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Pharmacokinetics of vancomycin in patients with different renal function levels
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| Zeitschriftentitel: | Open Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Open Medicine, 13, 2018, 1, S. 512-519 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Walter de Gruyter GmbH
|
| Schlagwörter: |
| author_facet |
Zaric, Radica Zivkovic Milovanovic, Jasmina Rosic, Nikola Milovanovic, Dragan Zecevic, Dejana Ruzic Folic, Marko Jankovic, Slobodan Zaric, Radica Zivkovic Milovanovic, Jasmina Rosic, Nikola Milovanovic, Dragan Zecevic, Dejana Ruzic Folic, Marko Jankovic, Slobodan |
|---|---|
| author |
Zaric, Radica Zivkovic Milovanovic, Jasmina Rosic, Nikola Milovanovic, Dragan Zecevic, Dejana Ruzic Folic, Marko Jankovic, Slobodan |
| spellingShingle |
Zaric, Radica Zivkovic Milovanovic, Jasmina Rosic, Nikola Milovanovic, Dragan Zecevic, Dejana Ruzic Folic, Marko Jankovic, Slobodan Open Medicine Pharmacokinetics of vancomycin in patients with different renal function levels General Medicine |
| author_sort |
zaric, radica zivkovic |
| spelling |
Zaric, Radica Zivkovic Milovanovic, Jasmina Rosic, Nikola Milovanovic, Dragan Zecevic, Dejana Ruzic Folic, Marko Jankovic, Slobodan 2391-5463 Walter de Gruyter GmbH General Medicine http://dx.doi.org/10.1515/med-2018-0068 <jats:title>Abstract</jats:title> <jats:p>There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim of our study was to compare the pharmacokinetic parameters and factors that may affect vancomycin pharmacokinetics in groups of patients with normal renal function and in those with chronic kidney failure. The study used a population pharmacokinetic modeling approach, based on plasma vancomycin concentrations and other data from 78 patients with chronic kidney failure and 32 patients with normal renal function. The model was developed using NONMEM software and validated by bootstrapping. The final model for patients with impaired kidney function was described by the following equation: CL (L/h) = 0.284 + 0.000596 x DD + 0.00194 x AST, and that for the patients with normal kidney function by: CL (L/h) = 0.0727 + 0.205 x FIB. If our results are confirmed by new studies on two similar populations, these factors could be considered when dosing vancomycin in patients with chronically damaged kidneys, as well as in patients with normal kidneys who frequently require high doses of vancomycin.</jats:p> Pharmacokinetics of vancomycin in patients with different renal function levels Open Medicine |
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Walter de Gruyter GmbH, 2018 |
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| title |
Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_unstemmed |
Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_full |
Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_fullStr |
Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_full_unstemmed |
Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_short |
Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_sort |
pharmacokinetics of vancomycin in patients with different renal function levels |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.1515/med-2018-0068 |
| publishDate |
2018 |
| physical |
512-519 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim of our study was to compare the pharmacokinetic parameters and factors that may affect vancomycin pharmacokinetics in groups of patients with normal renal function and in those with chronic kidney failure. The study used a population pharmacokinetic modeling approach, based on plasma vancomycin concentrations and other data from 78 patients with chronic kidney failure and 32 patients with normal renal function. The model was developed using NONMEM software and validated by bootstrapping. The final model for patients with impaired kidney function was described by the following equation: CL (L/h) = 0.284 + 0.000596 x DD + 0.00194 x AST, and that for the patients with normal kidney function by: CL (L/h) = 0.0727 + 0.205 x FIB. If our results are confirmed by new studies on two similar populations, these factors could be considered when dosing vancomycin in patients with chronically damaged kidneys, as well as in patients with normal kidneys who frequently require high doses of vancomycin.</jats:p> |
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| author | Zaric, Radica Zivkovic, Milovanovic, Jasmina, Rosic, Nikola, Milovanovic, Dragan, Zecevic, Dejana Ruzic, Folic, Marko, Jankovic, Slobodan |
| author_facet | Zaric, Radica Zivkovic, Milovanovic, Jasmina, Rosic, Nikola, Milovanovic, Dragan, Zecevic, Dejana Ruzic, Folic, Marko, Jankovic, Slobodan, Zaric, Radica Zivkovic, Milovanovic, Jasmina, Rosic, Nikola, Milovanovic, Dragan, Zecevic, Dejana Ruzic, Folic, Marko, Jankovic, Slobodan |
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| description | <jats:title>Abstract</jats:title> <jats:p>There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim of our study was to compare the pharmacokinetic parameters and factors that may affect vancomycin pharmacokinetics in groups of patients with normal renal function and in those with chronic kidney failure. The study used a population pharmacokinetic modeling approach, based on plasma vancomycin concentrations and other data from 78 patients with chronic kidney failure and 32 patients with normal renal function. The model was developed using NONMEM software and validated by bootstrapping. The final model for patients with impaired kidney function was described by the following equation: CL (L/h) = 0.284 + 0.000596 x DD + 0.00194 x AST, and that for the patients with normal kidney function by: CL (L/h) = 0.0727 + 0.205 x FIB. If our results are confirmed by new studies on two similar populations, these factors could be considered when dosing vancomycin in patients with chronically damaged kidneys, as well as in patients with normal kidneys who frequently require high doses of vancomycin.</jats:p> |
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| spelling | Zaric, Radica Zivkovic Milovanovic, Jasmina Rosic, Nikola Milovanovic, Dragan Zecevic, Dejana Ruzic Folic, Marko Jankovic, Slobodan 2391-5463 Walter de Gruyter GmbH General Medicine http://dx.doi.org/10.1515/med-2018-0068 <jats:title>Abstract</jats:title> <jats:p>There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim of our study was to compare the pharmacokinetic parameters and factors that may affect vancomycin pharmacokinetics in groups of patients with normal renal function and in those with chronic kidney failure. The study used a population pharmacokinetic modeling approach, based on plasma vancomycin concentrations and other data from 78 patients with chronic kidney failure and 32 patients with normal renal function. The model was developed using NONMEM software and validated by bootstrapping. The final model for patients with impaired kidney function was described by the following equation: CL (L/h) = 0.284 + 0.000596 x DD + 0.00194 x AST, and that for the patients with normal kidney function by: CL (L/h) = 0.0727 + 0.205 x FIB. If our results are confirmed by new studies on two similar populations, these factors could be considered when dosing vancomycin in patients with chronically damaged kidneys, as well as in patients with normal kidneys who frequently require high doses of vancomycin.</jats:p> Pharmacokinetics of vancomycin in patients with different renal function levels Open Medicine |
| spellingShingle | Zaric, Radica Zivkovic, Milovanovic, Jasmina, Rosic, Nikola, Milovanovic, Dragan, Zecevic, Dejana Ruzic, Folic, Marko, Jankovic, Slobodan, Open Medicine, Pharmacokinetics of vancomycin in patients with different renal function levels, General Medicine |
| title | Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_full | Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_fullStr | Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_full_unstemmed | Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_short | Pharmacokinetics of vancomycin in patients with different renal function levels |
| title_sort | pharmacokinetics of vancomycin in patients with different renal function levels |
| title_unstemmed | Pharmacokinetics of vancomycin in patients with different renal function levels |
| topic | General Medicine |
| url | http://dx.doi.org/10.1515/med-2018-0068 |