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Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing
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| Zeitschriftentitel: | Bioengineering |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Bioengineering, 7, 2020, 3, S. 115 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| Schlagwörter: |
| author_facet |
Bédard, Patrick Gauvin, Sara Ferland, Karel Caneparo, Christophe Pellerin, Ève Chabaud, Stéphane Bolduc, Stéphane Bédard, Patrick Gauvin, Sara Ferland, Karel Caneparo, Christophe Pellerin, Ève Chabaud, Stéphane Bolduc, Stéphane |
|---|---|
| author |
Bédard, Patrick Gauvin, Sara Ferland, Karel Caneparo, Christophe Pellerin, Ève Chabaud, Stéphane Bolduc, Stéphane |
| spellingShingle |
Bédard, Patrick Gauvin, Sara Ferland, Karel Caneparo, Christophe Pellerin, Ève Chabaud, Stéphane Bolduc, Stéphane Bioengineering Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing Bioengineering |
| author_sort |
bédard, patrick |
| spelling |
Bédard, Patrick Gauvin, Sara Ferland, Karel Caneparo, Christophe Pellerin, Ève Chabaud, Stéphane Bolduc, Stéphane 2306-5354 MDPI AG Bioengineering http://dx.doi.org/10.3390/bioengineering7030115 <jats:p>Animal testing has long been used in science to study complex biological phenomena that cannot be investigated using two-dimensional cell cultures in plastic dishes. With time, it appeared that more differences could exist between animal models and even more when translated to human patients. Innovative models became essential to develop more accurate knowledge. Tissue engineering provides some of those models, but it mostly relies on the use of prefabricated scaffolds on which cells are seeded. The self-assembly protocol has recently produced organ-specific human-derived three-dimensional models without the need for exogenous material. This strategy will help to achieve the 3R principles.</jats:p> Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing Bioengineering |
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| title |
Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
| title_unstemmed |
Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
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Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
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Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
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Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
| title_short |
Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
| title_sort |
innovative human three-dimensional tissue-engineered models as an alternative to animal testing |
| topic |
Bioengineering |
| url |
http://dx.doi.org/10.3390/bioengineering7030115 |
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2020 |
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115 |
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<jats:p>Animal testing has long been used in science to study complex biological phenomena that cannot be investigated using two-dimensional cell cultures in plastic dishes. With time, it appeared that more differences could exist between animal models and even more when translated to human patients. Innovative models became essential to develop more accurate knowledge. Tissue engineering provides some of those models, but it mostly relies on the use of prefabricated scaffolds on which cells are seeded. The self-assembly protocol has recently produced organ-specific human-derived three-dimensional models without the need for exogenous material. This strategy will help to achieve the 3R principles.</jats:p> |
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| author | Bédard, Patrick, Gauvin, Sara, Ferland, Karel, Caneparo, Christophe, Pellerin, Ève, Chabaud, Stéphane, Bolduc, Stéphane |
| author_facet | Bédard, Patrick, Gauvin, Sara, Ferland, Karel, Caneparo, Christophe, Pellerin, Ève, Chabaud, Stéphane, Bolduc, Stéphane, Bédard, Patrick, Gauvin, Sara, Ferland, Karel, Caneparo, Christophe, Pellerin, Ève, Chabaud, Stéphane, Bolduc, Stéphane |
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| description | <jats:p>Animal testing has long been used in science to study complex biological phenomena that cannot be investigated using two-dimensional cell cultures in plastic dishes. With time, it appeared that more differences could exist between animal models and even more when translated to human patients. Innovative models became essential to develop more accurate knowledge. Tissue engineering provides some of those models, but it mostly relies on the use of prefabricated scaffolds on which cells are seeded. The self-assembly protocol has recently produced organ-specific human-derived three-dimensional models without the need for exogenous material. This strategy will help to achieve the 3R principles.</jats:p> |
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| series | Bioengineering |
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| spelling | Bédard, Patrick Gauvin, Sara Ferland, Karel Caneparo, Christophe Pellerin, Ève Chabaud, Stéphane Bolduc, Stéphane 2306-5354 MDPI AG Bioengineering http://dx.doi.org/10.3390/bioengineering7030115 <jats:p>Animal testing has long been used in science to study complex biological phenomena that cannot be investigated using two-dimensional cell cultures in plastic dishes. With time, it appeared that more differences could exist between animal models and even more when translated to human patients. Innovative models became essential to develop more accurate knowledge. Tissue engineering provides some of those models, but it mostly relies on the use of prefabricated scaffolds on which cells are seeded. The self-assembly protocol has recently produced organ-specific human-derived three-dimensional models without the need for exogenous material. This strategy will help to achieve the 3R principles.</jats:p> Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing Bioengineering |
| spellingShingle | Bédard, Patrick, Gauvin, Sara, Ferland, Karel, Caneparo, Christophe, Pellerin, Ève, Chabaud, Stéphane, Bolduc, Stéphane, Bioengineering, Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing, Bioengineering |
| title | Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
| title_full | Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
| title_fullStr | Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
| title_full_unstemmed | Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
| title_short | Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
| title_sort | innovative human three-dimensional tissue-engineered models as an alternative to animal testing |
| title_unstemmed | Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing |
| topic | Bioengineering |
| url | http://dx.doi.org/10.3390/bioengineering7030115 |