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Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults
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| Zeitschriftentitel: | Journal of Fungi |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Journal of Fungi, 5, 2019, 3, S. 65 |
| Format: | E-Article |
| Sprache: | Englisch |
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MDPI AG
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Skipper, Caleb Abassi, Mahsa Boulware, David R Skipper, Caleb Abassi, Mahsa Boulware, David R |
|---|---|
| author |
Skipper, Caleb Abassi, Mahsa Boulware, David R |
| spellingShingle |
Skipper, Caleb Abassi, Mahsa Boulware, David R Journal of Fungi Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults Plant Science Ecology, Evolution, Behavior and Systematics Microbiology (medical) |
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skipper, caleb |
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Skipper, Caleb Abassi, Mahsa Boulware, David R 2309-608X MDPI AG Plant Science Ecology, Evolution, Behavior and Systematics Microbiology (medical) http://dx.doi.org/10.3390/jof5030065 <jats:p>Cryptococcal meningitis persists as a significant source of morbidity and mortality in persons with HIV/AIDS, particularly in sub-Saharan Africa. Despite increasing access to antiretrovirals, persons presenting with advanced HIV disease remains common, and Cryptococcus remains the most frequent etiology of adult meningitis. We performed a literature review and herein present the most up-to-date information on the diagnosis and management of cryptococcosis. Recent advances have dramatically improved the accessibility of timely and affordable diagnostics. The optimal initial antifungal management has been newly updated after the completion of a landmark clinical trial. Beyond antifungals, the control of intracranial pressure and mitigation of toxicities remain hallmarks of effective treatment. Cryptococcal meningitis continues to present challenging complications and continued research is needed.</jats:p> Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults Journal of Fungi |
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| title |
Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_unstemmed |
Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_full |
Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_fullStr |
Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_full_unstemmed |
Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_short |
Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_sort |
diagnosis and management of central nervous system cryptococcal infections in hiv-infected adults |
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Plant Science Ecology, Evolution, Behavior and Systematics Microbiology (medical) |
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<jats:p>Cryptococcal meningitis persists as a significant source of morbidity and mortality in persons with HIV/AIDS, particularly in sub-Saharan Africa. Despite increasing access to antiretrovirals, persons presenting with advanced HIV disease remains common, and Cryptococcus remains the most frequent etiology of adult meningitis. We performed a literature review and herein present the most up-to-date information on the diagnosis and management of cryptococcosis. Recent advances have dramatically improved the accessibility of timely and affordable diagnostics. The optimal initial antifungal management has been newly updated after the completion of a landmark clinical trial. Beyond antifungals, the control of intracranial pressure and mitigation of toxicities remain hallmarks of effective treatment. Cryptococcal meningitis continues to present challenging complications and continued research is needed.</jats:p> |
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| author | Skipper, Caleb, Abassi, Mahsa, Boulware, David R |
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| description | <jats:p>Cryptococcal meningitis persists as a significant source of morbidity and mortality in persons with HIV/AIDS, particularly in sub-Saharan Africa. Despite increasing access to antiretrovirals, persons presenting with advanced HIV disease remains common, and Cryptococcus remains the most frequent etiology of adult meningitis. We performed a literature review and herein present the most up-to-date information on the diagnosis and management of cryptococcosis. Recent advances have dramatically improved the accessibility of timely and affordable diagnostics. The optimal initial antifungal management has been newly updated after the completion of a landmark clinical trial. Beyond antifungals, the control of intracranial pressure and mitigation of toxicities remain hallmarks of effective treatment. Cryptococcal meningitis continues to present challenging complications and continued research is needed.</jats:p> |
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| spelling | Skipper, Caleb Abassi, Mahsa Boulware, David R 2309-608X MDPI AG Plant Science Ecology, Evolution, Behavior and Systematics Microbiology (medical) http://dx.doi.org/10.3390/jof5030065 <jats:p>Cryptococcal meningitis persists as a significant source of morbidity and mortality in persons with HIV/AIDS, particularly in sub-Saharan Africa. Despite increasing access to antiretrovirals, persons presenting with advanced HIV disease remains common, and Cryptococcus remains the most frequent etiology of adult meningitis. We performed a literature review and herein present the most up-to-date information on the diagnosis and management of cryptococcosis. Recent advances have dramatically improved the accessibility of timely and affordable diagnostics. The optimal initial antifungal management has been newly updated after the completion of a landmark clinical trial. Beyond antifungals, the control of intracranial pressure and mitigation of toxicities remain hallmarks of effective treatment. Cryptococcal meningitis continues to present challenging complications and continued research is needed.</jats:p> Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults Journal of Fungi |
| spellingShingle | Skipper, Caleb, Abassi, Mahsa, Boulware, David R, Journal of Fungi, Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults, Plant Science, Ecology, Evolution, Behavior and Systematics, Microbiology (medical) |
| title | Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_full | Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_fullStr | Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_full_unstemmed | Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_short | Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| title_sort | diagnosis and management of central nervous system cryptococcal infections in hiv-infected adults |
| title_unstemmed | Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults |
| topic | Plant Science, Ecology, Evolution, Behavior and Systematics, Microbiology (medical) |
| url | http://dx.doi.org/10.3390/jof5030065 |