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Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar
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| Zeitschriftentitel: | Journal of Histochemistry & Cytochemistry |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Journal of Histochemistry & Cytochemistry, 66, 2018, 5, S. 349-358 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
|
| Schlagwörter: |
| author_facet |
Hira, Vashendriya V.V. Aderetti, Diana A. van Noorden, Cornelis J.F. Hira, Vashendriya V.V. Aderetti, Diana A. van Noorden, Cornelis J.F. |
|---|---|
| author |
Hira, Vashendriya V.V. Aderetti, Diana A. van Noorden, Cornelis J.F. |
| spellingShingle |
Hira, Vashendriya V.V. Aderetti, Diana A. van Noorden, Cornelis J.F. Journal of Histochemistry & Cytochemistry Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar Histology Anatomy |
| author_sort |
hira, vashendriya v.v. |
| spelling |
Hira, Vashendriya V.V. Aderetti, Diana A. van Noorden, Cornelis J.F. 0022-1554 1551-5044 SAGE Publications Histology Anatomy http://dx.doi.org/10.1369/0022155417752676 <jats:p> Survival of primary brain tumor (glioblastoma) patients is seriously hampered by glioma stem cells (GSCs) that are distinct therapy-resistant self-replicating pluripotent cancer cells. GSCs reside in GSC niches, which are specific protective microenvironments in glioblastoma tumors. We have recently found that GSC niches are hypoxic periarteriolar, whereas in most studies, GSC niches are identified as hypoxic perivascular. The aim of this review is to critically evaluate the literature on perivascular GSC niches to establish whether these are periarteriolar, pericapillary, perivenular, and/or perilymphatic. We found six publications showing images of human glioblastoma tissue containing perivascular GSC niches without any specification of the vessel type. However, it is frequently assumed that these vessels are capillaries which are exchange vessels, whereas arterioles and venules are transport vessels. Closer inspection of the figures of these publications showed vessels that were not capillaries. Whether these vessels were arterioles or venules was difficult to determine in one case, but in the other cases, these were clearly arterioles and their perivascular niches were similar to the periarteriolar niches we have found. Therefore, we conclude that in human glioblastoma tumors, GSC niches are hypoxic periarteriolar and are structurally and functionally look-alikes of hematopoietic stem cell niches in the bone marrow. </jats:p> Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar Journal of Histochemistry & Cytochemistry |
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| title |
Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
| title_unstemmed |
Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
| title_full |
Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
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Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
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Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
| title_short |
Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
| title_sort |
glioma stem cell niches in human glioblastoma are periarteriolar |
| topic |
Histology Anatomy |
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http://dx.doi.org/10.1369/0022155417752676 |
| publishDate |
2018 |
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349-358 |
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<jats:p> Survival of primary brain tumor (glioblastoma) patients is seriously hampered by glioma stem cells (GSCs) that are distinct therapy-resistant self-replicating pluripotent cancer cells. GSCs reside in GSC niches, which are specific protective microenvironments in glioblastoma tumors. We have recently found that GSC niches are hypoxic periarteriolar, whereas in most studies, GSC niches are identified as hypoxic perivascular. The aim of this review is to critically evaluate the literature on perivascular GSC niches to establish whether these are periarteriolar, pericapillary, perivenular, and/or perilymphatic. We found six publications showing images of human glioblastoma tissue containing perivascular GSC niches without any specification of the vessel type. However, it is frequently assumed that these vessels are capillaries which are exchange vessels, whereas arterioles and venules are transport vessels. Closer inspection of the figures of these publications showed vessels that were not capillaries. Whether these vessels were arterioles or venules was difficult to determine in one case, but in the other cases, these were clearly arterioles and their perivascular niches were similar to the periarteriolar niches we have found. Therefore, we conclude that in human glioblastoma tumors, GSC niches are hypoxic periarteriolar and are structurally and functionally look-alikes of hematopoietic stem cell niches in the bone marrow. </jats:p> |
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| author | Hira, Vashendriya V.V., Aderetti, Diana A., van Noorden, Cornelis J.F. |
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| description | <jats:p> Survival of primary brain tumor (glioblastoma) patients is seriously hampered by glioma stem cells (GSCs) that are distinct therapy-resistant self-replicating pluripotent cancer cells. GSCs reside in GSC niches, which are specific protective microenvironments in glioblastoma tumors. We have recently found that GSC niches are hypoxic periarteriolar, whereas in most studies, GSC niches are identified as hypoxic perivascular. The aim of this review is to critically evaluate the literature on perivascular GSC niches to establish whether these are periarteriolar, pericapillary, perivenular, and/or perilymphatic. We found six publications showing images of human glioblastoma tissue containing perivascular GSC niches without any specification of the vessel type. However, it is frequently assumed that these vessels are capillaries which are exchange vessels, whereas arterioles and venules are transport vessels. Closer inspection of the figures of these publications showed vessels that were not capillaries. Whether these vessels were arterioles or venules was difficult to determine in one case, but in the other cases, these were clearly arterioles and their perivascular niches were similar to the periarteriolar niches we have found. Therefore, we conclude that in human glioblastoma tumors, GSC niches are hypoxic periarteriolar and are structurally and functionally look-alikes of hematopoietic stem cell niches in the bone marrow. </jats:p> |
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| spelling | Hira, Vashendriya V.V. Aderetti, Diana A. van Noorden, Cornelis J.F. 0022-1554 1551-5044 SAGE Publications Histology Anatomy http://dx.doi.org/10.1369/0022155417752676 <jats:p> Survival of primary brain tumor (glioblastoma) patients is seriously hampered by glioma stem cells (GSCs) that are distinct therapy-resistant self-replicating pluripotent cancer cells. GSCs reside in GSC niches, which are specific protective microenvironments in glioblastoma tumors. We have recently found that GSC niches are hypoxic periarteriolar, whereas in most studies, GSC niches are identified as hypoxic perivascular. The aim of this review is to critically evaluate the literature on perivascular GSC niches to establish whether these are periarteriolar, pericapillary, perivenular, and/or perilymphatic. We found six publications showing images of human glioblastoma tissue containing perivascular GSC niches without any specification of the vessel type. However, it is frequently assumed that these vessels are capillaries which are exchange vessels, whereas arterioles and venules are transport vessels. Closer inspection of the figures of these publications showed vessels that were not capillaries. Whether these vessels were arterioles or venules was difficult to determine in one case, but in the other cases, these were clearly arterioles and their perivascular niches were similar to the periarteriolar niches we have found. Therefore, we conclude that in human glioblastoma tumors, GSC niches are hypoxic periarteriolar and are structurally and functionally look-alikes of hematopoietic stem cell niches in the bone marrow. </jats:p> Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar Journal of Histochemistry & Cytochemistry |
| spellingShingle | Hira, Vashendriya V.V., Aderetti, Diana A., van Noorden, Cornelis J.F., Journal of Histochemistry & Cytochemistry, Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar, Histology, Anatomy |
| title | Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
| title_full | Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
| title_fullStr | Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
| title_full_unstemmed | Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
| title_short | Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
| title_sort | glioma stem cell niches in human glioblastoma are periarteriolar |
| title_unstemmed | Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar |
| topic | Histology, Anatomy |
| url | http://dx.doi.org/10.1369/0022155417752676 |