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IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM
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| Zeitschriftentitel: | International Journal of Applied Pharmaceutics |
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| Personen und Körperschaften: | , , , , |
| In: | International Journal of Applied Pharmaceutics, 2019, S. 251-255 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
Innovare Academic Sciences Pvt Ltd
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| Schlagwörter: |
| author_facet |
SETYANINGSIH, YUNI LATIF, ABDUL ASTUTY, HENDRI SYAFRUDDIN, DIN ASIH, PUJI BUDI SETIA SETYANINGSIH, YUNI LATIF, ABDUL ASTUTY, HENDRI SYAFRUDDIN, DIN ASIH, PUJI BUDI SETIA |
|---|---|
| author |
SETYANINGSIH, YUNI LATIF, ABDUL ASTUTY, HENDRI SYAFRUDDIN, DIN ASIH, PUJI BUDI SETIA |
| spellingShingle |
SETYANINGSIH, YUNI LATIF, ABDUL ASTUTY, HENDRI SYAFRUDDIN, DIN ASIH, PUJI BUDI SETIA International Journal of Applied Pharmaceutics IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM Pharmaceutical Science Pharmacology, Toxicology and Pharmaceutics (miscellaneous) |
| author_sort |
setyaningsih, yuni |
| spelling |
SETYANINGSIH, YUNI LATIF, ABDUL ASTUTY, HENDRI SYAFRUDDIN, DIN ASIH, PUJI BUDI SETIA 0975-7058 Innovare Academic Sciences Pvt Ltd Pharmaceutical Science Pharmacology, Toxicology and Pharmaceutics (miscellaneous) http://dx.doi.org/10.22159/ijap.2019.v11s1.16 <jats:p>Objective: This research aims to study the activity of a Streptomyces sp. fermentation product as an antimalarial modality in HepG2 cells.Methods: The effects of the product against Plasmodium falciparum 3D7 were examined using an in vitro technique parasite. The potency of theStreptomyces sp. fermentation product was examined by determining the half maximal inhibitory concentration (IC50), and the mechanism wasstudied using transmission electron microscopy (TEM). Toxicity tests were also conducted.Results: The Streptomyces sp. fermentation product had an IC50 of 0.001 μg/ml against the parasite, versus values of 0.054 and 0.022 μg/ml forquinidine and prodigiosin, respectively. TEM revealed no formation of hemozoin. The Streptomyces sp. fermentation product was non-toxic in HepG2cells based on its cytotoxicity concentration 50% of 1.380 μg/ml.Conclusion: The Streptomyces sp. fermentation product has potential as a potent and non-toxic antimalarial therapy.</jats:p> IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM International Journal of Applied Pharmaceutics |
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Innovare Academic Sciences Pvt Ltd, 2019 |
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Innovare Academic Sciences Pvt Ltd, 2019 |
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International Journal of Applied Pharmaceutics |
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| title |
IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_unstemmed |
IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_full |
IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_fullStr |
IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_full_unstemmed |
IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_short |
IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_sort |
in vitro potency and toxicity of streptomyces sp. fermentation product as an antimalarial therapy against plasmodium falciparum |
| topic |
Pharmaceutical Science Pharmacology, Toxicology and Pharmaceutics (miscellaneous) |
| url |
http://dx.doi.org/10.22159/ijap.2019.v11s1.16 |
| publishDate |
2019 |
| physical |
251-255 |
| description |
<jats:p>Objective: This research aims to study the activity of a Streptomyces sp. fermentation product as an antimalarial modality in HepG2 cells.Methods: The effects of the product against Plasmodium falciparum 3D7 were examined using an in vitro technique parasite. The potency of theStreptomyces sp. fermentation product was examined by determining the half maximal inhibitory concentration (IC50), and the mechanism wasstudied using transmission electron microscopy (TEM). Toxicity tests were also conducted.Results: The Streptomyces sp. fermentation product had an IC50 of 0.001 μg/ml against the parasite, versus values of 0.054 and 0.022 μg/ml forquinidine and prodigiosin, respectively. TEM revealed no formation of hemozoin. The Streptomyces sp. fermentation product was non-toxic in HepG2cells based on its cytotoxicity concentration 50% of 1.380 μg/ml.Conclusion: The Streptomyces sp. fermentation product has potential as a potent and non-toxic antimalarial therapy.</jats:p> |
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| author | SETYANINGSIH, YUNI, LATIF, ABDUL, ASTUTY, HENDRI, SYAFRUDDIN, DIN, ASIH, PUJI BUDI SETIA |
| author_facet | SETYANINGSIH, YUNI, LATIF, ABDUL, ASTUTY, HENDRI, SYAFRUDDIN, DIN, ASIH, PUJI BUDI SETIA, SETYANINGSIH, YUNI, LATIF, ABDUL, ASTUTY, HENDRI, SYAFRUDDIN, DIN, ASIH, PUJI BUDI SETIA |
| author_sort | setyaningsih, yuni |
| container_start_page | 251 |
| container_title | International Journal of Applied Pharmaceutics |
| description | <jats:p>Objective: This research aims to study the activity of a Streptomyces sp. fermentation product as an antimalarial modality in HepG2 cells.Methods: The effects of the product against Plasmodium falciparum 3D7 were examined using an in vitro technique parasite. The potency of theStreptomyces sp. fermentation product was examined by determining the half maximal inhibitory concentration (IC50), and the mechanism wasstudied using transmission electron microscopy (TEM). Toxicity tests were also conducted.Results: The Streptomyces sp. fermentation product had an IC50 of 0.001 μg/ml against the parasite, versus values of 0.054 and 0.022 μg/ml forquinidine and prodigiosin, respectively. TEM revealed no formation of hemozoin. The Streptomyces sp. fermentation product was non-toxic in HepG2cells based on its cytotoxicity concentration 50% of 1.380 μg/ml.Conclusion: The Streptomyces sp. fermentation product has potential as a potent and non-toxic antimalarial therapy.</jats:p> |
| doi_str_mv | 10.22159/ijap.2019.v11s1.16 |
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| spelling | SETYANINGSIH, YUNI LATIF, ABDUL ASTUTY, HENDRI SYAFRUDDIN, DIN ASIH, PUJI BUDI SETIA 0975-7058 Innovare Academic Sciences Pvt Ltd Pharmaceutical Science Pharmacology, Toxicology and Pharmaceutics (miscellaneous) http://dx.doi.org/10.22159/ijap.2019.v11s1.16 <jats:p>Objective: This research aims to study the activity of a Streptomyces sp. fermentation product as an antimalarial modality in HepG2 cells.Methods: The effects of the product against Plasmodium falciparum 3D7 were examined using an in vitro technique parasite. The potency of theStreptomyces sp. fermentation product was examined by determining the half maximal inhibitory concentration (IC50), and the mechanism wasstudied using transmission electron microscopy (TEM). Toxicity tests were also conducted.Results: The Streptomyces sp. fermentation product had an IC50 of 0.001 μg/ml against the parasite, versus values of 0.054 and 0.022 μg/ml forquinidine and prodigiosin, respectively. TEM revealed no formation of hemozoin. The Streptomyces sp. fermentation product was non-toxic in HepG2cells based on its cytotoxicity concentration 50% of 1.380 μg/ml.Conclusion: The Streptomyces sp. fermentation product has potential as a potent and non-toxic antimalarial therapy.</jats:p> IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM International Journal of Applied Pharmaceutics |
| spellingShingle | SETYANINGSIH, YUNI, LATIF, ABDUL, ASTUTY, HENDRI, SYAFRUDDIN, DIN, ASIH, PUJI BUDI SETIA, International Journal of Applied Pharmaceutics, IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM, Pharmaceutical Science, Pharmacology, Toxicology and Pharmaceutics (miscellaneous) |
| title | IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_full | IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_fullStr | IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_full_unstemmed | IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_short | IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| title_sort | in vitro potency and toxicity of streptomyces sp. fermentation product as an antimalarial therapy against plasmodium falciparum |
| title_unstemmed | IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM |
| topic | Pharmaceutical Science, Pharmacology, Toxicology and Pharmaceutics (miscellaneous) |
| url | http://dx.doi.org/10.22159/ijap.2019.v11s1.16 |