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Plasma homocysteine levels in patients with liver cirrhosis
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| Zeitschriftentitel: | Vojnosanitetski pregled |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Vojnosanitetski pregled, 70, 2013, 1, S. 57-60 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
National Library of Serbia
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| Schlagwörter: |
| author_facet |
Culafic, Djordje Markovic, Miroslav Obrenovic, Radmila Mijac, Dragana Culafic, Djordje Markovic, Miroslav Obrenovic, Radmila Mijac, Dragana |
|---|---|
| author |
Culafic, Djordje Markovic, Miroslav Obrenovic, Radmila Mijac, Dragana |
| spellingShingle |
Culafic, Djordje Markovic, Miroslav Obrenovic, Radmila Mijac, Dragana Vojnosanitetski pregled Plasma homocysteine levels in patients with liver cirrhosis Pharmacology (medical) |
| author_sort |
culafic, djordje |
| spelling |
Culafic, Djordje Markovic, Miroslav Obrenovic, Radmila Mijac, Dragana 0042-8450 2406-0720 National Library of Serbia Pharmacology (medical) http://dx.doi.org/10.2298/vsp110823032c <jats:p>Background/Aim. Homocysteine (2-amino-4-mercaptobutyric acid) is an amino acid that may be found in small quantities in all cells, and is quantitatively the major methionine metabolite. The most prevalent form is protein-bound homocysteine (about 80%), mostly to albumins. If catabolism of homocysteine is impaired either due to enzyme defect or deficiency of required intracellular cofactors, homocysteine accumulates in cells and reaches the circulation. The aim of our study was to determine homocysteine values and factors affecting homocysteine metabolism in patients with liver cirrhosis. Methods. The prospective study included 35 patients with liver cirrhosis and 30 age and sex matched healthy controls. All the examinations were based on: medical history, physical examination, laboratory tests including serum homocysteine levels and liver biopsy. The degree of liver failure was assessed according to the Child-Pugh classification. Results. The mean plasma homocysteine levels were much higher in the patients with liver cirrhosis than in the healthy controls (t-test, p < 0.001). There was no significant difference between the plasma homocysteine concentration and etiology of liver cirrhosis (ANOVA, p > 0.05). Correlation analysis showed a positive correlation between the homocysteine and creatinine concentrations and between the serum albumin and homocysteine values, (Pearson's correlation, p < 0.01, and p < 0.05 respectively). Conclusion. In liver cirrhosis, the genesis of homocysteinemia is multifactorial, influenced significantly by impaired catabolic liver function, renal failure and hypoalbuminemia.</jats:p> Plasma homocysteine levels in patients with liver cirrhosis Vojnosanitetski pregled |
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10.2298/vsp110823032c |
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Chemie und Pharmazie |
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National Library of Serbia, 2013 |
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National Library of Serbia, 2013 |
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0042-8450 2406-0720 |
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English |
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culafic2013plasmahomocysteinelevelsinpatientswithlivercirrhosis |
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2013 |
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National Library of Serbia |
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Vojnosanitetski pregled |
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49 |
| title |
Plasma homocysteine levels in patients with liver cirrhosis |
| title_unstemmed |
Plasma homocysteine levels in patients with liver cirrhosis |
| title_full |
Plasma homocysteine levels in patients with liver cirrhosis |
| title_fullStr |
Plasma homocysteine levels in patients with liver cirrhosis |
| title_full_unstemmed |
Plasma homocysteine levels in patients with liver cirrhosis |
| title_short |
Plasma homocysteine levels in patients with liver cirrhosis |
| title_sort |
plasma homocysteine levels in patients with liver cirrhosis |
| topic |
Pharmacology (medical) |
| url |
http://dx.doi.org/10.2298/vsp110823032c |
| publishDate |
2013 |
| physical |
57-60 |
| description |
<jats:p>Background/Aim. Homocysteine (2-amino-4-mercaptobutyric acid) is an amino
acid that may be found in small quantities in all cells, and is
quantitatively the major methionine metabolite. The most prevalent form is
protein-bound homocysteine (about 80%), mostly to albumins. If catabolism of
homocysteine is impaired either due to enzyme defect or deficiency of
required intracellular cofactors, homocysteine accumulates in cells and
reaches the circulation. The aim of our study was to determine homocysteine
values and factors affecting homocysteine metabolism in patients with liver
cirrhosis. Methods. The prospective study included 35 patients with liver
cirrhosis and 30 age and sex matched healthy controls. All the examinations
were based on: medical history, physical examination, laboratory tests
including serum homocysteine levels and liver biopsy. The degree of liver
failure was assessed according to the Child-Pugh classification. Results. The
mean plasma homocysteine levels were much higher in the patients with liver
cirrhosis than in the healthy controls (t-test, p < 0.001). There was no
significant difference between the plasma homocysteine concentration and
etiology of liver cirrhosis (ANOVA, p > 0.05). Correlation analysis showed a
positive correlation between the homocysteine and creatinine concentrations
and between the serum albumin and homocysteine values, (Pearson's
correlation, p < 0.01, and p < 0.05 respectively). Conclusion. In liver
cirrhosis, the genesis of homocysteinemia is multifactorial, influenced
significantly by impaired catabolic liver function, renal failure and
hypoalbuminemia.</jats:p> |
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| author | Culafic, Djordje, Markovic, Miroslav, Obrenovic, Radmila, Mijac, Dragana |
| author_facet | Culafic, Djordje, Markovic, Miroslav, Obrenovic, Radmila, Mijac, Dragana, Culafic, Djordje, Markovic, Miroslav, Obrenovic, Radmila, Mijac, Dragana |
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| description | <jats:p>Background/Aim. Homocysteine (2-amino-4-mercaptobutyric acid) is an amino acid that may be found in small quantities in all cells, and is quantitatively the major methionine metabolite. The most prevalent form is protein-bound homocysteine (about 80%), mostly to albumins. If catabolism of homocysteine is impaired either due to enzyme defect or deficiency of required intracellular cofactors, homocysteine accumulates in cells and reaches the circulation. The aim of our study was to determine homocysteine values and factors affecting homocysteine metabolism in patients with liver cirrhosis. Methods. The prospective study included 35 patients with liver cirrhosis and 30 age and sex matched healthy controls. All the examinations were based on: medical history, physical examination, laboratory tests including serum homocysteine levels and liver biopsy. The degree of liver failure was assessed according to the Child-Pugh classification. Results. The mean plasma homocysteine levels were much higher in the patients with liver cirrhosis than in the healthy controls (t-test, p < 0.001). There was no significant difference between the plasma homocysteine concentration and etiology of liver cirrhosis (ANOVA, p > 0.05). Correlation analysis showed a positive correlation between the homocysteine and creatinine concentrations and between the serum albumin and homocysteine values, (Pearson's correlation, p < 0.01, and p < 0.05 respectively). Conclusion. In liver cirrhosis, the genesis of homocysteinemia is multifactorial, influenced significantly by impaired catabolic liver function, renal failure and hypoalbuminemia.</jats:p> |
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| spelling | Culafic, Djordje Markovic, Miroslav Obrenovic, Radmila Mijac, Dragana 0042-8450 2406-0720 National Library of Serbia Pharmacology (medical) http://dx.doi.org/10.2298/vsp110823032c <jats:p>Background/Aim. Homocysteine (2-amino-4-mercaptobutyric acid) is an amino acid that may be found in small quantities in all cells, and is quantitatively the major methionine metabolite. The most prevalent form is protein-bound homocysteine (about 80%), mostly to albumins. If catabolism of homocysteine is impaired either due to enzyme defect or deficiency of required intracellular cofactors, homocysteine accumulates in cells and reaches the circulation. The aim of our study was to determine homocysteine values and factors affecting homocysteine metabolism in patients with liver cirrhosis. Methods. The prospective study included 35 patients with liver cirrhosis and 30 age and sex matched healthy controls. All the examinations were based on: medical history, physical examination, laboratory tests including serum homocysteine levels and liver biopsy. The degree of liver failure was assessed according to the Child-Pugh classification. Results. The mean plasma homocysteine levels were much higher in the patients with liver cirrhosis than in the healthy controls (t-test, p < 0.001). There was no significant difference between the plasma homocysteine concentration and etiology of liver cirrhosis (ANOVA, p > 0.05). Correlation analysis showed a positive correlation between the homocysteine and creatinine concentrations and between the serum albumin and homocysteine values, (Pearson's correlation, p < 0.01, and p < 0.05 respectively). Conclusion. In liver cirrhosis, the genesis of homocysteinemia is multifactorial, influenced significantly by impaired catabolic liver function, renal failure and hypoalbuminemia.</jats:p> Plasma homocysteine levels in patients with liver cirrhosis Vojnosanitetski pregled |
| spellingShingle | Culafic, Djordje, Markovic, Miroslav, Obrenovic, Radmila, Mijac, Dragana, Vojnosanitetski pregled, Plasma homocysteine levels in patients with liver cirrhosis, Pharmacology (medical) |
| title | Plasma homocysteine levels in patients with liver cirrhosis |
| title_full | Plasma homocysteine levels in patients with liver cirrhosis |
| title_fullStr | Plasma homocysteine levels in patients with liver cirrhosis |
| title_full_unstemmed | Plasma homocysteine levels in patients with liver cirrhosis |
| title_short | Plasma homocysteine levels in patients with liver cirrhosis |
| title_sort | plasma homocysteine levels in patients with liver cirrhosis |
| title_unstemmed | Plasma homocysteine levels in patients with liver cirrhosis |
| topic | Pharmacology (medical) |
| url | http://dx.doi.org/10.2298/vsp110823032c |