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Development of pulmonary oxygen toxicity in rats after hyperoxic exposure
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| Zeitschriftentitel: | Bulletin of the Veterinary Institute in Pulawy |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Bulletin of the Veterinary Institute in Pulawy, 58, 2014, 2, S. 305-310 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Walter de Gruyter GmbH
|
| author_facet |
Siermontowski, Piotr Pedrycz, Agnieszka Konarski, Maciej Kaczerska, Dorota Damme-Ostapowicz, Katarzyna van Olszański, Romuald Boratyński, Zbigniew Siermontowski, Piotr Pedrycz, Agnieszka Konarski, Maciej Kaczerska, Dorota Damme-Ostapowicz, Katarzyna van Olszański, Romuald Boratyński, Zbigniew |
|---|---|
| author |
Siermontowski, Piotr Pedrycz, Agnieszka Konarski, Maciej Kaczerska, Dorota Damme-Ostapowicz, Katarzyna van Olszański, Romuald Boratyński, Zbigniew |
| spellingShingle |
Siermontowski, Piotr Pedrycz, Agnieszka Konarski, Maciej Kaczerska, Dorota Damme-Ostapowicz, Katarzyna van Olszański, Romuald Boratyński, Zbigniew Bulletin of the Veterinary Institute in Pulawy Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| author_sort |
siermontowski, piotr |
| spelling |
Siermontowski, Piotr Pedrycz, Agnieszka Konarski, Maciej Kaczerska, Dorota Damme-Ostapowicz, Katarzyna van Olszański, Romuald Boratyński, Zbigniew 2300-3235 Walter de Gruyter GmbH http://dx.doi.org/10.2478/bvip-2014-0047 <jats:title>Abstract</jats:title> <jats:p> The aim of the study was to examine the effects of hyperbaric oxygen on lung aeration on an animal experimental model and compare the obtained results with the anticipated scope of damage to pulmonary parenchyma in humans under the same exposure conditions. The research was carried out on Black Hood rats that were kept in a hyperbaric chamber designed for animals in an atmosphere of pure oxygen and at overpressures of 0.15, 0.2, 0.3, 0.4, and 0.5 MPa for 1, 2 or 4 h. After sacrificing the animals, histopathological specimens were obtained encompassing cross-sections of entire lungs, which were subjected to qualitative and quantitative examination with the use of the 121-point Haug grid. A statistically significant decrease in pulmonary parenchyma was observed as a result of an increasing oxygen partial pressure as well as with prolonged exposure time. The intensification of changes observed was much higher than expected on the basis of calculations performed with the use of tables.</jats:p> Development of pulmonary oxygen toxicity in rats after hyperoxic exposure Bulletin of the Veterinary Institute in Pulawy |
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| title |
Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title_unstemmed |
Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title_full |
Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title_fullStr |
Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
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Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title_short |
Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
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development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
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http://dx.doi.org/10.2478/bvip-2014-0047 |
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2014 |
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305-310 |
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<jats:title>Abstract</jats:title>
<jats:p> The aim of the study was to examine the effects of hyperbaric oxygen on lung aeration on an animal experimental model and compare the obtained results with the anticipated scope of damage to pulmonary parenchyma in humans under the same exposure conditions. The research was carried out on Black Hood rats that were kept in a hyperbaric chamber designed for animals in an atmosphere of pure oxygen and at overpressures of 0.15, 0.2, 0.3, 0.4, and 0.5 MPa for 1, 2 or 4 h. After sacrificing the animals, histopathological specimens were obtained encompassing cross-sections of entire lungs, which were subjected to qualitative and quantitative examination with the use of the 121-point Haug grid. A statistically significant decrease in pulmonary parenchyma was observed as a result of an increasing oxygen partial pressure as well as with prolonged exposure time. The intensification of changes observed was much higher than expected on the basis of calculations performed with the use of tables.</jats:p> |
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| author | Siermontowski, Piotr, Pedrycz, Agnieszka, Konarski, Maciej, Kaczerska, Dorota, Damme-Ostapowicz, Katarzyna van, Olszański, Romuald, Boratyński, Zbigniew |
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| description | <jats:title>Abstract</jats:title> <jats:p> The aim of the study was to examine the effects of hyperbaric oxygen on lung aeration on an animal experimental model and compare the obtained results with the anticipated scope of damage to pulmonary parenchyma in humans under the same exposure conditions. The research was carried out on Black Hood rats that were kept in a hyperbaric chamber designed for animals in an atmosphere of pure oxygen and at overpressures of 0.15, 0.2, 0.3, 0.4, and 0.5 MPa for 1, 2 or 4 h. After sacrificing the animals, histopathological specimens were obtained encompassing cross-sections of entire lungs, which were subjected to qualitative and quantitative examination with the use of the 121-point Haug grid. A statistically significant decrease in pulmonary parenchyma was observed as a result of an increasing oxygen partial pressure as well as with prolonged exposure time. The intensification of changes observed was much higher than expected on the basis of calculations performed with the use of tables.</jats:p> |
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| spelling | Siermontowski, Piotr Pedrycz, Agnieszka Konarski, Maciej Kaczerska, Dorota Damme-Ostapowicz, Katarzyna van Olszański, Romuald Boratyński, Zbigniew 2300-3235 Walter de Gruyter GmbH http://dx.doi.org/10.2478/bvip-2014-0047 <jats:title>Abstract</jats:title> <jats:p> The aim of the study was to examine the effects of hyperbaric oxygen on lung aeration on an animal experimental model and compare the obtained results with the anticipated scope of damage to pulmonary parenchyma in humans under the same exposure conditions. The research was carried out on Black Hood rats that were kept in a hyperbaric chamber designed for animals in an atmosphere of pure oxygen and at overpressures of 0.15, 0.2, 0.3, 0.4, and 0.5 MPa for 1, 2 or 4 h. After sacrificing the animals, histopathological specimens were obtained encompassing cross-sections of entire lungs, which were subjected to qualitative and quantitative examination with the use of the 121-point Haug grid. A statistically significant decrease in pulmonary parenchyma was observed as a result of an increasing oxygen partial pressure as well as with prolonged exposure time. The intensification of changes observed was much higher than expected on the basis of calculations performed with the use of tables.</jats:p> Development of pulmonary oxygen toxicity in rats after hyperoxic exposure Bulletin of the Veterinary Institute in Pulawy |
| spellingShingle | Siermontowski, Piotr, Pedrycz, Agnieszka, Konarski, Maciej, Kaczerska, Dorota, Damme-Ostapowicz, Katarzyna van, Olszański, Romuald, Boratyński, Zbigniew, Bulletin of the Veterinary Institute in Pulawy, Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title | Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title_full | Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title_fullStr | Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title_full_unstemmed | Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title_short | Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title_sort | development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| title_unstemmed | Development of pulmonary oxygen toxicity in rats after hyperoxic exposure |
| url | http://dx.doi.org/10.2478/bvip-2014-0047 |