Eintrag weiter verarbeiten
New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015
Gespeichert in:
| Zeitschriftentitel: | Marine Drugs |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Marine Drugs, 17, 2019, 7, S. 398 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
|
| Schlagwörter: |
| author_facet |
Pang, Xiaoyan Cai, Guodi Lin, Xiuping Salendra, Limbadri Zhou, Xuefeng Yang, Bin Wang, Junjian Wang, Junfeng Xu, Shihai Liu, Yonghong Pang, Xiaoyan Cai, Guodi Lin, Xiuping Salendra, Limbadri Zhou, Xuefeng Yang, Bin Wang, Junjian Wang, Junfeng Xu, Shihai Liu, Yonghong |
|---|---|
| author |
Pang, Xiaoyan Cai, Guodi Lin, Xiuping Salendra, Limbadri Zhou, Xuefeng Yang, Bin Wang, Junjian Wang, Junfeng Xu, Shihai Liu, Yonghong |
| spellingShingle |
Pang, Xiaoyan Cai, Guodi Lin, Xiuping Salendra, Limbadri Zhou, Xuefeng Yang, Bin Wang, Junjian Wang, Junfeng Xu, Shihai Liu, Yonghong Marine Drugs New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science |
| author_sort |
pang, xiaoyan |
| spelling |
Pang, Xiaoyan Cai, Guodi Lin, Xiuping Salendra, Limbadri Zhou, Xuefeng Yang, Bin Wang, Junjian Wang, Junfeng Xu, Shihai Liu, Yonghong 1660-3397 MDPI AG Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science http://dx.doi.org/10.3390/md17070398 <jats:p>The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1–21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL.</jats:p> New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 Marine Drugs |
| doi_str_mv |
10.3390/md17070398 |
| facet_avail |
Online Free |
| finc_class_facet |
Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMzM5MC9tZDE3MDcwMzk4 |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMzM5MC9tZDE3MDcwMzk4 |
| institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 |
| imprint |
MDPI AG, 2019 |
| imprint_str_mv |
MDPI AG, 2019 |
| issn |
1660-3397 |
| issn_str_mv |
1660-3397 |
| language |
English |
| mega_collection |
MDPI AG (CrossRef) |
| match_str |
pang2019newalkaloidsandpolyketidesfromthemarinespongederivedfunguspenicilliumspscsio41015 |
| publishDateSort |
2019 |
| publisher |
MDPI AG |
| recordtype |
ai |
| record_format |
ai |
| series |
Marine Drugs |
| source_id |
49 |
| title |
New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_unstemmed |
New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_full |
New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_fullStr |
New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_full_unstemmed |
New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_short |
New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_sort |
new alkaloids and polyketides from the marine sponge-derived fungus penicillium sp. scsio41015 |
| topic |
Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science |
| url |
http://dx.doi.org/10.3390/md17070398 |
| publishDate |
2019 |
| physical |
398 |
| description |
<jats:p>The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1–21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL.</jats:p> |
| container_issue |
7 |
| container_start_page |
0 |
| container_title |
Marine Drugs |
| container_volume |
17 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792333894325895174 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:19:51.306Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=New+Alkaloids+and+Polyketides+from+the+Marine+Sponge-Derived+Fungus+Penicillium+sp.+SCSIO41015&rft.date=2019-07-05&genre=article&issn=1660-3397&volume=17&issue=7&pages=398&jtitle=Marine+Drugs&atitle=New+Alkaloids+and+Polyketides+from+the+Marine+Sponge-Derived+Fungus+Penicillium+sp.+SCSIO41015&aulast=Liu&aufirst=Yonghong&rft_id=info%3Adoi%2F10.3390%2Fmd17070398&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792333894325895174 |
| author | Pang, Xiaoyan, Cai, Guodi, Lin, Xiuping, Salendra, Limbadri, Zhou, Xuefeng, Yang, Bin, Wang, Junjian, Wang, Junfeng, Xu, Shihai, Liu, Yonghong |
| author_facet | Pang, Xiaoyan, Cai, Guodi, Lin, Xiuping, Salendra, Limbadri, Zhou, Xuefeng, Yang, Bin, Wang, Junjian, Wang, Junfeng, Xu, Shihai, Liu, Yonghong, Pang, Xiaoyan, Cai, Guodi, Lin, Xiuping, Salendra, Limbadri, Zhou, Xuefeng, Yang, Bin, Wang, Junjian, Wang, Junfeng, Xu, Shihai, Liu, Yonghong |
| author_sort | pang, xiaoyan |
| container_issue | 7 |
| container_start_page | 0 |
| container_title | Marine Drugs |
| container_volume | 17 |
| description | <jats:p>The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1–21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL.</jats:p> |
| doi_str_mv | 10.3390/md17070398 |
| facet_avail | Online, Free |
| finc_class_facet | Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMzM5MC9tZDE3MDcwMzk4 |
| imprint | MDPI AG, 2019 |
| imprint_str_mv | MDPI AG, 2019 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
| issn | 1660-3397 |
| issn_str_mv | 1660-3397 |
| language | English |
| last_indexed | 2024-03-01T14:19:51.306Z |
| match_str | pang2019newalkaloidsandpolyketidesfromthemarinespongederivedfunguspenicilliumspscsio41015 |
| mega_collection | MDPI AG (CrossRef) |
| physical | 398 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | MDPI AG |
| record_format | ai |
| recordtype | ai |
| series | Marine Drugs |
| source_id | 49 |
| spelling | Pang, Xiaoyan Cai, Guodi Lin, Xiuping Salendra, Limbadri Zhou, Xuefeng Yang, Bin Wang, Junjian Wang, Junfeng Xu, Shihai Liu, Yonghong 1660-3397 MDPI AG Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science http://dx.doi.org/10.3390/md17070398 <jats:p>The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1–21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL.</jats:p> New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 Marine Drugs |
| spellingShingle | Pang, Xiaoyan, Cai, Guodi, Lin, Xiuping, Salendra, Limbadri, Zhou, Xuefeng, Yang, Bin, Wang, Junjian, Wang, Junfeng, Xu, Shihai, Liu, Yonghong, Marine Drugs, New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015, Drug Discovery, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Pharmaceutical Science |
| title | New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_full | New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_fullStr | New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_full_unstemmed | New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_short | New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| title_sort | new alkaloids and polyketides from the marine sponge-derived fungus penicillium sp. scsio41015 |
| title_unstemmed | New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 |
| topic | Drug Discovery, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Pharmaceutical Science |
| url | http://dx.doi.org/10.3390/md17070398 |