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Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold
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| Zeitschriftentitel: | Science and Engineering of Composite Materials |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Science and Engineering of Composite Materials, 23, 2016, 1, S. 37-44 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Walter de Gruyter GmbH
|
| Schlagwörter: |
| author_facet |
Yang, Weizhong Yi, Yong Ma, Yuan Zhang, Li Gu, Jianwen Zhou, Dali Yang, Weizhong Yi, Yong Ma, Yuan Zhang, Li Gu, Jianwen Zhou, Dali |
|---|---|
| author |
Yang, Weizhong Yi, Yong Ma, Yuan Zhang, Li Gu, Jianwen Zhou, Dali |
| spellingShingle |
Yang, Weizhong Yi, Yong Ma, Yuan Zhang, Li Gu, Jianwen Zhou, Dali Science and Engineering of Composite Materials Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold Materials Chemistry Ceramics and Composites |
| author_sort |
yang, weizhong |
| spelling |
Yang, Weizhong Yi, Yong Ma, Yuan Zhang, Li Gu, Jianwen Zhou, Dali 2191-0359 0792-1233 Walter de Gruyter GmbH Materials Chemistry Ceramics and Composites http://dx.doi.org/10.1515/secm-2014-0100 <jats:title>Abstract</jats:title> <jats:p>Nano biphasic calcium phosphate (BCP) particles were synthesized using the sol-gel method. As-prepared BCP particles were combined with poly-L-lactide (PLLA) to fabricate nano-BCP/PLLA composite scaffold through a series of processing steps containing solvent self-diffusion, hot-pressing, and particulate leaching. The composite had a suitable porous structure for bone tissue engineering scaffold. In comparison, micro-BCP/PLLA scaffold was studied as well. Nano-BCP particles were distributed homogeneously in the PLLA matrix, and much more tiny crystallites exposed on the surface of the pore wall. Due to the finer inorganic particle distribution in the PLLA phase and the larger area of the bioactive phase exposed in the pore wall surface, nano-BCP/PLLA scaffold had enhanced compressive strength, good bioactivity, and superior cell viability. A nonstoichiometric apatite layer could be rapidly formed on the surface of nano- BCP/PLLA when soaked in simulated body fluid. The MG-63 cell viability of nano-BCP/PLLA scaffold is significantly higher than that of micro-BCP/PLLA scaffold. Therefore, nano-BCP/PLLA composite may be a suitable alternative for bone tissue engineering scaffold.</jats:p> Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold Science and Engineering of Composite Materials |
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| title |
Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_unstemmed |
Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_full |
Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_fullStr |
Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_full_unstemmed |
Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_short |
Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_sort |
preparation and characterization of nano biphasic calcium phosphate/poly-l-lactide composite scaffold |
| topic |
Materials Chemistry Ceramics and Composites |
| url |
http://dx.doi.org/10.1515/secm-2014-0100 |
| publishDate |
2016 |
| physical |
37-44 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Nano biphasic calcium phosphate (BCP) particles were synthesized using the sol-gel method. As-prepared BCP particles were combined with poly-L-lactide (PLLA) to fabricate nano-BCP/PLLA composite scaffold through a series of processing steps containing solvent self-diffusion, hot-pressing, and particulate leaching. The composite had a suitable porous structure for bone tissue engineering scaffold. In comparison, micro-BCP/PLLA scaffold was studied as well. Nano-BCP particles were distributed homogeneously in the PLLA matrix, and much more tiny crystallites exposed on the surface of the pore wall. Due to the finer inorganic particle distribution in the PLLA phase and the larger area of the bioactive phase exposed in the pore wall surface, nano-BCP/PLLA scaffold had enhanced compressive strength, good bioactivity, and superior cell viability. A nonstoichiometric apatite layer could be rapidly formed on the surface of nano- BCP/PLLA when soaked in simulated body fluid. The MG-63 cell viability of nano-BCP/PLLA scaffold is significantly higher than that of micro-BCP/PLLA scaffold. Therefore, nano-BCP/PLLA composite may be a suitable alternative for bone tissue engineering scaffold.</jats:p> |
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| author | Yang, Weizhong, Yi, Yong, Ma, Yuan, Zhang, Li, Gu, Jianwen, Zhou, Dali |
| author_facet | Yang, Weizhong, Yi, Yong, Ma, Yuan, Zhang, Li, Gu, Jianwen, Zhou, Dali, Yang, Weizhong, Yi, Yong, Ma, Yuan, Zhang, Li, Gu, Jianwen, Zhou, Dali |
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| description | <jats:title>Abstract</jats:title> <jats:p>Nano biphasic calcium phosphate (BCP) particles were synthesized using the sol-gel method. As-prepared BCP particles were combined with poly-L-lactide (PLLA) to fabricate nano-BCP/PLLA composite scaffold through a series of processing steps containing solvent self-diffusion, hot-pressing, and particulate leaching. The composite had a suitable porous structure for bone tissue engineering scaffold. In comparison, micro-BCP/PLLA scaffold was studied as well. Nano-BCP particles were distributed homogeneously in the PLLA matrix, and much more tiny crystallites exposed on the surface of the pore wall. Due to the finer inorganic particle distribution in the PLLA phase and the larger area of the bioactive phase exposed in the pore wall surface, nano-BCP/PLLA scaffold had enhanced compressive strength, good bioactivity, and superior cell viability. A nonstoichiometric apatite layer could be rapidly formed on the surface of nano- BCP/PLLA when soaked in simulated body fluid. The MG-63 cell viability of nano-BCP/PLLA scaffold is significantly higher than that of micro-BCP/PLLA scaffold. Therefore, nano-BCP/PLLA composite may be a suitable alternative for bone tissue engineering scaffold.</jats:p> |
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| physical | 37-44 |
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| spelling | Yang, Weizhong Yi, Yong Ma, Yuan Zhang, Li Gu, Jianwen Zhou, Dali 2191-0359 0792-1233 Walter de Gruyter GmbH Materials Chemistry Ceramics and Composites http://dx.doi.org/10.1515/secm-2014-0100 <jats:title>Abstract</jats:title> <jats:p>Nano biphasic calcium phosphate (BCP) particles were synthesized using the sol-gel method. As-prepared BCP particles were combined with poly-L-lactide (PLLA) to fabricate nano-BCP/PLLA composite scaffold through a series of processing steps containing solvent self-diffusion, hot-pressing, and particulate leaching. The composite had a suitable porous structure for bone tissue engineering scaffold. In comparison, micro-BCP/PLLA scaffold was studied as well. Nano-BCP particles were distributed homogeneously in the PLLA matrix, and much more tiny crystallites exposed on the surface of the pore wall. Due to the finer inorganic particle distribution in the PLLA phase and the larger area of the bioactive phase exposed in the pore wall surface, nano-BCP/PLLA scaffold had enhanced compressive strength, good bioactivity, and superior cell viability. A nonstoichiometric apatite layer could be rapidly formed on the surface of nano- BCP/PLLA when soaked in simulated body fluid. The MG-63 cell viability of nano-BCP/PLLA scaffold is significantly higher than that of micro-BCP/PLLA scaffold. Therefore, nano-BCP/PLLA composite may be a suitable alternative for bone tissue engineering scaffold.</jats:p> Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold Science and Engineering of Composite Materials |
| spellingShingle | Yang, Weizhong, Yi, Yong, Ma, Yuan, Zhang, Li, Gu, Jianwen, Zhou, Dali, Science and Engineering of Composite Materials, Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold, Materials Chemistry, Ceramics and Composites |
| title | Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_full | Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_fullStr | Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_full_unstemmed | Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_short | Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| title_sort | preparation and characterization of nano biphasic calcium phosphate/poly-l-lactide composite scaffold |
| title_unstemmed | Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold |
| topic | Materials Chemistry, Ceramics and Composites |
| url | http://dx.doi.org/10.1515/secm-2014-0100 |