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Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression
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| Zeitschriftentitel: | Stem Cells Translational Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , |
| In: | Stem Cells Translational Medicine, 2, 2013, 8, S. 595-606 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Eggenhofer, Elke Popp, Felix C. Mendicino, Michael Silber, Paula van't Hof, Wouter Renner, Philipp Hoogduijn, Martin J. Pinxteren, Jef van Rooijen, Nico Geissler, Edward K. Deans, Robert Schlitt, Hans J. Dahlke, Marc H. Eggenhofer, Elke Popp, Felix C. Mendicino, Michael Silber, Paula van't Hof, Wouter Renner, Philipp Hoogduijn, Martin J. Pinxteren, Jef van Rooijen, Nico Geissler, Edward K. Deans, Robert Schlitt, Hans J. Dahlke, Marc H. |
|---|---|
| author |
Eggenhofer, Elke Popp, Felix C. Mendicino, Michael Silber, Paula van't Hof, Wouter Renner, Philipp Hoogduijn, Martin J. Pinxteren, Jef van Rooijen, Nico Geissler, Edward K. Deans, Robert Schlitt, Hans J. Dahlke, Marc H. |
| spellingShingle |
Eggenhofer, Elke Popp, Felix C. Mendicino, Michael Silber, Paula van't Hof, Wouter Renner, Philipp Hoogduijn, Martin J. Pinxteren, Jef van Rooijen, Nico Geissler, Edward K. Deans, Robert Schlitt, Hans J. Dahlke, Marc H. Stem Cells Translational Medicine Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression Cell Biology Developmental Biology General Medicine |
| author_sort |
eggenhofer, elke |
| spelling |
Eggenhofer, Elke Popp, Felix C. Mendicino, Michael Silber, Paula van't Hof, Wouter Renner, Philipp Hoogduijn, Martin J. Pinxteren, Jef van Rooijen, Nico Geissler, Edward K. Deans, Robert Schlitt, Hans J. Dahlke, Marc H. 2157-6564 2157-6580 Oxford University Press (OUP) Cell Biology Developmental Biology General Medicine http://dx.doi.org/10.5966/sctm.2012-0166 <jats:title>Abstract</jats:title> <jats:p>Multipotent adult progenitor cells (MAPCs) are an adherent stem cell population that belongs to the mesenchymal-type progenitor cell family. Although MAPCs are emerging as candidate agents for immunomodulation after solid organ transplantation, their value requires further validation in a clinically relevant cell therapy model using an organ donor- and organ recipient-independent, third-party cell product. We report that stable allograft survival can be achieved following third-party MAPC infusion in a rat model of fully allogeneic, heterotopic heart transplantation. Furthermore, long-term accepted heart grafts recovered from MAPC-treated animals can be successfully retransplanted to naïve animals without additional immunosuppression. This prolongation of MAPC-mediated allograft acceptance depends upon a myeloid cell population since depletion of macrophages by clodronate abrogates the tolerogenic MAPC effect. We also show that MAPC-mediated allograft acceptance differs mechanistically from drug-induced tolerance regarding marker gene expression, T regulatory cell induction, retransplantability, and macrophage dependence. MAPC-based immunomodulation represents a promising pathway for clinical immunotherapy that has led us to initiate a phase I clinical trial for testing safety and feasibility of third-party MAPC therapy after liver transplantation.</jats:p> Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression Stem Cells Translational Medicine |
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| title |
Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_unstemmed |
Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_full |
Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_fullStr |
Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_full_unstemmed |
Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_short |
Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_sort |
heart grafts tolerized through third-party multipotent adult progenitor cells can be retransplanted to secondary hosts with no immunosuppression |
| topic |
Cell Biology Developmental Biology General Medicine |
| url |
http://dx.doi.org/10.5966/sctm.2012-0166 |
| publishDate |
2013 |
| physical |
595-606 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Multipotent adult progenitor cells (MAPCs) are an adherent stem cell population that belongs to the mesenchymal-type progenitor cell family. Although MAPCs are emerging as candidate agents for immunomodulation after solid organ transplantation, their value requires further validation in a clinically relevant cell therapy model using an organ donor- and organ recipient-independent, third-party cell product. We report that stable allograft survival can be achieved following third-party MAPC infusion in a rat model of fully allogeneic, heterotopic heart transplantation. Furthermore, long-term accepted heart grafts recovered from MAPC-treated animals can be successfully retransplanted to naïve animals without additional immunosuppression. This prolongation of MAPC-mediated allograft acceptance depends upon a myeloid cell population since depletion of macrophages by clodronate abrogates the tolerogenic MAPC effect. We also show that MAPC-mediated allograft acceptance differs mechanistically from drug-induced tolerance regarding marker gene expression, T regulatory cell induction, retransplantability, and macrophage dependence. MAPC-based immunomodulation represents a promising pathway for clinical immunotherapy that has led us to initiate a phase I clinical trial for testing safety and feasibility of third-party MAPC therapy after liver transplantation.</jats:p> |
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| author | Eggenhofer, Elke, Popp, Felix C., Mendicino, Michael, Silber, Paula, van't Hof, Wouter, Renner, Philipp, Hoogduijn, Martin J., Pinxteren, Jef, van Rooijen, Nico, Geissler, Edward K., Deans, Robert, Schlitt, Hans J., Dahlke, Marc H. |
| author_facet | Eggenhofer, Elke, Popp, Felix C., Mendicino, Michael, Silber, Paula, van't Hof, Wouter, Renner, Philipp, Hoogduijn, Martin J., Pinxteren, Jef, van Rooijen, Nico, Geissler, Edward K., Deans, Robert, Schlitt, Hans J., Dahlke, Marc H., Eggenhofer, Elke, Popp, Felix C., Mendicino, Michael, Silber, Paula, van't Hof, Wouter, Renner, Philipp, Hoogduijn, Martin J., Pinxteren, Jef, van Rooijen, Nico, Geissler, Edward K., Deans, Robert, Schlitt, Hans J., Dahlke, Marc H. |
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| description | <jats:title>Abstract</jats:title> <jats:p>Multipotent adult progenitor cells (MAPCs) are an adherent stem cell population that belongs to the mesenchymal-type progenitor cell family. Although MAPCs are emerging as candidate agents for immunomodulation after solid organ transplantation, their value requires further validation in a clinically relevant cell therapy model using an organ donor- and organ recipient-independent, third-party cell product. We report that stable allograft survival can be achieved following third-party MAPC infusion in a rat model of fully allogeneic, heterotopic heart transplantation. Furthermore, long-term accepted heart grafts recovered from MAPC-treated animals can be successfully retransplanted to naïve animals without additional immunosuppression. This prolongation of MAPC-mediated allograft acceptance depends upon a myeloid cell population since depletion of macrophages by clodronate abrogates the tolerogenic MAPC effect. We also show that MAPC-mediated allograft acceptance differs mechanistically from drug-induced tolerance regarding marker gene expression, T regulatory cell induction, retransplantability, and macrophage dependence. MAPC-based immunomodulation represents a promising pathway for clinical immunotherapy that has led us to initiate a phase I clinical trial for testing safety and feasibility of third-party MAPC therapy after liver transplantation.</jats:p> |
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| spelling | Eggenhofer, Elke Popp, Felix C. Mendicino, Michael Silber, Paula van't Hof, Wouter Renner, Philipp Hoogduijn, Martin J. Pinxteren, Jef van Rooijen, Nico Geissler, Edward K. Deans, Robert Schlitt, Hans J. Dahlke, Marc H. 2157-6564 2157-6580 Oxford University Press (OUP) Cell Biology Developmental Biology General Medicine http://dx.doi.org/10.5966/sctm.2012-0166 <jats:title>Abstract</jats:title> <jats:p>Multipotent adult progenitor cells (MAPCs) are an adherent stem cell population that belongs to the mesenchymal-type progenitor cell family. Although MAPCs are emerging as candidate agents for immunomodulation after solid organ transplantation, their value requires further validation in a clinically relevant cell therapy model using an organ donor- and organ recipient-independent, third-party cell product. We report that stable allograft survival can be achieved following third-party MAPC infusion in a rat model of fully allogeneic, heterotopic heart transplantation. Furthermore, long-term accepted heart grafts recovered from MAPC-treated animals can be successfully retransplanted to naïve animals without additional immunosuppression. This prolongation of MAPC-mediated allograft acceptance depends upon a myeloid cell population since depletion of macrophages by clodronate abrogates the tolerogenic MAPC effect. We also show that MAPC-mediated allograft acceptance differs mechanistically from drug-induced tolerance regarding marker gene expression, T regulatory cell induction, retransplantability, and macrophage dependence. MAPC-based immunomodulation represents a promising pathway for clinical immunotherapy that has led us to initiate a phase I clinical trial for testing safety and feasibility of third-party MAPC therapy after liver transplantation.</jats:p> Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression Stem Cells Translational Medicine |
| spellingShingle | Eggenhofer, Elke, Popp, Felix C., Mendicino, Michael, Silber, Paula, van't Hof, Wouter, Renner, Philipp, Hoogduijn, Martin J., Pinxteren, Jef, van Rooijen, Nico, Geissler, Edward K., Deans, Robert, Schlitt, Hans J., Dahlke, Marc H., Stem Cells Translational Medicine, Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression, Cell Biology, Developmental Biology, General Medicine |
| title | Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_full | Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_fullStr | Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_full_unstemmed | Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_short | Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| title_sort | heart grafts tolerized through third-party multipotent adult progenitor cells can be retransplanted to secondary hosts with no immunosuppression |
| title_unstemmed | Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression |
| topic | Cell Biology, Developmental Biology, General Medicine |
| url | http://dx.doi.org/10.5966/sctm.2012-0166 |