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Regulating complement in the kidney: insights from CFHR5 nephropathy
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| Zeitschriftentitel: | Disease Models & Mechanisms |
|---|---|
| Personen und Körperschaften: | , |
| In: | Disease Models & Mechanisms, 4, 2011, 6, S. 721-726 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
|
| Schlagwörter: |
| author_facet |
Gale, Daniel P. Pickering, Matthew C. Gale, Daniel P. Pickering, Matthew C. |
|---|---|
| author |
Gale, Daniel P. Pickering, Matthew C. |
| spellingShingle |
Gale, Daniel P. Pickering, Matthew C. Disease Models & Mechanisms Regulating complement in the kidney: insights from CFHR5 nephropathy General Biochemistry, Genetics and Molecular Biology Immunology and Microbiology (miscellaneous) Medicine (miscellaneous) Neuroscience (miscellaneous) |
| author_sort |
gale, daniel p. |
| spelling |
Gale, Daniel P. Pickering, Matthew C. 1754-8411 1754-8403 The Company of Biologists General Biochemistry, Genetics and Molecular Biology Immunology and Microbiology (miscellaneous) Medicine (miscellaneous) Neuroscience (miscellaneous) http://dx.doi.org/10.1242/dmm.008052 <jats:p>Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and kidney failure. Its identification suggests a role for the CFHR5 protein in the regulation of complement in the kidney. In this review, we discuss how studying CFHR5 nephropathy can contribute to our understanding of the role of complement in kidney diseases such as dense deposit disease, C3 glomerulonephritis and atypical haemolytic uraemic syndrome.</jats:p> Regulating complement in the kidney: insights from CFHR5 nephropathy Disease Models & Mechanisms |
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| title |
Regulating complement in the kidney: insights from CFHR5 nephropathy |
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Regulating complement in the kidney: insights from CFHR5 nephropathy |
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Regulating complement in the kidney: insights from CFHR5 nephropathy |
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Regulating complement in the kidney: insights from CFHR5 nephropathy |
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Regulating complement in the kidney: insights from CFHR5 nephropathy |
| title_short |
Regulating complement in the kidney: insights from CFHR5 nephropathy |
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regulating complement in the kidney: insights from cfhr5 nephropathy |
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General Biochemistry, Genetics and Molecular Biology Immunology and Microbiology (miscellaneous) Medicine (miscellaneous) Neuroscience (miscellaneous) |
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http://dx.doi.org/10.1242/dmm.008052 |
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2011 |
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721-726 |
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<jats:p>Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and kidney failure. Its identification suggests a role for the CFHR5 protein in the regulation of complement in the kidney. In this review, we discuss how studying CFHR5 nephropathy can contribute to our understanding of the role of complement in kidney diseases such as dense deposit disease, C3 glomerulonephritis and atypical haemolytic uraemic syndrome.</jats:p> |
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| description | <jats:p>Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and kidney failure. Its identification suggests a role for the CFHR5 protein in the regulation of complement in the kidney. In this review, we discuss how studying CFHR5 nephropathy can contribute to our understanding of the role of complement in kidney diseases such as dense deposit disease, C3 glomerulonephritis and atypical haemolytic uraemic syndrome.</jats:p> |
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| spelling | Gale, Daniel P. Pickering, Matthew C. 1754-8411 1754-8403 The Company of Biologists General Biochemistry, Genetics and Molecular Biology Immunology and Microbiology (miscellaneous) Medicine (miscellaneous) Neuroscience (miscellaneous) http://dx.doi.org/10.1242/dmm.008052 <jats:p>Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and kidney failure. Its identification suggests a role for the CFHR5 protein in the regulation of complement in the kidney. In this review, we discuss how studying CFHR5 nephropathy can contribute to our understanding of the role of complement in kidney diseases such as dense deposit disease, C3 glomerulonephritis and atypical haemolytic uraemic syndrome.</jats:p> Regulating complement in the kidney: insights from CFHR5 nephropathy Disease Models & Mechanisms |
| spellingShingle | Gale, Daniel P., Pickering, Matthew C., Disease Models & Mechanisms, Regulating complement in the kidney: insights from CFHR5 nephropathy, General Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology (miscellaneous), Medicine (miscellaneous), Neuroscience (miscellaneous) |
| title | Regulating complement in the kidney: insights from CFHR5 nephropathy |
| title_full | Regulating complement in the kidney: insights from CFHR5 nephropathy |
| title_fullStr | Regulating complement in the kidney: insights from CFHR5 nephropathy |
| title_full_unstemmed | Regulating complement in the kidney: insights from CFHR5 nephropathy |
| title_short | Regulating complement in the kidney: insights from CFHR5 nephropathy |
| title_sort | regulating complement in the kidney: insights from cfhr5 nephropathy |
| title_unstemmed | Regulating complement in the kidney: insights from CFHR5 nephropathy |
| topic | General Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology (miscellaneous), Medicine (miscellaneous), Neuroscience (miscellaneous) |
| url | http://dx.doi.org/10.1242/dmm.008052 |