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Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum
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| Zeitschriftentitel: | Marine Drugs |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Marine Drugs, 17, 2019, 1, S. 66 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| Schlagwörter: |
| author_facet |
Zhang, Wei Kwak, Minseok Park, Hae-Bin Okimura, Takasi Oda, Tatsuya Lee, Peter Jin, Jun-O Zhang, Wei Kwak, Minseok Park, Hae-Bin Okimura, Takasi Oda, Tatsuya Lee, Peter Jin, Jun-O |
|---|---|
| author |
Zhang, Wei Kwak, Minseok Park, Hae-Bin Okimura, Takasi Oda, Tatsuya Lee, Peter Jin, Jun-O |
| spellingShingle |
Zhang, Wei Kwak, Minseok Park, Hae-Bin Okimura, Takasi Oda, Tatsuya Lee, Peter Jin, Jun-O Marine Drugs Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science |
| author_sort |
zhang, wei |
| spelling |
Zhang, Wei Kwak, Minseok Park, Hae-Bin Okimura, Takasi Oda, Tatsuya Lee, Peter Jin, Jun-O 1660-3397 MDPI AG Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science http://dx.doi.org/10.3390/md17010066 <jats:p>In our previous study, we showed that ascophyllan purified from Ascophyllum nodosum treatment promotes mouse dendritic cell (DC) activation in vivo, further induces an antigen-specific immune response and has anticancer effects in mice. However, the effect of ascophyllan has not been studied in human immune cells, specifically in terms of activation of human monocyte-derived DCs (MDDCs) and human peripheral blood DCs (PBDCs). We found that the treatment with ascophyllan induced morphological changes in MDDCs and upregulated co-stimulatory molecules and major histocompatibility complex class I (MHC I) and MHC II expression. In addition, pro-inflammatory cytokine levels in culture medium was also dramatically increased following ascophyllan treatment of MDDCs. Moreover, ascophyllan promoted phosphorylation of ERK, p38 and JNK signaling pathways, and inhibition of p38 almost completely suppressed the ascophyllan-induced activation of MDDCs. Finally, treatment with ascophyllan induced activation of BDCA1 and BDCA3 PBDCs. Thus, these data suggest that ascophyllan could be used as an immune stimulator in humans.</jats:p> Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum Marine Drugs |
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| title |
Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_unstemmed |
Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_full |
Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_fullStr |
Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_full_unstemmed |
Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_short |
Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_sort |
activation of human dendritic cells by ascophyllan purified from ascophyllum nodosum |
| topic |
Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science |
| url |
http://dx.doi.org/10.3390/md17010066 |
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2019 |
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66 |
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<jats:p>In our previous study, we showed that ascophyllan purified from Ascophyllum nodosum treatment promotes mouse dendritic cell (DC) activation in vivo, further induces an antigen-specific immune response and has anticancer effects in mice. However, the effect of ascophyllan has not been studied in human immune cells, specifically in terms of activation of human monocyte-derived DCs (MDDCs) and human peripheral blood DCs (PBDCs). We found that the treatment with ascophyllan induced morphological changes in MDDCs and upregulated co-stimulatory molecules and major histocompatibility complex class I (MHC I) and MHC II expression. In addition, pro-inflammatory cytokine levels in culture medium was also dramatically increased following ascophyllan treatment of MDDCs. Moreover, ascophyllan promoted phosphorylation of ERK, p38 and JNK signaling pathways, and inhibition of p38 almost completely suppressed the ascophyllan-induced activation of MDDCs. Finally, treatment with ascophyllan induced activation of BDCA1 and BDCA3 PBDCs. Thus, these data suggest that ascophyllan could be used as an immune stimulator in humans.</jats:p> |
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| author | Zhang, Wei, Kwak, Minseok, Park, Hae-Bin, Okimura, Takasi, Oda, Tatsuya, Lee, Peter, Jin, Jun-O |
| author_facet | Zhang, Wei, Kwak, Minseok, Park, Hae-Bin, Okimura, Takasi, Oda, Tatsuya, Lee, Peter, Jin, Jun-O, Zhang, Wei, Kwak, Minseok, Park, Hae-Bin, Okimura, Takasi, Oda, Tatsuya, Lee, Peter, Jin, Jun-O |
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| description | <jats:p>In our previous study, we showed that ascophyllan purified from Ascophyllum nodosum treatment promotes mouse dendritic cell (DC) activation in vivo, further induces an antigen-specific immune response and has anticancer effects in mice. However, the effect of ascophyllan has not been studied in human immune cells, specifically in terms of activation of human monocyte-derived DCs (MDDCs) and human peripheral blood DCs (PBDCs). We found that the treatment with ascophyllan induced morphological changes in MDDCs and upregulated co-stimulatory molecules and major histocompatibility complex class I (MHC I) and MHC II expression. In addition, pro-inflammatory cytokine levels in culture medium was also dramatically increased following ascophyllan treatment of MDDCs. Moreover, ascophyllan promoted phosphorylation of ERK, p38 and JNK signaling pathways, and inhibition of p38 almost completely suppressed the ascophyllan-induced activation of MDDCs. Finally, treatment with ascophyllan induced activation of BDCA1 and BDCA3 PBDCs. Thus, these data suggest that ascophyllan could be used as an immune stimulator in humans.</jats:p> |
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| spelling | Zhang, Wei Kwak, Minseok Park, Hae-Bin Okimura, Takasi Oda, Tatsuya Lee, Peter Jin, Jun-O 1660-3397 MDPI AG Drug Discovery Pharmacology, Toxicology and Pharmaceutics (miscellaneous) Pharmaceutical Science http://dx.doi.org/10.3390/md17010066 <jats:p>In our previous study, we showed that ascophyllan purified from Ascophyllum nodosum treatment promotes mouse dendritic cell (DC) activation in vivo, further induces an antigen-specific immune response and has anticancer effects in mice. However, the effect of ascophyllan has not been studied in human immune cells, specifically in terms of activation of human monocyte-derived DCs (MDDCs) and human peripheral blood DCs (PBDCs). We found that the treatment with ascophyllan induced morphological changes in MDDCs and upregulated co-stimulatory molecules and major histocompatibility complex class I (MHC I) and MHC II expression. In addition, pro-inflammatory cytokine levels in culture medium was also dramatically increased following ascophyllan treatment of MDDCs. Moreover, ascophyllan promoted phosphorylation of ERK, p38 and JNK signaling pathways, and inhibition of p38 almost completely suppressed the ascophyllan-induced activation of MDDCs. Finally, treatment with ascophyllan induced activation of BDCA1 and BDCA3 PBDCs. Thus, these data suggest that ascophyllan could be used as an immune stimulator in humans.</jats:p> Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum Marine Drugs |
| spellingShingle | Zhang, Wei, Kwak, Minseok, Park, Hae-Bin, Okimura, Takasi, Oda, Tatsuya, Lee, Peter, Jin, Jun-O, Marine Drugs, Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum, Drug Discovery, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Pharmaceutical Science |
| title | Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_full | Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_fullStr | Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_full_unstemmed | Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_short | Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| title_sort | activation of human dendritic cells by ascophyllan purified from ascophyllum nodosum |
| title_unstemmed | Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum |
| topic | Drug Discovery, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Pharmaceutical Science |
| url | http://dx.doi.org/10.3390/md17010066 |