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Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage
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| Zeitschriftentitel: | Polymers |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Polymers, 11, 2019, 12, S. 1971 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| Schlagwörter: |
| author_facet |
Leu, Tsai-Hsueh Wei, Yang Hwua, Yi-Shi Huang, Xiao-Juan Huang, Jung-Tang Chung, Ren-Jei Leu, Tsai-Hsueh Wei, Yang Hwua, Yi-Shi Huang, Xiao-Juan Huang, Jung-Tang Chung, Ren-Jei |
|---|---|
| author |
Leu, Tsai-Hsueh Wei, Yang Hwua, Yi-Shi Huang, Xiao-Juan Huang, Jung-Tang Chung, Ren-Jei |
| spellingShingle |
Leu, Tsai-Hsueh Wei, Yang Hwua, Yi-Shi Huang, Xiao-Juan Huang, Jung-Tang Chung, Ren-Jei Polymers Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage Polymers and Plastics General Chemistry |
| author_sort |
leu, tsai-hsueh |
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Leu, Tsai-Hsueh Wei, Yang Hwua, Yi-Shi Huang, Xiao-Juan Huang, Jung-Tang Chung, Ren-Jei 2073-4360 MDPI AG Polymers and Plastics General Chemistry http://dx.doi.org/10.3390/polym11121971 <jats:p>Kyphoplasty is an important treatment for stabilizing spine fractures due to osteoporosis. However, leakage of polymethyl-methacrylate (PMMA) bone cement during this procedure into the spinal canal has been reported to cause many adverse effects. In this study, we prepared an implantable membrane to serve as a barrier that avoids PMMA cement leakage during kyphoplasty procedures through a hybrid composite made of poly-l-lactic acid (PLLA) and tricalcium silicate (C3S), with the addition of C3S into PLLA matrix, showing enhanced mechanical and anti-degradation properties while keeping good cytocompatibility when compared to PLLA alone and most importantly, when this material design was applied under standardized PMMA cement injection conditions, no posterior wall leakage was observed after the kyphoplasty procedure in pig lumbar vertebral bone models. Testing results assess its effectiveness for clinical practice.</jats:p> Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage Polymers |
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| title |
Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_unstemmed |
Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_full |
Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_fullStr |
Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_full_unstemmed |
Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_short |
Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_sort |
fabrication of plla/c3s composite membrane for the prevention of bone cement leakage |
| topic |
Polymers and Plastics General Chemistry |
| url |
http://dx.doi.org/10.3390/polym11121971 |
| publishDate |
2019 |
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1971 |
| description |
<jats:p>Kyphoplasty is an important treatment for stabilizing spine fractures due to osteoporosis. However, leakage of polymethyl-methacrylate (PMMA) bone cement during this procedure into the spinal canal has been reported to cause many adverse effects. In this study, we prepared an implantable membrane to serve as a barrier that avoids PMMA cement leakage during kyphoplasty procedures through a hybrid composite made of poly-l-lactic acid (PLLA) and tricalcium silicate (C3S), with the addition of C3S into PLLA matrix, showing enhanced mechanical and anti-degradation properties while keeping good cytocompatibility when compared to PLLA alone and most importantly, when this material design was applied under standardized PMMA cement injection conditions, no posterior wall leakage was observed after the kyphoplasty procedure in pig lumbar vertebral bone models. Testing results assess its effectiveness for clinical practice.</jats:p> |
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| author | Leu, Tsai-Hsueh, Wei, Yang, Hwua, Yi-Shi, Huang, Xiao-Juan, Huang, Jung-Tang, Chung, Ren-Jei |
| author_facet | Leu, Tsai-Hsueh, Wei, Yang, Hwua, Yi-Shi, Huang, Xiao-Juan, Huang, Jung-Tang, Chung, Ren-Jei, Leu, Tsai-Hsueh, Wei, Yang, Hwua, Yi-Shi, Huang, Xiao-Juan, Huang, Jung-Tang, Chung, Ren-Jei |
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| description | <jats:p>Kyphoplasty is an important treatment for stabilizing spine fractures due to osteoporosis. However, leakage of polymethyl-methacrylate (PMMA) bone cement during this procedure into the spinal canal has been reported to cause many adverse effects. In this study, we prepared an implantable membrane to serve as a barrier that avoids PMMA cement leakage during kyphoplasty procedures through a hybrid composite made of poly-l-lactic acid (PLLA) and tricalcium silicate (C3S), with the addition of C3S into PLLA matrix, showing enhanced mechanical and anti-degradation properties while keeping good cytocompatibility when compared to PLLA alone and most importantly, when this material design was applied under standardized PMMA cement injection conditions, no posterior wall leakage was observed after the kyphoplasty procedure in pig lumbar vertebral bone models. Testing results assess its effectiveness for clinical practice.</jats:p> |
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| spelling | Leu, Tsai-Hsueh Wei, Yang Hwua, Yi-Shi Huang, Xiao-Juan Huang, Jung-Tang Chung, Ren-Jei 2073-4360 MDPI AG Polymers and Plastics General Chemistry http://dx.doi.org/10.3390/polym11121971 <jats:p>Kyphoplasty is an important treatment for stabilizing spine fractures due to osteoporosis. However, leakage of polymethyl-methacrylate (PMMA) bone cement during this procedure into the spinal canal has been reported to cause many adverse effects. In this study, we prepared an implantable membrane to serve as a barrier that avoids PMMA cement leakage during kyphoplasty procedures through a hybrid composite made of poly-l-lactic acid (PLLA) and tricalcium silicate (C3S), with the addition of C3S into PLLA matrix, showing enhanced mechanical and anti-degradation properties while keeping good cytocompatibility when compared to PLLA alone and most importantly, when this material design was applied under standardized PMMA cement injection conditions, no posterior wall leakage was observed after the kyphoplasty procedure in pig lumbar vertebral bone models. Testing results assess its effectiveness for clinical practice.</jats:p> Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage Polymers |
| spellingShingle | Leu, Tsai-Hsueh, Wei, Yang, Hwua, Yi-Shi, Huang, Xiao-Juan, Huang, Jung-Tang, Chung, Ren-Jei, Polymers, Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage, Polymers and Plastics, General Chemistry |
| title | Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_full | Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_fullStr | Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_full_unstemmed | Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_short | Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| title_sort | fabrication of plla/c3s composite membrane for the prevention of bone cement leakage |
| title_unstemmed | Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage |
| topic | Polymers and Plastics, General Chemistry |
| url | http://dx.doi.org/10.3390/polym11121971 |