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Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery
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| Zeitschriftentitel: | Serbian Journal of Experimental and Clinical Research |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Serbian Journal of Experimental and Clinical Research, 20, 2019, 2, S. 27-36 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Centre for Evaluation in Education and Science (CEON/CEES)
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| Schlagwörter: |
| author_facet |
Jovanovic, Danijela Milovanovic, Dragan R. Jeremic, Nevena Nikolic, Tamara Stojic, Isidora Jakovljevic, Vladimir Vukovic, Natalija Jovanovic, Danijela Milovanovic, Dragan R. Jeremic, Nevena Nikolic, Tamara Stojic, Isidora Jakovljevic, Vladimir Vukovic, Natalija |
|---|---|
| author |
Jovanovic, Danijela Milovanovic, Dragan R. Jeremic, Nevena Nikolic, Tamara Stojic, Isidora Jakovljevic, Vladimir Vukovic, Natalija |
| spellingShingle |
Jovanovic, Danijela Milovanovic, Dragan R. Jeremic, Nevena Nikolic, Tamara Stojic, Isidora Jakovljevic, Vladimir Vukovic, Natalija Serbian Journal of Experimental and Clinical Research Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery General Medicine |
| author_sort |
jovanovic, danijela |
| spelling |
Jovanovic, Danijela Milovanovic, Dragan R. Jeremic, Nevena Nikolic, Tamara Stojic, Isidora Jakovljevic, Vladimir Vukovic, Natalija 2335-075X 1820-8665 Centre for Evaluation in Education and Science (CEON/CEES) General Medicine http://dx.doi.org/10.1515/sjecr-2017-0046 <jats:title>Abstract</jats:title> <jats:p>Study aimed to investigate relationship between oxidative stress markers and postoperative recovery in woman after abdominal hysterectomy, as well as to test the hypothesis that different analgesics differently influence redox status.</jats:p> <jats:p>The quality of recovery was evaluated with a QoR-40 questionnaire in fifty-one patients who underwent abdominal hysterectomy, preoperatively and on the 1<jats:sup>st</jats:sup>, 2<jats:sup>nd</jats:sup>, 3<jats:sup>rd</jats:sup> postoperative days (POD1,2,3). Blood samples were collected at baseline (T0), 3 (T1), 24 (T2), 48 (T3) and 72 (T4) hours after surgery. Oxidative stress markers concentrations (TBARS, NO<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>, H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>, O<jats:sub>2</jats:sub> <jats:sup>−</jats:sup> ) as well as antioxidative enzymes (SOD, CAT, and GSH) were analyzed.</jats:p> <jats:p>QoR-40 total score significantly declined on POD1 and POD2 and returned to baseline levels on POD3 (p<0.001). H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> levels significantly decreased from T0 to T3 and then, increased at T4 (p=0,011). Changes of TBARS and H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> from T0 to T3 showed significant and negative correlation (r=−0.303, p=0.046). There was no significant correlation between QoR-40 total score and any parameter of oxidative stress response (p>0.05). Changes in TBARS levels from T0 to T3 were statistically significant between the study subgroups primarily due to increase of the concentrations in patients receiving paracetamol (p=0.031). Patients age, duration of surgery and cigarette smoking status showed significant influcences on and association with some oxidative stress response markers (TBARS, O<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>, CAT) (p<0.05).</jats:p> <jats:p>Women who underwent hysterectomy had significant changes of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and TBARS activity however, those changes were not associated with changes of QoR-40 total scores during recovery.</jats:p> Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery Serbian Journal of Experimental and Clinical Research |
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Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
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Serbian Journal of Experimental and Clinical Research |
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| title |
Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_unstemmed |
Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_full |
Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_fullStr |
Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_full_unstemmed |
Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_short |
Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_sort |
oxidative stress parameters after abdominal hysterectomy and their relationships with quality of recovery |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.1515/sjecr-2017-0046 |
| publishDate |
2019 |
| physical |
27-36 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Study aimed to investigate relationship between oxidative stress markers and postoperative recovery in woman after abdominal hysterectomy, as well as to test the hypothesis that different analgesics differently influence redox status.</jats:p>
<jats:p>The quality of recovery was evaluated with a QoR-40 questionnaire in fifty-one patients who underwent abdominal hysterectomy, preoperatively and on the 1<jats:sup>st</jats:sup>, 2<jats:sup>nd</jats:sup>, 3<jats:sup>rd</jats:sup> postoperative days (POD1,2,3). Blood samples were collected at baseline (T0), 3 (T1), 24 (T2), 48 (T3) and 72 (T4) hours after surgery. Oxidative stress markers concentrations (TBARS, NO<jats:sub>2</jats:sub>
<jats:sup>−</jats:sup>, H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>, O<jats:sub>2</jats:sub>
<jats:sup>−</jats:sup> ) as well as antioxidative enzymes (SOD, CAT, and GSH) were analyzed.</jats:p>
<jats:p>QoR-40 total score significantly declined on POD1 and POD2 and returned to baseline levels on POD3 (p<0.001). H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> levels significantly decreased from T0 to T3 and then, increased at T4 (p=0,011). Changes of TBARS and H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> from T0 to T3 showed significant and negative correlation (r=−0.303, p=0.046). There was no significant correlation between QoR-40 total score and any parameter of oxidative stress response (p>0.05). Changes in TBARS levels from T0 to T3 were statistically significant between the study subgroups primarily due to increase of the concentrations in patients receiving paracetamol (p=0.031). Patients age, duration of surgery and cigarette smoking status showed significant influcences on and association with some oxidative stress response markers (TBARS, O<jats:sub>2</jats:sub>
<jats:sup>−</jats:sup>, CAT) (p<0.05).</jats:p>
<jats:p>Women who underwent hysterectomy had significant changes of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and TBARS activity however, those changes were not associated with changes of QoR-40 total scores during recovery.</jats:p> |
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| author | Jovanovic, Danijela, Milovanovic, Dragan R., Jeremic, Nevena, Nikolic, Tamara, Stojic, Isidora, Jakovljevic, Vladimir, Vukovic, Natalija |
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| description | <jats:title>Abstract</jats:title> <jats:p>Study aimed to investigate relationship between oxidative stress markers and postoperative recovery in woman after abdominal hysterectomy, as well as to test the hypothesis that different analgesics differently influence redox status.</jats:p> <jats:p>The quality of recovery was evaluated with a QoR-40 questionnaire in fifty-one patients who underwent abdominal hysterectomy, preoperatively and on the 1<jats:sup>st</jats:sup>, 2<jats:sup>nd</jats:sup>, 3<jats:sup>rd</jats:sup> postoperative days (POD1,2,3). Blood samples were collected at baseline (T0), 3 (T1), 24 (T2), 48 (T3) and 72 (T4) hours after surgery. Oxidative stress markers concentrations (TBARS, NO<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>, H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>, O<jats:sub>2</jats:sub> <jats:sup>−</jats:sup> ) as well as antioxidative enzymes (SOD, CAT, and GSH) were analyzed.</jats:p> <jats:p>QoR-40 total score significantly declined on POD1 and POD2 and returned to baseline levels on POD3 (p<0.001). H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> levels significantly decreased from T0 to T3 and then, increased at T4 (p=0,011). Changes of TBARS and H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> from T0 to T3 showed significant and negative correlation (r=−0.303, p=0.046). There was no significant correlation between QoR-40 total score and any parameter of oxidative stress response (p>0.05). Changes in TBARS levels from T0 to T3 were statistically significant between the study subgroups primarily due to increase of the concentrations in patients receiving paracetamol (p=0.031). Patients age, duration of surgery and cigarette smoking status showed significant influcences on and association with some oxidative stress response markers (TBARS, O<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>, CAT) (p<0.05).</jats:p> <jats:p>Women who underwent hysterectomy had significant changes of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and TBARS activity however, those changes were not associated with changes of QoR-40 total scores during recovery.</jats:p> |
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| spelling | Jovanovic, Danijela Milovanovic, Dragan R. Jeremic, Nevena Nikolic, Tamara Stojic, Isidora Jakovljevic, Vladimir Vukovic, Natalija 2335-075X 1820-8665 Centre for Evaluation in Education and Science (CEON/CEES) General Medicine http://dx.doi.org/10.1515/sjecr-2017-0046 <jats:title>Abstract</jats:title> <jats:p>Study aimed to investigate relationship between oxidative stress markers and postoperative recovery in woman after abdominal hysterectomy, as well as to test the hypothesis that different analgesics differently influence redox status.</jats:p> <jats:p>The quality of recovery was evaluated with a QoR-40 questionnaire in fifty-one patients who underwent abdominal hysterectomy, preoperatively and on the 1<jats:sup>st</jats:sup>, 2<jats:sup>nd</jats:sup>, 3<jats:sup>rd</jats:sup> postoperative days (POD1,2,3). Blood samples were collected at baseline (T0), 3 (T1), 24 (T2), 48 (T3) and 72 (T4) hours after surgery. Oxidative stress markers concentrations (TBARS, NO<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>, H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>, O<jats:sub>2</jats:sub> <jats:sup>−</jats:sup> ) as well as antioxidative enzymes (SOD, CAT, and GSH) were analyzed.</jats:p> <jats:p>QoR-40 total score significantly declined on POD1 and POD2 and returned to baseline levels on POD3 (p<0.001). H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> levels significantly decreased from T0 to T3 and then, increased at T4 (p=0,011). Changes of TBARS and H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> from T0 to T3 showed significant and negative correlation (r=−0.303, p=0.046). There was no significant correlation between QoR-40 total score and any parameter of oxidative stress response (p>0.05). Changes in TBARS levels from T0 to T3 were statistically significant between the study subgroups primarily due to increase of the concentrations in patients receiving paracetamol (p=0.031). Patients age, duration of surgery and cigarette smoking status showed significant influcences on and association with some oxidative stress response markers (TBARS, O<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>, CAT) (p<0.05).</jats:p> <jats:p>Women who underwent hysterectomy had significant changes of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and TBARS activity however, those changes were not associated with changes of QoR-40 total scores during recovery.</jats:p> Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery Serbian Journal of Experimental and Clinical Research |
| spellingShingle | Jovanovic, Danijela, Milovanovic, Dragan R., Jeremic, Nevena, Nikolic, Tamara, Stojic, Isidora, Jakovljevic, Vladimir, Vukovic, Natalija, Serbian Journal of Experimental and Clinical Research, Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery, General Medicine |
| title | Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_full | Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_fullStr | Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_full_unstemmed | Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_short | Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| title_sort | oxidative stress parameters after abdominal hysterectomy and their relationships with quality of recovery |
| title_unstemmed | Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery |
| topic | General Medicine |
| url | http://dx.doi.org/10.1515/sjecr-2017-0046 |