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Beneficial effects of baicalein on a model of allergic rhinitis
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| Zeitschriftentitel: | Acta Pharmaceutica |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Acta Pharmaceutica, 70, 2020, 1, S. 35-47 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Walter de Gruyter GmbH
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| Schlagwörter: |
| author_facet |
Liu, Tao Xu, Jing Wu, Yungang Li, Xiaoxia Ding, Detao Ma, Dengdian Yao, Mengwei Wei, Wenzhong Zhang, Wei Wang, Shaohua Yao, Jing Li, Xiaoyu Liu, Tao Xu, Jing Wu, Yungang Li, Xiaoxia Ding, Detao Ma, Dengdian Yao, Mengwei Wei, Wenzhong Zhang, Wei Wang, Shaohua Yao, Jing Li, Xiaoyu |
|---|---|
| author |
Liu, Tao Xu, Jing Wu, Yungang Li, Xiaoxia Ding, Detao Ma, Dengdian Yao, Mengwei Wei, Wenzhong Zhang, Wei Wang, Shaohua Yao, Jing Li, Xiaoyu |
| spellingShingle |
Liu, Tao Xu, Jing Wu, Yungang Li, Xiaoxia Ding, Detao Ma, Dengdian Yao, Mengwei Wei, Wenzhong Zhang, Wei Wang, Shaohua Yao, Jing Li, Xiaoyu Acta Pharmaceutica Beneficial effects of baicalein on a model of allergic rhinitis Pharmaceutical Science Pharmacology General Medicine |
| author_sort |
liu, tao |
| spelling |
Liu, Tao Xu, Jing Wu, Yungang Li, Xiaoxia Ding, Detao Ma, Dengdian Yao, Mengwei Wei, Wenzhong Zhang, Wei Wang, Shaohua Yao, Jing Li, Xiaoyu 1846-9558 Walter de Gruyter GmbH Pharmaceutical Science Pharmacology General Medicine http://dx.doi.org/10.2478/acph-2020-0009 <jats:title>Abstract</jats:title> <jats:p>Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the <jats:italic>in vivo</jats:italic> protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.</jats:p> Beneficial effects of baicalein on a model of allergic rhinitis Acta Pharmaceutica |
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10.2478/acph-2020-0009 |
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| title |
Beneficial effects of baicalein on a model of allergic rhinitis |
| title_unstemmed |
Beneficial effects of baicalein on a model of allergic rhinitis |
| title_full |
Beneficial effects of baicalein on a model of allergic rhinitis |
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Beneficial effects of baicalein on a model of allergic rhinitis |
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Beneficial effects of baicalein on a model of allergic rhinitis |
| title_short |
Beneficial effects of baicalein on a model of allergic rhinitis |
| title_sort |
beneficial effects of baicalein on a model of allergic rhinitis |
| topic |
Pharmaceutical Science Pharmacology General Medicine |
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http://dx.doi.org/10.2478/acph-2020-0009 |
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2020 |
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35-47 |
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<jats:title>Abstract</jats:title>
<jats:p>Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the <jats:italic>in vivo</jats:italic> protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.</jats:p> |
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| author | Liu, Tao, Xu, Jing, Wu, Yungang, Li, Xiaoxia, Ding, Detao, Ma, Dengdian, Yao, Mengwei, Wei, Wenzhong, Zhang, Wei, Wang, Shaohua, Yao, Jing, Li, Xiaoyu |
| author_facet | Liu, Tao, Xu, Jing, Wu, Yungang, Li, Xiaoxia, Ding, Detao, Ma, Dengdian, Yao, Mengwei, Wei, Wenzhong, Zhang, Wei, Wang, Shaohua, Yao, Jing, Li, Xiaoyu, Liu, Tao, Xu, Jing, Wu, Yungang, Li, Xiaoxia, Ding, Detao, Ma, Dengdian, Yao, Mengwei, Wei, Wenzhong, Zhang, Wei, Wang, Shaohua, Yao, Jing, Li, Xiaoyu |
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| description | <jats:title>Abstract</jats:title> <jats:p>Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the <jats:italic>in vivo</jats:italic> protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.</jats:p> |
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| imprint_str_mv | Walter de Gruyter GmbH, 2020 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
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| spelling | Liu, Tao Xu, Jing Wu, Yungang Li, Xiaoxia Ding, Detao Ma, Dengdian Yao, Mengwei Wei, Wenzhong Zhang, Wei Wang, Shaohua Yao, Jing Li, Xiaoyu 1846-9558 Walter de Gruyter GmbH Pharmaceutical Science Pharmacology General Medicine http://dx.doi.org/10.2478/acph-2020-0009 <jats:title>Abstract</jats:title> <jats:p>Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the <jats:italic>in vivo</jats:italic> protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.</jats:p> Beneficial effects of baicalein on a model of allergic rhinitis Acta Pharmaceutica |
| spellingShingle | Liu, Tao, Xu, Jing, Wu, Yungang, Li, Xiaoxia, Ding, Detao, Ma, Dengdian, Yao, Mengwei, Wei, Wenzhong, Zhang, Wei, Wang, Shaohua, Yao, Jing, Li, Xiaoyu, Acta Pharmaceutica, Beneficial effects of baicalein on a model of allergic rhinitis, Pharmaceutical Science, Pharmacology, General Medicine |
| title | Beneficial effects of baicalein on a model of allergic rhinitis |
| title_full | Beneficial effects of baicalein on a model of allergic rhinitis |
| title_fullStr | Beneficial effects of baicalein on a model of allergic rhinitis |
| title_full_unstemmed | Beneficial effects of baicalein on a model of allergic rhinitis |
| title_short | Beneficial effects of baicalein on a model of allergic rhinitis |
| title_sort | beneficial effects of baicalein on a model of allergic rhinitis |
| title_unstemmed | Beneficial effects of baicalein on a model of allergic rhinitis |
| topic | Pharmaceutical Science, Pharmacology, General Medicine |
| url | http://dx.doi.org/10.2478/acph-2020-0009 |