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Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalom...
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Zeitschriftentitel: | Serbian Journal of Experimental and Clinical Research |
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Personen und Körperschaften: | , , , , , , , |
In: | Serbian Journal of Experimental and Clinical Research, 15, 2014, 4, S. 183-190 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Walter de Gruyter GmbH
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Schlagwörter: |
author_facet |
Milovanovic, Jelena Arsenijevic, Aleksandar Stojanovic, Bojana Milovanovic, Marija Jonjic, Stipan Popovic, Branka Arsenijevic, Nebojsa Lukic, Miodrag L. Milovanovic, Jelena Arsenijevic, Aleksandar Stojanovic, Bojana Milovanovic, Marija Jonjic, Stipan Popovic, Branka Arsenijevic, Nebojsa Lukic, Miodrag L. |
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author |
Milovanovic, Jelena Arsenijevic, Aleksandar Stojanovic, Bojana Milovanovic, Marija Jonjic, Stipan Popovic, Branka Arsenijevic, Nebojsa Lukic, Miodrag L. |
spellingShingle |
Milovanovic, Jelena Arsenijevic, Aleksandar Stojanovic, Bojana Milovanovic, Marija Jonjic, Stipan Popovic, Branka Arsenijevic, Nebojsa Lukic, Miodrag L. Serbian Journal of Experimental and Clinical Research Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa General Medicine |
author_sort |
milovanovic, jelena |
spelling |
Milovanovic, Jelena Arsenijevic, Aleksandar Stojanovic, Bojana Milovanovic, Marija Jonjic, Stipan Popovic, Branka Arsenijevic, Nebojsa Lukic, Miodrag L. 2335-075X 1820-8665 Walter de Gruyter GmbH General Medicine http://dx.doi.org/10.2478/sjecr-2014-0023 <jats:title>ABSTRACT</jats:title> <jats:p> Viral infection has been identified as the most likely environmental trigger of multiple sclerosis (MS). There are conflicting data regarding the role of cytomegalovirus (CMV) in MS pathogenesis. </jats:p> <jats:p>We utilised experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice and murine cytomegalovirus (MCMV), the murine homolog of CMV, to examine the mechanism by which viral infection enhances autoimmune neuroinflammation. Mice subjected to latent neonatal MCMV infection developed the typical characteristics of EAE. Similar to MS, the MCMV-infected EAE-induced mice developed infiltrates in the central nervous system (CNS) composed of similar percentages of CD4+ and CD8+ T cells. The influx of both Th 1 and Th 17 cells into the CNS of MCMV- infected EAE-induced mice was observed. Interestingly, the development of autoimmune neuroinflammation after latent MCMV infection was accompanied by a significant influx of Tc17 cells (CD8+IL-17+ and CD8+RoRγt+) but not Tc1, cells. Our results suggest that latent MCMV infection affects the development of inflammatory lymphocytes that exhibit encephalitogenic potential, thereby mediating increased CNS pathology following EAE induction, and that CMV represents a possible environmental factor in the pathogenesis of MS and other autoimmune diseases</jats:p> Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa Serbian Journal of Experimental and Clinical Research |
doi_str_mv |
10.2478/sjecr-2014-0023 |
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Walter de Gruyter GmbH, 2014 |
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Walter de Gruyter GmbH, 2014 |
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title |
Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_unstemmed |
Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_full |
Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_fullStr |
Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_full_unstemmed |
Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_short |
Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_sort |
latent murine cytomegalovirus infection contributes to eae pathogenesis / latentna infekcija mišjim citomegalovirusom ima ulogu u patogenezi eksperimentalnog autoimunskog encefalomijelitisa |
topic |
General Medicine |
url |
http://dx.doi.org/10.2478/sjecr-2014-0023 |
publishDate |
2014 |
physical |
183-190 |
description |
<jats:title>ABSTRACT</jats:title>
<jats:p> Viral infection has been identified as the most likely environmental trigger of multiple sclerosis (MS). There are conflicting data regarding the role of cytomegalovirus (CMV) in MS pathogenesis. </jats:p>
<jats:p>We utilised experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice and murine cytomegalovirus (MCMV), the murine homolog of CMV, to examine the mechanism by which viral infection enhances autoimmune neuroinflammation. Mice subjected to latent neonatal MCMV infection developed the typical characteristics of EAE. Similar to MS, the MCMV-infected EAE-induced mice developed infiltrates in the central nervous system (CNS) composed of similar percentages of CD4+ and CD8+ T cells. The influx of both Th 1 and Th 17 cells into the CNS of MCMV- infected EAE-induced mice was observed. Interestingly, the development of autoimmune neuroinflammation after latent MCMV infection was accompanied by a significant influx of Tc17 cells (CD8+IL-17+ and CD8+RoRγt+) but not Tc1, cells. Our results suggest that latent MCMV infection affects the development of inflammatory lymphocytes that exhibit encephalitogenic potential, thereby mediating increased CNS pathology following EAE induction, and that CMV represents a possible environmental factor in the pathogenesis of MS and other autoimmune diseases</jats:p> |
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author | Milovanovic, Jelena, Arsenijevic, Aleksandar, Stojanovic, Bojana, Milovanovic, Marija, Jonjic, Stipan, Popovic, Branka, Arsenijevic, Nebojsa, Lukic, Miodrag L. |
author_facet | Milovanovic, Jelena, Arsenijevic, Aleksandar, Stojanovic, Bojana, Milovanovic, Marija, Jonjic, Stipan, Popovic, Branka, Arsenijevic, Nebojsa, Lukic, Miodrag L., Milovanovic, Jelena, Arsenijevic, Aleksandar, Stojanovic, Bojana, Milovanovic, Marija, Jonjic, Stipan, Popovic, Branka, Arsenijevic, Nebojsa, Lukic, Miodrag L. |
author_sort | milovanovic, jelena |
container_issue | 4 |
container_start_page | 183 |
container_title | Serbian Journal of Experimental and Clinical Research |
container_volume | 15 |
description | <jats:title>ABSTRACT</jats:title> <jats:p> Viral infection has been identified as the most likely environmental trigger of multiple sclerosis (MS). There are conflicting data regarding the role of cytomegalovirus (CMV) in MS pathogenesis. </jats:p> <jats:p>We utilised experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice and murine cytomegalovirus (MCMV), the murine homolog of CMV, to examine the mechanism by which viral infection enhances autoimmune neuroinflammation. Mice subjected to latent neonatal MCMV infection developed the typical characteristics of EAE. Similar to MS, the MCMV-infected EAE-induced mice developed infiltrates in the central nervous system (CNS) composed of similar percentages of CD4+ and CD8+ T cells. The influx of both Th 1 and Th 17 cells into the CNS of MCMV- infected EAE-induced mice was observed. Interestingly, the development of autoimmune neuroinflammation after latent MCMV infection was accompanied by a significant influx of Tc17 cells (CD8+IL-17+ and CD8+RoRγt+) but not Tc1, cells. Our results suggest that latent MCMV infection affects the development of inflammatory lymphocytes that exhibit encephalitogenic potential, thereby mediating increased CNS pathology following EAE induction, and that CMV represents a possible environmental factor in the pathogenesis of MS and other autoimmune diseases</jats:p> |
doi_str_mv | 10.2478/sjecr-2014-0023 |
facet_avail | Online, Free |
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imprint_str_mv | Walter de Gruyter GmbH, 2014 |
institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
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match_str | milovanovic2014latentmurinecytomegalovirusinfectioncontributestoeaepathogenesislatentnainfekcijamisjimcitomegalovirusomimauloguupatogenezieksperimentalnogautoimunskogencefalomijelitisa |
mega_collection | Walter de Gruyter GmbH (CrossRef) |
physical | 183-190 |
publishDate | 2014 |
publishDateSort | 2014 |
publisher | Walter de Gruyter GmbH |
record_format | ai |
recordtype | ai |
series | Serbian Journal of Experimental and Clinical Research |
source_id | 49 |
spelling | Milovanovic, Jelena Arsenijevic, Aleksandar Stojanovic, Bojana Milovanovic, Marija Jonjic, Stipan Popovic, Branka Arsenijevic, Nebojsa Lukic, Miodrag L. 2335-075X 1820-8665 Walter de Gruyter GmbH General Medicine http://dx.doi.org/10.2478/sjecr-2014-0023 <jats:title>ABSTRACT</jats:title> <jats:p> Viral infection has been identified as the most likely environmental trigger of multiple sclerosis (MS). There are conflicting data regarding the role of cytomegalovirus (CMV) in MS pathogenesis. </jats:p> <jats:p>We utilised experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice and murine cytomegalovirus (MCMV), the murine homolog of CMV, to examine the mechanism by which viral infection enhances autoimmune neuroinflammation. Mice subjected to latent neonatal MCMV infection developed the typical characteristics of EAE. Similar to MS, the MCMV-infected EAE-induced mice developed infiltrates in the central nervous system (CNS) composed of similar percentages of CD4+ and CD8+ T cells. The influx of both Th 1 and Th 17 cells into the CNS of MCMV- infected EAE-induced mice was observed. Interestingly, the development of autoimmune neuroinflammation after latent MCMV infection was accompanied by a significant influx of Tc17 cells (CD8+IL-17+ and CD8+RoRγt+) but not Tc1, cells. Our results suggest that latent MCMV infection affects the development of inflammatory lymphocytes that exhibit encephalitogenic potential, thereby mediating increased CNS pathology following EAE induction, and that CMV represents a possible environmental factor in the pathogenesis of MS and other autoimmune diseases</jats:p> Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa Serbian Journal of Experimental and Clinical Research |
spellingShingle | Milovanovic, Jelena, Arsenijevic, Aleksandar, Stojanovic, Bojana, Milovanovic, Marija, Jonjic, Stipan, Popovic, Branka, Arsenijevic, Nebojsa, Lukic, Miodrag L., Serbian Journal of Experimental and Clinical Research, Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa, General Medicine |
title | Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_full | Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_fullStr | Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_full_unstemmed | Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_short | Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
title_sort | latent murine cytomegalovirus infection contributes to eae pathogenesis / latentna infekcija mišjim citomegalovirusom ima ulogu u patogenezi eksperimentalnog autoimunskog encefalomijelitisa |
title_unstemmed | Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis / Latentna Infekcija Mišjim Citomegalovirusom Ima Ulogu U Patogenezi Eksperimentalnog Autoimunskog Encefalomijelitisa |
topic | General Medicine |
url | http://dx.doi.org/10.2478/sjecr-2014-0023 |