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Cadherins at cell-autonomous membrane contacts control macropinocytosis
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| Zeitschriftentitel: | Journal of Cell Science |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Journal of Cell Science, 124, 2011, 12, S. 2013-2020 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
|
| Schlagwörter: |
| author_facet |
Sabatini, Peter J. B. Zhang, Ming Silverman-Gavrila, Rosalind V. Bendeck, Michelle P. Sabatini, Peter J. B. Zhang, Ming Silverman-Gavrila, Rosalind V. Bendeck, Michelle P. |
|---|---|
| author |
Sabatini, Peter J. B. Zhang, Ming Silverman-Gavrila, Rosalind V. Bendeck, Michelle P. |
| spellingShingle |
Sabatini, Peter J. B. Zhang, Ming Silverman-Gavrila, Rosalind V. Bendeck, Michelle P. Journal of Cell Science Cadherins at cell-autonomous membrane contacts control macropinocytosis Cell Biology |
| author_sort |
sabatini, peter j. b. |
| spelling |
Sabatini, Peter J. B. Zhang, Ming Silverman-Gavrila, Rosalind V. Bendeck, Michelle P. 1477-9137 0021-9533 The Company of Biologists Cell Biology http://dx.doi.org/10.1242/jcs.076901 <jats:p>Cadherins aggregate and stabilize cell–cell junctions through interactions with adjacent cells. In addition, N-cadherin and E-cadherin concentrate at free edges or at the lamellipodia of migrating cells and are found within large vesicles called macropinosomes, which develop from membrane ruffles. The binding properties of cadherins have not previously been associated with the localization of cadherins at membrane ruffles; however, we report that the dorsal, ventral and lateral membrane contacts that occur as a result of the overlap of membrane ruffles aggregate N-cadherin, and that both N-cadherin and E-cadherin promote macropinosome closure and fluid-phase uptake in macropinosomes. These data reveal a previously unsuspected function for cadherin-mediated cell–cell adhesion molecules in the closure of cell-autonomous membrane contacts at membrane ruffles, resulting in macropinocytosis.</jats:p> Cadherins at cell-autonomous membrane contacts control macropinocytosis Journal of Cell Science |
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| title |
Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_unstemmed |
Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_full |
Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_fullStr |
Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_full_unstemmed |
Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_short |
Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_sort |
cadherins at cell-autonomous membrane contacts control macropinocytosis |
| topic |
Cell Biology |
| url |
http://dx.doi.org/10.1242/jcs.076901 |
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2011 |
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2013-2020 |
| description |
<jats:p>Cadherins aggregate and stabilize cell–cell junctions through interactions with adjacent cells. In addition, N-cadherin and E-cadherin concentrate at free edges or at the lamellipodia of migrating cells and are found within large vesicles called macropinosomes, which develop from membrane ruffles. The binding properties of cadherins have not previously been associated with the localization of cadherins at membrane ruffles; however, we report that the dorsal, ventral and lateral membrane contacts that occur as a result of the overlap of membrane ruffles aggregate N-cadherin, and that both N-cadherin and E-cadherin promote macropinosome closure and fluid-phase uptake in macropinosomes. These data reveal a previously unsuspected function for cadherin-mediated cell–cell adhesion molecules in the closure of cell-autonomous membrane contacts at membrane ruffles, resulting in macropinocytosis.</jats:p> |
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| author | Sabatini, Peter J. B., Zhang, Ming, Silverman-Gavrila, Rosalind V., Bendeck, Michelle P. |
| author_facet | Sabatini, Peter J. B., Zhang, Ming, Silverman-Gavrila, Rosalind V., Bendeck, Michelle P., Sabatini, Peter J. B., Zhang, Ming, Silverman-Gavrila, Rosalind V., Bendeck, Michelle P. |
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| description | <jats:p>Cadherins aggregate and stabilize cell–cell junctions through interactions with adjacent cells. In addition, N-cadherin and E-cadherin concentrate at free edges or at the lamellipodia of migrating cells and are found within large vesicles called macropinosomes, which develop from membrane ruffles. The binding properties of cadherins have not previously been associated with the localization of cadherins at membrane ruffles; however, we report that the dorsal, ventral and lateral membrane contacts that occur as a result of the overlap of membrane ruffles aggregate N-cadherin, and that both N-cadherin and E-cadherin promote macropinosome closure and fluid-phase uptake in macropinosomes. These data reveal a previously unsuspected function for cadherin-mediated cell–cell adhesion molecules in the closure of cell-autonomous membrane contacts at membrane ruffles, resulting in macropinocytosis.</jats:p> |
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| spelling | Sabatini, Peter J. B. Zhang, Ming Silverman-Gavrila, Rosalind V. Bendeck, Michelle P. 1477-9137 0021-9533 The Company of Biologists Cell Biology http://dx.doi.org/10.1242/jcs.076901 <jats:p>Cadherins aggregate and stabilize cell–cell junctions through interactions with adjacent cells. In addition, N-cadherin and E-cadherin concentrate at free edges or at the lamellipodia of migrating cells and are found within large vesicles called macropinosomes, which develop from membrane ruffles. The binding properties of cadherins have not previously been associated with the localization of cadherins at membrane ruffles; however, we report that the dorsal, ventral and lateral membrane contacts that occur as a result of the overlap of membrane ruffles aggregate N-cadherin, and that both N-cadherin and E-cadherin promote macropinosome closure and fluid-phase uptake in macropinosomes. These data reveal a previously unsuspected function for cadherin-mediated cell–cell adhesion molecules in the closure of cell-autonomous membrane contacts at membrane ruffles, resulting in macropinocytosis.</jats:p> Cadherins at cell-autonomous membrane contacts control macropinocytosis Journal of Cell Science |
| spellingShingle | Sabatini, Peter J. B., Zhang, Ming, Silverman-Gavrila, Rosalind V., Bendeck, Michelle P., Journal of Cell Science, Cadherins at cell-autonomous membrane contacts control macropinocytosis, Cell Biology |
| title | Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_full | Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_fullStr | Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_full_unstemmed | Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_short | Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_sort | cadherins at cell-autonomous membrane contacts control macropinocytosis |
| title_unstemmed | Cadherins at cell-autonomous membrane contacts control macropinocytosis |
| topic | Cell Biology |
| url | http://dx.doi.org/10.1242/jcs.076901 |