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Phytochemical analysis and gastroprotective activity of an olive leaf extract
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| Zeitschriftentitel: | Journal of the Serbian Chemical Society |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Journal of the Serbian Chemical Society, 74, 2009, 4, S. 367-377 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
National Library of Serbia
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| Schlagwörter: |
| author_facet |
Dekanski, Dragana Janicijevic-Hudomal, Snezana Tadic, Vanja Markovic, Goran Arsic, Ivana Mitrovic, Dusan Dekanski, Dragana Janicijevic-Hudomal, Snezana Tadic, Vanja Markovic, Goran Arsic, Ivana Mitrovic, Dusan |
|---|---|
| author |
Dekanski, Dragana Janicijevic-Hudomal, Snezana Tadic, Vanja Markovic, Goran Arsic, Ivana Mitrovic, Dusan |
| spellingShingle |
Dekanski, Dragana Janicijevic-Hudomal, Snezana Tadic, Vanja Markovic, Goran Arsic, Ivana Mitrovic, Dusan Journal of the Serbian Chemical Society Phytochemical analysis and gastroprotective activity of an olive leaf extract General Chemistry |
| author_sort |
dekanski, dragana |
| spelling |
Dekanski, Dragana Janicijevic-Hudomal, Snezana Tadic, Vanja Markovic, Goran Arsic, Ivana Mitrovic, Dusan 0352-5139 1820-7421 National Library of Serbia General Chemistry http://dx.doi.org/10.2298/jsc0904367d <jats:p>Some medicinal features of olive leaf have been known for centuries. It has been traditionally used as an antimicrobial and to prevent and treat diabetes mellitus and heart disease. Whether olive leaf, a natural antioxidant, influences the gastric defense mechanism and exhibits gastroprotection against experimentally-induced gastric lesions remains unknown. In this study, the content of total phenols, total flavonoids and tannins in olive leaf extract (OLE) were determined. Seven phenolic compounds were identified and quantified (oleuropein, caffeic acid, luteolin, luteolin-7-O-glucoside, apigenin-7-O-glucoside, quercetin, and chryseriol). Furthermore, the protective activity of the OLE in gastric mucosal injury induced by a corrosive concentration of ethanol was investigated. In relation to the control group, pretreatment with OLE (40, 80 and 120 mg kg-1) significantly (p < 0.001) attenuated the gastric lesions induced by absolute ethanol. The protective effect of the OLE was similar to that obtained with a reference drug, ranitidine. The results obtained indicate that OLE possesses significant gastroprotective activity, and that the presence of compounds with antioxidative properties would probably explain this effect.</jats:p> Phytochemical analysis and gastroprotective activity of an olive leaf extract Journal of the Serbian Chemical Society |
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Phytochemical analysis and gastroprotective activity of an olive leaf extract |
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Phytochemical analysis and gastroprotective activity of an olive leaf extract |
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Phytochemical analysis and gastroprotective activity of an olive leaf extract |
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Phytochemical analysis and gastroprotective activity of an olive leaf extract |
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Phytochemical analysis and gastroprotective activity of an olive leaf extract |
| title_short |
Phytochemical analysis and gastroprotective activity of an olive leaf extract |
| title_sort |
phytochemical analysis and gastroprotective activity of an olive leaf extract |
| topic |
General Chemistry |
| url |
http://dx.doi.org/10.2298/jsc0904367d |
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2009 |
| physical |
367-377 |
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<jats:p>Some medicinal features of olive leaf have been known for centuries. It has been traditionally used as an antimicrobial and to prevent and treat diabetes mellitus and heart disease. Whether olive leaf, a natural antioxidant, influences the gastric defense mechanism and exhibits gastroprotection against experimentally-induced gastric lesions remains unknown. In this study, the content of total phenols, total flavonoids and tannins in olive leaf extract (OLE) were determined. Seven phenolic compounds were identified and quantified (oleuropein, caffeic acid, luteolin, luteolin-7-O-glucoside, apigenin-7-O-glucoside, quercetin, and chryseriol). Furthermore, the protective activity of the OLE in gastric mucosal injury induced by a corrosive concentration of ethanol was investigated. In relation to the control group, pretreatment with OLE (40, 80 and 120 mg kg-1) significantly (p < 0.001) attenuated the gastric lesions induced by absolute ethanol. The protective effect of the OLE was similar to that obtained with a reference drug, ranitidine. The results obtained indicate that OLE possesses significant gastroprotective activity, and that the presence of compounds with antioxidative properties would probably explain this effect.</jats:p> |
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| author | Dekanski, Dragana, Janicijevic-Hudomal, Snezana, Tadic, Vanja, Markovic, Goran, Arsic, Ivana, Mitrovic, Dusan |
| author_facet | Dekanski, Dragana, Janicijevic-Hudomal, Snezana, Tadic, Vanja, Markovic, Goran, Arsic, Ivana, Mitrovic, Dusan, Dekanski, Dragana, Janicijevic-Hudomal, Snezana, Tadic, Vanja, Markovic, Goran, Arsic, Ivana, Mitrovic, Dusan |
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| description | <jats:p>Some medicinal features of olive leaf have been known for centuries. It has been traditionally used as an antimicrobial and to prevent and treat diabetes mellitus and heart disease. Whether olive leaf, a natural antioxidant, influences the gastric defense mechanism and exhibits gastroprotection against experimentally-induced gastric lesions remains unknown. In this study, the content of total phenols, total flavonoids and tannins in olive leaf extract (OLE) were determined. Seven phenolic compounds were identified and quantified (oleuropein, caffeic acid, luteolin, luteolin-7-O-glucoside, apigenin-7-O-glucoside, quercetin, and chryseriol). Furthermore, the protective activity of the OLE in gastric mucosal injury induced by a corrosive concentration of ethanol was investigated. In relation to the control group, pretreatment with OLE (40, 80 and 120 mg kg-1) significantly (p < 0.001) attenuated the gastric lesions induced by absolute ethanol. The protective effect of the OLE was similar to that obtained with a reference drug, ranitidine. The results obtained indicate that OLE possesses significant gastroprotective activity, and that the presence of compounds with antioxidative properties would probably explain this effect.</jats:p> |
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| physical | 367-377 |
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| spelling | Dekanski, Dragana Janicijevic-Hudomal, Snezana Tadic, Vanja Markovic, Goran Arsic, Ivana Mitrovic, Dusan 0352-5139 1820-7421 National Library of Serbia General Chemistry http://dx.doi.org/10.2298/jsc0904367d <jats:p>Some medicinal features of olive leaf have been known for centuries. It has been traditionally used as an antimicrobial and to prevent and treat diabetes mellitus and heart disease. Whether olive leaf, a natural antioxidant, influences the gastric defense mechanism and exhibits gastroprotection against experimentally-induced gastric lesions remains unknown. In this study, the content of total phenols, total flavonoids and tannins in olive leaf extract (OLE) were determined. Seven phenolic compounds were identified and quantified (oleuropein, caffeic acid, luteolin, luteolin-7-O-glucoside, apigenin-7-O-glucoside, quercetin, and chryseriol). Furthermore, the protective activity of the OLE in gastric mucosal injury induced by a corrosive concentration of ethanol was investigated. In relation to the control group, pretreatment with OLE (40, 80 and 120 mg kg-1) significantly (p < 0.001) attenuated the gastric lesions induced by absolute ethanol. The protective effect of the OLE was similar to that obtained with a reference drug, ranitidine. The results obtained indicate that OLE possesses significant gastroprotective activity, and that the presence of compounds with antioxidative properties would probably explain this effect.</jats:p> Phytochemical analysis and gastroprotective activity of an olive leaf extract Journal of the Serbian Chemical Society |
| spellingShingle | Dekanski, Dragana, Janicijevic-Hudomal, Snezana, Tadic, Vanja, Markovic, Goran, Arsic, Ivana, Mitrovic, Dusan, Journal of the Serbian Chemical Society, Phytochemical analysis and gastroprotective activity of an olive leaf extract, General Chemistry |
| title | Phytochemical analysis and gastroprotective activity of an olive leaf extract |
| title_full | Phytochemical analysis and gastroprotective activity of an olive leaf extract |
| title_fullStr | Phytochemical analysis and gastroprotective activity of an olive leaf extract |
| title_full_unstemmed | Phytochemical analysis and gastroprotective activity of an olive leaf extract |
| title_short | Phytochemical analysis and gastroprotective activity of an olive leaf extract |
| title_sort | phytochemical analysis and gastroprotective activity of an olive leaf extract |
| title_unstemmed | Phytochemical analysis and gastroprotective activity of an olive leaf extract |
| topic | General Chemistry |
| url | http://dx.doi.org/10.2298/jsc0904367d |