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Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors
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| Zeitschriftentitel: | Sensors |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Sensors, 20, 2020, 8, S. 2420 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| Schlagwörter: |
| author_facet |
Stefan-van Staden, Raluca-Ioana Gheorghe, Damaris-Cristina Jinga, Viorel Sima, Cristian Sorin Geanta, Marius Stefan-van Staden, Raluca-Ioana Gheorghe, Damaris-Cristina Jinga, Viorel Sima, Cristian Sorin Geanta, Marius |
|---|---|
| author |
Stefan-van Staden, Raluca-Ioana Gheorghe, Damaris-Cristina Jinga, Viorel Sima, Cristian Sorin Geanta, Marius |
| spellingShingle |
Stefan-van Staden, Raluca-Ioana Gheorghe, Damaris-Cristina Jinga, Viorel Sima, Cristian Sorin Geanta, Marius Sensors Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors Electrical and Electronic Engineering Biochemistry Instrumentation Atomic and Molecular Physics, and Optics Analytical Chemistry |
| author_sort |
stefan-van staden, raluca-ioana |
| spelling |
Stefan-van Staden, Raluca-Ioana Gheorghe, Damaris-Cristina Jinga, Viorel Sima, Cristian Sorin Geanta, Marius 1424-8220 MDPI AG Electrical and Electronic Engineering Biochemistry Instrumentation Atomic and Molecular Physics, and Optics Analytical Chemistry http://dx.doi.org/10.3390/s20082420 <jats:p>Bladder cancer is one of the most common urologic malignancies, which is more frequent in men than in women. The early diagnosis for this type of cancer still remains a challenge, therefore, the development of a fast screening test for whole blood and tumor tissue samples may save lives. Four biomarkers, p53, E-cadherin, bladder tumor antigen (BTA), and hyaluronic acid were considered for the screening tests using stochastic needle sensors. Three stochastic needle sensors, based on graphite powder and modified with three types of chitosan, were designed and characterized for the screening test. The proposed sensors showed low limits of quantification, and high sensitivity and selectivity levels. The recoveries of p53, E-cadherin, BTA, and hyaluronic acid in whole blood samples and tissue samples were higher than 95.00% with a relative standard deviation lower than 1.00%.</jats:p> Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors Sensors |
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| title |
Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_unstemmed |
Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_full |
Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_fullStr |
Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_full_unstemmed |
Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_short |
Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_sort |
fast screening of whole blood and tumor tissue for bladder cancer biomarkers using stochastic needle sensors |
| topic |
Electrical and Electronic Engineering Biochemistry Instrumentation Atomic and Molecular Physics, and Optics Analytical Chemistry |
| url |
http://dx.doi.org/10.3390/s20082420 |
| publishDate |
2020 |
| physical |
2420 |
| description |
<jats:p>Bladder cancer is one of the most common urologic malignancies, which is more frequent in men than in women. The early diagnosis for this type of cancer still remains a challenge, therefore, the development of a fast screening test for whole blood and tumor tissue samples may save lives. Four biomarkers, p53, E-cadherin, bladder tumor antigen (BTA), and hyaluronic acid were considered for the screening tests using stochastic needle sensors. Three stochastic needle sensors, based on graphite powder and modified with three types of chitosan, were designed and characterized for the screening test. The proposed sensors showed low limits of quantification, and high sensitivity and selectivity levels. The recoveries of p53, E-cadherin, BTA, and hyaluronic acid in whole blood samples and tissue samples were higher than 95.00% with a relative standard deviation lower than 1.00%.</jats:p> |
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| author | Stefan-van Staden, Raluca-Ioana, Gheorghe, Damaris-Cristina, Jinga, Viorel, Sima, Cristian Sorin, Geanta, Marius |
| author_facet | Stefan-van Staden, Raluca-Ioana, Gheorghe, Damaris-Cristina, Jinga, Viorel, Sima, Cristian Sorin, Geanta, Marius, Stefan-van Staden, Raluca-Ioana, Gheorghe, Damaris-Cristina, Jinga, Viorel, Sima, Cristian Sorin, Geanta, Marius |
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| description | <jats:p>Bladder cancer is one of the most common urologic malignancies, which is more frequent in men than in women. The early diagnosis for this type of cancer still remains a challenge, therefore, the development of a fast screening test for whole blood and tumor tissue samples may save lives. Four biomarkers, p53, E-cadherin, bladder tumor antigen (BTA), and hyaluronic acid were considered for the screening tests using stochastic needle sensors. Three stochastic needle sensors, based on graphite powder and modified with three types of chitosan, were designed and characterized for the screening test. The proposed sensors showed low limits of quantification, and high sensitivity and selectivity levels. The recoveries of p53, E-cadherin, BTA, and hyaluronic acid in whole blood samples and tissue samples were higher than 95.00% with a relative standard deviation lower than 1.00%.</jats:p> |
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| spelling | Stefan-van Staden, Raluca-Ioana Gheorghe, Damaris-Cristina Jinga, Viorel Sima, Cristian Sorin Geanta, Marius 1424-8220 MDPI AG Electrical and Electronic Engineering Biochemistry Instrumentation Atomic and Molecular Physics, and Optics Analytical Chemistry http://dx.doi.org/10.3390/s20082420 <jats:p>Bladder cancer is one of the most common urologic malignancies, which is more frequent in men than in women. The early diagnosis for this type of cancer still remains a challenge, therefore, the development of a fast screening test for whole blood and tumor tissue samples may save lives. Four biomarkers, p53, E-cadherin, bladder tumor antigen (BTA), and hyaluronic acid were considered for the screening tests using stochastic needle sensors. Three stochastic needle sensors, based on graphite powder and modified with three types of chitosan, were designed and characterized for the screening test. The proposed sensors showed low limits of quantification, and high sensitivity and selectivity levels. The recoveries of p53, E-cadherin, BTA, and hyaluronic acid in whole blood samples and tissue samples were higher than 95.00% with a relative standard deviation lower than 1.00%.</jats:p> Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors Sensors |
| spellingShingle | Stefan-van Staden, Raluca-Ioana, Gheorghe, Damaris-Cristina, Jinga, Viorel, Sima, Cristian Sorin, Geanta, Marius, Sensors, Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors, Electrical and Electronic Engineering, Biochemistry, Instrumentation, Atomic and Molecular Physics, and Optics, Analytical Chemistry |
| title | Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_full | Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_fullStr | Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_full_unstemmed | Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_short | Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| title_sort | fast screening of whole blood and tumor tissue for bladder cancer biomarkers using stochastic needle sensors |
| title_unstemmed | Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors |
| topic | Electrical and Electronic Engineering, Biochemistry, Instrumentation, Atomic and Molecular Physics, and Optics, Analytical Chemistry |
| url | http://dx.doi.org/10.3390/s20082420 |