Eintrag weiter verarbeiten
Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure
Gespeichert in:
| Zeitschriftentitel: | Journal of Medical Biochemistry |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Journal of Medical Biochemistry, 37, 2018, 3, S. 299-306 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
Centre for Evaluation in Education and Science (CEON/CEES)
|
| author_facet |
Turcato, Gianni Cervellin, Gianfranco Bonora, Antonio Prati, Danieli Zorzi, Elisabetta Ricci, Giorgio Salvagno, Gian Luca Maccagnani, Antonio Lippi, Giuseppe Turcato, Gianni Cervellin, Gianfranco Bonora, Antonio Prati, Danieli Zorzi, Elisabetta Ricci, Giorgio Salvagno, Gian Luca Maccagnani, Antonio Lippi, Giuseppe |
|---|---|
| author |
Turcato, Gianni Cervellin, Gianfranco Bonora, Antonio Prati, Danieli Zorzi, Elisabetta Ricci, Giorgio Salvagno, Gian Luca Maccagnani, Antonio Lippi, Giuseppe |
| spellingShingle |
Turcato, Gianni Cervellin, Gianfranco Bonora, Antonio Prati, Danieli Zorzi, Elisabetta Ricci, Giorgio Salvagno, Gian Luca Maccagnani, Antonio Lippi, Giuseppe Journal of Medical Biochemistry Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| author_sort |
turcato, gianni |
| spelling |
Turcato, Gianni Cervellin, Gianfranco Bonora, Antonio Prati, Danieli Zorzi, Elisabetta Ricci, Giorgio Salvagno, Gian Luca Maccagnani, Antonio Lippi, Giuseppe 1452-8266 Centre for Evaluation in Education and Science (CEON/CEES) http://dx.doi.org/10.1515/jomb-2017-0054 <jats:title>Summary</jats:title><jats:p>The usual history of chronic heart failure (HF) is characterized by frequent episodes of acute decompensation (ADHF), needing urgent management in the emergency department (ED). Since the diagnostic accuracy of routine laboratory tests remains quite limited for predicting short-term mortality in ADHF, this retrospective study investigated the potential significance of combining red blood cell distribution width (RDW) with other conventional tests for prognosticating ADHF upon ED admission. We conducted a retrospective study including visits for episodes of ADHF recorded in the ED of the Uni versity Hospital of Verona throughout a 4-year period. Demo - graphic and clinical features were recorded upon patient presentation. All patients were subjected to standard Chest X-ray, electrocardiogram (ECG) and laboratory testing in - cluding creatinine, blood urea nitrogen, B-type natriuretic peptide (BNP), complete blood cell count (CBC), sodium, chloride, potassium and RDW. The 30-day overall mortality after ED presentation was defined as primary endpoint. Results: The values of sodium, creatinine, BNP and RDW were higher in patients who died than in those who survived, whilst hypochloremia was more frequent in patients who died than in those who survived. The multivariate model, incorporating these parameters, displayed a modest efficiency for predicting 30-day mortality after ED admission (AUC, 0.701; 95% CI, 0.662-0.738; p=0.001). Notably, the inclusion of RDW in the model significantly enhanced prediction efficiency, with an AUC of 0.723 (95% CI, 0.693-0.763; p<0.001). These results were confirmed with net reclassification improvement (NRI) analysis, showing that combination of RDW with conventional laboratory tests resulted in a much better prediction performance (net reclassification index, 0.222; p=0.001). The results of our study show that prognostic assessment of ADHF patients in the ED can be significantly improved by combining RDW with other conventional laboratory tests.</jats:p> Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure Journal of Medical Biochemistry |
| doi_str_mv |
10.1515/jomb-2017-0054 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUxNS9qb21iLTIwMTctMDA1NA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUxNS9qb21iLTIwMTctMDA1NA |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
Centre for Evaluation in Education and Science (CEON/CEES), 2018 |
| imprint_str_mv |
Centre for Evaluation in Education and Science (CEON/CEES), 2018 |
| issn |
1452-8266 |
| issn_str_mv |
1452-8266 |
| language |
Undetermined |
| mega_collection |
Centre for Evaluation in Education and Science (CEON/CEES) (CrossRef) |
| match_str |
turcato2018redbloodcelldistributionwidthimprovesreclassificationofpatientsadmittedtotheemergencydepartmentwithacutedecompensatedheartfailure |
| publishDateSort |
2018 |
| publisher |
Centre for Evaluation in Education and Science (CEON/CEES) |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Medical Biochemistry |
| source_id |
49 |
| title |
Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_unstemmed |
Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_full |
Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_fullStr |
Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_full_unstemmed |
Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_short |
Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_sort |
red blood cell distribution width improves reclassification of patients admitted to the emergency department with acute decompensated heart failure |
| url |
http://dx.doi.org/10.1515/jomb-2017-0054 |
| publishDate |
2018 |
| physical |
299-306 |
| description |
<jats:title>Summary</jats:title><jats:p>The usual history of chronic heart failure (HF) is characterized by frequent episodes of acute decompensation (ADHF), needing urgent management in the emergency department (ED). Since the diagnostic accuracy of routine laboratory tests remains quite limited for predicting short-term mortality in ADHF, this retrospective study investigated the potential significance of combining red blood cell distribution width (RDW) with other conventional tests for prognosticating ADHF upon ED admission. We conducted a retrospective study including visits for episodes of ADHF recorded in the ED of the Uni versity Hospital of Verona throughout a 4-year period. Demo - graphic and clinical features were recorded upon patient presentation. All patients were subjected to standard Chest X-ray, electrocardiogram (ECG) and laboratory testing in - cluding creatinine, blood urea nitrogen, B-type natriuretic peptide (BNP), complete blood cell count (CBC), sodium, chloride, potassium and RDW. The 30-day overall mortality after ED presentation was defined as primary endpoint. Results: The values of sodium, creatinine, BNP and RDW were higher in patients who died than in those who survived, whilst hypochloremia was more frequent in patients who died than in those who survived. The multivariate model, incorporating these parameters, displayed a modest efficiency for predicting 30-day mortality after ED admission (AUC, 0.701; 95% CI, 0.662-0.738; p=0.001). Notably, the inclusion of RDW in the model significantly enhanced prediction efficiency, with an AUC of 0.723 (95% CI, 0.693-0.763; p<0.001). These results were confirmed with net reclassification improvement (NRI) analysis, showing that combination of RDW with conventional laboratory tests resulted in a much better prediction performance (net reclassification index, 0.222; p=0.001). The results of our study show that prognostic assessment of ADHF patients in the ED can be significantly improved by combining RDW with other conventional laboratory tests.</jats:p> |
| container_issue |
3 |
| container_start_page |
299 |
| container_title |
Journal of Medical Biochemistry |
| container_volume |
37 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792339373105086470 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:47:04.744Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Red+Blood+Cell+Distribution+Width+Improves+Reclassification+of+Patients+Admitted+to+the+Emergency+Department+with+Acute+Decompensated+Heart+Failure&rft.date=2018-07-01&genre=article&issn=1452-8266&volume=37&issue=3&spage=299&epage=306&pages=299-306&jtitle=Journal+of+Medical+Biochemistry&atitle=Red+Blood+Cell+Distribution+Width+Improves+Reclassification+of+Patients+Admitted+to+the+Emergency+Department+with+Acute+Decompensated+Heart+Failure&aulast=Lippi&aufirst=Giuseppe&rft_id=info%3Adoi%2F10.1515%2Fjomb-2017-0054&rft.language%5B0%5D=und |
| SOLR | |
| _version_ | 1792339373105086470 |
| author | Turcato, Gianni, Cervellin, Gianfranco, Bonora, Antonio, Prati, Danieli, Zorzi, Elisabetta, Ricci, Giorgio, Salvagno, Gian Luca, Maccagnani, Antonio, Lippi, Giuseppe |
| author_facet | Turcato, Gianni, Cervellin, Gianfranco, Bonora, Antonio, Prati, Danieli, Zorzi, Elisabetta, Ricci, Giorgio, Salvagno, Gian Luca, Maccagnani, Antonio, Lippi, Giuseppe, Turcato, Gianni, Cervellin, Gianfranco, Bonora, Antonio, Prati, Danieli, Zorzi, Elisabetta, Ricci, Giorgio, Salvagno, Gian Luca, Maccagnani, Antonio, Lippi, Giuseppe |
| author_sort | turcato, gianni |
| container_issue | 3 |
| container_start_page | 299 |
| container_title | Journal of Medical Biochemistry |
| container_volume | 37 |
| description | <jats:title>Summary</jats:title><jats:p>The usual history of chronic heart failure (HF) is characterized by frequent episodes of acute decompensation (ADHF), needing urgent management in the emergency department (ED). Since the diagnostic accuracy of routine laboratory tests remains quite limited for predicting short-term mortality in ADHF, this retrospective study investigated the potential significance of combining red blood cell distribution width (RDW) with other conventional tests for prognosticating ADHF upon ED admission. We conducted a retrospective study including visits for episodes of ADHF recorded in the ED of the Uni versity Hospital of Verona throughout a 4-year period. Demo - graphic and clinical features were recorded upon patient presentation. All patients were subjected to standard Chest X-ray, electrocardiogram (ECG) and laboratory testing in - cluding creatinine, blood urea nitrogen, B-type natriuretic peptide (BNP), complete blood cell count (CBC), sodium, chloride, potassium and RDW. The 30-day overall mortality after ED presentation was defined as primary endpoint. Results: The values of sodium, creatinine, BNP and RDW were higher in patients who died than in those who survived, whilst hypochloremia was more frequent in patients who died than in those who survived. The multivariate model, incorporating these parameters, displayed a modest efficiency for predicting 30-day mortality after ED admission (AUC, 0.701; 95% CI, 0.662-0.738; p=0.001). Notably, the inclusion of RDW in the model significantly enhanced prediction efficiency, with an AUC of 0.723 (95% CI, 0.693-0.763; p<0.001). These results were confirmed with net reclassification improvement (NRI) analysis, showing that combination of RDW with conventional laboratory tests resulted in a much better prediction performance (net reclassification index, 0.222; p=0.001). The results of our study show that prognostic assessment of ADHF patients in the ED can be significantly improved by combining RDW with other conventional laboratory tests.</jats:p> |
| doi_str_mv | 10.1515/jomb-2017-0054 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUxNS9qb21iLTIwMTctMDA1NA |
| imprint | Centre for Evaluation in Education and Science (CEON/CEES), 2018 |
| imprint_str_mv | Centre for Evaluation in Education and Science (CEON/CEES), 2018 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1452-8266 |
| issn_str_mv | 1452-8266 |
| language | Undetermined |
| last_indexed | 2024-03-01T15:47:04.744Z |
| match_str | turcato2018redbloodcelldistributionwidthimprovesreclassificationofpatientsadmittedtotheemergencydepartmentwithacutedecompensatedheartfailure |
| mega_collection | Centre for Evaluation in Education and Science (CEON/CEES) (CrossRef) |
| physical | 299-306 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | Centre for Evaluation in Education and Science (CEON/CEES) |
| record_format | ai |
| recordtype | ai |
| series | Journal of Medical Biochemistry |
| source_id | 49 |
| spelling | Turcato, Gianni Cervellin, Gianfranco Bonora, Antonio Prati, Danieli Zorzi, Elisabetta Ricci, Giorgio Salvagno, Gian Luca Maccagnani, Antonio Lippi, Giuseppe 1452-8266 Centre for Evaluation in Education and Science (CEON/CEES) http://dx.doi.org/10.1515/jomb-2017-0054 <jats:title>Summary</jats:title><jats:p>The usual history of chronic heart failure (HF) is characterized by frequent episodes of acute decompensation (ADHF), needing urgent management in the emergency department (ED). Since the diagnostic accuracy of routine laboratory tests remains quite limited for predicting short-term mortality in ADHF, this retrospective study investigated the potential significance of combining red blood cell distribution width (RDW) with other conventional tests for prognosticating ADHF upon ED admission. We conducted a retrospective study including visits for episodes of ADHF recorded in the ED of the Uni versity Hospital of Verona throughout a 4-year period. Demo - graphic and clinical features were recorded upon patient presentation. All patients were subjected to standard Chest X-ray, electrocardiogram (ECG) and laboratory testing in - cluding creatinine, blood urea nitrogen, B-type natriuretic peptide (BNP), complete blood cell count (CBC), sodium, chloride, potassium and RDW. The 30-day overall mortality after ED presentation was defined as primary endpoint. Results: The values of sodium, creatinine, BNP and RDW were higher in patients who died than in those who survived, whilst hypochloremia was more frequent in patients who died than in those who survived. The multivariate model, incorporating these parameters, displayed a modest efficiency for predicting 30-day mortality after ED admission (AUC, 0.701; 95% CI, 0.662-0.738; p=0.001). Notably, the inclusion of RDW in the model significantly enhanced prediction efficiency, with an AUC of 0.723 (95% CI, 0.693-0.763; p<0.001). These results were confirmed with net reclassification improvement (NRI) analysis, showing that combination of RDW with conventional laboratory tests resulted in a much better prediction performance (net reclassification index, 0.222; p=0.001). The results of our study show that prognostic assessment of ADHF patients in the ED can be significantly improved by combining RDW with other conventional laboratory tests.</jats:p> Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure Journal of Medical Biochemistry |
| spellingShingle | Turcato, Gianni, Cervellin, Gianfranco, Bonora, Antonio, Prati, Danieli, Zorzi, Elisabetta, Ricci, Giorgio, Salvagno, Gian Luca, Maccagnani, Antonio, Lippi, Giuseppe, Journal of Medical Biochemistry, Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title | Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_full | Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_fullStr | Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_full_unstemmed | Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_short | Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| title_sort | red blood cell distribution width improves reclassification of patients admitted to the emergency department with acute decompensated heart failure |
| title_unstemmed | Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure |
| url | http://dx.doi.org/10.1515/jomb-2017-0054 |