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The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study
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| Zeitschriftentitel: | Vojnosanitetski pregled |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Vojnosanitetski pregled, 69, 2012, 12, S. 1076-1083 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
National Library of Serbia
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| Schlagwörter: |
| author_facet |
Bubalo, Marija Lazic, Zoran Matic, Smiljana Tatic, Zoran Milovic, Radomir Petkovic-Curcin, Aleksandra Djurdjevic, Dragan Loncarevic, Slobodan Bubalo, Marija Lazic, Zoran Matic, Smiljana Tatic, Zoran Milovic, Radomir Petkovic-Curcin, Aleksandra Djurdjevic, Dragan Loncarevic, Slobodan |
|---|---|
| author |
Bubalo, Marija Lazic, Zoran Matic, Smiljana Tatic, Zoran Milovic, Radomir Petkovic-Curcin, Aleksandra Djurdjevic, Dragan Loncarevic, Slobodan |
| spellingShingle |
Bubalo, Marija Lazic, Zoran Matic, Smiljana Tatic, Zoran Milovic, Radomir Petkovic-Curcin, Aleksandra Djurdjevic, Dragan Loncarevic, Slobodan Vojnosanitetski pregled The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study Pharmacology (medical) |
| author_sort |
bubalo, marija |
| spelling |
Bubalo, Marija Lazic, Zoran Matic, Smiljana Tatic, Zoran Milovic, Radomir Petkovic-Curcin, Aleksandra Djurdjevic, Dragan Loncarevic, Slobodan 0042-8450 2406-0720 National Library of Serbia Pharmacology (medical) http://dx.doi.org/10.2298/vsp1212076b <jats:p>Background/Aim. A wide range of resorbable and nonresorbable membranes have been investigated over the last two decades. The barrier membrane protects the defect from ingrowth of soft tissue cells and allows bone progenitor cells to develop bone within a blood clot that is formed beneath the barrier membrane. The membranes are applied to reconstruct small bony defect prior to implantation, to cover dehiscences and fenestrations around dental implants. The aim of this study was to evaluate the influence of human resorbable demineralized membrane (RHDM) thickness on bone regeneration. Methods. The experiment, approved by Ethical Committee, was performed on 6 dogs and conducted into three phases. Bone defects were created in all the 6 dogs on the left side of the mandible, 8 weeks after extraction of second, third and fourth premolars. One defect was covered with RHDM 100 ? thick, one with RHDM 200 ? thick, and the third defect left empty (control defect). The histopathological analysis was done 2, 4 and 6 months after the surgery. In the third phase samples of bone tissue were taken and subjected to histopathological analysis. Results. In all the 6 dogs the defects treated with RHDM 200 ? thick showed higher level of bone regeneration in comparison with the defect treated with RHDM 100 ? thick and especially with empty defect. Conclusion. Our results demonstrated that the thicker membrane showed the least soft tissue ingrowths and promoted better bone formation at 6 months compared with a thinner one.</jats:p> The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study Vojnosanitetski pregled |
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10.2298/vsp1212076b |
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National Library of Serbia, 2012 |
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National Library of Serbia, 2012 |
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0042-8450 2406-0720 |
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Vojnosanitetski pregled |
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49 |
| title |
The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_unstemmed |
The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_full |
The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_fullStr |
The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_full_unstemmed |
The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_short |
The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_sort |
the impact of thickness of resorbable membrane of human origin on the ossification of bone defects: a pathohistologic study |
| topic |
Pharmacology (medical) |
| url |
http://dx.doi.org/10.2298/vsp1212076b |
| publishDate |
2012 |
| physical |
1076-1083 |
| description |
<jats:p>Background/Aim. A wide range of resorbable and nonresorbable membranes have
been investigated over the last two decades. The barrier membrane protects
the defect from ingrowth of soft tissue cells and allows bone progenitor
cells to develop bone within a blood clot that is formed beneath the barrier
membrane. The membranes are applied to reconstruct small bony defect prior to
implantation, to cover dehiscences and fenestrations around dental implants.
The aim of this study was to evaluate the influence of human resorbable
demineralized membrane (RHDM) thickness on bone regeneration. Methods. The
experiment, approved by Ethical Committee, was performed on 6 dogs and
conducted into three phases. Bone defects were created in all the 6 dogs on
the left side of the mandible, 8 weeks after extraction of second, third and
fourth premolars. One defect was covered with RHDM 100 ? thick, one with RHDM
200 ? thick, and the third defect left empty (control defect). The
histopathological analysis was done 2, 4 and 6 months after the surgery. In
the third phase samples of bone tissue were taken and subjected to
histopathological analysis. Results. In all the 6 dogs the defects treated
with RHDM 200 ? thick showed higher level of bone regeneration in comparison
with the defect treated with RHDM 100 ? thick and especially with empty
defect. Conclusion. Our results demonstrated that the thicker membrane showed
the least soft tissue ingrowths and promoted better bone formation at 6
months compared with a thinner one.</jats:p> |
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| author | Bubalo, Marija, Lazic, Zoran, Matic, Smiljana, Tatic, Zoran, Milovic, Radomir, Petkovic-Curcin, Aleksandra, Djurdjevic, Dragan, Loncarevic, Slobodan |
| author_facet | Bubalo, Marija, Lazic, Zoran, Matic, Smiljana, Tatic, Zoran, Milovic, Radomir, Petkovic-Curcin, Aleksandra, Djurdjevic, Dragan, Loncarevic, Slobodan, Bubalo, Marija, Lazic, Zoran, Matic, Smiljana, Tatic, Zoran, Milovic, Radomir, Petkovic-Curcin, Aleksandra, Djurdjevic, Dragan, Loncarevic, Slobodan |
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| description | <jats:p>Background/Aim. A wide range of resorbable and nonresorbable membranes have been investigated over the last two decades. The barrier membrane protects the defect from ingrowth of soft tissue cells and allows bone progenitor cells to develop bone within a blood clot that is formed beneath the barrier membrane. The membranes are applied to reconstruct small bony defect prior to implantation, to cover dehiscences and fenestrations around dental implants. The aim of this study was to evaluate the influence of human resorbable demineralized membrane (RHDM) thickness on bone regeneration. Methods. The experiment, approved by Ethical Committee, was performed on 6 dogs and conducted into three phases. Bone defects were created in all the 6 dogs on the left side of the mandible, 8 weeks after extraction of second, third and fourth premolars. One defect was covered with RHDM 100 ? thick, one with RHDM 200 ? thick, and the third defect left empty (control defect). The histopathological analysis was done 2, 4 and 6 months after the surgery. In the third phase samples of bone tissue were taken and subjected to histopathological analysis. Results. In all the 6 dogs the defects treated with RHDM 200 ? thick showed higher level of bone regeneration in comparison with the defect treated with RHDM 100 ? thick and especially with empty defect. Conclusion. Our results demonstrated that the thicker membrane showed the least soft tissue ingrowths and promoted better bone formation at 6 months compared with a thinner one.</jats:p> |
| doi_str_mv | 10.2298/vsp1212076b |
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| imprint | National Library of Serbia, 2012 |
| imprint_str_mv | National Library of Serbia, 2012 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2 |
| issn | 0042-8450, 2406-0720 |
| issn_str_mv | 0042-8450, 2406-0720 |
| language | English |
| last_indexed | 2024-03-01T16:59:37.095Z |
| match_str | bubalo2012theimpactofthicknessofresorbablemembraneofhumanoriginontheossificationofbonedefectsapathohistologicstudy |
| mega_collection | National Library of Serbia (CrossRef) |
| physical | 1076-1083 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| publisher | National Library of Serbia |
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| series | Vojnosanitetski pregled |
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| spelling | Bubalo, Marija Lazic, Zoran Matic, Smiljana Tatic, Zoran Milovic, Radomir Petkovic-Curcin, Aleksandra Djurdjevic, Dragan Loncarevic, Slobodan 0042-8450 2406-0720 National Library of Serbia Pharmacology (medical) http://dx.doi.org/10.2298/vsp1212076b <jats:p>Background/Aim. A wide range of resorbable and nonresorbable membranes have been investigated over the last two decades. The barrier membrane protects the defect from ingrowth of soft tissue cells and allows bone progenitor cells to develop bone within a blood clot that is formed beneath the barrier membrane. The membranes are applied to reconstruct small bony defect prior to implantation, to cover dehiscences and fenestrations around dental implants. The aim of this study was to evaluate the influence of human resorbable demineralized membrane (RHDM) thickness on bone regeneration. Methods. The experiment, approved by Ethical Committee, was performed on 6 dogs and conducted into three phases. Bone defects were created in all the 6 dogs on the left side of the mandible, 8 weeks after extraction of second, third and fourth premolars. One defect was covered with RHDM 100 ? thick, one with RHDM 200 ? thick, and the third defect left empty (control defect). The histopathological analysis was done 2, 4 and 6 months after the surgery. In the third phase samples of bone tissue were taken and subjected to histopathological analysis. Results. In all the 6 dogs the defects treated with RHDM 200 ? thick showed higher level of bone regeneration in comparison with the defect treated with RHDM 100 ? thick and especially with empty defect. Conclusion. Our results demonstrated that the thicker membrane showed the least soft tissue ingrowths and promoted better bone formation at 6 months compared with a thinner one.</jats:p> The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study Vojnosanitetski pregled |
| spellingShingle | Bubalo, Marija, Lazic, Zoran, Matic, Smiljana, Tatic, Zoran, Milovic, Radomir, Petkovic-Curcin, Aleksandra, Djurdjevic, Dragan, Loncarevic, Slobodan, Vojnosanitetski pregled, The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study, Pharmacology (medical) |
| title | The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_full | The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_fullStr | The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_full_unstemmed | The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_short | The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| title_sort | the impact of thickness of resorbable membrane of human origin on the ossification of bone defects: a pathohistologic study |
| title_unstemmed | The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study |
| topic | Pharmacology (medical) |
| url | http://dx.doi.org/10.2298/vsp1212076b |