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Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico
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| Zeitschriftentitel: | Journal of Medical Biochemistry |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Journal of Medical Biochemistry, 38, 2019, 4, S. 461-467 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
Centre for Evaluation in Education and Science (CEON/CEES)
|
| author_facet |
Leal-Ugarte, Evelia Peralta-Leal, Valeria Meza-Espinoza, Juan Pablo Durán-González, Jorge Macías-Gómez, Nelly Bocanegra-Alonso, Anabel Lara-Ramos, José Ramón Leal-Ugarte, Evelia Peralta-Leal, Valeria Meza-Espinoza, Juan Pablo Durán-González, Jorge Macías-Gómez, Nelly Bocanegra-Alonso, Anabel Lara-Ramos, José Ramón |
|---|---|
| author |
Leal-Ugarte, Evelia Peralta-Leal, Valeria Meza-Espinoza, Juan Pablo Durán-González, Jorge Macías-Gómez, Nelly Bocanegra-Alonso, Anabel Lara-Ramos, José Ramón |
| spellingShingle |
Leal-Ugarte, Evelia Peralta-Leal, Valeria Meza-Espinoza, Juan Pablo Durán-González, Jorge Macías-Gómez, Nelly Bocanegra-Alonso, Anabel Lara-Ramos, José Ramón Journal of Medical Biochemistry Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| author_sort |
leal-ugarte, evelia |
| spelling |
Leal-Ugarte, Evelia Peralta-Leal, Valeria Meza-Espinoza, Juan Pablo Durán-González, Jorge Macías-Gómez, Nelly Bocanegra-Alonso, Anabel Lara-Ramos, José Ramón 1452-8266 Centre for Evaluation in Education and Science (CEON/CEES) http://dx.doi.org/10.2478/jomb-2018-0046 <jats:title>Summary</jats:title> <jats:sec id="j_jomb-2018-0046_s_005"> <jats:title>Background</jats:title> <jats:p>Methylenetetrahydrofolate reductase (<jats:italic>MTHFR</jats:italic>) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism with obesity and biochemical variables in young individuals of Mexico.</jats:p></jats:sec> <jats:sec id="j_jomb-2018-0046_s_006"> <jats:title>Methods</jats:title> <jats:p>A total of 316 young individuals were included in the study, 172 with normal weight (NW) and 144 with over weight/obesity. Body mass index (BMI) was classified as NW, overweight, and obesity. Also, waist circumference was measured. Moreover, glucose, total cholesterol, and triglycerides were determined. Genotyping for <jats:italic>MTHFR</jats:italic> 677C>T polymorphism was performed by the PCR-RFLP method.</jats:p></jats:sec> <jats:sec id="j_jomb-2018-0046_s_007"> <jats:title>Results</jats:title> <jats:p>There was no difference in the distribution of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW. However, an analysis stratified by gender showed a significant protector effect of the TT genotype against obesity in males and elevated waist circumference in females. Also, overweight/obese individuals with TT genotype had less risk of high cholesterol or triglycerides than overweight/obese subjects with the other genotypes.</jats:p></jats:sec> <jats:sec id="j_jomb-2018-0046_s_008"> <jats:title>Conclusions</jats:title> <jats:p>These results suggest that the <jats:italic>MTHFR</jats:italic> 677T polymorphism might not be a risk factor for being overweight/obesity. Rather, on the basis of our results, this variant could be a protector effect. However, further large-scale population-based studies are still necessary to clarify the role of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism in overweight, obesity, and lipid profile level.</jats:p></jats:sec> Association of the MTHFR 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico Journal of Medical Biochemistry |
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10.2478/jomb-2018-0046 |
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Online Free |
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Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
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Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
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1452-8266 |
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2019 |
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Centre for Evaluation in Education and Science (CEON/CEES) |
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ai |
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Journal of Medical Biochemistry |
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49 |
| title |
Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_unstemmed |
Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_full |
Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_fullStr |
Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_full_unstemmed |
Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_short |
Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_sort |
association of the mthfr 677c>t polymorphism with obesity and biochemical variables in a young population of mexico |
| url |
http://dx.doi.org/10.2478/jomb-2018-0046 |
| publishDate |
2019 |
| physical |
461-467 |
| description |
<jats:title>Summary</jats:title>
<jats:sec id="j_jomb-2018-0046_s_005">
<jats:title>Background</jats:title>
<jats:p>Methylenetetrahydrofolate reductase (<jats:italic>MTHFR</jats:italic>) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism with obesity and biochemical variables in young individuals of Mexico.</jats:p></jats:sec>
<jats:sec id="j_jomb-2018-0046_s_006">
<jats:title>Methods</jats:title>
<jats:p>A total of 316 young individuals were included in the study, 172 with normal weight (NW) and 144 with over weight/obesity. Body mass index (BMI) was classified as NW, overweight, and obesity. Also, waist circumference was measured. Moreover, glucose, total cholesterol, and triglycerides were determined. Genotyping for <jats:italic>MTHFR</jats:italic> 677C>T polymorphism was performed by the PCR-RFLP method.</jats:p></jats:sec>
<jats:sec id="j_jomb-2018-0046_s_007">
<jats:title>Results</jats:title>
<jats:p>There was no difference in the distribution of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW. However, an analysis stratified by gender showed a significant protector effect of the TT genotype against obesity in males and elevated waist circumference in females. Also, overweight/obese individuals with TT genotype had less risk of high cholesterol or triglycerides than overweight/obese subjects with the other genotypes.</jats:p></jats:sec>
<jats:sec id="j_jomb-2018-0046_s_008">
<jats:title>Conclusions</jats:title>
<jats:p>These results suggest that the <jats:italic>MTHFR</jats:italic> 677T polymorphism might not be a risk factor for being overweight/obesity. Rather, on the basis of our results, this variant could be a protector effect. However, further large-scale population-based studies are still necessary to clarify the role of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism in overweight, obesity, and lipid profile level.</jats:p></jats:sec> |
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| author | Leal-Ugarte, Evelia, Peralta-Leal, Valeria, Meza-Espinoza, Juan Pablo, Durán-González, Jorge, Macías-Gómez, Nelly, Bocanegra-Alonso, Anabel, Lara-Ramos, José Ramón |
| author_facet | Leal-Ugarte, Evelia, Peralta-Leal, Valeria, Meza-Espinoza, Juan Pablo, Durán-González, Jorge, Macías-Gómez, Nelly, Bocanegra-Alonso, Anabel, Lara-Ramos, José Ramón, Leal-Ugarte, Evelia, Peralta-Leal, Valeria, Meza-Espinoza, Juan Pablo, Durán-González, Jorge, Macías-Gómez, Nelly, Bocanegra-Alonso, Anabel, Lara-Ramos, José Ramón |
| author_sort | leal-ugarte, evelia |
| container_issue | 4 |
| container_start_page | 461 |
| container_title | Journal of Medical Biochemistry |
| container_volume | 38 |
| description | <jats:title>Summary</jats:title> <jats:sec id="j_jomb-2018-0046_s_005"> <jats:title>Background</jats:title> <jats:p>Methylenetetrahydrofolate reductase (<jats:italic>MTHFR</jats:italic>) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism with obesity and biochemical variables in young individuals of Mexico.</jats:p></jats:sec> <jats:sec id="j_jomb-2018-0046_s_006"> <jats:title>Methods</jats:title> <jats:p>A total of 316 young individuals were included in the study, 172 with normal weight (NW) and 144 with over weight/obesity. Body mass index (BMI) was classified as NW, overweight, and obesity. Also, waist circumference was measured. Moreover, glucose, total cholesterol, and triglycerides were determined. Genotyping for <jats:italic>MTHFR</jats:italic> 677C>T polymorphism was performed by the PCR-RFLP method.</jats:p></jats:sec> <jats:sec id="j_jomb-2018-0046_s_007"> <jats:title>Results</jats:title> <jats:p>There was no difference in the distribution of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW. However, an analysis stratified by gender showed a significant protector effect of the TT genotype against obesity in males and elevated waist circumference in females. Also, overweight/obese individuals with TT genotype had less risk of high cholesterol or triglycerides than overweight/obese subjects with the other genotypes.</jats:p></jats:sec> <jats:sec id="j_jomb-2018-0046_s_008"> <jats:title>Conclusions</jats:title> <jats:p>These results suggest that the <jats:italic>MTHFR</jats:italic> 677T polymorphism might not be a risk factor for being overweight/obesity. Rather, on the basis of our results, this variant could be a protector effect. However, further large-scale population-based studies are still necessary to clarify the role of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism in overweight, obesity, and lipid profile level.</jats:p></jats:sec> |
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| imprint | Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
| imprint_str_mv | Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 461-467 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Centre for Evaluation in Education and Science (CEON/CEES) |
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| series | Journal of Medical Biochemistry |
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| spelling | Leal-Ugarte, Evelia Peralta-Leal, Valeria Meza-Espinoza, Juan Pablo Durán-González, Jorge Macías-Gómez, Nelly Bocanegra-Alonso, Anabel Lara-Ramos, José Ramón 1452-8266 Centre for Evaluation in Education and Science (CEON/CEES) http://dx.doi.org/10.2478/jomb-2018-0046 <jats:title>Summary</jats:title> <jats:sec id="j_jomb-2018-0046_s_005"> <jats:title>Background</jats:title> <jats:p>Methylenetetrahydrofolate reductase (<jats:italic>MTHFR</jats:italic>) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism with obesity and biochemical variables in young individuals of Mexico.</jats:p></jats:sec> <jats:sec id="j_jomb-2018-0046_s_006"> <jats:title>Methods</jats:title> <jats:p>A total of 316 young individuals were included in the study, 172 with normal weight (NW) and 144 with over weight/obesity. Body mass index (BMI) was classified as NW, overweight, and obesity. Also, waist circumference was measured. Moreover, glucose, total cholesterol, and triglycerides were determined. Genotyping for <jats:italic>MTHFR</jats:italic> 677C>T polymorphism was performed by the PCR-RFLP method.</jats:p></jats:sec> <jats:sec id="j_jomb-2018-0046_s_007"> <jats:title>Results</jats:title> <jats:p>There was no difference in the distribution of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW. However, an analysis stratified by gender showed a significant protector effect of the TT genotype against obesity in males and elevated waist circumference in females. Also, overweight/obese individuals with TT genotype had less risk of high cholesterol or triglycerides than overweight/obese subjects with the other genotypes.</jats:p></jats:sec> <jats:sec id="j_jomb-2018-0046_s_008"> <jats:title>Conclusions</jats:title> <jats:p>These results suggest that the <jats:italic>MTHFR</jats:italic> 677T polymorphism might not be a risk factor for being overweight/obesity. Rather, on the basis of our results, this variant could be a protector effect. However, further large-scale population-based studies are still necessary to clarify the role of the <jats:italic>MTHFR</jats:italic> 677C>T polymorphism in overweight, obesity, and lipid profile level.</jats:p></jats:sec> Association of the MTHFR 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico Journal of Medical Biochemistry |
| spellingShingle | Leal-Ugarte, Evelia, Peralta-Leal, Valeria, Meza-Espinoza, Juan Pablo, Durán-González, Jorge, Macías-Gómez, Nelly, Bocanegra-Alonso, Anabel, Lara-Ramos, José Ramón, Journal of Medical Biochemistry, Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title | Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_full | Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_fullStr | Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_full_unstemmed | Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_short | Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| title_sort | association of the mthfr 677c>t polymorphism with obesity and biochemical variables in a young population of mexico |
| title_unstemmed | Association of the MTHFR 677CT polymorphism with obesity and biochemical variables in a young population of Mexico |
| url | http://dx.doi.org/10.2478/jomb-2018-0046 |