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Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols
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| Zeitschriftentitel: | Antioxidants |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Antioxidants, 10, 2021, 2, S. 217 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| Schlagwörter: |
| author_facet |
Ferramosca, Alessandra Lorenzetti, Stefano Di Giacomo, Mariangela Lunetti, Paola Murrieri, Francesco Capobianco, Loredana Dolce, Vincenza Coppola, Lamberto Zara, Vincenzo Ferramosca, Alessandra Lorenzetti, Stefano Di Giacomo, Mariangela Lunetti, Paola Murrieri, Francesco Capobianco, Loredana Dolce, Vincenza Coppola, Lamberto Zara, Vincenzo |
|---|---|
| author |
Ferramosca, Alessandra Lorenzetti, Stefano Di Giacomo, Mariangela Lunetti, Paola Murrieri, Francesco Capobianco, Loredana Dolce, Vincenza Coppola, Lamberto Zara, Vincenzo |
| spellingShingle |
Ferramosca, Alessandra Lorenzetti, Stefano Di Giacomo, Mariangela Lunetti, Paola Murrieri, Francesco Capobianco, Loredana Dolce, Vincenza Coppola, Lamberto Zara, Vincenzo Antioxidants Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols Cell Biology Clinical Biochemistry Molecular Biology Biochemistry Physiology |
| author_sort |
ferramosca, alessandra |
| spelling |
Ferramosca, Alessandra Lorenzetti, Stefano Di Giacomo, Mariangela Lunetti, Paola Murrieri, Francesco Capobianco, Loredana Dolce, Vincenza Coppola, Lamberto Zara, Vincenzo 2076-3921 MDPI AG Cell Biology Clinical Biochemistry Molecular Biology Biochemistry Physiology http://dx.doi.org/10.3390/antiox10020217 <jats:p>Plant bioactives, such as polyphenols, can differentially affect (positively or negatively) sperm quality, depending on their concentration. These molecules have been proposed as natural scavengers of reactive oxygen species (ROS) for male infertility treatment. However, few data are available about their effects on the molecular mechanisms related to sperm quality and, in particular, to sperm mitochondrial function. We investigated the effects of quercetin, naringenin, genistein, apigenin, luteolin, and resveratrol at the concentration of 0.1–1000 nM on mitochondrial respiration efficiency. Upon chemical exposure, spermatozoa were swollen in a hypotonic solution and used for polarographic assays of mitochondrial respiration. All tested compounds, except for apigenin, caused a significant increase in the mitochondrial respiration efficiency at the concentration of 0.1 nM, and a significant decrease starting from concentrations of 10 nM. The analysis of oxygen consumption rate in the active and in the resting state of mitochondrial respiration suggested different mechanisms by which the tested compounds modulate mitochondrial function. Therefore, by virtue of their ability to stimulate the respiration active state, quercetin, genistein, and luteolin were found to improve mitochondrial function in asthenozoospermic samples. Our results are relevant to the debate on the promises and perils of natural antioxidants in nutraceutical supplementation.</jats:p> Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols Antioxidants |
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| title |
Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
| title_unstemmed |
Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
| title_full |
Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
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Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
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Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
| title_short |
Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
| title_sort |
modulation of human sperm mitochondrial respiration efficiency by plant polyphenols |
| topic |
Cell Biology Clinical Biochemistry Molecular Biology Biochemistry Physiology |
| url |
http://dx.doi.org/10.3390/antiox10020217 |
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2021 |
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217 |
| description |
<jats:p>Plant bioactives, such as polyphenols, can differentially affect (positively or negatively) sperm quality, depending on their concentration. These molecules have been proposed as natural scavengers of reactive oxygen species (ROS) for male infertility treatment. However, few data are available about their effects on the molecular mechanisms related to sperm quality and, in particular, to sperm mitochondrial function. We investigated the effects of quercetin, naringenin, genistein, apigenin, luteolin, and resveratrol at the concentration of 0.1–1000 nM on mitochondrial respiration efficiency. Upon chemical exposure, spermatozoa were swollen in a hypotonic solution and used for polarographic assays of mitochondrial respiration. All tested compounds, except for apigenin, caused a significant increase in the mitochondrial respiration efficiency at the concentration of 0.1 nM, and a significant decrease starting from concentrations of 10 nM. The analysis of oxygen consumption rate in the active and in the resting state of mitochondrial respiration suggested different mechanisms by which the tested compounds modulate mitochondrial function. Therefore, by virtue of their ability to stimulate the respiration active state, quercetin, genistein, and luteolin were found to improve mitochondrial function in asthenozoospermic samples. Our results are relevant to the debate on the promises and perils of natural antioxidants in nutraceutical supplementation.</jats:p> |
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| author | Ferramosca, Alessandra, Lorenzetti, Stefano, Di Giacomo, Mariangela, Lunetti, Paola, Murrieri, Francesco, Capobianco, Loredana, Dolce, Vincenza, Coppola, Lamberto, Zara, Vincenzo |
| author_facet | Ferramosca, Alessandra, Lorenzetti, Stefano, Di Giacomo, Mariangela, Lunetti, Paola, Murrieri, Francesco, Capobianco, Loredana, Dolce, Vincenza, Coppola, Lamberto, Zara, Vincenzo, Ferramosca, Alessandra, Lorenzetti, Stefano, Di Giacomo, Mariangela, Lunetti, Paola, Murrieri, Francesco, Capobianco, Loredana, Dolce, Vincenza, Coppola, Lamberto, Zara, Vincenzo |
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| description | <jats:p>Plant bioactives, such as polyphenols, can differentially affect (positively or negatively) sperm quality, depending on their concentration. These molecules have been proposed as natural scavengers of reactive oxygen species (ROS) for male infertility treatment. However, few data are available about their effects on the molecular mechanisms related to sperm quality and, in particular, to sperm mitochondrial function. We investigated the effects of quercetin, naringenin, genistein, apigenin, luteolin, and resveratrol at the concentration of 0.1–1000 nM on mitochondrial respiration efficiency. Upon chemical exposure, spermatozoa were swollen in a hypotonic solution and used for polarographic assays of mitochondrial respiration. All tested compounds, except for apigenin, caused a significant increase in the mitochondrial respiration efficiency at the concentration of 0.1 nM, and a significant decrease starting from concentrations of 10 nM. The analysis of oxygen consumption rate in the active and in the resting state of mitochondrial respiration suggested different mechanisms by which the tested compounds modulate mitochondrial function. Therefore, by virtue of their ability to stimulate the respiration active state, quercetin, genistein, and luteolin were found to improve mitochondrial function in asthenozoospermic samples. Our results are relevant to the debate on the promises and perils of natural antioxidants in nutraceutical supplementation.</jats:p> |
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| imprint_str_mv | MDPI AG, 2021 |
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| physical | 217 |
| publishDate | 2021 |
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| spelling | Ferramosca, Alessandra Lorenzetti, Stefano Di Giacomo, Mariangela Lunetti, Paola Murrieri, Francesco Capobianco, Loredana Dolce, Vincenza Coppola, Lamberto Zara, Vincenzo 2076-3921 MDPI AG Cell Biology Clinical Biochemistry Molecular Biology Biochemistry Physiology http://dx.doi.org/10.3390/antiox10020217 <jats:p>Plant bioactives, such as polyphenols, can differentially affect (positively or negatively) sperm quality, depending on their concentration. These molecules have been proposed as natural scavengers of reactive oxygen species (ROS) for male infertility treatment. However, few data are available about their effects on the molecular mechanisms related to sperm quality and, in particular, to sperm mitochondrial function. We investigated the effects of quercetin, naringenin, genistein, apigenin, luteolin, and resveratrol at the concentration of 0.1–1000 nM on mitochondrial respiration efficiency. Upon chemical exposure, spermatozoa were swollen in a hypotonic solution and used for polarographic assays of mitochondrial respiration. All tested compounds, except for apigenin, caused a significant increase in the mitochondrial respiration efficiency at the concentration of 0.1 nM, and a significant decrease starting from concentrations of 10 nM. The analysis of oxygen consumption rate in the active and in the resting state of mitochondrial respiration suggested different mechanisms by which the tested compounds modulate mitochondrial function. Therefore, by virtue of their ability to stimulate the respiration active state, quercetin, genistein, and luteolin were found to improve mitochondrial function in asthenozoospermic samples. Our results are relevant to the debate on the promises and perils of natural antioxidants in nutraceutical supplementation.</jats:p> Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols Antioxidants |
| spellingShingle | Ferramosca, Alessandra, Lorenzetti, Stefano, Di Giacomo, Mariangela, Lunetti, Paola, Murrieri, Francesco, Capobianco, Loredana, Dolce, Vincenza, Coppola, Lamberto, Zara, Vincenzo, Antioxidants, Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols, Cell Biology, Clinical Biochemistry, Molecular Biology, Biochemistry, Physiology |
| title | Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
| title_full | Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
| title_fullStr | Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
| title_full_unstemmed | Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
| title_short | Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
| title_sort | modulation of human sperm mitochondrial respiration efficiency by plant polyphenols |
| title_unstemmed | Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols |
| topic | Cell Biology, Clinical Biochemistry, Molecular Biology, Biochemistry, Physiology |
| url | http://dx.doi.org/10.3390/antiox10020217 |