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Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview
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| Zeitschriftentitel: | Endocrine Regulations |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Endocrine Regulations, 50, 2016, 2, S. 72-82 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Walter de Gruyter GmbH
|
| Schlagwörter: |
| author_facet |
Lestanova, Z. Bacova, Z. Bakos, Jan Lestanova, Z. Bacova, Z. Bakos, Jan |
|---|---|
| author |
Lestanova, Z. Bacova, Z. Bakos, Jan |
| spellingShingle |
Lestanova, Z. Bacova, Z. Bakos, Jan Endocrine Regulations Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview Endocrinology Endocrinology, Diabetes and Metabolism |
| author_sort |
lestanova, z. |
| spelling |
Lestanova, Z. Bacova, Z. Bakos, Jan 1336-0329 Walter de Gruyter GmbH Endocrinology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1515/enr-2016-0011 <jats:title>Abstract</jats:title> <jats:p>The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides. However, regardless of the differences in the local responses elicited by neuropeptides, there exist certain functional similarities in the effects of neuropeptides, mediated by their receptors. In the present review, data of the relevant studies, focused on G protein-coupled receptors activated by neuropeptides, are summarized. Particularly, receptors that activate phosphatidylinositol-calcium system and protein kinase C pathways, resulting in the reorganization of the neuronal cytoskeleton and changes in the neuronal morphology, are discussed. Based on our data received, we are showing that oxytocin increases the gene expression of GTPase cell division cycle protein 42 (Cdc42), implicated in many aspects of the neuronal growth and morphology. We are also paying a special attention to neurite extension and retraction in the context of neuropeptide regulation.</jats:p> Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview Endocrine Regulations |
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Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
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Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
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Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
| title_fullStr |
Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
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Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
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Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
| title_sort |
mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
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Endocrinology Endocrinology, Diabetes and Metabolism |
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http://dx.doi.org/10.1515/enr-2016-0011 |
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2016 |
| physical |
72-82 |
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<jats:title>Abstract</jats:title>
<jats:p>The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides. However, regardless of the differences in the local responses elicited by neuropeptides, there exist certain functional similarities in the effects of neuropeptides, mediated by their receptors. In the present review, data of the relevant studies, focused on G protein-coupled receptors activated by neuropeptides, are summarized. Particularly, receptors that activate phosphatidylinositol-calcium system and protein kinase C pathways, resulting in the reorganization of the neuronal cytoskeleton and changes in the neuronal morphology, are discussed. Based on our data received, we are showing that oxytocin increases the gene expression of GTPase cell division cycle protein 42 (Cdc42), implicated in many aspects of the neuronal growth and morphology. We are also paying a special attention to neurite extension and retraction in the context of neuropeptide regulation.</jats:p> |
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| description | <jats:title>Abstract</jats:title> <jats:p>The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides. However, regardless of the differences in the local responses elicited by neuropeptides, there exist certain functional similarities in the effects of neuropeptides, mediated by their receptors. In the present review, data of the relevant studies, focused on G protein-coupled receptors activated by neuropeptides, are summarized. Particularly, receptors that activate phosphatidylinositol-calcium system and protein kinase C pathways, resulting in the reorganization of the neuronal cytoskeleton and changes in the neuronal morphology, are discussed. Based on our data received, we are showing that oxytocin increases the gene expression of GTPase cell division cycle protein 42 (Cdc42), implicated in many aspects of the neuronal growth and morphology. We are also paying a special attention to neurite extension and retraction in the context of neuropeptide regulation.</jats:p> |
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| source_id | 49 |
| spelling | Lestanova, Z. Bacova, Z. Bakos, Jan 1336-0329 Walter de Gruyter GmbH Endocrinology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1515/enr-2016-0011 <jats:title>Abstract</jats:title> <jats:p>The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides. However, regardless of the differences in the local responses elicited by neuropeptides, there exist certain functional similarities in the effects of neuropeptides, mediated by their receptors. In the present review, data of the relevant studies, focused on G protein-coupled receptors activated by neuropeptides, are summarized. Particularly, receptors that activate phosphatidylinositol-calcium system and protein kinase C pathways, resulting in the reorganization of the neuronal cytoskeleton and changes in the neuronal morphology, are discussed. Based on our data received, we are showing that oxytocin increases the gene expression of GTPase cell division cycle protein 42 (Cdc42), implicated in many aspects of the neuronal growth and morphology. We are also paying a special attention to neurite extension and retraction in the context of neuropeptide regulation.</jats:p> Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview Endocrine Regulations |
| spellingShingle | Lestanova, Z., Bacova, Z., Bakos, Jan, Endocrine Regulations, Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview, Endocrinology, Endocrinology, Diabetes and Metabolism |
| title | Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
| title_full | Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
| title_fullStr | Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
| title_full_unstemmed | Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
| title_short | Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
| title_sort | mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
| title_unstemmed | Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview |
| topic | Endocrinology, Endocrinology, Diabetes and Metabolism |
| url | http://dx.doi.org/10.1515/enr-2016-0011 |