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In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells
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| Zeitschriftentitel: | Turkish Journal of Biochemistry |
|---|---|
| Personen und Körperschaften: | , |
| In: | Turkish Journal of Biochemistry, 44, 2019, 6, S. 761-768 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Walter de Gruyter GmbH
|
| Schlagwörter: |
| author_facet |
Guney Eskiler, Gamze Kani, Ibrahim Guney Eskiler, Gamze Kani, Ibrahim |
|---|---|
| author |
Guney Eskiler, Gamze Kani, Ibrahim |
| spellingShingle |
Guney Eskiler, Gamze Kani, Ibrahim Turkish Journal of Biochemistry In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells Biochemistry (medical) Clinical Biochemistry Molecular Biology Biochemistry |
| author_sort |
guney eskiler, gamze |
| spelling |
Guney Eskiler, Gamze Kani, Ibrahim 1303-829X 0250-4685 Walter de Gruyter GmbH Biochemistry (medical) Clinical Biochemistry Molecular Biology Biochemistry http://dx.doi.org/10.1515/tjb-2019-0013 <jats:title>Abstract</jats:title> <jats:sec id="j_tjb-2019-0013_s_999_w2aab3b7c34b1b6b1aab1c15b1Aa"> <jats:title>Background</jats:title> <jats:p>The synthesis of new ligand and transition metal complexes have drawn great attention in cancer treatment due to excellent DNA cleavage activities and high antitumor activity.</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_998_w2aab3b7c34b1b6b1aab1c15b2Aa"> <jats:title>Objective</jats:title> <jats:p>The purpose of this study was to synthesize a new Zn(II) complex with 2,2′-bipyridine (bpy) ligand, [Zn(bpy)<jats:sub>2</jats:sub>(H<jats:sub>2</jats:sub>O)]2(ClO<jats:sub>4</jats:sub>), and to investigate the potential therapeutic activity against breast cancer.</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_997_w2aab3b7c34b1b6b1aab1c15b3Aa"> <jats:title>Materials and methods</jats:title> <jats:p>Zn(II) complex was obtained and structurally characterized using crystallography and other spectroscopic methods. The cytotoxic and apoptotic effects of Zn(II) complex on MCF7 breast cancer and HUVEC control cells were evaluated by WST-1, Annexin V and cell cycle analysis.</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_996_w2aab3b7c34b1b6b1aab1c15b4Aa"> <jats:title>Results</jats:title> <jats:p>The spectroscopic data demonstrated that Zn(II) complex was successfully synthesized. Furthermore, Zn(II) complex exhibited significant cytotoxic effect on MCF7 breast cancer and HUVEC cells (p < 0.01). MCF7 and HUVEC cells proliferation was reduced to 11.0% and 52.6%, respectively at 10 μM for 48 h. Additionally, Zn(II) complex significantly induced apoptotic cell death (84.87%) and caused S phase arrest (36.4%) in MCF7 cells at 10 μM (p < 0.01).</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_995_w2aab3b7c34b1b6b1aab1c15b5Aa"> <jats:title>Conclusions</jats:title> <jats:p>Zn(II) complex has great therapeutic potential for the treatment of breast cancer. However, further studies are warranted to identify the underlying mechanisms of apoptotic cell death and to reduce the toxicity of Zn(II) complex on control cells.</jats:p> </jats:sec> <i>In vitro</i> apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells Turkish Journal of Biochemistry |
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10.1515/tjb-2019-0013 |
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Medizin Biologie Chemie und Pharmazie |
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Walter de Gruyter GmbH, 2019 |
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Walter de Gruyter GmbH, 2019 |
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1303-829X 0250-4685 |
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Walter de Gruyter GmbH |
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Turkish Journal of Biochemistry |
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49 |
| title |
In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_unstemmed |
In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_full |
In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_fullStr |
In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_full_unstemmed |
In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_short |
In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_sort |
<i>in vitro</i> apoptotic effect of zinc(ii) complex with n-donor heterocyclic ligand on breast cancer cells |
| topic |
Biochemistry (medical) Clinical Biochemistry Molecular Biology Biochemistry |
| url |
http://dx.doi.org/10.1515/tjb-2019-0013 |
| publishDate |
2019 |
| physical |
761-768 |
| description |
<jats:title>Abstract</jats:title>
<jats:sec id="j_tjb-2019-0013_s_999_w2aab3b7c34b1b6b1aab1c15b1Aa">
<jats:title>Background</jats:title>
<jats:p>The synthesis of new ligand and transition metal complexes have drawn great attention in cancer treatment due to excellent DNA cleavage activities and high antitumor activity.</jats:p>
</jats:sec>
<jats:sec id="j_tjb-2019-0013_s_998_w2aab3b7c34b1b6b1aab1c15b2Aa">
<jats:title>Objective</jats:title>
<jats:p>The purpose of this study was to synthesize a new Zn(II) complex with 2,2′-bipyridine (bpy) ligand, [Zn(bpy)<jats:sub>2</jats:sub>(H<jats:sub>2</jats:sub>O)]2(ClO<jats:sub>4</jats:sub>), and to investigate the potential therapeutic activity against breast cancer.</jats:p>
</jats:sec>
<jats:sec id="j_tjb-2019-0013_s_997_w2aab3b7c34b1b6b1aab1c15b3Aa">
<jats:title>Materials and methods</jats:title>
<jats:p>Zn(II) complex was obtained and structurally characterized using crystallography and other spectroscopic methods. The cytotoxic and apoptotic effects of Zn(II) complex on MCF7 breast cancer and HUVEC control cells were evaluated by WST-1, Annexin V and cell cycle analysis.</jats:p>
</jats:sec>
<jats:sec id="j_tjb-2019-0013_s_996_w2aab3b7c34b1b6b1aab1c15b4Aa">
<jats:title>Results</jats:title>
<jats:p>The spectroscopic data demonstrated that Zn(II) complex was successfully synthesized. Furthermore, Zn(II) complex exhibited significant cytotoxic effect on MCF7 breast cancer and HUVEC cells (p < 0.01). MCF7 and HUVEC cells proliferation was reduced to 11.0% and 52.6%, respectively at 10 μM for 48 h. Additionally, Zn(II) complex significantly induced apoptotic cell death (84.87%) and caused S phase arrest (36.4%) in MCF7 cells at 10 μM (p < 0.01).</jats:p>
</jats:sec>
<jats:sec id="j_tjb-2019-0013_s_995_w2aab3b7c34b1b6b1aab1c15b5Aa">
<jats:title>Conclusions</jats:title>
<jats:p>Zn(II) complex has great therapeutic potential for the treatment of breast cancer. However, further studies are warranted to identify the underlying mechanisms of apoptotic cell death and to reduce the toxicity of Zn(II) complex on control cells.</jats:p>
</jats:sec> |
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| author | Guney Eskiler, Gamze, Kani, Ibrahim |
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| description | <jats:title>Abstract</jats:title> <jats:sec id="j_tjb-2019-0013_s_999_w2aab3b7c34b1b6b1aab1c15b1Aa"> <jats:title>Background</jats:title> <jats:p>The synthesis of new ligand and transition metal complexes have drawn great attention in cancer treatment due to excellent DNA cleavage activities and high antitumor activity.</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_998_w2aab3b7c34b1b6b1aab1c15b2Aa"> <jats:title>Objective</jats:title> <jats:p>The purpose of this study was to synthesize a new Zn(II) complex with 2,2′-bipyridine (bpy) ligand, [Zn(bpy)<jats:sub>2</jats:sub>(H<jats:sub>2</jats:sub>O)]2(ClO<jats:sub>4</jats:sub>), and to investigate the potential therapeutic activity against breast cancer.</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_997_w2aab3b7c34b1b6b1aab1c15b3Aa"> <jats:title>Materials and methods</jats:title> <jats:p>Zn(II) complex was obtained and structurally characterized using crystallography and other spectroscopic methods. The cytotoxic and apoptotic effects of Zn(II) complex on MCF7 breast cancer and HUVEC control cells were evaluated by WST-1, Annexin V and cell cycle analysis.</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_996_w2aab3b7c34b1b6b1aab1c15b4Aa"> <jats:title>Results</jats:title> <jats:p>The spectroscopic data demonstrated that Zn(II) complex was successfully synthesized. Furthermore, Zn(II) complex exhibited significant cytotoxic effect on MCF7 breast cancer and HUVEC cells (p < 0.01). MCF7 and HUVEC cells proliferation was reduced to 11.0% and 52.6%, respectively at 10 μM for 48 h. Additionally, Zn(II) complex significantly induced apoptotic cell death (84.87%) and caused S phase arrest (36.4%) in MCF7 cells at 10 μM (p < 0.01).</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_995_w2aab3b7c34b1b6b1aab1c15b5Aa"> <jats:title>Conclusions</jats:title> <jats:p>Zn(II) complex has great therapeutic potential for the treatment of breast cancer. However, further studies are warranted to identify the underlying mechanisms of apoptotic cell death and to reduce the toxicity of Zn(II) complex on control cells.</jats:p> </jats:sec> |
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| spelling | Guney Eskiler, Gamze Kani, Ibrahim 1303-829X 0250-4685 Walter de Gruyter GmbH Biochemistry (medical) Clinical Biochemistry Molecular Biology Biochemistry http://dx.doi.org/10.1515/tjb-2019-0013 <jats:title>Abstract</jats:title> <jats:sec id="j_tjb-2019-0013_s_999_w2aab3b7c34b1b6b1aab1c15b1Aa"> <jats:title>Background</jats:title> <jats:p>The synthesis of new ligand and transition metal complexes have drawn great attention in cancer treatment due to excellent DNA cleavage activities and high antitumor activity.</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_998_w2aab3b7c34b1b6b1aab1c15b2Aa"> <jats:title>Objective</jats:title> <jats:p>The purpose of this study was to synthesize a new Zn(II) complex with 2,2′-bipyridine (bpy) ligand, [Zn(bpy)<jats:sub>2</jats:sub>(H<jats:sub>2</jats:sub>O)]2(ClO<jats:sub>4</jats:sub>), and to investigate the potential therapeutic activity against breast cancer.</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_997_w2aab3b7c34b1b6b1aab1c15b3Aa"> <jats:title>Materials and methods</jats:title> <jats:p>Zn(II) complex was obtained and structurally characterized using crystallography and other spectroscopic methods. The cytotoxic and apoptotic effects of Zn(II) complex on MCF7 breast cancer and HUVEC control cells were evaluated by WST-1, Annexin V and cell cycle analysis.</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_996_w2aab3b7c34b1b6b1aab1c15b4Aa"> <jats:title>Results</jats:title> <jats:p>The spectroscopic data demonstrated that Zn(II) complex was successfully synthesized. Furthermore, Zn(II) complex exhibited significant cytotoxic effect on MCF7 breast cancer and HUVEC cells (p < 0.01). MCF7 and HUVEC cells proliferation was reduced to 11.0% and 52.6%, respectively at 10 μM for 48 h. Additionally, Zn(II) complex significantly induced apoptotic cell death (84.87%) and caused S phase arrest (36.4%) in MCF7 cells at 10 μM (p < 0.01).</jats:p> </jats:sec> <jats:sec id="j_tjb-2019-0013_s_995_w2aab3b7c34b1b6b1aab1c15b5Aa"> <jats:title>Conclusions</jats:title> <jats:p>Zn(II) complex has great therapeutic potential for the treatment of breast cancer. However, further studies are warranted to identify the underlying mechanisms of apoptotic cell death and to reduce the toxicity of Zn(II) complex on control cells.</jats:p> </jats:sec> <i>In vitro</i> apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells Turkish Journal of Biochemistry |
| spellingShingle | Guney Eskiler, Gamze, Kani, Ibrahim, Turkish Journal of Biochemistry, In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells, Biochemistry (medical), Clinical Biochemistry, Molecular Biology, Biochemistry |
| title | In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_full | In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_fullStr | In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_full_unstemmed | In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_short | In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| title_sort | <i>in vitro</i> apoptotic effect of zinc(ii) complex with n-donor heterocyclic ligand on breast cancer cells |
| title_unstemmed | In vitro apoptotic effect of Zinc(II) complex with N-donor heterocyclic ligand on breast cancer cells |
| topic | Biochemistry (medical), Clinical Biochemistry, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.1515/tjb-2019-0013 |