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Prognostic significance of perineural invasion in localized prostate cancer.
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| Zeitschriftentitel: | Journal of Clinical Oncology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , |
| In: | Journal of Clinical Oncology, 33, 2015, 7_suppl, S. 30-30 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Clinical Oncology (ASCO)
|
| Schlagwörter: |
| author_facet |
Lu, Louis Singhal, Udit Skolarus, Ted A. Palapattu, Ganesh S. Montgomery, Jeffrey Scott Weizer, Alon Z. Hollenbeck, Brent K. Miller, David Christopher McNamara, Alyssa Mehra, Rohit Tomlins, Scott A. Hamstra, Daniel A. Morgan, Todd Matthew Feng, Felix Yi-Chung Lu, Louis Singhal, Udit Skolarus, Ted A. Palapattu, Ganesh S. Montgomery, Jeffrey Scott Weizer, Alon Z. Hollenbeck, Brent K. Miller, David Christopher McNamara, Alyssa Mehra, Rohit Tomlins, Scott A. Hamstra, Daniel A. Morgan, Todd Matthew Feng, Felix Yi-Chung |
|---|---|
| author |
Lu, Louis Singhal, Udit Skolarus, Ted A. Palapattu, Ganesh S. Montgomery, Jeffrey Scott Weizer, Alon Z. Hollenbeck, Brent K. Miller, David Christopher McNamara, Alyssa Mehra, Rohit Tomlins, Scott A. Hamstra, Daniel A. Morgan, Todd Matthew Feng, Felix Yi-Chung |
| spellingShingle |
Lu, Louis Singhal, Udit Skolarus, Ted A. Palapattu, Ganesh S. Montgomery, Jeffrey Scott Weizer, Alon Z. Hollenbeck, Brent K. Miller, David Christopher McNamara, Alyssa Mehra, Rohit Tomlins, Scott A. Hamstra, Daniel A. Morgan, Todd Matthew Feng, Felix Yi-Chung Journal of Clinical Oncology Prognostic significance of perineural invasion in localized prostate cancer. Cancer Research Oncology |
| author_sort |
lu, louis |
| spelling |
Lu, Louis Singhal, Udit Skolarus, Ted A. Palapattu, Ganesh S. Montgomery, Jeffrey Scott Weizer, Alon Z. Hollenbeck, Brent K. Miller, David Christopher McNamara, Alyssa Mehra, Rohit Tomlins, Scott A. Hamstra, Daniel A. Morgan, Todd Matthew Feng, Felix Yi-Chung 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2015.33.7_suppl.30 <jats:p> 30 </jats:p><jats:p> Background: While perineural invasion (PNI) has been associated with poorer clinical outcomes in prostate cancer patients, it is not well defined as a predictor of long-term endpoints in newly diagnosed prostate cancer. Therefore, we evaluated the role of PNI as a prognostic marker in patients with localized prostate cancer who underwent surgery or radiation. Methods: We analyzed a prospectively collected cohort of 5,034 consecutive patients with localized prostate cancer treated with surgery (n = 4,207) or radiation (n = 827) at University of Michigan from 1994-2013. The primary outcome measured was metastasis-free survival, with secondary outcomes of PSA-recurrence free survival and overall survival (OS). Covariates included age, treatment year, race, comorbidity index, pre-treatment PSA, Gleason score, and T-stage. Survival analysis was estimated using the Kaplan-Meir method, and multivariable analysis was performed using a Cox proportional hazards model. Results: 22.6% of surgery patients and 37.5% of radiation patients had PNI. 169 patients developed metastasis a median of 44 months (IQR 21-83 months) after primary therapy. In the combined cohort, PNI was a predictor of metastasis and PSA recurrence, but not OS (Table 1). For surgery, PNI was a predictor of metastasis, PSA recurrence, and OS. For radiation, PNI was a predictor of metastasis and PSA recurrence, but not OS. Conclusions: PNI is an independent predictor of long-term outcomes in newly diagnosed prostate cancer patients regardless of subsequent therapy. These data support the importance of PNI as a key factor denoting potentially aggressive prostate cancer and importing a significant increase in the likelihood of eventual metastatic progression. [Table: see text] </jats:p> Prognostic significance of perineural invasion in localized prostate cancer. Journal of Clinical Oncology |
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| title |
Prognostic significance of perineural invasion in localized prostate cancer. |
| title_unstemmed |
Prognostic significance of perineural invasion in localized prostate cancer. |
| title_full |
Prognostic significance of perineural invasion in localized prostate cancer. |
| title_fullStr |
Prognostic significance of perineural invasion in localized prostate cancer. |
| title_full_unstemmed |
Prognostic significance of perineural invasion in localized prostate cancer. |
| title_short |
Prognostic significance of perineural invasion in localized prostate cancer. |
| title_sort |
prognostic significance of perineural invasion in localized prostate cancer. |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1200/jco.2015.33.7_suppl.30 |
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2015 |
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30-30 |
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<jats:p> 30 </jats:p><jats:p> Background: While perineural invasion (PNI) has been associated with poorer clinical outcomes in prostate cancer patients, it is not well defined as a predictor of long-term endpoints in newly diagnosed prostate cancer. Therefore, we evaluated the role of PNI as a prognostic marker in patients with localized prostate cancer who underwent surgery or radiation. Methods: We analyzed a prospectively collected cohort of 5,034 consecutive patients with localized prostate cancer treated with surgery (n = 4,207) or radiation (n = 827) at University of Michigan from 1994-2013. The primary outcome measured was metastasis-free survival, with secondary outcomes of PSA-recurrence free survival and overall survival (OS). Covariates included age, treatment year, race, comorbidity index, pre-treatment PSA, Gleason score, and T-stage. Survival analysis was estimated using the Kaplan-Meir method, and multivariable analysis was performed using a Cox proportional hazards model. Results: 22.6% of surgery patients and 37.5% of radiation patients had PNI. 169 patients developed metastasis a median of 44 months (IQR 21-83 months) after primary therapy. In the combined cohort, PNI was a predictor of metastasis and PSA recurrence, but not OS (Table 1). For surgery, PNI was a predictor of metastasis, PSA recurrence, and OS. For radiation, PNI was a predictor of metastasis and PSA recurrence, but not OS. Conclusions: PNI is an independent predictor of long-term outcomes in newly diagnosed prostate cancer patients regardless of subsequent therapy. These data support the importance of PNI as a key factor denoting potentially aggressive prostate cancer and importing a significant increase in the likelihood of eventual metastatic progression. [Table: see text] </jats:p> |
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| author | Lu, Louis, Singhal, Udit, Skolarus, Ted A., Palapattu, Ganesh S., Montgomery, Jeffrey Scott, Weizer, Alon Z., Hollenbeck, Brent K., Miller, David Christopher, McNamara, Alyssa, Mehra, Rohit, Tomlins, Scott A., Hamstra, Daniel A., Morgan, Todd Matthew, Feng, Felix Yi-Chung |
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| description | <jats:p> 30 </jats:p><jats:p> Background: While perineural invasion (PNI) has been associated with poorer clinical outcomes in prostate cancer patients, it is not well defined as a predictor of long-term endpoints in newly diagnosed prostate cancer. Therefore, we evaluated the role of PNI as a prognostic marker in patients with localized prostate cancer who underwent surgery or radiation. Methods: We analyzed a prospectively collected cohort of 5,034 consecutive patients with localized prostate cancer treated with surgery (n = 4,207) or radiation (n = 827) at University of Michigan from 1994-2013. The primary outcome measured was metastasis-free survival, with secondary outcomes of PSA-recurrence free survival and overall survival (OS). Covariates included age, treatment year, race, comorbidity index, pre-treatment PSA, Gleason score, and T-stage. Survival analysis was estimated using the Kaplan-Meir method, and multivariable analysis was performed using a Cox proportional hazards model. Results: 22.6% of surgery patients and 37.5% of radiation patients had PNI. 169 patients developed metastasis a median of 44 months (IQR 21-83 months) after primary therapy. In the combined cohort, PNI was a predictor of metastasis and PSA recurrence, but not OS (Table 1). For surgery, PNI was a predictor of metastasis, PSA recurrence, and OS. For radiation, PNI was a predictor of metastasis and PSA recurrence, but not OS. Conclusions: PNI is an independent predictor of long-term outcomes in newly diagnosed prostate cancer patients regardless of subsequent therapy. These data support the importance of PNI as a key factor denoting potentially aggressive prostate cancer and importing a significant increase in the likelihood of eventual metastatic progression. [Table: see text] </jats:p> |
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| spelling | Lu, Louis Singhal, Udit Skolarus, Ted A. Palapattu, Ganesh S. Montgomery, Jeffrey Scott Weizer, Alon Z. Hollenbeck, Brent K. Miller, David Christopher McNamara, Alyssa Mehra, Rohit Tomlins, Scott A. Hamstra, Daniel A. Morgan, Todd Matthew Feng, Felix Yi-Chung 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2015.33.7_suppl.30 <jats:p> 30 </jats:p><jats:p> Background: While perineural invasion (PNI) has been associated with poorer clinical outcomes in prostate cancer patients, it is not well defined as a predictor of long-term endpoints in newly diagnosed prostate cancer. Therefore, we evaluated the role of PNI as a prognostic marker in patients with localized prostate cancer who underwent surgery or radiation. Methods: We analyzed a prospectively collected cohort of 5,034 consecutive patients with localized prostate cancer treated with surgery (n = 4,207) or radiation (n = 827) at University of Michigan from 1994-2013. The primary outcome measured was metastasis-free survival, with secondary outcomes of PSA-recurrence free survival and overall survival (OS). Covariates included age, treatment year, race, comorbidity index, pre-treatment PSA, Gleason score, and T-stage. Survival analysis was estimated using the Kaplan-Meir method, and multivariable analysis was performed using a Cox proportional hazards model. Results: 22.6% of surgery patients and 37.5% of radiation patients had PNI. 169 patients developed metastasis a median of 44 months (IQR 21-83 months) after primary therapy. In the combined cohort, PNI was a predictor of metastasis and PSA recurrence, but not OS (Table 1). For surgery, PNI was a predictor of metastasis, PSA recurrence, and OS. For radiation, PNI was a predictor of metastasis and PSA recurrence, but not OS. Conclusions: PNI is an independent predictor of long-term outcomes in newly diagnosed prostate cancer patients regardless of subsequent therapy. These data support the importance of PNI as a key factor denoting potentially aggressive prostate cancer and importing a significant increase in the likelihood of eventual metastatic progression. [Table: see text] </jats:p> Prognostic significance of perineural invasion in localized prostate cancer. Journal of Clinical Oncology |
| spellingShingle | Lu, Louis, Singhal, Udit, Skolarus, Ted A., Palapattu, Ganesh S., Montgomery, Jeffrey Scott, Weizer, Alon Z., Hollenbeck, Brent K., Miller, David Christopher, McNamara, Alyssa, Mehra, Rohit, Tomlins, Scott A., Hamstra, Daniel A., Morgan, Todd Matthew, Feng, Felix Yi-Chung, Journal of Clinical Oncology, Prognostic significance of perineural invasion in localized prostate cancer., Cancer Research, Oncology |
| title | Prognostic significance of perineural invasion in localized prostate cancer. |
| title_full | Prognostic significance of perineural invasion in localized prostate cancer. |
| title_fullStr | Prognostic significance of perineural invasion in localized prostate cancer. |
| title_full_unstemmed | Prognostic significance of perineural invasion in localized prostate cancer. |
| title_short | Prognostic significance of perineural invasion in localized prostate cancer. |
| title_sort | prognostic significance of perineural invasion in localized prostate cancer. |
| title_unstemmed | Prognostic significance of perineural invasion in localized prostate cancer. |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1200/jco.2015.33.7_suppl.30 |