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Delayed hemolytic transfusion reaction due to anti-JKa
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| Zeitschriftentitel: | Acta chirurgica Iugoslavica |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Acta chirurgica Iugoslavica, 52, 2005, 3, S. 111-115 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
National Library of Serbia
|
| Schlagwörter: |
| author_facet |
Vucelic, D. Savic, N. Djordjevic, R. Vucelic, D. Savic, N. Djordjevic, R. |
|---|---|
| author |
Vucelic, D. Savic, N. Djordjevic, R. |
| spellingShingle |
Vucelic, D. Savic, N. Djordjevic, R. Acta chirurgica Iugoslavica Delayed hemolytic transfusion reaction due to anti-JKa General Medicine |
| author_sort |
vucelic, d. |
| spelling |
Vucelic, D. Savic, N. Djordjevic, R. 0354-950X 2406-0887 National Library of Serbia General Medicine http://dx.doi.org/10.2298/aci0503111v <jats:p>Background: Kidd antibodies are very heterogeneous and difficult to detect. They have been frequently implicated in delayed hemolytic transfusion reactions (DHTRs). Case report: A 64year old female (6 pregnancies, 2 deliveries, 4 abortions) with none red cell (RBC) transfusions in the history was admitted to hospital due to pneumonia and severe anemia. On admittance hemoglobin (Hb) level was 63g/L and hematocrit (Ht) 0,21L/L. The blood sample of the patient was sent to laboratory for serologic testing since RBC transfusions were required. Patient appeared to beO Rh(D)+ with negative both direct antiglobulin (DAT) and routine antibody screen (ID-DiaCell I+II+III-P). Three units of packed RBCs with negative crossmatch (tube method) were prepared. Patient received two units on Day 2 and one more on Day3 without any discomfort. Hematological values after the third unit were: Hb 116g/L and Ht 0,37L/L. On Day 6 she started to feel week, tired, with nausea and mild jaundice. Her Hb and Ht had dropped to 99g/L and 0,33L/L respectively, with tendency of dropping further (Day 7: Hb 83g/L,Ht 0,26L/L). Total serum bilirubin was 58,9 umol/L (normal range 20,5 umol/L) and direct fraction was 14,9 umol/L (normal range 7 umol/L). DTHR was suspected. Antibody identification performed by ID-DiaMed Gel Techique (GT) showed the presence of anti-Jka with dosage phenomenon. All three previously transfused units were typed Jka and the patient?s RBCs were Jk(a-b+). She received two units of Jka negative packed RBCs and was well enough to be discharged on Day 14. Conclusion: It is important to monitor clinical effect of transfusion regularly and to provide good team work between specialists of transfusion medicine and related medical staff. The policy of transfusion practice is to keep pretransfusion sample for three weeks and to perform cross-match tests on the samples no older then 24h and 48h respectively.</jats:p> Delayed hemolytic transfusion reaction due to anti-JKa Acta chirurgica Iugoslavica |
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Delayed hemolytic transfusion reaction due to anti-JKa |
| title_unstemmed |
Delayed hemolytic transfusion reaction due to anti-JKa |
| title_full |
Delayed hemolytic transfusion reaction due to anti-JKa |
| title_fullStr |
Delayed hemolytic transfusion reaction due to anti-JKa |
| title_full_unstemmed |
Delayed hemolytic transfusion reaction due to anti-JKa |
| title_short |
Delayed hemolytic transfusion reaction due to anti-JKa |
| title_sort |
delayed hemolytic transfusion reaction due to anti-jka |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.2298/aci0503111v |
| publishDate |
2005 |
| physical |
111-115 |
| description |
<jats:p>Background: Kidd antibodies are very heterogeneous and difficult to detect. They have been frequently implicated in delayed hemolytic transfusion reactions (DHTRs). Case report: A 64year old female (6 pregnancies, 2 deliveries, 4 abortions) with none red cell (RBC) transfusions in the history was admitted to hospital due to pneumonia and severe anemia. On admittance hemoglobin (Hb) level was 63g/L and hematocrit (Ht) 0,21L/L. The blood sample of the patient was sent to laboratory for serologic testing since RBC transfusions were required. Patient appeared to beO Rh(D)+ with negative both direct antiglobulin (DAT) and routine antibody screen (ID-DiaCell I+II+III-P). Three units of packed RBCs with negative crossmatch (tube method) were prepared. Patient received two units on Day 2 and one more on Day3 without any discomfort. Hematological values after the third unit were: Hb 116g/L and Ht 0,37L/L. On Day 6 she started to feel week, tired, with nausea and mild jaundice. Her Hb and Ht had dropped to 99g/L and 0,33L/L respectively, with tendency of dropping further (Day 7: Hb 83g/L,Ht 0,26L/L). Total serum bilirubin was 58,9 umol/L (normal range 20,5 umol/L) and direct fraction was 14,9 umol/L (normal range 7 umol/L). DTHR was suspected. Antibody identification performed by ID-DiaMed Gel Techique (GT) showed the presence of anti-Jka with dosage phenomenon. All three previously transfused units were typed Jka and the patient?s RBCs were Jk(a-b+). She received two units of Jka negative packed RBCs and was well enough to be discharged on Day 14. Conclusion: It is important to monitor clinical effect of transfusion regularly and to provide good team work between specialists of transfusion medicine and related medical staff. The policy of transfusion practice is to keep pretransfusion sample for three weeks and to perform cross-match tests on the samples no older then 24h and 48h respectively.</jats:p> |
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| author | Vucelic, D., Savic, N., Djordjevic, R. |
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| description | <jats:p>Background: Kidd antibodies are very heterogeneous and difficult to detect. They have been frequently implicated in delayed hemolytic transfusion reactions (DHTRs). Case report: A 64year old female (6 pregnancies, 2 deliveries, 4 abortions) with none red cell (RBC) transfusions in the history was admitted to hospital due to pneumonia and severe anemia. On admittance hemoglobin (Hb) level was 63g/L and hematocrit (Ht) 0,21L/L. The blood sample of the patient was sent to laboratory for serologic testing since RBC transfusions were required. Patient appeared to beO Rh(D)+ with negative both direct antiglobulin (DAT) and routine antibody screen (ID-DiaCell I+II+III-P). Three units of packed RBCs with negative crossmatch (tube method) were prepared. Patient received two units on Day 2 and one more on Day3 without any discomfort. Hematological values after the third unit were: Hb 116g/L and Ht 0,37L/L. On Day 6 she started to feel week, tired, with nausea and mild jaundice. Her Hb and Ht had dropped to 99g/L and 0,33L/L respectively, with tendency of dropping further (Day 7: Hb 83g/L,Ht 0,26L/L). Total serum bilirubin was 58,9 umol/L (normal range 20,5 umol/L) and direct fraction was 14,9 umol/L (normal range 7 umol/L). DTHR was suspected. Antibody identification performed by ID-DiaMed Gel Techique (GT) showed the presence of anti-Jka with dosage phenomenon. All three previously transfused units were typed Jka and the patient?s RBCs were Jk(a-b+). She received two units of Jka negative packed RBCs and was well enough to be discharged on Day 14. Conclusion: It is important to monitor clinical effect of transfusion regularly and to provide good team work between specialists of transfusion medicine and related medical staff. The policy of transfusion practice is to keep pretransfusion sample for three weeks and to perform cross-match tests on the samples no older then 24h and 48h respectively.</jats:p> |
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| spelling | Vucelic, D. Savic, N. Djordjevic, R. 0354-950X 2406-0887 National Library of Serbia General Medicine http://dx.doi.org/10.2298/aci0503111v <jats:p>Background: Kidd antibodies are very heterogeneous and difficult to detect. They have been frequently implicated in delayed hemolytic transfusion reactions (DHTRs). Case report: A 64year old female (6 pregnancies, 2 deliveries, 4 abortions) with none red cell (RBC) transfusions in the history was admitted to hospital due to pneumonia and severe anemia. On admittance hemoglobin (Hb) level was 63g/L and hematocrit (Ht) 0,21L/L. The blood sample of the patient was sent to laboratory for serologic testing since RBC transfusions were required. Patient appeared to beO Rh(D)+ with negative both direct antiglobulin (DAT) and routine antibody screen (ID-DiaCell I+II+III-P). Three units of packed RBCs with negative crossmatch (tube method) were prepared. Patient received two units on Day 2 and one more on Day3 without any discomfort. Hematological values after the third unit were: Hb 116g/L and Ht 0,37L/L. On Day 6 she started to feel week, tired, with nausea and mild jaundice. Her Hb and Ht had dropped to 99g/L and 0,33L/L respectively, with tendency of dropping further (Day 7: Hb 83g/L,Ht 0,26L/L). Total serum bilirubin was 58,9 umol/L (normal range 20,5 umol/L) and direct fraction was 14,9 umol/L (normal range 7 umol/L). DTHR was suspected. Antibody identification performed by ID-DiaMed Gel Techique (GT) showed the presence of anti-Jka with dosage phenomenon. All three previously transfused units were typed Jka and the patient?s RBCs were Jk(a-b+). She received two units of Jka negative packed RBCs and was well enough to be discharged on Day 14. Conclusion: It is important to monitor clinical effect of transfusion regularly and to provide good team work between specialists of transfusion medicine and related medical staff. The policy of transfusion practice is to keep pretransfusion sample for three weeks and to perform cross-match tests on the samples no older then 24h and 48h respectively.</jats:p> Delayed hemolytic transfusion reaction due to anti-JKa Acta chirurgica Iugoslavica |
| spellingShingle | Vucelic, D., Savic, N., Djordjevic, R., Acta chirurgica Iugoslavica, Delayed hemolytic transfusion reaction due to anti-JKa, General Medicine |
| title | Delayed hemolytic transfusion reaction due to anti-JKa |
| title_full | Delayed hemolytic transfusion reaction due to anti-JKa |
| title_fullStr | Delayed hemolytic transfusion reaction due to anti-JKa |
| title_full_unstemmed | Delayed hemolytic transfusion reaction due to anti-JKa |
| title_short | Delayed hemolytic transfusion reaction due to anti-JKa |
| title_sort | delayed hemolytic transfusion reaction due to anti-jka |
| title_unstemmed | Delayed hemolytic transfusion reaction due to anti-JKa |
| topic | General Medicine |
| url | http://dx.doi.org/10.2298/aci0503111v |