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Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy
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| Zeitschriftentitel: | Journal of Medical Biochemistry |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Journal of Medical Biochemistry, 38, 2019, 1, S. 71-82 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
Centre for Evaluation in Education and Science (CEON/CEES)
|
| author_facet |
Belovic, Dušica Kocijančić Plešinac, Snežana Dotlić, Jelena Radojević, Ana Savić Akšam, Slavica Cvjetićanin, Mirjana Marjanović Kocijančić, Aleksandar Belovic, Dušica Kocijančić Plešinac, Snežana Dotlić, Jelena Radojević, Ana Savić Akšam, Slavica Cvjetićanin, Mirjana Marjanović Kocijančić, Aleksandar |
|---|---|
| author |
Belovic, Dušica Kocijančić Plešinac, Snežana Dotlić, Jelena Radojević, Ana Savić Akšam, Slavica Cvjetićanin, Mirjana Marjanović Kocijančić, Aleksandar |
| spellingShingle |
Belovic, Dušica Kocijančić Plešinac, Snežana Dotlić, Jelena Radojević, Ana Savić Akšam, Slavica Cvjetićanin, Mirjana Marjanović Kocijančić, Aleksandar Journal of Medical Biochemistry Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| author_sort |
belovic, dušica kocijančić |
| spelling |
Belovic, Dušica Kocijančić Plešinac, Snežana Dotlić, Jelena Radojević, Ana Savić Akšam, Slavica Cvjetićanin, Mirjana Marjanović Kocijančić, Aleksandar 1452-8266 Centre for Evaluation in Education and Science (CEON/CEES) http://dx.doi.org/10.2478/jomb-2018-0001 <jats:title>Summary</jats:title><jats:p><jats:bold>Background:</jats:bold>Gestational hypertension (GH) and pre eclampsia (PE) are the most common gestational complications. Several placental biochemical markers are used to predict GH/PE, but with conflicting results.</jats:p><jats:p><jats:bold>Methods:</jats:bold>The study aim was to estimate the biochemical markers’ ability to predict hypertensive disorders in pregnancy. On the first ultrasonographic examination, 104 healthy pregnant women were recruited. At the regular pregnancy check-ups, BMI, blood pressure, occurrence of gestational hypertension (early or late onset), preeclampsia, eclampsia and other complications were recorded. Serum concentrations (in multiples of median – MoM) of human chorionic gonadotropin (HCG) and pregnancyassociated plasma protein A (PAPPA) were measured from the 11th to 14th gestational week, while HCG, alpha feto protein (AFP), estriol and inhibin were determined between the 16th and 19th gestational week.</jats:p><jats:p><jats:bold>Results:</jats:bold>Hypertensive disorders throughout pregnancy were diagnosed in 20.2% women. Early-onset GH was registered in 7 and PE in 6 patients, while 14 had late-onset GH and 10 additional women PE. There were no significant differences (p≥0.05) in biochemical markers concentrations between women with and without GH/PE. PAPPA levels in the first and HCG in the second trimester correlated with early and late GH/PE. Moreover, higher AFP concentrations were registered in women with preeclampsia signs/symptoms. According to ROC analysis, AFP>1.05 MoM properly identified 80% of GH/PE cases. Obtained models imply that HCG, PAPPA and AFP should be used for GH/PE prediction.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold>Biochemical markers HCG, PAPPA and AFP could be useful in predicting gestational hypertension and preeclampsia. However, different markers should be used for early and late onset GH/PE.</jats:p> Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy Journal of Medical Biochemistry |
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| title |
Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_unstemmed |
Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_full |
Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_fullStr |
Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_full_unstemmed |
Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_short |
Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_sort |
biochemical markers for prediction of hypertensive disorders of pregnancy |
| url |
http://dx.doi.org/10.2478/jomb-2018-0001 |
| publishDate |
2019 |
| physical |
71-82 |
| description |
<jats:title>Summary</jats:title><jats:p><jats:bold>Background:</jats:bold>Gestational hypertension (GH) and pre eclampsia (PE) are the most common gestational complications. Several placental biochemical markers are used to predict GH/PE, but with conflicting results.</jats:p><jats:p><jats:bold>Methods:</jats:bold>The study aim was to estimate the biochemical markers’ ability to predict hypertensive disorders in pregnancy. On the first ultrasonographic examination, 104 healthy pregnant women were recruited. At the regular pregnancy check-ups, BMI, blood pressure, occurrence of gestational hypertension (early or late onset), preeclampsia, eclampsia and other complications were recorded. Serum concentrations (in multiples of median – MoM) of human chorionic gonadotropin (HCG) and pregnancyassociated plasma protein A (PAPPA) were measured from the 11th to 14th gestational week, while HCG, alpha feto protein (AFP), estriol and inhibin were determined between the 16th and 19th gestational week.</jats:p><jats:p><jats:bold>Results:</jats:bold>Hypertensive disorders throughout pregnancy were diagnosed in 20.2% women. Early-onset GH was registered in 7 and PE in 6 patients, while 14 had late-onset GH and 10 additional women PE. There were no significant differences (p≥0.05) in biochemical markers concentrations between women with and without GH/PE. PAPPA levels in the first and HCG in the second trimester correlated with early and late GH/PE. Moreover, higher AFP concentrations were registered in women with preeclampsia signs/symptoms. According to ROC analysis, AFP>1.05 MoM properly identified 80% of GH/PE cases. Obtained models imply that HCG, PAPPA and AFP should be used for GH/PE prediction.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold>Biochemical markers HCG, PAPPA and AFP could be useful in predicting gestational hypertension and preeclampsia. However, different markers should be used for early and late onset GH/PE.</jats:p> |
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| author | Belovic, Dušica Kocijančić, Plešinac, Snežana, Dotlić, Jelena, Radojević, Ana Savić, Akšam, Slavica, Cvjetićanin, Mirjana Marjanović, Kocijančić, Aleksandar |
| author_facet | Belovic, Dušica Kocijančić, Plešinac, Snežana, Dotlić, Jelena, Radojević, Ana Savić, Akšam, Slavica, Cvjetićanin, Mirjana Marjanović, Kocijančić, Aleksandar, Belovic, Dušica Kocijančić, Plešinac, Snežana, Dotlić, Jelena, Radojević, Ana Savić, Akšam, Slavica, Cvjetićanin, Mirjana Marjanović, Kocijančić, Aleksandar |
| author_sort | belovic, dušica kocijančić |
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| description | <jats:title>Summary</jats:title><jats:p><jats:bold>Background:</jats:bold>Gestational hypertension (GH) and pre eclampsia (PE) are the most common gestational complications. Several placental biochemical markers are used to predict GH/PE, but with conflicting results.</jats:p><jats:p><jats:bold>Methods:</jats:bold>The study aim was to estimate the biochemical markers’ ability to predict hypertensive disorders in pregnancy. On the first ultrasonographic examination, 104 healthy pregnant women were recruited. At the regular pregnancy check-ups, BMI, blood pressure, occurrence of gestational hypertension (early or late onset), preeclampsia, eclampsia and other complications were recorded. Serum concentrations (in multiples of median – MoM) of human chorionic gonadotropin (HCG) and pregnancyassociated plasma protein A (PAPPA) were measured from the 11th to 14th gestational week, while HCG, alpha feto protein (AFP), estriol and inhibin were determined between the 16th and 19th gestational week.</jats:p><jats:p><jats:bold>Results:</jats:bold>Hypertensive disorders throughout pregnancy were diagnosed in 20.2% women. Early-onset GH was registered in 7 and PE in 6 patients, while 14 had late-onset GH and 10 additional women PE. There were no significant differences (p≥0.05) in biochemical markers concentrations between women with and without GH/PE. PAPPA levels in the first and HCG in the second trimester correlated with early and late GH/PE. Moreover, higher AFP concentrations were registered in women with preeclampsia signs/symptoms. According to ROC analysis, AFP>1.05 MoM properly identified 80% of GH/PE cases. Obtained models imply that HCG, PAPPA and AFP should be used for GH/PE prediction.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold>Biochemical markers HCG, PAPPA and AFP could be useful in predicting gestational hypertension and preeclampsia. However, different markers should be used for early and late onset GH/PE.</jats:p> |
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| imprint | Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
| imprint_str_mv | Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 71-82 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Centre for Evaluation in Education and Science (CEON/CEES) |
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| series | Journal of Medical Biochemistry |
| source_id | 49 |
| spelling | Belovic, Dušica Kocijančić Plešinac, Snežana Dotlić, Jelena Radojević, Ana Savić Akšam, Slavica Cvjetićanin, Mirjana Marjanović Kocijančić, Aleksandar 1452-8266 Centre for Evaluation in Education and Science (CEON/CEES) http://dx.doi.org/10.2478/jomb-2018-0001 <jats:title>Summary</jats:title><jats:p><jats:bold>Background:</jats:bold>Gestational hypertension (GH) and pre eclampsia (PE) are the most common gestational complications. Several placental biochemical markers are used to predict GH/PE, but with conflicting results.</jats:p><jats:p><jats:bold>Methods:</jats:bold>The study aim was to estimate the biochemical markers’ ability to predict hypertensive disorders in pregnancy. On the first ultrasonographic examination, 104 healthy pregnant women were recruited. At the regular pregnancy check-ups, BMI, blood pressure, occurrence of gestational hypertension (early or late onset), preeclampsia, eclampsia and other complications were recorded. Serum concentrations (in multiples of median – MoM) of human chorionic gonadotropin (HCG) and pregnancyassociated plasma protein A (PAPPA) were measured from the 11th to 14th gestational week, while HCG, alpha feto protein (AFP), estriol and inhibin were determined between the 16th and 19th gestational week.</jats:p><jats:p><jats:bold>Results:</jats:bold>Hypertensive disorders throughout pregnancy were diagnosed in 20.2% women. Early-onset GH was registered in 7 and PE in 6 patients, while 14 had late-onset GH and 10 additional women PE. There were no significant differences (p≥0.05) in biochemical markers concentrations between women with and without GH/PE. PAPPA levels in the first and HCG in the second trimester correlated with early and late GH/PE. Moreover, higher AFP concentrations were registered in women with preeclampsia signs/symptoms. According to ROC analysis, AFP>1.05 MoM properly identified 80% of GH/PE cases. Obtained models imply that HCG, PAPPA and AFP should be used for GH/PE prediction.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold>Biochemical markers HCG, PAPPA and AFP could be useful in predicting gestational hypertension and preeclampsia. However, different markers should be used for early and late onset GH/PE.</jats:p> Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy Journal of Medical Biochemistry |
| spellingShingle | Belovic, Dušica Kocijančić, Plešinac, Snežana, Dotlić, Jelena, Radojević, Ana Savić, Akšam, Slavica, Cvjetićanin, Mirjana Marjanović, Kocijančić, Aleksandar, Journal of Medical Biochemistry, Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_full | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_fullStr | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_full_unstemmed | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_short | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| title_sort | biochemical markers for prediction of hypertensive disorders of pregnancy |
| title_unstemmed | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
| url | http://dx.doi.org/10.2478/jomb-2018-0001 |