Eintrag weiter verarbeiten
Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment
Gespeichert in:
| Zeitschriftentitel: | Stem Cells Translational Medicine |
|---|---|
| Personen und Körperschaften: | , |
| In: | Stem Cells Translational Medicine, 2, 2013, 1, S. 25-32 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Sung, Anthony D. Chao, Nelson J. Sung, Anthony D. Chao, Nelson J. |
|---|---|
| author |
Sung, Anthony D. Chao, Nelson J. |
| spellingShingle |
Sung, Anthony D. Chao, Nelson J. Stem Cells Translational Medicine Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment Cell Biology Developmental Biology General Medicine |
| author_sort |
sung, anthony d. |
| spelling |
Sung, Anthony D. Chao, Nelson J. 2157-6564 2157-6580 Oxford University Press (OUP) Cell Biology Developmental Biology General Medicine http://dx.doi.org/10.5966/sctm.2012-0115 <jats:title>Abstract</jats:title><jats:p>Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplant (AHSCT) associated with significant morbidity and mortality. This review focuses on the pathophysiology, clinical features, prevention, and treatment of acute GVHD. Specifically, we explain how new discoveries in immunology have expanded our understanding of GVHD, in which tissue damage from chemotherapy or radiation results in cytokine release, which activates T cells, resulting in proliferation and differentiation, trafficking to target organs, and tissue destruction and inflammation. Insights into the mechanisms of this disease relate directly to the development of preventive strategies and therapies, such as immunosuppression, T-cell depletion, calcineurin inhibitors, CCR5 antagonists, gut decontamination, extracorporeal photopheresis, and more. We also discuss how GVHD affects the gut, liver, and skin, as well as diagnosis, grading, and scoring. We end by examining future directions of treatment, including new immunomodulators and biomarkers. Understanding the immunobiology of GVHD and developing effective preventions and treatments are critical to the continuing success of AHSCT.</jats:p> Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment Stem Cells Translational Medicine |
| doi_str_mv |
10.5966/sctm.2012-0115 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNTk2Ni9zY3RtLjIwMTItMDExNQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNTk2Ni9zY3RtLjIwMTItMDExNQ |
| institution |
DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 |
| imprint |
Oxford University Press (OUP), 2013 |
| imprint_str_mv |
Oxford University Press (OUP), 2013 |
| issn |
2157-6564 2157-6580 |
| issn_str_mv |
2157-6564 2157-6580 |
| language |
English |
| mega_collection |
Oxford University Press (OUP) (CrossRef) |
| match_str |
sung2013concisereviewacutegraftversushostdiseaseimmunobiologypreventionandtreatment |
| publishDateSort |
2013 |
| publisher |
Oxford University Press (OUP) |
| recordtype |
ai |
| record_format |
ai |
| series |
Stem Cells Translational Medicine |
| source_id |
49 |
| title |
Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_unstemmed |
Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_full |
Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_fullStr |
Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_full_unstemmed |
Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_short |
Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_sort |
concise review: acute graft-versus-host disease: immunobiology, prevention, and treatment |
| topic |
Cell Biology Developmental Biology General Medicine |
| url |
http://dx.doi.org/10.5966/sctm.2012-0115 |
| publishDate |
2013 |
| physical |
25-32 |
| description |
<jats:title>Abstract</jats:title><jats:p>Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplant (AHSCT) associated with significant morbidity and mortality. This review focuses on the pathophysiology, clinical features, prevention, and treatment of acute GVHD. Specifically, we explain how new discoveries in immunology have expanded our understanding of GVHD, in which tissue damage from chemotherapy or radiation results in cytokine release, which activates T cells, resulting in proliferation and differentiation, trafficking to target organs, and tissue destruction and inflammation. Insights into the mechanisms of this disease relate directly to the development of preventive strategies and therapies, such as immunosuppression, T-cell depletion, calcineurin inhibitors, CCR5 antagonists, gut decontamination, extracorporeal photopheresis, and more. We also discuss how GVHD affects the gut, liver, and skin, as well as diagnosis, grading, and scoring. We end by examining future directions of treatment, including new immunomodulators and biomarkers. Understanding the immunobiology of GVHD and developing effective preventions and treatments are critical to the continuing success of AHSCT.</jats:p> |
| container_issue |
1 |
| container_start_page |
25 |
| container_title |
Stem Cells Translational Medicine |
| container_volume |
2 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792343374876901381 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T16:50:31.36Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Concise+Review%3A+Acute+Graft-Versus-Host+Disease%3A+Immunobiology%2C+Prevention%2C+and+Treatment&rft.date=2013-01-01&genre=article&issn=2157-6580&volume=2&issue=1&spage=25&epage=32&pages=25-32&jtitle=Stem+Cells+Translational+Medicine&atitle=Concise+Review%3A+Acute+Graft-Versus-Host+Disease%3A+Immunobiology%2C+Prevention%2C+and+Treatment&aulast=Chao&aufirst=Nelson+J.&rft_id=info%3Adoi%2F10.5966%2Fsctm.2012-0115&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792343374876901381 |
| author | Sung, Anthony D., Chao, Nelson J. |
| author_facet | Sung, Anthony D., Chao, Nelson J., Sung, Anthony D., Chao, Nelson J. |
| author_sort | sung, anthony d. |
| container_issue | 1 |
| container_start_page | 25 |
| container_title | Stem Cells Translational Medicine |
| container_volume | 2 |
| description | <jats:title>Abstract</jats:title><jats:p>Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplant (AHSCT) associated with significant morbidity and mortality. This review focuses on the pathophysiology, clinical features, prevention, and treatment of acute GVHD. Specifically, we explain how new discoveries in immunology have expanded our understanding of GVHD, in which tissue damage from chemotherapy or radiation results in cytokine release, which activates T cells, resulting in proliferation and differentiation, trafficking to target organs, and tissue destruction and inflammation. Insights into the mechanisms of this disease relate directly to the development of preventive strategies and therapies, such as immunosuppression, T-cell depletion, calcineurin inhibitors, CCR5 antagonists, gut decontamination, extracorporeal photopheresis, and more. We also discuss how GVHD affects the gut, liver, and skin, as well as diagnosis, grading, and scoring. We end by examining future directions of treatment, including new immunomodulators and biomarkers. Understanding the immunobiology of GVHD and developing effective preventions and treatments are critical to the continuing success of AHSCT.</jats:p> |
| doi_str_mv | 10.5966/sctm.2012-0115 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNTk2Ni9zY3RtLjIwMTItMDExNQ |
| imprint | Oxford University Press (OUP), 2013 |
| imprint_str_mv | Oxford University Press (OUP), 2013 |
| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
| issn | 2157-6564, 2157-6580 |
| issn_str_mv | 2157-6564, 2157-6580 |
| language | English |
| last_indexed | 2024-03-01T16:50:31.36Z |
| match_str | sung2013concisereviewacutegraftversushostdiseaseimmunobiologypreventionandtreatment |
| mega_collection | Oxford University Press (OUP) (CrossRef) |
| physical | 25-32 |
| publishDate | 2013 |
| publishDateSort | 2013 |
| publisher | Oxford University Press (OUP) |
| record_format | ai |
| recordtype | ai |
| series | Stem Cells Translational Medicine |
| source_id | 49 |
| spelling | Sung, Anthony D. Chao, Nelson J. 2157-6564 2157-6580 Oxford University Press (OUP) Cell Biology Developmental Biology General Medicine http://dx.doi.org/10.5966/sctm.2012-0115 <jats:title>Abstract</jats:title><jats:p>Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplant (AHSCT) associated with significant morbidity and mortality. This review focuses on the pathophysiology, clinical features, prevention, and treatment of acute GVHD. Specifically, we explain how new discoveries in immunology have expanded our understanding of GVHD, in which tissue damage from chemotherapy or radiation results in cytokine release, which activates T cells, resulting in proliferation and differentiation, trafficking to target organs, and tissue destruction and inflammation. Insights into the mechanisms of this disease relate directly to the development of preventive strategies and therapies, such as immunosuppression, T-cell depletion, calcineurin inhibitors, CCR5 antagonists, gut decontamination, extracorporeal photopheresis, and more. We also discuss how GVHD affects the gut, liver, and skin, as well as diagnosis, grading, and scoring. We end by examining future directions of treatment, including new immunomodulators and biomarkers. Understanding the immunobiology of GVHD and developing effective preventions and treatments are critical to the continuing success of AHSCT.</jats:p> Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment Stem Cells Translational Medicine |
| spellingShingle | Sung, Anthony D., Chao, Nelson J., Stem Cells Translational Medicine, Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment, Cell Biology, Developmental Biology, General Medicine |
| title | Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_full | Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_fullStr | Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_full_unstemmed | Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_short | Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| title_sort | concise review: acute graft-versus-host disease: immunobiology, prevention, and treatment |
| title_unstemmed | Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment |
| topic | Cell Biology, Developmental Biology, General Medicine |
| url | http://dx.doi.org/10.5966/sctm.2012-0115 |