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Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.
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| Zeitschriftentitel: | Marine Drugs |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Marine Drugs, 18, 2020, 6, S. 310 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| Schlagwörter: |
| author_facet |
Kapustina, Irina I. Makarieva, Tatyana N. Guzii, Alla G. Kalinovsky, Anatoly I. Popov, Roman S. Dyshlovoy, Sergey A. Grebnev, Boris B. von Amsberg, Gunhild Stonik, Valentin A. Kapustina, Irina I. Makarieva, Tatyana N. Guzii, Alla G. Kalinovsky, Anatoly I. Popov, Roman S. Dyshlovoy, Sergey A. Grebnev, Boris B. von Amsberg, Gunhild Stonik, Valentin A. |
|---|---|
| author |
Kapustina, Irina I. Makarieva, Tatyana N. Guzii, Alla G. Kalinovsky, Anatoly I. Popov, Roman S. Dyshlovoy, Sergey A. Grebnev, Boris B. von Amsberg, Gunhild Stonik, Valentin A. |
| spellingShingle |
Kapustina, Irina I. Makarieva, Tatyana N. Guzii, Alla G. Kalinovsky, Anatoly I. Popov, Roman S. Dyshlovoy, Sergey A. Grebnev, Boris B. von Amsberg, Gunhild Stonik, Valentin A. Marine Drugs Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science |
| author_sort |
kapustina, irina i. |
| spelling |
Kapustina, Irina I. Makarieva, Tatyana N. Guzii, Alla G. Kalinovsky, Anatoly I. Popov, Roman S. Dyshlovoy, Sergey A. Grebnev, Boris B. von Amsberg, Gunhild Stonik, Valentin A. 1660-3397 MDPI AG Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science http://dx.doi.org/10.3390/md18060310 <jats:p>Leptogorgins A–C (1–3), new humulane sesquiterpenoids, and leptogorgoid A (4), a new dihydroxyketosteroid, were isolated from the gorgonian Leptogorgia sp. collected from the South China Sea. The structures were established using MS and NMR data. The absolute configuration of 1 was confirmed by a modification of Mosher’s method. Configurations of double bonds followed from NMR data, including NOE correlations. This is the first report of humulane-type sesquiterpenoids from marine invertebrates. Sesquiterpenoids leptogorgins A (1) and B (2) exhibited a moderate cytotoxicity and some selectivity against human drug-resistant prostate cancer cells 22Rv1.</jats:p> Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. Marine Drugs |
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| title |
Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_unstemmed |
Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_full |
Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_fullStr |
Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_full_unstemmed |
Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_short |
Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_sort |
leptogorgins a–c, humulane sesquiterpenoids from the vietnamese gorgonian leptogorgia sp. |
| topic |
Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science |
| url |
http://dx.doi.org/10.3390/md18060310 |
| publishDate |
2020 |
| physical |
310 |
| description |
<jats:p>Leptogorgins A–C (1–3), new humulane sesquiterpenoids, and leptogorgoid A (4), a new dihydroxyketosteroid, were isolated from the gorgonian Leptogorgia sp. collected from the South China Sea. The structures were established using MS and NMR data. The absolute configuration of 1 was confirmed by a modification of Mosher’s method. Configurations of double bonds followed from NMR data, including NOE correlations. This is the first report of humulane-type sesquiterpenoids from marine invertebrates. Sesquiterpenoids leptogorgins A (1) and B (2) exhibited a moderate cytotoxicity and some selectivity against human drug-resistant prostate cancer cells 22Rv1.</jats:p> |
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| author | Kapustina, Irina I., Makarieva, Tatyana N., Guzii, Alla G., Kalinovsky, Anatoly I., Popov, Roman S., Dyshlovoy, Sergey A., Grebnev, Boris B., von Amsberg, Gunhild, Stonik, Valentin A. |
| author_facet | Kapustina, Irina I., Makarieva, Tatyana N., Guzii, Alla G., Kalinovsky, Anatoly I., Popov, Roman S., Dyshlovoy, Sergey A., Grebnev, Boris B., von Amsberg, Gunhild, Stonik, Valentin A., Kapustina, Irina I., Makarieva, Tatyana N., Guzii, Alla G., Kalinovsky, Anatoly I., Popov, Roman S., Dyshlovoy, Sergey A., Grebnev, Boris B., von Amsberg, Gunhild, Stonik, Valentin A. |
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| description | <jats:p>Leptogorgins A–C (1–3), new humulane sesquiterpenoids, and leptogorgoid A (4), a new dihydroxyketosteroid, were isolated from the gorgonian Leptogorgia sp. collected from the South China Sea. The structures were established using MS and NMR data. The absolute configuration of 1 was confirmed by a modification of Mosher’s method. Configurations of double bonds followed from NMR data, including NOE correlations. This is the first report of humulane-type sesquiterpenoids from marine invertebrates. Sesquiterpenoids leptogorgins A (1) and B (2) exhibited a moderate cytotoxicity and some selectivity against human drug-resistant prostate cancer cells 22Rv1.</jats:p> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Kapustina, Irina I. Makarieva, Tatyana N. Guzii, Alla G. Kalinovsky, Anatoly I. Popov, Roman S. Dyshlovoy, Sergey A. Grebnev, Boris B. von Amsberg, Gunhild Stonik, Valentin A. 1660-3397 MDPI AG Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science http://dx.doi.org/10.3390/md18060310 <jats:p>Leptogorgins A–C (1–3), new humulane sesquiterpenoids, and leptogorgoid A (4), a new dihydroxyketosteroid, were isolated from the gorgonian Leptogorgia sp. collected from the South China Sea. The structures were established using MS and NMR data. The absolute configuration of 1 was confirmed by a modification of Mosher’s method. Configurations of double bonds followed from NMR data, including NOE correlations. This is the first report of humulane-type sesquiterpenoids from marine invertebrates. Sesquiterpenoids leptogorgins A (1) and B (2) exhibited a moderate cytotoxicity and some selectivity against human drug-resistant prostate cancer cells 22Rv1.</jats:p> Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. Marine Drugs |
| spellingShingle | Kapustina, Irina I., Makarieva, Tatyana N., Guzii, Alla G., Kalinovsky, Anatoly I., Popov, Roman S., Dyshlovoy, Sergey A., Grebnev, Boris B., von Amsberg, Gunhild, Stonik, Valentin A., Marine Drugs, Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp., Drug Discovery, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Pharmaceutical Science |
| title | Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_full | Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_fullStr | Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_full_unstemmed | Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_short | Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| title_sort | leptogorgins a–c, humulane sesquiterpenoids from the vietnamese gorgonian leptogorgia sp. |
| title_unstemmed | Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. |
| topic | Drug Discovery, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Pharmaceutical Science |
| url | http://dx.doi.org/10.3390/md18060310 |