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Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart
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| Zeitschriftentitel: | Serbian Journal of Experimental and Clinical Research |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Serbian Journal of Experimental and Clinical Research, 16, 2015, 3, S. 193-199 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Walter de Gruyter GmbH
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| Schlagwörter: |
| author_facet |
Plecevic, Sasa Pechanova, Olga Barta, Andrej Vranic, Aleksandra Jeremic, Jovana Arsenijevic, Ljiljana Jeremic, Nevena Jakovljevic, Vladimir Jevdjevic, Maja Stanojevic, Dejan Plecevic, Sasa Pechanova, Olga Barta, Andrej Vranic, Aleksandra Jeremic, Jovana Arsenijevic, Ljiljana Jeremic, Nevena Jakovljevic, Vladimir Jevdjevic, Maja Stanojevic, Dejan |
|---|---|
| author |
Plecevic, Sasa Pechanova, Olga Barta, Andrej Vranic, Aleksandra Jeremic, Jovana Arsenijevic, Ljiljana Jeremic, Nevena Jakovljevic, Vladimir Jevdjevic, Maja Stanojevic, Dejan |
| spellingShingle |
Plecevic, Sasa Pechanova, Olga Barta, Andrej Vranic, Aleksandra Jeremic, Jovana Arsenijevic, Ljiljana Jeremic, Nevena Jakovljevic, Vladimir Jevdjevic, Maja Stanojevic, Dejan Serbian Journal of Experimental and Clinical Research Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart General Medicine |
| author_sort |
plecevic, sasa |
| spelling |
Plecevic, Sasa Pechanova, Olga Barta, Andrej Vranic, Aleksandra Jeremic, Jovana Arsenijevic, Ljiljana Jeremic, Nevena Jakovljevic, Vladimir Jevdjevic, Maja Stanojevic, Dejan 2335-075X Walter de Gruyter GmbH General Medicine http://dx.doi.org/10.1515/sjecr-2015-0025 <jats:title>Abstract</jats:title> <jats:p>Increased activity of the renin-angiotensin-aldosterone system (RAAS) plays a significant role in the development and progression of various cardio-metabolic diseases, such as hypertension, atherosclerosis and heart failure. Aliskiren is the newest antihypertensive drug and the first orally active direct renin inhibitor to become available for clinical use. This study investigated the acute and direct effects of Aliskiren on different parameters of oxidative stress on isolated rat heart. The hearts of male Wistar albino rats (n = 24, 8 per experimental group, age 8 weeks, body mass 180–200 g), were excised and retrogradely perfused according to the Langendorfftechnique at a gradually increasing perfusion pressure (40-120 cmH<jats:sub>2</jats:sub>O). Markers of oxidative stress (NO<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>, TBARS, H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and O<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>) were measured spectrophotometrically after perfusion with three different concentrations of Aliskiren (0.1 μM, 1 μM, and 10 μM). The results demonstrated possible dose-dependent cardioprotective properties of Aliskiren, particularly with higher CPP. Lipid peroxidation (TBARS) levels decreased with the highest dose of Aliskiren and higher CPP, and the same trend was observed in nitrite (NO<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>) and hydrogen peroxide (H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>) levels. These findings indicate that the acute effects of Aliskiren do not likely promote the production of reactive oxygen species upon higher pressure with the highest dose. Aliskiren may exert beneficial effects on oxidative stress biomarkers.</jats:p> Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart Serbian Journal of Experimental and Clinical Research |
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| title |
Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_unstemmed |
Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_full |
Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_fullStr |
Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_full_unstemmed |
Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_short |
Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_sort |
effects of the direct renin inhibitor aliskiren on oxidative stress in isolated rat heart |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.1515/sjecr-2015-0025 |
| publishDate |
2015 |
| physical |
193-199 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Increased activity of the renin-angiotensin-aldosterone system (RAAS) plays a significant role in the development and progression of various cardio-metabolic diseases, such as hypertension, atherosclerosis and heart failure. Aliskiren is the newest antihypertensive drug and the first orally active direct renin inhibitor to become available for clinical use. This study investigated the acute and direct effects of Aliskiren on different parameters of oxidative stress on isolated rat heart. The hearts of male Wistar albino rats (n = 24, 8 per experimental group, age 8 weeks, body mass 180–200 g), were excised and retrogradely perfused according to the Langendorfftechnique at a gradually increasing perfusion pressure (40-120 cmH<jats:sub>2</jats:sub>O). Markers of oxidative stress (NO<jats:sub>2</jats:sub>
<jats:sup>−</jats:sup>, TBARS, H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and O<jats:sub>2</jats:sub>
<jats:sup>−</jats:sup>) were measured spectrophotometrically after perfusion with three different concentrations of Aliskiren (0.1 μM, 1 μM, and 10 μM). The results demonstrated possible dose-dependent cardioprotective properties of Aliskiren, particularly with higher CPP. Lipid peroxidation (TBARS) levels decreased with the highest dose of Aliskiren and higher CPP, and the same trend was observed in nitrite (NO<jats:sub>2</jats:sub>
<jats:sup>−</jats:sup>) and hydrogen peroxide (H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>) levels. These findings indicate that the acute effects of Aliskiren do not likely promote the production of reactive oxygen species upon higher pressure with the highest dose. Aliskiren may exert beneficial effects on oxidative stress biomarkers.</jats:p> |
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| author | Plecevic, Sasa, Pechanova, Olga, Barta, Andrej, Vranic, Aleksandra, Jeremic, Jovana, Arsenijevic, Ljiljana, Jeremic, Nevena, Jakovljevic, Vladimir, Jevdjevic, Maja, Stanojevic, Dejan |
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| description | <jats:title>Abstract</jats:title> <jats:p>Increased activity of the renin-angiotensin-aldosterone system (RAAS) plays a significant role in the development and progression of various cardio-metabolic diseases, such as hypertension, atherosclerosis and heart failure. Aliskiren is the newest antihypertensive drug and the first orally active direct renin inhibitor to become available for clinical use. This study investigated the acute and direct effects of Aliskiren on different parameters of oxidative stress on isolated rat heart. The hearts of male Wistar albino rats (n = 24, 8 per experimental group, age 8 weeks, body mass 180–200 g), were excised and retrogradely perfused according to the Langendorfftechnique at a gradually increasing perfusion pressure (40-120 cmH<jats:sub>2</jats:sub>O). Markers of oxidative stress (NO<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>, TBARS, H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and O<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>) were measured spectrophotometrically after perfusion with three different concentrations of Aliskiren (0.1 μM, 1 μM, and 10 μM). The results demonstrated possible dose-dependent cardioprotective properties of Aliskiren, particularly with higher CPP. Lipid peroxidation (TBARS) levels decreased with the highest dose of Aliskiren and higher CPP, and the same trend was observed in nitrite (NO<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>) and hydrogen peroxide (H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>) levels. These findings indicate that the acute effects of Aliskiren do not likely promote the production of reactive oxygen species upon higher pressure with the highest dose. Aliskiren may exert beneficial effects on oxidative stress biomarkers.</jats:p> |
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| imprint_str_mv | Walter de Gruyter GmbH, 2015 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 193-199 |
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| series | Serbian Journal of Experimental and Clinical Research |
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| spelling | Plecevic, Sasa Pechanova, Olga Barta, Andrej Vranic, Aleksandra Jeremic, Jovana Arsenijevic, Ljiljana Jeremic, Nevena Jakovljevic, Vladimir Jevdjevic, Maja Stanojevic, Dejan 2335-075X Walter de Gruyter GmbH General Medicine http://dx.doi.org/10.1515/sjecr-2015-0025 <jats:title>Abstract</jats:title> <jats:p>Increased activity of the renin-angiotensin-aldosterone system (RAAS) plays a significant role in the development and progression of various cardio-metabolic diseases, such as hypertension, atherosclerosis and heart failure. Aliskiren is the newest antihypertensive drug and the first orally active direct renin inhibitor to become available for clinical use. This study investigated the acute and direct effects of Aliskiren on different parameters of oxidative stress on isolated rat heart. The hearts of male Wistar albino rats (n = 24, 8 per experimental group, age 8 weeks, body mass 180–200 g), were excised and retrogradely perfused according to the Langendorfftechnique at a gradually increasing perfusion pressure (40-120 cmH<jats:sub>2</jats:sub>O). Markers of oxidative stress (NO<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>, TBARS, H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and O<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>) were measured spectrophotometrically after perfusion with three different concentrations of Aliskiren (0.1 μM, 1 μM, and 10 μM). The results demonstrated possible dose-dependent cardioprotective properties of Aliskiren, particularly with higher CPP. Lipid peroxidation (TBARS) levels decreased with the highest dose of Aliskiren and higher CPP, and the same trend was observed in nitrite (NO<jats:sub>2</jats:sub> <jats:sup>−</jats:sup>) and hydrogen peroxide (H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>) levels. These findings indicate that the acute effects of Aliskiren do not likely promote the production of reactive oxygen species upon higher pressure with the highest dose. Aliskiren may exert beneficial effects on oxidative stress biomarkers.</jats:p> Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart Serbian Journal of Experimental and Clinical Research |
| spellingShingle | Plecevic, Sasa, Pechanova, Olga, Barta, Andrej, Vranic, Aleksandra, Jeremic, Jovana, Arsenijevic, Ljiljana, Jeremic, Nevena, Jakovljevic, Vladimir, Jevdjevic, Maja, Stanojevic, Dejan, Serbian Journal of Experimental and Clinical Research, Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart, General Medicine |
| title | Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_full | Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_fullStr | Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_full_unstemmed | Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_short | Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| title_sort | effects of the direct renin inhibitor aliskiren on oxidative stress in isolated rat heart |
| title_unstemmed | Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart |
| topic | General Medicine |
| url | http://dx.doi.org/10.1515/sjecr-2015-0025 |