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Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences
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| Zeitschriftentitel: | RNA |
|---|---|
| Personen und Körperschaften: | , |
| In: | RNA, 10, 2004, 11, S. 1695-1697 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cold Spring Harbor Laboratory
|
| Schlagwörter: |
| author_facet |
JIN, YONGFENG BIAN, TENGFEI JIN, YONGFENG BIAN, TENGFEI |
|---|---|
| author |
JIN, YONGFENG BIAN, TENGFEI |
| spellingShingle |
JIN, YONGFENG BIAN, TENGFEI RNA Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences Molecular Biology |
| author_sort |
jin, yongfeng |
| spelling |
JIN, YONGFENG BIAN, TENGFEI 1355-8382 1469-9001 Cold Spring Harbor Laboratory Molecular Biology http://dx.doi.org/10.1261/rna.7610404 <jats:p>A comparison of <jats:italic>Arabidopsis</jats:italic> DNA sequences revealed that the final nucleotides at the 3′ end of approximately half of the <jats:italic>Arabidopsis</jats:italic> mRNAs, immediately upstream of the poly(A) tail, differ from the corresponding genomic sequences. This suggests that extra nucleotides were added to these mRNAs at their 3′ termini prior to polyadenylation. Among the mRNAs containing additional nucleotides, approximately 65% had a single additional nucleotide, with the nucleotide C added most often. This nontemplated addition before the addition of the poly(A) sequence could be a major contributing factor to the often observed heterogeneity in transcription products. These findings should be helpful in the elucidation of the mechanisms of mRNA 3′-end processing.</jats:p> Nontemplated nucleotide addition prior to polyadenylation: A comparison of <i>Arabidopsis</i> cDNA and genomic sequences RNA |
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10.1261/rna.7610404 |
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Cold Spring Harbor Laboratory, 2004 |
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Cold Spring Harbor Laboratory, 2004 |
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| title |
Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_unstemmed |
Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_full |
Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_fullStr |
Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_full_unstemmed |
Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_short |
Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_sort |
nontemplated nucleotide addition prior to polyadenylation: a comparison of <i>arabidopsis</i> cdna and genomic sequences |
| topic |
Molecular Biology |
| url |
http://dx.doi.org/10.1261/rna.7610404 |
| publishDate |
2004 |
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1695-1697 |
| description |
<jats:p>A comparison of <jats:italic>Arabidopsis</jats:italic> DNA sequences revealed that the final nucleotides at the 3′ end of approximately half of the <jats:italic>Arabidopsis</jats:italic> mRNAs, immediately upstream of the poly(A) tail, differ from the corresponding genomic sequences. This suggests that extra nucleotides were added to these mRNAs at their 3′ termini prior to polyadenylation. Among the mRNAs containing additional nucleotides, approximately 65% had a single additional nucleotide, with the nucleotide C added most often. This nontemplated addition before the addition of the poly(A) sequence could be a major contributing factor to the often observed heterogeneity in transcription products. These findings should be helpful in the elucidation of the mechanisms of mRNA 3′-end processing.</jats:p> |
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| author | JIN, YONGFENG, BIAN, TENGFEI |
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| description | <jats:p>A comparison of <jats:italic>Arabidopsis</jats:italic> DNA sequences revealed that the final nucleotides at the 3′ end of approximately half of the <jats:italic>Arabidopsis</jats:italic> mRNAs, immediately upstream of the poly(A) tail, differ from the corresponding genomic sequences. This suggests that extra nucleotides were added to these mRNAs at their 3′ termini prior to polyadenylation. Among the mRNAs containing additional nucleotides, approximately 65% had a single additional nucleotide, with the nucleotide C added most often. This nontemplated addition before the addition of the poly(A) sequence could be a major contributing factor to the often observed heterogeneity in transcription products. These findings should be helpful in the elucidation of the mechanisms of mRNA 3′-end processing.</jats:p> |
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| imprint_str_mv | Cold Spring Harbor Laboratory, 2004 |
| institution | DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
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| spelling | JIN, YONGFENG BIAN, TENGFEI 1355-8382 1469-9001 Cold Spring Harbor Laboratory Molecular Biology http://dx.doi.org/10.1261/rna.7610404 <jats:p>A comparison of <jats:italic>Arabidopsis</jats:italic> DNA sequences revealed that the final nucleotides at the 3′ end of approximately half of the <jats:italic>Arabidopsis</jats:italic> mRNAs, immediately upstream of the poly(A) tail, differ from the corresponding genomic sequences. This suggests that extra nucleotides were added to these mRNAs at their 3′ termini prior to polyadenylation. Among the mRNAs containing additional nucleotides, approximately 65% had a single additional nucleotide, with the nucleotide C added most often. This nontemplated addition before the addition of the poly(A) sequence could be a major contributing factor to the often observed heterogeneity in transcription products. These findings should be helpful in the elucidation of the mechanisms of mRNA 3′-end processing.</jats:p> Nontemplated nucleotide addition prior to polyadenylation: A comparison of <i>Arabidopsis</i> cDNA and genomic sequences RNA |
| spellingShingle | JIN, YONGFENG, BIAN, TENGFEI, RNA, Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences, Molecular Biology |
| title | Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_full | Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_fullStr | Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_full_unstemmed | Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_short | Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| title_sort | nontemplated nucleotide addition prior to polyadenylation: a comparison of <i>arabidopsis</i> cdna and genomic sequences |
| title_unstemmed | Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences |
| topic | Molecular Biology |
| url | http://dx.doi.org/10.1261/rna.7610404 |