Eintrag weiter verarbeiten
Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy
Gespeichert in:
| Zeitschriftentitel: | Serbian Journal of Experimental and Clinical Research |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Serbian Journal of Experimental and Clinical Research, 20, 2019, 1, S. 39-46 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Centre for Evaluation in Education and Science (CEON/CEES)
|
| Schlagwörter: |
| author_facet |
Micev, Marjan Basaric, Dragan Micev, Milena Cosic Galun, Danijel Micev, Marjan Basaric, Dragan Micev, Milena Cosic Galun, Danijel |
|---|---|
| author |
Micev, Marjan Basaric, Dragan Micev, Milena Cosic Galun, Danijel |
| spellingShingle |
Micev, Marjan Basaric, Dragan Micev, Milena Cosic Galun, Danijel Serbian Journal of Experimental and Clinical Research Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy General Medicine |
| author_sort |
micev, marjan |
| spelling |
Micev, Marjan Basaric, Dragan Micev, Milena Cosic Galun, Danijel 2335-075X 1820-8665 Centre for Evaluation in Education and Science (CEON/CEES) General Medicine http://dx.doi.org/10.1515/sjecr-2017-0025 <jats:title>Abstract</jats:title> <jats:p>Sinusoidal obstruction syndrome („blue liver syndrome“) has been frequently associated with oxaliplatin-based neoadjuvant chemotherapy in patients with colorectal liver metastasis. Hepatotoxic vascular lesions in the nontumourous liver parenchyma result in hypoperfusion and tissue hypoxia leading to lower tumour response to oncologic treatment and to increase the risk of liver metastasectomies. Furthermore, hepatic parenchyma injuries could be aggravated by hepatic resection itself. Contrary to standard surgical techniques, radiofrequency assisted liver resection significantly reduce harmful intraoperative blood loss and perfusion-reperfusion effects. We compared histological alterations in 59 specimens of bloodless radiofrequency-assisted liver recetions made for colorectal metastases to those in 38 specimens of standard liver resections. In general, the main histologic alterations in both examined groups related to oxaliplatin include SOS lesions (69.35%), fibrosis (50.95%) and steatosis (38%). After scoring of histopathological parameters based on modified criteria according to Rubbia-Brandt et al., they were statistically insignificant between both groups for portal and/or porto-portal fibrosis (59.3% vs 47.4%, respectively) and moderate/severe macrovacuolar steatosis (10.2% vs 26.3%). Similar distribution between groups was shown for surgical hepatitis with „borderline“ statistical significance (23,7% vs 42,1%, p= 0.05). However, there were significant differencies in vascular lesions, particularly for hemorrhagic centrilobular necrosis (10,2% vs 31,5%, p= 0.01) and peliosis (15,2% vs 36,8%, p= 0.04), but were not significant for sinusoidal dilatation and congestion as well as surgical necrosis. Highgrade vascular lesions such as hemorrhagic centrilobular necrosis and peliosis are less frequent in cases of radiofrequency-assisted liver recetions and might be associated with better clinical outcome in these patients.</jats:p> Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy Serbian Journal of Experimental and Clinical Research |
| doi_str_mv |
10.1515/sjecr-2017-0025 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUxNS9zamVjci0yMDE3LTAwMjU |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUxNS9zamVjci0yMDE3LTAwMjU |
| institution |
DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 |
| imprint |
Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
| imprint_str_mv |
Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
| issn |
2335-075X 1820-8665 |
| issn_str_mv |
2335-075X 1820-8665 |
| language |
English |
| mega_collection |
Centre for Evaluation in Education and Science (CEON/CEES) (CrossRef) |
| match_str |
micev2019histopathologyofhepaticsinusoidalobstructionsyndromeafterneoadjuvantoxaliplatinbasedchemotherapy |
| publishDateSort |
2019 |
| publisher |
Centre for Evaluation in Education and Science (CEON/CEES) |
| recordtype |
ai |
| record_format |
ai |
| series |
Serbian Journal of Experimental and Clinical Research |
| source_id |
49 |
| title |
Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_unstemmed |
Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_full |
Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_fullStr |
Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_full_unstemmed |
Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_short |
Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_sort |
histopathology of hepatic sinusoidal obstruction syndrome after neoadjuvant oxaliplatin-based chemotherapy |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.1515/sjecr-2017-0025 |
| publishDate |
2019 |
| physical |
39-46 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Sinusoidal obstruction syndrome („blue liver syndrome“) has been frequently associated with oxaliplatin-based neoadjuvant chemotherapy in patients with colorectal liver metastasis. Hepatotoxic vascular lesions in the nontumourous liver parenchyma result in hypoperfusion and tissue hypoxia leading to lower tumour response to oncologic treatment and to increase the risk of liver metastasectomies. Furthermore, hepatic parenchyma injuries could be aggravated by hepatic resection itself. Contrary to standard surgical techniques, radiofrequency assisted liver resection significantly reduce harmful intraoperative blood loss and perfusion-reperfusion effects. We compared histological alterations in 59 specimens of bloodless radiofrequency-assisted liver recetions made for colorectal metastases to those in 38 specimens of standard liver resections. In general, the main histologic alterations in both examined groups related to oxaliplatin include SOS lesions (69.35%), fibrosis (50.95%) and steatosis (38%). After scoring of histopathological parameters based on modified criteria according to Rubbia-Brandt et al., they were statistically insignificant between both groups for portal and/or porto-portal fibrosis (59.3% vs 47.4%, respectively) and moderate/severe macrovacuolar steatosis (10.2% vs 26.3%). Similar distribution between groups was shown for surgical hepatitis with „borderline“ statistical significance (23,7% vs 42,1%, p= 0.05). However, there were significant differencies in vascular lesions, particularly for hemorrhagic centrilobular necrosis (10,2% vs 31,5%, p= 0.01) and peliosis (15,2% vs 36,8%, p= 0.04), but were not significant for sinusoidal dilatation and congestion as well as surgical necrosis. Highgrade vascular lesions such as hemorrhagic centrilobular necrosis and peliosis are less frequent in cases of radiofrequency-assisted liver recetions and might be associated with better clinical outcome in these patients.</jats:p> |
| container_issue |
1 |
| container_start_page |
39 |
| container_title |
Serbian Journal of Experimental and Clinical Research |
| container_volume |
20 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792321827245129729 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T11:08:00.166Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Histopathology+of+Hepatic+Sinusoidal+Obstruction+Syndrome+After+Neoadjuvant+Oxaliplatin-Based+Chemotherapy&rft.date=2019-03-01&genre=article&issn=1820-8665&volume=20&issue=1&spage=39&epage=46&pages=39-46&jtitle=Serbian+Journal+of+Experimental+and+Clinical+Research&atitle=Histopathology+of+Hepatic+Sinusoidal+Obstruction+Syndrome+After+Neoadjuvant+Oxaliplatin-Based+Chemotherapy&aulast=Galun&aufirst=Danijel&rft_id=info%3Adoi%2F10.1515%2Fsjecr-2017-0025&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792321827245129729 |
| author | Micev, Marjan, Basaric, Dragan, Micev, Milena Cosic, Galun, Danijel |
| author_facet | Micev, Marjan, Basaric, Dragan, Micev, Milena Cosic, Galun, Danijel, Micev, Marjan, Basaric, Dragan, Micev, Milena Cosic, Galun, Danijel |
| author_sort | micev, marjan |
| container_issue | 1 |
| container_start_page | 39 |
| container_title | Serbian Journal of Experimental and Clinical Research |
| container_volume | 20 |
| description | <jats:title>Abstract</jats:title> <jats:p>Sinusoidal obstruction syndrome („blue liver syndrome“) has been frequently associated with oxaliplatin-based neoadjuvant chemotherapy in patients with colorectal liver metastasis. Hepatotoxic vascular lesions in the nontumourous liver parenchyma result in hypoperfusion and tissue hypoxia leading to lower tumour response to oncologic treatment and to increase the risk of liver metastasectomies. Furthermore, hepatic parenchyma injuries could be aggravated by hepatic resection itself. Contrary to standard surgical techniques, radiofrequency assisted liver resection significantly reduce harmful intraoperative blood loss and perfusion-reperfusion effects. We compared histological alterations in 59 specimens of bloodless radiofrequency-assisted liver recetions made for colorectal metastases to those in 38 specimens of standard liver resections. In general, the main histologic alterations in both examined groups related to oxaliplatin include SOS lesions (69.35%), fibrosis (50.95%) and steatosis (38%). After scoring of histopathological parameters based on modified criteria according to Rubbia-Brandt et al., they were statistically insignificant between both groups for portal and/or porto-portal fibrosis (59.3% vs 47.4%, respectively) and moderate/severe macrovacuolar steatosis (10.2% vs 26.3%). Similar distribution between groups was shown for surgical hepatitis with „borderline“ statistical significance (23,7% vs 42,1%, p= 0.05). However, there were significant differencies in vascular lesions, particularly for hemorrhagic centrilobular necrosis (10,2% vs 31,5%, p= 0.01) and peliosis (15,2% vs 36,8%, p= 0.04), but were not significant for sinusoidal dilatation and congestion as well as surgical necrosis. Highgrade vascular lesions such as hemorrhagic centrilobular necrosis and peliosis are less frequent in cases of radiofrequency-assisted liver recetions and might be associated with better clinical outcome in these patients.</jats:p> |
| doi_str_mv | 10.1515/sjecr-2017-0025 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUxNS9zamVjci0yMDE3LTAwMjU |
| imprint | Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
| imprint_str_mv | Centre for Evaluation in Education and Science (CEON/CEES), 2019 |
| institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
| issn | 2335-075X, 1820-8665 |
| issn_str_mv | 2335-075X, 1820-8665 |
| language | English |
| last_indexed | 2024-03-01T11:08:00.166Z |
| match_str | micev2019histopathologyofhepaticsinusoidalobstructionsyndromeafterneoadjuvantoxaliplatinbasedchemotherapy |
| mega_collection | Centre for Evaluation in Education and Science (CEON/CEES) (CrossRef) |
| physical | 39-46 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Centre for Evaluation in Education and Science (CEON/CEES) |
| record_format | ai |
| recordtype | ai |
| series | Serbian Journal of Experimental and Clinical Research |
| source_id | 49 |
| spelling | Micev, Marjan Basaric, Dragan Micev, Milena Cosic Galun, Danijel 2335-075X 1820-8665 Centre for Evaluation in Education and Science (CEON/CEES) General Medicine http://dx.doi.org/10.1515/sjecr-2017-0025 <jats:title>Abstract</jats:title> <jats:p>Sinusoidal obstruction syndrome („blue liver syndrome“) has been frequently associated with oxaliplatin-based neoadjuvant chemotherapy in patients with colorectal liver metastasis. Hepatotoxic vascular lesions in the nontumourous liver parenchyma result in hypoperfusion and tissue hypoxia leading to lower tumour response to oncologic treatment and to increase the risk of liver metastasectomies. Furthermore, hepatic parenchyma injuries could be aggravated by hepatic resection itself. Contrary to standard surgical techniques, radiofrequency assisted liver resection significantly reduce harmful intraoperative blood loss and perfusion-reperfusion effects. We compared histological alterations in 59 specimens of bloodless radiofrequency-assisted liver recetions made for colorectal metastases to those in 38 specimens of standard liver resections. In general, the main histologic alterations in both examined groups related to oxaliplatin include SOS lesions (69.35%), fibrosis (50.95%) and steatosis (38%). After scoring of histopathological parameters based on modified criteria according to Rubbia-Brandt et al., they were statistically insignificant between both groups for portal and/or porto-portal fibrosis (59.3% vs 47.4%, respectively) and moderate/severe macrovacuolar steatosis (10.2% vs 26.3%). Similar distribution between groups was shown for surgical hepatitis with „borderline“ statistical significance (23,7% vs 42,1%, p= 0.05). However, there were significant differencies in vascular lesions, particularly for hemorrhagic centrilobular necrosis (10,2% vs 31,5%, p= 0.01) and peliosis (15,2% vs 36,8%, p= 0.04), but were not significant for sinusoidal dilatation and congestion as well as surgical necrosis. Highgrade vascular lesions such as hemorrhagic centrilobular necrosis and peliosis are less frequent in cases of radiofrequency-assisted liver recetions and might be associated with better clinical outcome in these patients.</jats:p> Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy Serbian Journal of Experimental and Clinical Research |
| spellingShingle | Micev, Marjan, Basaric, Dragan, Micev, Milena Cosic, Galun, Danijel, Serbian Journal of Experimental and Clinical Research, Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy, General Medicine |
| title | Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_full | Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_fullStr | Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_full_unstemmed | Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_short | Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| title_sort | histopathology of hepatic sinusoidal obstruction syndrome after neoadjuvant oxaliplatin-based chemotherapy |
| title_unstemmed | Histopathology of Hepatic Sinusoidal Obstruction Syndrome After Neoadjuvant Oxaliplatin-Based Chemotherapy |
| topic | General Medicine |
| url | http://dx.doi.org/10.1515/sjecr-2017-0025 |