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Adjuvant Imatinib for GI Stromal Tumors: When and For How Long?
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| Zeitschriftentitel: | Journal of Clinical Oncology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Clinical Oncology, 34, 2016, 3, S. 215-218 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Clinical Oncology (ASCO)
|
| Schlagwörter: |
| author_facet |
Benjamin, Robert S. Casali, Paolo Giovanni Benjamin, Robert S. Casali, Paolo Giovanni |
|---|---|
| author |
Benjamin, Robert S. Casali, Paolo Giovanni |
| spellingShingle |
Benjamin, Robert S. Casali, Paolo Giovanni Journal of Clinical Oncology Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? Cancer Research Oncology |
| author_sort |
benjamin, robert s. |
| spelling |
Benjamin, Robert S. Casali, Paolo Giovanni 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2015.64.0102 <jats:p> The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. </jats:p><jats:p> A 45-year-old woman presented with syncope. She was severely anemic, with a hemoglobin level of 6 g/dL, and was found to have lower GI bleeding. A diagnostic colonoscopy was negative. A subsequent computed tomography scan of the abdomen and pelvis was performed, revealing a 3.2 × 3 × 2.9–cm contrast-enhancing right lower-quadrant mass arising from the wall of the ileum. There was no evidence of metastatic disease. The patient underwent laparotomy, and a 3.5-cm mass was resected with negative margins. Pathology revealed a GI stromal tumor with mixed spindle and epithelioid features involving the mucosa and submucosa ( Fig 1A ). The tumor cells were positive for CD117 (c-kit) ( Fig 1B ) and DOG-1( Fig 1C ). There were eight to 10 mitoses per 50 high-power fields ( Fig 1D ). Molecular studies showed a 42-base pair deletion in exon 11 of the KIT gene that would delete all or part of codons 558 to 572 (V559_D572del) and would change the 558-encoding amino acid from Lys to Asn (K558N). </jats:p> Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? Journal of Clinical Oncology |
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| title |
Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_unstemmed |
Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_full |
Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_fullStr |
Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_full_unstemmed |
Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_short |
Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_sort |
adjuvant imatinib for gi stromal tumors: when and for how long? |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1200/jco.2015.64.0102 |
| publishDate |
2016 |
| physical |
215-218 |
| description |
<jats:p> The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. </jats:p><jats:p> A 45-year-old woman presented with syncope. She was severely anemic, with a hemoglobin level of 6 g/dL, and was found to have lower GI bleeding. A diagnostic colonoscopy was negative. A subsequent computed tomography scan of the abdomen and pelvis was performed, revealing a 3.2 × 3 × 2.9–cm contrast-enhancing right lower-quadrant mass arising from the wall of the ileum. There was no evidence of metastatic disease. The patient underwent laparotomy, and a 3.5-cm mass was resected with negative margins. Pathology revealed a GI stromal tumor with mixed spindle and epithelioid features involving the mucosa and submucosa ( Fig 1A ). The tumor cells were positive for CD117 (c-kit) ( Fig 1B ) and DOG-1( Fig 1C ). There were eight to 10 mitoses per 50 high-power fields ( Fig 1D ). Molecular studies showed a 42-base pair deletion in exon 11 of the KIT gene that would delete all or part of codons 558 to 572 (V559_D572del) and would change the 558-encoding amino acid from Lys to Asn (K558N). </jats:p> |
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| description | <jats:p> The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. </jats:p><jats:p> A 45-year-old woman presented with syncope. She was severely anemic, with a hemoglobin level of 6 g/dL, and was found to have lower GI bleeding. A diagnostic colonoscopy was negative. A subsequent computed tomography scan of the abdomen and pelvis was performed, revealing a 3.2 × 3 × 2.9–cm contrast-enhancing right lower-quadrant mass arising from the wall of the ileum. There was no evidence of metastatic disease. The patient underwent laparotomy, and a 3.5-cm mass was resected with negative margins. Pathology revealed a GI stromal tumor with mixed spindle and epithelioid features involving the mucosa and submucosa ( Fig 1A ). The tumor cells were positive for CD117 (c-kit) ( Fig 1B ) and DOG-1( Fig 1C ). There were eight to 10 mitoses per 50 high-power fields ( Fig 1D ). Molecular studies showed a 42-base pair deletion in exon 11 of the KIT gene that would delete all or part of codons 558 to 572 (V559_D572del) and would change the 558-encoding amino acid from Lys to Asn (K558N). </jats:p> |
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| spelling | Benjamin, Robert S. Casali, Paolo Giovanni 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2015.64.0102 <jats:p> The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. </jats:p><jats:p> A 45-year-old woman presented with syncope. She was severely anemic, with a hemoglobin level of 6 g/dL, and was found to have lower GI bleeding. A diagnostic colonoscopy was negative. A subsequent computed tomography scan of the abdomen and pelvis was performed, revealing a 3.2 × 3 × 2.9–cm contrast-enhancing right lower-quadrant mass arising from the wall of the ileum. There was no evidence of metastatic disease. The patient underwent laparotomy, and a 3.5-cm mass was resected with negative margins. Pathology revealed a GI stromal tumor with mixed spindle and epithelioid features involving the mucosa and submucosa ( Fig 1A ). The tumor cells were positive for CD117 (c-kit) ( Fig 1B ) and DOG-1( Fig 1C ). There were eight to 10 mitoses per 50 high-power fields ( Fig 1D ). Molecular studies showed a 42-base pair deletion in exon 11 of the KIT gene that would delete all or part of codons 558 to 572 (V559_D572del) and would change the 558-encoding amino acid from Lys to Asn (K558N). </jats:p> Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? Journal of Clinical Oncology |
| spellingShingle | Benjamin, Robert S., Casali, Paolo Giovanni, Journal of Clinical Oncology, Adjuvant Imatinib for GI Stromal Tumors: When and For How Long?, Cancer Research, Oncology |
| title | Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_full | Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_fullStr | Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_full_unstemmed | Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_short | Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| title_sort | adjuvant imatinib for gi stromal tumors: when and for how long? |
| title_unstemmed | Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1200/jco.2015.64.0102 |