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Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional...
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| Zeitschriftentitel: | Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. |
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| Personen und Körperschaften: | , , , , , , |
| In: | Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., 73, 2019, 4, S. 312-316 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Walter de Gruyter GmbH
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| Schlagwörter: |
| author_facet |
Laizāne, Gunta Ķīvīte, Anda Grope, Ilze Smane, Liene Miklaševics, Edvīns Ozoliņa, Laura Gardovska, Dace Laizāne, Gunta Ķīvīte, Anda Grope, Ilze Smane, Liene Miklaševics, Edvīns Ozoliņa, Laura Gardovska, Dace |
|---|---|
| author |
Laizāne, Gunta Ķīvīte, Anda Grope, Ilze Smane, Liene Miklaševics, Edvīns Ozoliņa, Laura Gardovska, Dace |
| spellingShingle |
Laizāne, Gunta Ķīvīte, Anda Grope, Ilze Smane, Liene Miklaševics, Edvīns Ozoliņa, Laura Gardovska, Dace Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia Multidisciplinary |
| author_sort |
laizāne, gunta |
| spelling |
Laizāne, Gunta Ķīvīte, Anda Grope, Ilze Smane, Liene Miklaševics, Edvīns Ozoliņa, Laura Gardovska, Dace 1407-009X Walter de Gruyter GmbH Multidisciplinary http://dx.doi.org/10.2478/prolas-2019-0049 <jats:title>Abstract</jats:title> <jats:p>In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children’s Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age < 5 years, G4P[8] (45.5%), G2P[4] (18.2%), G9P[8], G3P[8], and G1P[8] (9.1%) in children of age > 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.</jats:p> Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. |
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Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_unstemmed |
Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_full |
Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_fullStr |
Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_full_unstemmed |
Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_short |
Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_sort |
clinical characterisation of rota virus infection associated with most commonly circulating genotypes in children hospitalised in children’s university hospital: a cross-sectional study in latvia |
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Multidisciplinary |
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http://dx.doi.org/10.2478/prolas-2019-0049 |
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2019 |
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312-316 |
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<jats:title>Abstract</jats:title>
<jats:p>In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children’s Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age < 5 years, G4P[8] (45.5%), G2P[4] (18.2%), G9P[8], G3P[8], and G1P[8] (9.1%) in children of age > 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.</jats:p> |
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| description | <jats:title>Abstract</jats:title> <jats:p>In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children’s Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age < 5 years, G4P[8] (45.5%), G2P[4] (18.2%), G9P[8], G3P[8], and G1P[8] (9.1%) in children of age > 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.</jats:p> |
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| spelling | Laizāne, Gunta Ķīvīte, Anda Grope, Ilze Smane, Liene Miklaševics, Edvīns Ozoliņa, Laura Gardovska, Dace 1407-009X Walter de Gruyter GmbH Multidisciplinary http://dx.doi.org/10.2478/prolas-2019-0049 <jats:title>Abstract</jats:title> <jats:p>In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children’s Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age < 5 years, G4P[8] (45.5%), G2P[4] (18.2%), G9P[8], G3P[8], and G1P[8] (9.1%) in children of age > 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.</jats:p> Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. |
| spellingShingle | Laizāne, Gunta, Ķīvīte, Anda, Grope, Ilze, Smane, Liene, Miklaševics, Edvīns, Ozoliņa, Laura, Gardovska, Dace, Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia, Multidisciplinary |
| title | Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_full | Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_fullStr | Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_full_unstemmed | Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_short | Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| title_sort | clinical characterisation of rota virus infection associated with most commonly circulating genotypes in children hospitalised in children’s university hospital: a cross-sectional study in latvia |
| title_unstemmed | Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.2478/prolas-2019-0049 |