.org/10.7785/tcrt.2012.500354 <jats:p> Chordomas are uncommon neoplasms and there is still controversy regarding establishment of diagnosis and management. The aim of this study was to evaluate efficacy and toxicity of fractionated stereotactic radiosurgery (FSRS) in skull base chordomas. There were 4 female (36%) and 7 male (64%) patients. FSRS was delivered with CyberKnife (Accuray Inc., Sunnyvale, CA). The median tumor volume was 14.7 cc (range, 3.9–40.5 cc). The median marginal tumor dose was 30 Gy (range, 20–36 Gy) in a median 5 fractions (range, 3–5 fractions). The median follow-up time was 42 months (range, 17–63 months). At the time of analysis, 10 (91%) patients were alive and 1 (9%) had died due to tumor progression. Of 10 patients, 8 (73%) had stable disease and the remaining 2 (18%) had progressive disease. The actuarial overall survival (OS) after FSRS was 91% at two-years. Two patients developed radiation-induced brain necrosis as a complication in the 8<jats:sup>th</jats:sup> and 28<jats:sup>th</jats:sup> months of follow-up, respectively. Our results with robotic FSRS in skull base chordomas are promising for selected patients. However, due to the slow growth pattern of skull base chordomas, a longer follow-up is required to determine exact treatment results and late morbidity. </jats:p> Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas Technology in Cancer Research & Treatment |
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| title |
Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_unstemmed |
Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_full |
Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_fullStr |
Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_full_unstemmed |
Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_short |
Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_sort |
fractionated stereotactic radiosurgery treatment results for skull base chordomas |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.7785/tcrt.2012.500354 |
| publishDate |
2014 |
| physical |
11-19 |
| description |
<jats:p> Chordomas are uncommon neoplasms and there is still controversy regarding establishment of diagnosis and management. The aim of this study was to evaluate efficacy and toxicity of fractionated stereotactic radiosurgery (FSRS) in skull base chordomas. There were 4 female (36%) and 7 male (64%) patients. FSRS was delivered with CyberKnife (Accuray Inc., Sunnyvale, CA). The median tumor volume was 14.7 cc (range, 3.9–40.5 cc). The median marginal tumor dose was 30 Gy (range, 20–36 Gy) in a median 5 fractions (range, 3–5 fractions). The median follow-up time was 42 months (range, 17–63 months). At the time of analysis, 10 (91%) patients were alive and 1 (9%) had died due to tumor progression. Of 10 patients, 8 (73%) had stable disease and the remaining 2 (18%) had progressive disease. The actuarial overall survival (OS) after FSRS was 91% at two-years. Two patients developed radiation-induced brain necrosis as a complication in the 8<jats:sup>th</jats:sup> and 28<jats:sup>th</jats:sup> months of follow-up, respectively. Our results with robotic FSRS in skull base chordomas are promising for selected patients. However, due to the slow growth pattern of skull base chordomas, a longer follow-up is required to determine exact treatment results and late morbidity. </jats:p> |
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| author | Zorlu, F., Gultekin, M., Cengiz, M., Yildiz, F., Akyol, F., Gurkaynak, M., Ozyigit, G. |
| author_facet | Zorlu, F., Gultekin, M., Cengiz, M., Yildiz, F., Akyol, F., Gurkaynak, M., Ozyigit, G., Zorlu, F., Gultekin, M., Cengiz, M., Yildiz, F., Akyol, F., Gurkaynak, M., Ozyigit, G. |
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| description | <jats:p> Chordomas are uncommon neoplasms and there is still controversy regarding establishment of diagnosis and management. The aim of this study was to evaluate efficacy and toxicity of fractionated stereotactic radiosurgery (FSRS) in skull base chordomas. There were 4 female (36%) and 7 male (64%) patients. FSRS was delivered with CyberKnife (Accuray Inc., Sunnyvale, CA). The median tumor volume was 14.7 cc (range, 3.9–40.5 cc). The median marginal tumor dose was 30 Gy (range, 20–36 Gy) in a median 5 fractions (range, 3–5 fractions). The median follow-up time was 42 months (range, 17–63 months). At the time of analysis, 10 (91%) patients were alive and 1 (9%) had died due to tumor progression. Of 10 patients, 8 (73%) had stable disease and the remaining 2 (18%) had progressive disease. The actuarial overall survival (OS) after FSRS was 91% at two-years. Two patients developed radiation-induced brain necrosis as a complication in the 8<jats:sup>th</jats:sup> and 28<jats:sup>th</jats:sup> months of follow-up, respectively. Our results with robotic FSRS in skull base chordomas are promising for selected patients. However, due to the slow growth pattern of skull base chordomas, a longer follow-up is required to determine exact treatment results and late morbidity. </jats:p> |
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| spelling | Zorlu, F. Gultekin, M. Cengiz, M. Yildiz, F. Akyol, F. Gurkaynak, M. Ozyigit, G. 1533-0346 1533-0338 SAGE Publications Cancer Research Oncology http://dx.doi.org/10.7785/tcrt.2012.500354 <jats:p> Chordomas are uncommon neoplasms and there is still controversy regarding establishment of diagnosis and management. The aim of this study was to evaluate efficacy and toxicity of fractionated stereotactic radiosurgery (FSRS) in skull base chordomas. There were 4 female (36%) and 7 male (64%) patients. FSRS was delivered with CyberKnife (Accuray Inc., Sunnyvale, CA). The median tumor volume was 14.7 cc (range, 3.9–40.5 cc). The median marginal tumor dose was 30 Gy (range, 20–36 Gy) in a median 5 fractions (range, 3–5 fractions). The median follow-up time was 42 months (range, 17–63 months). At the time of analysis, 10 (91%) patients were alive and 1 (9%) had died due to tumor progression. Of 10 patients, 8 (73%) had stable disease and the remaining 2 (18%) had progressive disease. The actuarial overall survival (OS) after FSRS was 91% at two-years. Two patients developed radiation-induced brain necrosis as a complication in the 8<jats:sup>th</jats:sup> and 28<jats:sup>th</jats:sup> months of follow-up, respectively. Our results with robotic FSRS in skull base chordomas are promising for selected patients. However, due to the slow growth pattern of skull base chordomas, a longer follow-up is required to determine exact treatment results and late morbidity. </jats:p> Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas Technology in Cancer Research & Treatment |
| spellingShingle | Zorlu, F., Gultekin, M., Cengiz, M., Yildiz, F., Akyol, F., Gurkaynak, M., Ozyigit, G., Technology in Cancer Research & Treatment, Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas, Cancer Research, Oncology |
| title | Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_full | Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_fullStr | Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_full_unstemmed | Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_short | Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| title_sort | fractionated stereotactic radiosurgery treatment results for skull base chordomas |
| title_unstemmed | Fractionated Stereotactic Radiosurgery Treatment Results for Skull Base Chordomas |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.7785/tcrt.2012.500354 |