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Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes
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| Zeitschriftentitel: | Diabetes Care |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Diabetes Care, 35, 2012, 11, S. 2317-2323 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Diabetes Association
|
| Schlagwörter: |
| author_facet |
Penno, Giuseppe Solini, Anna Zoppini, Giacomo Orsi, Emanuela Zerbini, Gianpaolo Trevisan, Roberto Gruden, Gabriella Cavalot, Franco Laviola, Luigi Morano, Susanna Nicolucci, Antonio Pugliese, Giuseppe Penno, Giuseppe Solini, Anna Zoppini, Giacomo Orsi, Emanuela Zerbini, Gianpaolo Trevisan, Roberto Gruden, Gabriella Cavalot, Franco Laviola, Luigi Morano, Susanna Nicolucci, Antonio Pugliese, Giuseppe |
|---|---|
| author |
Penno, Giuseppe Solini, Anna Zoppini, Giacomo Orsi, Emanuela Zerbini, Gianpaolo Trevisan, Roberto Gruden, Gabriella Cavalot, Franco Laviola, Luigi Morano, Susanna Nicolucci, Antonio Pugliese, Giuseppe |
| spellingShingle |
Penno, Giuseppe Solini, Anna Zoppini, Giacomo Orsi, Emanuela Zerbini, Gianpaolo Trevisan, Roberto Gruden, Gabriella Cavalot, Franco Laviola, Luigi Morano, Susanna Nicolucci, Antonio Pugliese, Giuseppe Diabetes Care Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes Advanced and Specialized Nursing Endocrinology, Diabetes and Metabolism Internal Medicine |
| author_sort |
penno, giuseppe |
| spelling |
Penno, Giuseppe Solini, Anna Zoppini, Giacomo Orsi, Emanuela Zerbini, Gianpaolo Trevisan, Roberto Gruden, Gabriella Cavalot, Franco Laviola, Luigi Morano, Susanna Nicolucci, Antonio Pugliese, Giuseppe 0149-5992 1935-5548 American Diabetes Association Advanced and Specialized Nursing Endocrinology, Diabetes and Metabolism Internal Medicine http://dx.doi.org/10.2337/dc12-0628 <jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>To evaluate the rate and determinants of concordance between advanced diabetic retinopathy (DR) and chronic kidney disease (CKD), as assessed by both albuminuria and estimated glomerular filtration rate (eGFR), in the large cohort of the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>Patients with type 2 diabetes (n = 15,773) visiting consecutively 19 hospital–based diabetes clinics in years 2007 and 2008 were examined. DR was assessed by dilated fundoscopy. CKD was defined based on albuminuria and eGFR.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>CKD was present in 58.64% of subjects with advanced DR, whereas advanced DR was detectable only in 15.28% of individuals with any CKD and correlated with the albuminuric CKD phenotypes more than with the nonalbuminuric phenotype. Age, male sex, diabetes duration, hemoglobin A1c, hypertension, triglycerides, previous cardiovascular disease, and, inversely, HDL-cholesterol correlated independently with the presence of any CKD in individuals with advanced DR; correlates differed according to the presence of albuminuria, reduced eGFR, or both. Conversely, factors associated with the presence of advanced DR in subjects with any CKD were diabetes treatment, previous cardiovascular disease, albuminuria, and, inversely, smoking, eGFR, and age at diagnosis.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Concordance of CKD with advanced DR is low in subjects with type 2 diabetes, and CKD without advanced DR is more frequent than isolated advanced DR, at variance with type 1 diabetes. Factors independently associated with the presence of any CKD in individuals with advanced DR differ, at least in part, from those correlating with the presence of advanced DR in subjects with any CKD and by CKD phenotype.</jats:p> </jats:sec> Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes Diabetes Care |
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| title |
Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_unstemmed |
Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_full |
Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_fullStr |
Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_full_unstemmed |
Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_short |
Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_sort |
rate and determinants of association between advanced retinopathy and chronic kidney disease in patients with type 2 diabetes |
| topic |
Advanced and Specialized Nursing Endocrinology, Diabetes and Metabolism Internal Medicine |
| url |
http://dx.doi.org/10.2337/dc12-0628 |
| publishDate |
2012 |
| physical |
2317-2323 |
| description |
<jats:sec>
<jats:title>OBJECTIVE</jats:title>
<jats:p>To evaluate the rate and determinants of concordance between advanced diabetic retinopathy (DR) and chronic kidney disease (CKD), as assessed by both albuminuria and estimated glomerular filtration rate (eGFR), in the large cohort of the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>RESEARCH DESIGN AND METHODS</jats:title>
<jats:p>Patients with type 2 diabetes (n = 15,773) visiting consecutively 19 hospital–based diabetes clinics in years 2007 and 2008 were examined. DR was assessed by dilated fundoscopy. CKD was defined based on albuminuria and eGFR.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>RESULTS</jats:title>
<jats:p>CKD was present in 58.64% of subjects with advanced DR, whereas advanced DR was detectable only in 15.28% of individuals with any CKD and correlated with the albuminuric CKD phenotypes more than with the nonalbuminuric phenotype. Age, male sex, diabetes duration, hemoglobin A1c, hypertension, triglycerides, previous cardiovascular disease, and, inversely, HDL-cholesterol correlated independently with the presence of any CKD in individuals with advanced DR; correlates differed according to the presence of albuminuria, reduced eGFR, or both. Conversely, factors associated with the presence of advanced DR in subjects with any CKD were diabetes treatment, previous cardiovascular disease, albuminuria, and, inversely, smoking, eGFR, and age at diagnosis.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>CONCLUSIONS</jats:title>
<jats:p>Concordance of CKD with advanced DR is low in subjects with type 2 diabetes, and CKD without advanced DR is more frequent than isolated advanced DR, at variance with type 1 diabetes. Factors independently associated with the presence of any CKD in individuals with advanced DR differ, at least in part, from those correlating with the presence of advanced DR in subjects with any CKD and by CKD phenotype.</jats:p>
</jats:sec> |
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| author | Penno, Giuseppe, Solini, Anna, Zoppini, Giacomo, Orsi, Emanuela, Zerbini, Gianpaolo, Trevisan, Roberto, Gruden, Gabriella, Cavalot, Franco, Laviola, Luigi, Morano, Susanna, Nicolucci, Antonio, Pugliese, Giuseppe |
| author_facet | Penno, Giuseppe, Solini, Anna, Zoppini, Giacomo, Orsi, Emanuela, Zerbini, Gianpaolo, Trevisan, Roberto, Gruden, Gabriella, Cavalot, Franco, Laviola, Luigi, Morano, Susanna, Nicolucci, Antonio, Pugliese, Giuseppe, Penno, Giuseppe, Solini, Anna, Zoppini, Giacomo, Orsi, Emanuela, Zerbini, Gianpaolo, Trevisan, Roberto, Gruden, Gabriella, Cavalot, Franco, Laviola, Luigi, Morano, Susanna, Nicolucci, Antonio, Pugliese, Giuseppe |
| author_sort | penno, giuseppe |
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| description | <jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>To evaluate the rate and determinants of concordance between advanced diabetic retinopathy (DR) and chronic kidney disease (CKD), as assessed by both albuminuria and estimated glomerular filtration rate (eGFR), in the large cohort of the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>Patients with type 2 diabetes (n = 15,773) visiting consecutively 19 hospital–based diabetes clinics in years 2007 and 2008 were examined. DR was assessed by dilated fundoscopy. CKD was defined based on albuminuria and eGFR.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>CKD was present in 58.64% of subjects with advanced DR, whereas advanced DR was detectable only in 15.28% of individuals with any CKD and correlated with the albuminuric CKD phenotypes more than with the nonalbuminuric phenotype. Age, male sex, diabetes duration, hemoglobin A1c, hypertension, triglycerides, previous cardiovascular disease, and, inversely, HDL-cholesterol correlated independently with the presence of any CKD in individuals with advanced DR; correlates differed according to the presence of albuminuria, reduced eGFR, or both. Conversely, factors associated with the presence of advanced DR in subjects with any CKD were diabetes treatment, previous cardiovascular disease, albuminuria, and, inversely, smoking, eGFR, and age at diagnosis.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Concordance of CKD with advanced DR is low in subjects with type 2 diabetes, and CKD without advanced DR is more frequent than isolated advanced DR, at variance with type 1 diabetes. Factors independently associated with the presence of any CKD in individuals with advanced DR differ, at least in part, from those correlating with the presence of advanced DR in subjects with any CKD and by CKD phenotype.</jats:p> </jats:sec> |
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| imprint | American Diabetes Association, 2012 |
| imprint_str_mv | American Diabetes Association, 2012 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| spelling | Penno, Giuseppe Solini, Anna Zoppini, Giacomo Orsi, Emanuela Zerbini, Gianpaolo Trevisan, Roberto Gruden, Gabriella Cavalot, Franco Laviola, Luigi Morano, Susanna Nicolucci, Antonio Pugliese, Giuseppe 0149-5992 1935-5548 American Diabetes Association Advanced and Specialized Nursing Endocrinology, Diabetes and Metabolism Internal Medicine http://dx.doi.org/10.2337/dc12-0628 <jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>To evaluate the rate and determinants of concordance between advanced diabetic retinopathy (DR) and chronic kidney disease (CKD), as assessed by both albuminuria and estimated glomerular filtration rate (eGFR), in the large cohort of the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>Patients with type 2 diabetes (n = 15,773) visiting consecutively 19 hospital–based diabetes clinics in years 2007 and 2008 were examined. DR was assessed by dilated fundoscopy. CKD was defined based on albuminuria and eGFR.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>CKD was present in 58.64% of subjects with advanced DR, whereas advanced DR was detectable only in 15.28% of individuals with any CKD and correlated with the albuminuric CKD phenotypes more than with the nonalbuminuric phenotype. Age, male sex, diabetes duration, hemoglobin A1c, hypertension, triglycerides, previous cardiovascular disease, and, inversely, HDL-cholesterol correlated independently with the presence of any CKD in individuals with advanced DR; correlates differed according to the presence of albuminuria, reduced eGFR, or both. Conversely, factors associated with the presence of advanced DR in subjects with any CKD were diabetes treatment, previous cardiovascular disease, albuminuria, and, inversely, smoking, eGFR, and age at diagnosis.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Concordance of CKD with advanced DR is low in subjects with type 2 diabetes, and CKD without advanced DR is more frequent than isolated advanced DR, at variance with type 1 diabetes. Factors independently associated with the presence of any CKD in individuals with advanced DR differ, at least in part, from those correlating with the presence of advanced DR in subjects with any CKD and by CKD phenotype.</jats:p> </jats:sec> Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes Diabetes Care |
| spellingShingle | Penno, Giuseppe, Solini, Anna, Zoppini, Giacomo, Orsi, Emanuela, Zerbini, Gianpaolo, Trevisan, Roberto, Gruden, Gabriella, Cavalot, Franco, Laviola, Luigi, Morano, Susanna, Nicolucci, Antonio, Pugliese, Giuseppe, Diabetes Care, Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes, Advanced and Specialized Nursing, Endocrinology, Diabetes and Metabolism, Internal Medicine |
| title | Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_full | Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_fullStr | Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_full_unstemmed | Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_short | Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| title_sort | rate and determinants of association between advanced retinopathy and chronic kidney disease in patients with type 2 diabetes |
| title_unstemmed | Rate and Determinants of Association Between Advanced Retinopathy and Chronic Kidney Disease in Patients With Type 2 Diabetes |
| topic | Advanced and Specialized Nursing, Endocrinology, Diabetes and Metabolism, Internal Medicine |
| url | http://dx.doi.org/10.2337/dc12-0628 |