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Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue
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| Zeitschriftentitel: | EMBO reports |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | EMBO reports, 18, 2017, 4, S. 645-657 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Springer Science and Business Media LLC
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| Schlagwörter: |
| author_facet |
Hui, Xiaoyan Zhang, Mingliang Gu, Ping Li, Kuai Gao, Yuan Wu, Donghai Wang, Yu Xu, Aimin Hui, Xiaoyan Zhang, Mingliang Gu, Ping Li, Kuai Gao, Yuan Wu, Donghai Wang, Yu Xu, Aimin |
|---|---|
| author |
Hui, Xiaoyan Zhang, Mingliang Gu, Ping Li, Kuai Gao, Yuan Wu, Donghai Wang, Yu Xu, Aimin |
| spellingShingle |
Hui, Xiaoyan Zhang, Mingliang Gu, Ping Li, Kuai Gao, Yuan Wu, Donghai Wang, Yu Xu, Aimin EMBO reports Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue Genetics Molecular Biology Biochemistry |
| author_sort |
hui, xiaoyan |
| spelling |
Hui, Xiaoyan Zhang, Mingliang Gu, Ping Li, Kuai Gao, Yuan Wu, Donghai Wang, Yu Xu, Aimin 1469-221X 1469-3178 Springer Science and Business Media LLC Genetics Molecular Biology Biochemistry http://dx.doi.org/10.15252/embr.201643184 <jats:title>Abstract</jats:title><jats:p>Adipose tissue inflammation, characterized by augmented infiltration and altered polarization of macrophages, contributes to insulin resistance and its associated metabolic diseases. The <jats:styled-content style="fixed-case">NAD</jats:styled-content><jats:sup>+</jats:sup>‐dependent deacetylase <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 serves as a guardian against metabolic disorders in multiple tissues. To dissect the roles of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipose tissues, metabolic phenotypes of mice with selective ablation of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipocytes and myeloid cells were monitored. Compared to myeloid‐specific <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 depletion, mice with adipocyte‐selective deletion of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 are more susceptible to diet‐induced insulin resistance. The phenotypic changes in adipocyte‐selective <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 knockout mice are associated with an increased number of adipose‐resident macrophages and their polarization toward the pro‐inflammatory M1 subtype. Mechanistically, <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipocytes modulates expression and secretion of several adipokines, including adiponectin, <jats:styled-content style="fixed-case">MCP</jats:styled-content>‐1, and interleukin 4, which in turn alters recruitment and polarization of the macrophages in adipose tissues. In adipocytes, <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 deacetylates the transcription factor <jats:styled-content style="fixed-case">NFAT</jats:styled-content>c1 and thereby enhances the binding of <jats:styled-content style="fixed-case">NFAT</jats:styled-content>c1 to the <jats:italic>Il4</jats:italic> gene promoter. These findings suggest that adipocyte <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 controls systemic glucose homeostasis and insulin sensitivity via the cross talk with adipose‐resident macrophages.</jats:p> Adipocyte <scp>SIRT</scp>1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue EMBO reports |
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10.15252/embr.201643184 |
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Springer Science and Business Media LLC, 2017 |
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Springer Science and Business Media LLC, 2017 |
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| title |
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_unstemmed |
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_full |
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_fullStr |
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_full_unstemmed |
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_short |
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_sort |
adipocyte <scp>sirt</scp>1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| topic |
Genetics Molecular Biology Biochemistry |
| url |
http://dx.doi.org/10.15252/embr.201643184 |
| publishDate |
2017 |
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645-657 |
| description |
<jats:title>Abstract</jats:title><jats:p>Adipose tissue inflammation, characterized by augmented infiltration and altered polarization of macrophages, contributes to insulin resistance and its associated metabolic diseases. The <jats:styled-content style="fixed-case">NAD</jats:styled-content><jats:sup>+</jats:sup>‐dependent deacetylase <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 serves as a guardian against metabolic disorders in multiple tissues. To dissect the roles of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipose tissues, metabolic phenotypes of mice with selective ablation of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipocytes and myeloid cells were monitored. Compared to myeloid‐specific <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 depletion, mice with adipocyte‐selective deletion of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 are more susceptible to diet‐induced insulin resistance. The phenotypic changes in adipocyte‐selective <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 knockout mice are associated with an increased number of adipose‐resident macrophages and their polarization toward the pro‐inflammatory M1 subtype. Mechanistically, <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipocytes modulates expression and secretion of several adipokines, including adiponectin, <jats:styled-content style="fixed-case">MCP</jats:styled-content>‐1, and interleukin 4, which in turn alters recruitment and polarization of the macrophages in adipose tissues. In adipocytes, <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 deacetylates the transcription factor <jats:styled-content style="fixed-case">NFAT</jats:styled-content>c1 and thereby enhances the binding of <jats:styled-content style="fixed-case">NFAT</jats:styled-content>c1 to the <jats:italic>Il4</jats:italic> gene promoter. These findings suggest that adipocyte <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 controls systemic glucose homeostasis and insulin sensitivity via the cross talk with adipose‐resident macrophages.</jats:p> |
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| description | <jats:title>Abstract</jats:title><jats:p>Adipose tissue inflammation, characterized by augmented infiltration and altered polarization of macrophages, contributes to insulin resistance and its associated metabolic diseases. The <jats:styled-content style="fixed-case">NAD</jats:styled-content><jats:sup>+</jats:sup>‐dependent deacetylase <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 serves as a guardian against metabolic disorders in multiple tissues. To dissect the roles of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipose tissues, metabolic phenotypes of mice with selective ablation of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipocytes and myeloid cells were monitored. Compared to myeloid‐specific <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 depletion, mice with adipocyte‐selective deletion of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 are more susceptible to diet‐induced insulin resistance. The phenotypic changes in adipocyte‐selective <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 knockout mice are associated with an increased number of adipose‐resident macrophages and their polarization toward the pro‐inflammatory M1 subtype. Mechanistically, <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipocytes modulates expression and secretion of several adipokines, including adiponectin, <jats:styled-content style="fixed-case">MCP</jats:styled-content>‐1, and interleukin 4, which in turn alters recruitment and polarization of the macrophages in adipose tissues. In adipocytes, <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 deacetylates the transcription factor <jats:styled-content style="fixed-case">NFAT</jats:styled-content>c1 and thereby enhances the binding of <jats:styled-content style="fixed-case">NFAT</jats:styled-content>c1 to the <jats:italic>Il4</jats:italic> gene promoter. These findings suggest that adipocyte <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 controls systemic glucose homeostasis and insulin sensitivity via the cross talk with adipose‐resident macrophages.</jats:p> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Hui, Xiaoyan Zhang, Mingliang Gu, Ping Li, Kuai Gao, Yuan Wu, Donghai Wang, Yu Xu, Aimin 1469-221X 1469-3178 Springer Science and Business Media LLC Genetics Molecular Biology Biochemistry http://dx.doi.org/10.15252/embr.201643184 <jats:title>Abstract</jats:title><jats:p>Adipose tissue inflammation, characterized by augmented infiltration and altered polarization of macrophages, contributes to insulin resistance and its associated metabolic diseases. The <jats:styled-content style="fixed-case">NAD</jats:styled-content><jats:sup>+</jats:sup>‐dependent deacetylase <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 serves as a guardian against metabolic disorders in multiple tissues. To dissect the roles of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipose tissues, metabolic phenotypes of mice with selective ablation of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipocytes and myeloid cells were monitored. Compared to myeloid‐specific <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 depletion, mice with adipocyte‐selective deletion of <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 are more susceptible to diet‐induced insulin resistance. The phenotypic changes in adipocyte‐selective <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 knockout mice are associated with an increased number of adipose‐resident macrophages and their polarization toward the pro‐inflammatory M1 subtype. Mechanistically, <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 in adipocytes modulates expression and secretion of several adipokines, including adiponectin, <jats:styled-content style="fixed-case">MCP</jats:styled-content>‐1, and interleukin 4, which in turn alters recruitment and polarization of the macrophages in adipose tissues. In adipocytes, <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 deacetylates the transcription factor <jats:styled-content style="fixed-case">NFAT</jats:styled-content>c1 and thereby enhances the binding of <jats:styled-content style="fixed-case">NFAT</jats:styled-content>c1 to the <jats:italic>Il4</jats:italic> gene promoter. These findings suggest that adipocyte <jats:styled-content style="fixed-case">SIRT</jats:styled-content>1 controls systemic glucose homeostasis and insulin sensitivity via the cross talk with adipose‐resident macrophages.</jats:p> Adipocyte <scp>SIRT</scp>1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue EMBO reports |
| spellingShingle | Hui, Xiaoyan, Zhang, Mingliang, Gu, Ping, Li, Kuai, Gao, Yuan, Wu, Donghai, Wang, Yu, Xu, Aimin, EMBO reports, Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue, Genetics, Molecular Biology, Biochemistry |
| title | Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_full | Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_fullStr | Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_full_unstemmed | Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_short | Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_sort | adipocyte <scp>sirt</scp>1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| title_unstemmed | Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue |
| topic | Genetics, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.15252/embr.201643184 |