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Update on Phototherapy and Childhood Cancer in a Northern California Cohort
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Zeitschriftentitel: | Pediatrics |
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Personen und Körperschaften: | , , , |
In: | Pediatrics, 148, 2021, 5 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
American Academy of Pediatrics (AAP)
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Schlagwörter: |
author_facet |
Digitale, Jean C. Kim, Mi-Ok Kuzniewicz, Michael W. Newman, Thomas B. Digitale, Jean C. Kim, Mi-Ok Kuzniewicz, Michael W. Newman, Thomas B. |
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author |
Digitale, Jean C. Kim, Mi-Ok Kuzniewicz, Michael W. Newman, Thomas B. |
spellingShingle |
Digitale, Jean C. Kim, Mi-Ok Kuzniewicz, Michael W. Newman, Thomas B. Pediatrics Update on Phototherapy and Childhood Cancer in a Northern California Cohort Pediatrics, Perinatology and Child Health |
author_sort |
digitale, jean c. |
spelling |
Digitale, Jean C. Kim, Mi-Ok Kuzniewicz, Michael W. Newman, Thomas B. 0031-4005 1098-4275 American Academy of Pediatrics (AAP) Pediatrics, Perinatology and Child Health http://dx.doi.org/10.1542/peds.2021-051033 <jats:sec><jats:title /></jats:sec><jats:sec><jats:title>OBJECTIVES</jats:title><jats:p>We aimed to reassess the relationship between phototherapy and cancer in an extended version of a previous cohort and to replicate a report from Quebec of increased cancer risk after phototherapy beginning at age 4 years.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>This cohort study included 139 100 children born at ≥35 weeks’ gestation from 1995 to 2017, followed through March 16, 2019, in Kaiser Permanente Northern California hospitals who had a qualifying bilirubin level from −3 mg/dL to +4.9 mg/dL from the American Academy of Pediatrics phototherapy threshold; an additional 40 780 children and 5 years of follow-up from our previous report. The exposure was inpatient phototherapy (yes or no), and the outcomes were various types of childhood cancer. We used Cox proportional hazard models, controlling for propensity-score quintiles, and allowed for time-dependent exposure effects to assess for the risk of cancer after a latent period.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Over a mean (SD) follow-up of 8.2 (5.7) years, the crude incidence of cancer per 100 000 person-years was 25.1 among those exposed to phototherapy and 19.2 among those not exposed (233 cases of cancer). After propensity adjustment, phototherapy was not associated with any cancer (hazard ratio [HR]: 1.13, 95% confidence interval [CI]: 0.83–1.54), hematopoietic cancer (HR: 1.17, 95% CI: 0.74–1.83), or solid tumors (HR: 1.01, 95% CI: 0.65–1.58). We also found no association with cancer diagnoses at age ≥4 years.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>We did not confirm previous, concerning associations between phototherapy and adjusted risk of any cancer, nonlymphocytic leukemia, or brain and/or central nervous systems tumors in later childhood.</jats:p></jats:sec> Update on Phototherapy and Childhood Cancer in a Northern California Cohort Pediatrics |
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title |
Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_unstemmed |
Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_full |
Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_fullStr |
Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_full_unstemmed |
Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_short |
Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_sort |
update on phototherapy and childhood cancer in a northern california cohort |
topic |
Pediatrics, Perinatology and Child Health |
url |
http://dx.doi.org/10.1542/peds.2021-051033 |
publishDate |
2021 |
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<jats:sec><jats:title /></jats:sec><jats:sec><jats:title>OBJECTIVES</jats:title><jats:p>We aimed to reassess the relationship between phototherapy and cancer in an extended version of a previous cohort and to replicate a report from Quebec of increased cancer risk after phototherapy beginning at age 4 years.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>This cohort study included 139 100 children born at ≥35 weeks’ gestation from 1995 to 2017, followed through March 16, 2019, in Kaiser Permanente Northern California hospitals who had a qualifying bilirubin level from −3 mg/dL to +4.9 mg/dL from the American Academy of Pediatrics phototherapy threshold; an additional 40 780 children and 5 years of follow-up from our previous report. The exposure was inpatient phototherapy (yes or no), and the outcomes were various types of childhood cancer. We used Cox proportional hazard models, controlling for propensity-score quintiles, and allowed for time-dependent exposure effects to assess for the risk of cancer after a latent period.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Over a mean (SD) follow-up of 8.2 (5.7) years, the crude incidence of cancer per 100 000 person-years was 25.1 among those exposed to phototherapy and 19.2 among those not exposed (233 cases of cancer). After propensity adjustment, phototherapy was not associated with any cancer (hazard ratio [HR]: 1.13, 95% confidence interval [CI]: 0.83–1.54), hematopoietic cancer (HR: 1.17, 95% CI: 0.74–1.83), or solid tumors (HR: 1.01, 95% CI: 0.65–1.58). We also found no association with cancer diagnoses at age ≥4 years.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>We did not confirm previous, concerning associations between phototherapy and adjusted risk of any cancer, nonlymphocytic leukemia, or brain and/or central nervous systems tumors in later childhood.</jats:p></jats:sec> |
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author | Digitale, Jean C., Kim, Mi-Ok, Kuzniewicz, Michael W., Newman, Thomas B. |
author_facet | Digitale, Jean C., Kim, Mi-Ok, Kuzniewicz, Michael W., Newman, Thomas B., Digitale, Jean C., Kim, Mi-Ok, Kuzniewicz, Michael W., Newman, Thomas B. |
author_sort | digitale, jean c. |
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container_title | Pediatrics |
container_volume | 148 |
description | <jats:sec><jats:title /></jats:sec><jats:sec><jats:title>OBJECTIVES</jats:title><jats:p>We aimed to reassess the relationship between phototherapy and cancer in an extended version of a previous cohort and to replicate a report from Quebec of increased cancer risk after phototherapy beginning at age 4 years.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>This cohort study included 139 100 children born at ≥35 weeks’ gestation from 1995 to 2017, followed through March 16, 2019, in Kaiser Permanente Northern California hospitals who had a qualifying bilirubin level from −3 mg/dL to +4.9 mg/dL from the American Academy of Pediatrics phototherapy threshold; an additional 40 780 children and 5 years of follow-up from our previous report. The exposure was inpatient phototherapy (yes or no), and the outcomes were various types of childhood cancer. We used Cox proportional hazard models, controlling for propensity-score quintiles, and allowed for time-dependent exposure effects to assess for the risk of cancer after a latent period.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Over a mean (SD) follow-up of 8.2 (5.7) years, the crude incidence of cancer per 100 000 person-years was 25.1 among those exposed to phototherapy and 19.2 among those not exposed (233 cases of cancer). After propensity adjustment, phototherapy was not associated with any cancer (hazard ratio [HR]: 1.13, 95% confidence interval [CI]: 0.83–1.54), hematopoietic cancer (HR: 1.17, 95% CI: 0.74–1.83), or solid tumors (HR: 1.01, 95% CI: 0.65–1.58). We also found no association with cancer diagnoses at age ≥4 years.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>We did not confirm previous, concerning associations between phototherapy and adjusted risk of any cancer, nonlymphocytic leukemia, or brain and/or central nervous systems tumors in later childhood.</jats:p></jats:sec> |
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spelling | Digitale, Jean C. Kim, Mi-Ok Kuzniewicz, Michael W. Newman, Thomas B. 0031-4005 1098-4275 American Academy of Pediatrics (AAP) Pediatrics, Perinatology and Child Health http://dx.doi.org/10.1542/peds.2021-051033 <jats:sec><jats:title /></jats:sec><jats:sec><jats:title>OBJECTIVES</jats:title><jats:p>We aimed to reassess the relationship between phototherapy and cancer in an extended version of a previous cohort and to replicate a report from Quebec of increased cancer risk after phototherapy beginning at age 4 years.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>This cohort study included 139 100 children born at ≥35 weeks’ gestation from 1995 to 2017, followed through March 16, 2019, in Kaiser Permanente Northern California hospitals who had a qualifying bilirubin level from −3 mg/dL to +4.9 mg/dL from the American Academy of Pediatrics phototherapy threshold; an additional 40 780 children and 5 years of follow-up from our previous report. The exposure was inpatient phototherapy (yes or no), and the outcomes were various types of childhood cancer. We used Cox proportional hazard models, controlling for propensity-score quintiles, and allowed for time-dependent exposure effects to assess for the risk of cancer after a latent period.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Over a mean (SD) follow-up of 8.2 (5.7) years, the crude incidence of cancer per 100 000 person-years was 25.1 among those exposed to phototherapy and 19.2 among those not exposed (233 cases of cancer). After propensity adjustment, phototherapy was not associated with any cancer (hazard ratio [HR]: 1.13, 95% confidence interval [CI]: 0.83–1.54), hematopoietic cancer (HR: 1.17, 95% CI: 0.74–1.83), or solid tumors (HR: 1.01, 95% CI: 0.65–1.58). We also found no association with cancer diagnoses at age ≥4 years.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>We did not confirm previous, concerning associations between phototherapy and adjusted risk of any cancer, nonlymphocytic leukemia, or brain and/or central nervous systems tumors in later childhood.</jats:p></jats:sec> Update on Phototherapy and Childhood Cancer in a Northern California Cohort Pediatrics |
spellingShingle | Digitale, Jean C., Kim, Mi-Ok, Kuzniewicz, Michael W., Newman, Thomas B., Pediatrics, Update on Phototherapy and Childhood Cancer in a Northern California Cohort, Pediatrics, Perinatology and Child Health |
title | Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_full | Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_fullStr | Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_full_unstemmed | Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_short | Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
title_sort | update on phototherapy and childhood cancer in a northern california cohort |
title_unstemmed | Update on Phototherapy and Childhood Cancer in a Northern California Cohort |
topic | Pediatrics, Perinatology and Child Health |
url | http://dx.doi.org/10.1542/peds.2021-051033 |