Eintrag weiter verarbeiten
Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα
Gespeichert in:
| Zeitschriftentitel: | The Journal of Immunology |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | The Journal of Immunology, 168, 2002, 5, S. 2127-2138 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The American Association of Immunologists
|
| Schlagwörter: |
| author_facet |
Siemasko, Karyn Skaggs, Brian J. Kabak, Shara Williamson, Edward Brown, Bruce K. Song, Wenxia Clark, Marcus R. Siemasko, Karyn Skaggs, Brian J. Kabak, Shara Williamson, Edward Brown, Bruce K. Song, Wenxia Clark, Marcus R. |
|---|---|
| author |
Siemasko, Karyn Skaggs, Brian J. Kabak, Shara Williamson, Edward Brown, Bruce K. Song, Wenxia Clark, Marcus R. |
| spellingShingle |
Siemasko, Karyn Skaggs, Brian J. Kabak, Shara Williamson, Edward Brown, Bruce K. Song, Wenxia Clark, Marcus R. The Journal of Immunology Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα Immunology Immunology and Allergy |
| author_sort |
siemasko, karyn |
| spelling |
Siemasko, Karyn Skaggs, Brian J. Kabak, Shara Williamson, Edward Brown, Bruce K. Song, Wenxia Clark, Marcus R. 0022-1767 1550-6606 The American Association of Immunologists Immunology Immunology and Allergy http://dx.doi.org/10.4049/jimmunol.168.5.2127 <jats:title>Abstract</jats:title> <jats:p>Ags that cross-link the B cell Ag receptor are preferentially and rapidly delivered to the MHC class II-enriched compartment for processing into peptides and subsequent loading onto MHC class II. Proper sorting of Ag/receptor complexes requires the recruitment of Syk to the phosphorylated immunoreceptor tyrosine-based activation motif tyrosines of the B cell Ag receptor constituent Igα. We postulated that the Igα nonimmunoreceptor tyrosine-based activation motif tyrosines, Y176 and Y204, contributed to receptor trafficking. Igα(YΔF176,204)/Igβ receptors were targeted to late endosomes, but were excluded from the vesicle lumen and could not facilitate the presentation of Ag to T cells. Subsequent analysis demonstrated that phosphorylation of Y176/Y204 recruited the B cell linker protein, Vav, and Grb2. Reconstitution of Igα(YΔF176,204)/Igβ with the B cell linker protein rescued both receptor-facilitated Ag presentation and entry into the MHC class II-enriched compartment. Thus, aggregation accelerates receptor trafficking by recruiting two separate signaling modules required for transit through sequential checkpoints.</jats:p> Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα The Journal of Immunology |
| doi_str_mv |
10.4049/jimmunol.168.5.2127 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNDA0OS9qaW1tdW5vbC4xNjguNS4yMTI3 |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNDA0OS9qaW1tdW5vbC4xNjguNS4yMTI3 |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
The American Association of Immunologists, 2002 |
| imprint_str_mv |
The American Association of Immunologists, 2002 |
| issn |
0022-1767 1550-6606 |
| issn_str_mv |
0022-1767 1550-6606 |
| language |
English |
| mega_collection |
The American Association of Immunologists (CrossRef) |
| match_str |
siemasko2002receptorfacilitatedantigenpresentationrequirestherecruitmentofbcelllinkerproteintoiga |
| publishDateSort |
2002 |
| publisher |
The American Association of Immunologists |
| recordtype |
ai |
| record_format |
ai |
| series |
The Journal of Immunology |
| source_id |
49 |
| title |
Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_unstemmed |
Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_full |
Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_fullStr |
Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_full_unstemmed |
Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_short |
Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_sort |
receptor-facilitated antigen presentation requires the recruitment of b cell linker protein to igα |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.4049/jimmunol.168.5.2127 |
| publishDate |
2002 |
| physical |
2127-2138 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Ags that cross-link the B cell Ag receptor are preferentially and rapidly delivered to the MHC class II-enriched compartment for processing into peptides and subsequent loading onto MHC class II. Proper sorting of Ag/receptor complexes requires the recruitment of Syk to the phosphorylated immunoreceptor tyrosine-based activation motif tyrosines of the B cell Ag receptor constituent Igα. We postulated that the Igα nonimmunoreceptor tyrosine-based activation motif tyrosines, Y176 and Y204, contributed to receptor trafficking. Igα(YΔF176,204)/Igβ receptors were targeted to late endosomes, but were excluded from the vesicle lumen and could not facilitate the presentation of Ag to T cells. Subsequent analysis demonstrated that phosphorylation of Y176/Y204 recruited the B cell linker protein, Vav, and Grb2. Reconstitution of Igα(YΔF176,204)/Igβ with the B cell linker protein rescued both receptor-facilitated Ag presentation and entry into the MHC class II-enriched compartment. Thus, aggregation accelerates receptor trafficking by recruiting two separate signaling modules required for transit through sequential checkpoints.</jats:p> |
| container_issue |
5 |
| container_start_page |
2127 |
| container_title |
The Journal of Immunology |
| container_volume |
168 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792338736965484550 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:36:44.541Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Receptor-Facilitated+Antigen+Presentation+Requires+the+Recruitment+of+B+Cell+Linker+Protein+to+Ig%CE%B1&rft.date=2002-03-01&genre=article&issn=1550-6606&volume=168&issue=5&spage=2127&epage=2138&pages=2127-2138&jtitle=The+Journal+of+Immunology&atitle=Receptor-Facilitated+Antigen+Presentation+Requires+the+Recruitment+of+B+Cell+Linker+Protein+to+Ig%CE%B1&aulast=Clark&aufirst=Marcus+R.&rft_id=info%3Adoi%2F10.4049%2Fjimmunol.168.5.2127&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792338736965484550 |
| author | Siemasko, Karyn, Skaggs, Brian J., Kabak, Shara, Williamson, Edward, Brown, Bruce K., Song, Wenxia, Clark, Marcus R. |
| author_facet | Siemasko, Karyn, Skaggs, Brian J., Kabak, Shara, Williamson, Edward, Brown, Bruce K., Song, Wenxia, Clark, Marcus R., Siemasko, Karyn, Skaggs, Brian J., Kabak, Shara, Williamson, Edward, Brown, Bruce K., Song, Wenxia, Clark, Marcus R. |
| author_sort | siemasko, karyn |
| container_issue | 5 |
| container_start_page | 2127 |
| container_title | The Journal of Immunology |
| container_volume | 168 |
| description | <jats:title>Abstract</jats:title> <jats:p>Ags that cross-link the B cell Ag receptor are preferentially and rapidly delivered to the MHC class II-enriched compartment for processing into peptides and subsequent loading onto MHC class II. Proper sorting of Ag/receptor complexes requires the recruitment of Syk to the phosphorylated immunoreceptor tyrosine-based activation motif tyrosines of the B cell Ag receptor constituent Igα. We postulated that the Igα nonimmunoreceptor tyrosine-based activation motif tyrosines, Y176 and Y204, contributed to receptor trafficking. Igα(YΔF176,204)/Igβ receptors were targeted to late endosomes, but were excluded from the vesicle lumen and could not facilitate the presentation of Ag to T cells. Subsequent analysis demonstrated that phosphorylation of Y176/Y204 recruited the B cell linker protein, Vav, and Grb2. Reconstitution of Igα(YΔF176,204)/Igβ with the B cell linker protein rescued both receptor-facilitated Ag presentation and entry into the MHC class II-enriched compartment. Thus, aggregation accelerates receptor trafficking by recruiting two separate signaling modules required for transit through sequential checkpoints.</jats:p> |
| doi_str_mv | 10.4049/jimmunol.168.5.2127 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNDA0OS9qaW1tdW5vbC4xNjguNS4yMTI3 |
| imprint | The American Association of Immunologists, 2002 |
| imprint_str_mv | The American Association of Immunologists, 2002 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0022-1767, 1550-6606 |
| issn_str_mv | 0022-1767, 1550-6606 |
| language | English |
| last_indexed | 2024-03-01T15:36:44.541Z |
| match_str | siemasko2002receptorfacilitatedantigenpresentationrequirestherecruitmentofbcelllinkerproteintoiga |
| mega_collection | The American Association of Immunologists (CrossRef) |
| physical | 2127-2138 |
| publishDate | 2002 |
| publishDateSort | 2002 |
| publisher | The American Association of Immunologists |
| record_format | ai |
| recordtype | ai |
| series | The Journal of Immunology |
| source_id | 49 |
| spelling | Siemasko, Karyn Skaggs, Brian J. Kabak, Shara Williamson, Edward Brown, Bruce K. Song, Wenxia Clark, Marcus R. 0022-1767 1550-6606 The American Association of Immunologists Immunology Immunology and Allergy http://dx.doi.org/10.4049/jimmunol.168.5.2127 <jats:title>Abstract</jats:title> <jats:p>Ags that cross-link the B cell Ag receptor are preferentially and rapidly delivered to the MHC class II-enriched compartment for processing into peptides and subsequent loading onto MHC class II. Proper sorting of Ag/receptor complexes requires the recruitment of Syk to the phosphorylated immunoreceptor tyrosine-based activation motif tyrosines of the B cell Ag receptor constituent Igα. We postulated that the Igα nonimmunoreceptor tyrosine-based activation motif tyrosines, Y176 and Y204, contributed to receptor trafficking. Igα(YΔF176,204)/Igβ receptors were targeted to late endosomes, but were excluded from the vesicle lumen and could not facilitate the presentation of Ag to T cells. Subsequent analysis demonstrated that phosphorylation of Y176/Y204 recruited the B cell linker protein, Vav, and Grb2. Reconstitution of Igα(YΔF176,204)/Igβ with the B cell linker protein rescued both receptor-facilitated Ag presentation and entry into the MHC class II-enriched compartment. Thus, aggregation accelerates receptor trafficking by recruiting two separate signaling modules required for transit through sequential checkpoints.</jats:p> Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα The Journal of Immunology |
| spellingShingle | Siemasko, Karyn, Skaggs, Brian J., Kabak, Shara, Williamson, Edward, Brown, Bruce K., Song, Wenxia, Clark, Marcus R., The Journal of Immunology, Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα, Immunology, Immunology and Allergy |
| title | Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_full | Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_fullStr | Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_full_unstemmed | Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_short | Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| title_sort | receptor-facilitated antigen presentation requires the recruitment of b cell linker protein to igα |
| title_unstemmed | Receptor-Facilitated Antigen Presentation Requires the Recruitment of B Cell Linker Protein to Igα |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.4049/jimmunol.168.5.2127 |