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Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses...
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| Zeitschriftentitel: | Nuclear Receptor Signaling |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Nuclear Receptor Signaling, 6, 2008, 1, S. nrs.06007 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Gallo, Dominique Haddad, Iman Laurent, Guy Vinh, Joëlle Jacquemotte, Françoise Jacquot, Yves Leclercq, Guy Gallo, Dominique Haddad, Iman Laurent, Guy Vinh, Joëlle Jacquemotte, Françoise Jacquot, Yves Leclercq, Guy |
|---|---|
| author |
Gallo, Dominique Haddad, Iman Laurent, Guy Vinh, Joëlle Jacquemotte, Françoise Jacquot, Yves Leclercq, Guy |
| spellingShingle |
Gallo, Dominique Haddad, Iman Laurent, Guy Vinh, Joëlle Jacquemotte, Françoise Jacquot, Yves Leclercq, Guy Nuclear Receptor Signaling Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? General Medicine |
| author_sort |
gallo, dominique |
| spelling |
Gallo, Dominique Haddad, Iman Laurent, Guy Vinh, Joëlle Jacquemotte, Françoise Jacquot, Yves Leclercq, Guy 1550-7629 1550-7629 SAGE Publications General Medicine http://dx.doi.org/10.1621/nrs.06007 <jats:p>The way in which estrogen receptor α (ERα) mediates gene transcription and hormone-dependent cancer cell proliferation is now being largely reconsidered in view of several recent discoveries. ERα-mediated transcription appears to be a cyclic and transient process where the proteasome - and thus receptor degradation - plays a pivotal role. In view of our recent investigations, which demonstrate the estrogenic activity of a synthetic peptide corresponding to a regulatory motif of the receptor (ERα17p), we propose that ERα proteasomal degradation could induce the emergence of regulatory peptide(s). The latter would function as a signal and contribute to the ERα activation process, amplifying the initial hormonal stimulation and giving rise to sustained estrogenic response.</jats:p> Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? Nuclear Receptor Signaling |
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| title |
Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_unstemmed |
Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_full |
Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_fullStr |
Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_full_unstemmed |
Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_short |
Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_sort |
regulatory function of the p295-t311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.1621/nrs.06007 |
| publishDate |
2008 |
| physical |
nrs.06007 |
| description |
<jats:p>The way in which estrogen receptor α (ERα) mediates gene transcription and hormone-dependent cancer cell proliferation is now being largely reconsidered in view of several recent discoveries. ERα-mediated transcription appears to be a cyclic and transient process where the proteasome - and thus receptor degradation - plays a pivotal role. In view of our recent investigations, which demonstrate the estrogenic activity of a synthetic peptide corresponding to a regulatory motif of the receptor (ERα17p), we propose that ERα proteasomal degradation could induce the emergence of regulatory peptide(s). The latter would function as a signal and contribute to the ERα activation process, amplifying the initial hormonal stimulation and giving rise to sustained estrogenic response.</jats:p> |
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| author | Gallo, Dominique, Haddad, Iman, Laurent, Guy, Vinh, Joëlle, Jacquemotte, Françoise, Jacquot, Yves, Leclercq, Guy |
| author_facet | Gallo, Dominique, Haddad, Iman, Laurent, Guy, Vinh, Joëlle, Jacquemotte, Françoise, Jacquot, Yves, Leclercq, Guy, Gallo, Dominique, Haddad, Iman, Laurent, Guy, Vinh, Joëlle, Jacquemotte, Françoise, Jacquot, Yves, Leclercq, Guy |
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| description | <jats:p>The way in which estrogen receptor α (ERα) mediates gene transcription and hormone-dependent cancer cell proliferation is now being largely reconsidered in view of several recent discoveries. ERα-mediated transcription appears to be a cyclic and transient process where the proteasome - and thus receptor degradation - plays a pivotal role. In view of our recent investigations, which demonstrate the estrogenic activity of a synthetic peptide corresponding to a regulatory motif of the receptor (ERα17p), we propose that ERα proteasomal degradation could induce the emergence of regulatory peptide(s). The latter would function as a signal and contribute to the ERα activation process, amplifying the initial hormonal stimulation and giving rise to sustained estrogenic response.</jats:p> |
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| spelling | Gallo, Dominique Haddad, Iman Laurent, Guy Vinh, Joëlle Jacquemotte, Françoise Jacquot, Yves Leclercq, Guy 1550-7629 1550-7629 SAGE Publications General Medicine http://dx.doi.org/10.1621/nrs.06007 <jats:p>The way in which estrogen receptor α (ERα) mediates gene transcription and hormone-dependent cancer cell proliferation is now being largely reconsidered in view of several recent discoveries. ERα-mediated transcription appears to be a cyclic and transient process where the proteasome - and thus receptor degradation - plays a pivotal role. In view of our recent investigations, which demonstrate the estrogenic activity of a synthetic peptide corresponding to a regulatory motif of the receptor (ERα17p), we propose that ERα proteasomal degradation could induce the emergence of regulatory peptide(s). The latter would function as a signal and contribute to the ERα activation process, amplifying the initial hormonal stimulation and giving rise to sustained estrogenic response.</jats:p> Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? Nuclear Receptor Signaling |
| spellingShingle | Gallo, Dominique, Haddad, Iman, Laurent, Guy, Vinh, Joëlle, Jacquemotte, Françoise, Jacquot, Yves, Leclercq, Guy, Nuclear Receptor Signaling, Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses?, General Medicine |
| title | Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_full | Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_fullStr | Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_full_unstemmed | Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_short | Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_sort | regulatory function of the p295-t311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| title_unstemmed | Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? |
| topic | General Medicine |
| url | http://dx.doi.org/10.1621/nrs.06007 |