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Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle
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| Zeitschriftentitel: | Cancers |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Cancers, 11, 2019, 11, S. 1816 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
|
| Schlagwörter: |
| author_facet |
Meng, Guanmin Wuest, Melinda Tang, Xiaoyun Dufour, Jennifer Zhao, YuanYuan Curtis, Jonathan M. McMullen, Todd P. W. Murray, David Wuest, Frank Brindley, David N. Meng, Guanmin Wuest, Melinda Tang, Xiaoyun Dufour, Jennifer Zhao, YuanYuan Curtis, Jonathan M. McMullen, Todd P. W. Murray, David Wuest, Frank Brindley, David N. |
|---|---|
| author |
Meng, Guanmin Wuest, Melinda Tang, Xiaoyun Dufour, Jennifer Zhao, YuanYuan Curtis, Jonathan M. McMullen, Todd P. W. Murray, David Wuest, Frank Brindley, David N. |
| spellingShingle |
Meng, Guanmin Wuest, Melinda Tang, Xiaoyun Dufour, Jennifer Zhao, YuanYuan Curtis, Jonathan M. McMullen, Todd P. W. Murray, David Wuest, Frank Brindley, David N. Cancers Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle Cancer Research Oncology |
| author_sort |
meng, guanmin |
| spelling |
Meng, Guanmin Wuest, Melinda Tang, Xiaoyun Dufour, Jennifer Zhao, YuanYuan Curtis, Jonathan M. McMullen, Todd P. W. Murray, David Wuest, Frank Brindley, David N. 2072-6694 MDPI AG Cancer Research Oncology http://dx.doi.org/10.3390/cancers11111816 <jats:p>Breast cancer patients are usually treated with multiple fractions of radiotherapy (RT) to the whole breast after lumpectomy. We hypothesized that repeated fractions of RT would progressively activate the autotaxin–lysophosphatidate-inflammatory cycle. To test this, a normal breast fat pad and a fat pad containing a mouse 4T1 tumor were irradiated with X-rays using a small-animal “image-guided” RT platform. A single RT dose of 7.5 Gy and three daily doses of 7.5 Gy increased ATX activity and decreased plasma adiponectin concentrations. The concentrations of IL-6 and TNFα in plasma and of VEGF, G-CSF, CCL11 and CXCL10 in the irradiated fat pad were increased, but only after three fractions of RT. In 4T1 breast tumor-bearing mice, three fractions of 7.5 Gy augmented tumor-induced increases in plasma ATX activity and decreased adiponectin levels in the tumor-associated mammary fat pad. There were also increased expressions of multiple inflammatory mediators in the tumor-associated mammary fat pad and in tumors, which was accompanied by increased infiltration of CD45+ leukocytes into tumor-associated adipose tissue. This work provides novel evidence that increased ATX production is an early response to RT and that repeated fractions of RT activate the autotaxin–lysophosphatidate-inflammatory cycle. This wound healing response to RT-induced damage could decrease the efficacy of further fractions of RT.</jats:p> Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle Cancers |
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10.3390/cancers11111816 |
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MDPI AG, 2019 |
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MDPI AG, 2019 |
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2072-6694 |
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| title |
Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_unstemmed |
Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_full |
Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_fullStr |
Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_full_unstemmed |
Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_short |
Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_sort |
repeated fractions of x-radiation to the breast fat pads of mice augment activation of the autotaxin-lysophosphatidate-inflammatory cycle |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.3390/cancers11111816 |
| publishDate |
2019 |
| physical |
1816 |
| description |
<jats:p>Breast cancer patients are usually treated with multiple fractions of radiotherapy (RT) to the whole breast after lumpectomy. We hypothesized that repeated fractions of RT would progressively activate the autotaxin–lysophosphatidate-inflammatory cycle. To test this, a normal breast fat pad and a fat pad containing a mouse 4T1 tumor were irradiated with X-rays using a small-animal “image-guided” RT platform. A single RT dose of 7.5 Gy and three daily doses of 7.5 Gy increased ATX activity and decreased plasma adiponectin concentrations. The concentrations of IL-6 and TNFα in plasma and of VEGF, G-CSF, CCL11 and CXCL10 in the irradiated fat pad were increased, but only after three fractions of RT. In 4T1 breast tumor-bearing mice, three fractions of 7.5 Gy augmented tumor-induced increases in plasma ATX activity and decreased adiponectin levels in the tumor-associated mammary fat pad. There were also increased expressions of multiple inflammatory mediators in the tumor-associated mammary fat pad and in tumors, which was accompanied by increased infiltration of CD45+ leukocytes into tumor-associated adipose tissue. This work provides novel evidence that increased ATX production is an early response to RT and that repeated fractions of RT activate the autotaxin–lysophosphatidate-inflammatory cycle. This wound healing response to RT-induced damage could decrease the efficacy of further fractions of RT.</jats:p> |
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| author | Meng, Guanmin, Wuest, Melinda, Tang, Xiaoyun, Dufour, Jennifer, Zhao, YuanYuan, Curtis, Jonathan M., McMullen, Todd P. W., Murray, David, Wuest, Frank, Brindley, David N. |
| author_facet | Meng, Guanmin, Wuest, Melinda, Tang, Xiaoyun, Dufour, Jennifer, Zhao, YuanYuan, Curtis, Jonathan M., McMullen, Todd P. W., Murray, David, Wuest, Frank, Brindley, David N., Meng, Guanmin, Wuest, Melinda, Tang, Xiaoyun, Dufour, Jennifer, Zhao, YuanYuan, Curtis, Jonathan M., McMullen, Todd P. W., Murray, David, Wuest, Frank, Brindley, David N. |
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| description | <jats:p>Breast cancer patients are usually treated with multiple fractions of radiotherapy (RT) to the whole breast after lumpectomy. We hypothesized that repeated fractions of RT would progressively activate the autotaxin–lysophosphatidate-inflammatory cycle. To test this, a normal breast fat pad and a fat pad containing a mouse 4T1 tumor were irradiated with X-rays using a small-animal “image-guided” RT platform. A single RT dose of 7.5 Gy and three daily doses of 7.5 Gy increased ATX activity and decreased plasma adiponectin concentrations. The concentrations of IL-6 and TNFα in plasma and of VEGF, G-CSF, CCL11 and CXCL10 in the irradiated fat pad were increased, but only after three fractions of RT. In 4T1 breast tumor-bearing mice, three fractions of 7.5 Gy augmented tumor-induced increases in plasma ATX activity and decreased adiponectin levels in the tumor-associated mammary fat pad. There were also increased expressions of multiple inflammatory mediators in the tumor-associated mammary fat pad and in tumors, which was accompanied by increased infiltration of CD45+ leukocytes into tumor-associated adipose tissue. This work provides novel evidence that increased ATX production is an early response to RT and that repeated fractions of RT activate the autotaxin–lysophosphatidate-inflammatory cycle. This wound healing response to RT-induced damage could decrease the efficacy of further fractions of RT.</jats:p> |
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| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
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| spelling | Meng, Guanmin Wuest, Melinda Tang, Xiaoyun Dufour, Jennifer Zhao, YuanYuan Curtis, Jonathan M. McMullen, Todd P. W. Murray, David Wuest, Frank Brindley, David N. 2072-6694 MDPI AG Cancer Research Oncology http://dx.doi.org/10.3390/cancers11111816 <jats:p>Breast cancer patients are usually treated with multiple fractions of radiotherapy (RT) to the whole breast after lumpectomy. We hypothesized that repeated fractions of RT would progressively activate the autotaxin–lysophosphatidate-inflammatory cycle. To test this, a normal breast fat pad and a fat pad containing a mouse 4T1 tumor were irradiated with X-rays using a small-animal “image-guided” RT platform. A single RT dose of 7.5 Gy and three daily doses of 7.5 Gy increased ATX activity and decreased plasma adiponectin concentrations. The concentrations of IL-6 and TNFα in plasma and of VEGF, G-CSF, CCL11 and CXCL10 in the irradiated fat pad were increased, but only after three fractions of RT. In 4T1 breast tumor-bearing mice, three fractions of 7.5 Gy augmented tumor-induced increases in plasma ATX activity and decreased adiponectin levels in the tumor-associated mammary fat pad. There were also increased expressions of multiple inflammatory mediators in the tumor-associated mammary fat pad and in tumors, which was accompanied by increased infiltration of CD45+ leukocytes into tumor-associated adipose tissue. This work provides novel evidence that increased ATX production is an early response to RT and that repeated fractions of RT activate the autotaxin–lysophosphatidate-inflammatory cycle. This wound healing response to RT-induced damage could decrease the efficacy of further fractions of RT.</jats:p> Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle Cancers |
| spellingShingle | Meng, Guanmin, Wuest, Melinda, Tang, Xiaoyun, Dufour, Jennifer, Zhao, YuanYuan, Curtis, Jonathan M., McMullen, Todd P. W., Murray, David, Wuest, Frank, Brindley, David N., Cancers, Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle, Cancer Research, Oncology |
| title | Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_full | Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_fullStr | Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_full_unstemmed | Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_short | Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| title_sort | repeated fractions of x-radiation to the breast fat pads of mice augment activation of the autotaxin-lysophosphatidate-inflammatory cycle |
| title_unstemmed | Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.3390/cancers11111816 |