Eintrag weiter verarbeiten
Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia
Gespeichert in:
| Zeitschriftentitel: | Canadian Journal of Physiology and Pharmacology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Canadian Journal of Physiology and Pharmacology, 96, 2018, 10, S. 1040-1049 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Canadian Science Publishing
|
| Schlagwörter: |
| author_facet |
Nikolic Turnic, Tamara R. Jakovljevic, Vladimir Lj. Djuric, Dragan M. Jeremic, Nevena S. Jeremic, Jovana N. Milosavljevic, Isidora M. Srejovic, Ivan M. Selakovic, Dragica V. Zivkovic, Vladimir I. Nikolic Turnic, Tamara R. Jakovljevic, Vladimir Lj. Djuric, Dragan M. Jeremic, Nevena S. Jeremic, Jovana N. Milosavljevic, Isidora M. Srejovic, Ivan M. Selakovic, Dragica V. Zivkovic, Vladimir I. |
|---|---|
| author |
Nikolic Turnic, Tamara R. Jakovljevic, Vladimir Lj. Djuric, Dragan M. Jeremic, Nevena S. Jeremic, Jovana N. Milosavljevic, Isidora M. Srejovic, Ivan M. Selakovic, Dragica V. Zivkovic, Vladimir I. |
| spellingShingle |
Nikolic Turnic, Tamara R. Jakovljevic, Vladimir Lj. Djuric, Dragan M. Jeremic, Nevena S. Jeremic, Jovana N. Milosavljevic, Isidora M. Srejovic, Ivan M. Selakovic, Dragica V. Zivkovic, Vladimir I. Canadian Journal of Physiology and Pharmacology Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia Physiology (medical) Pharmacology General Medicine Physiology |
| author_sort |
nikolic turnic, tamara r. |
| spelling |
Nikolic Turnic, Tamara R. Jakovljevic, Vladimir Lj. Djuric, Dragan M. Jeremic, Nevena S. Jeremic, Jovana N. Milosavljevic, Isidora M. Srejovic, Ivan M. Selakovic, Dragica V. Zivkovic, Vladimir I. 0008-4212 1205-7541 Canadian Science Publishing Physiology (medical) Pharmacology General Medicine Physiology http://dx.doi.org/10.1139/cjpp-2018-0102 <jats:p>The aim of this study was to assess the impact of atorvastatin and simvastatin on myocardial contractility during the different degrees of hyperhomocysteinemia (HHcy) in rats. Study was conducted on adult male Wistar albino rats (n = 90; 4 weeks old; 100 ± 15 g body mass) in which HHcy was achieved by dietary manipulation. Animals were exposed to pharmacology treatment with atorvastatin in dose of 3 mg/kg per day i.p. or simvastatin in dose of 5 mg/kg per day i.p. at the same time every day, according to equivalent therapeutic doses of these statins (10 mg atorvastatin = 20 mg simvastatin). After the dietary manipulation and pharmacological treatment and confirmation of HHcy, all animals were sacrificed, hearts were isolated, and cardiac function was tested according to the Langendorff technique. Size of recovery of maximum rate of left ventricular development (dp/dt<jats:sub>max</jats:sub>), minimum rate of left ventricular development (dp/dt<jats:sub>min</jats:sub>), systolic left ventricular development, diastolic left ventricular development, heart rate, and coronary flow at the 40, 60, 80, 100, and 120 cmH<jats:sub>2</jats:sub>O coronary perfusion pressure were measured in state of physiological condition (homocysteine less than 15 μmol/L), mild HHcy, and moderate HHcy. Atorvastatin treatment significantly attenuated homocysteine-induced impairment of myocyte contractility and dominantly decreased dp/dt<jats:sub>max</jats:sub>, dp/dt<jats:sub>min</jats:sub>, and heart rate and induced greater changes in systolic left ventricular development compared with simvastatin. Treatment with atorvastatin seems able to revert systolic abnormalities and improve contractility during the different degrees of HHcy.</jats:p> Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia Canadian Journal of Physiology and Pharmacology |
| doi_str_mv |
10.1139/cjpp-2018-0102 |
| facet_avail |
Online |
| finc_class_facet |
Biologie Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzOS9janBwLTIwMTgtMDEwMg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzOS9janBwLTIwMTgtMDEwMg |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 |
| imprint |
Canadian Science Publishing, 2018 |
| imprint_str_mv |
Canadian Science Publishing, 2018 |
| issn |
0008-4212 1205-7541 |
| issn_str_mv |
0008-4212 1205-7541 |
| language |
English |
| mega_collection |
Canadian Science Publishing (CrossRef) |
| match_str |
nikolicturnic2018efficiencyofatorvastatinandsimvastatininimprovingcardiacfunctionduringthedifferentdegreesofhyperhomocysteinemia |
| publishDateSort |
2018 |
| publisher |
Canadian Science Publishing |
| recordtype |
ai |
| record_format |
ai |
| series |
Canadian Journal of Physiology and Pharmacology |
| source_id |
49 |
| title |
Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_unstemmed |
Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_full |
Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_fullStr |
Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_full_unstemmed |
Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_short |
Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_sort |
efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| topic |
Physiology (medical) Pharmacology General Medicine Physiology |
| url |
http://dx.doi.org/10.1139/cjpp-2018-0102 |
| publishDate |
2018 |
| physical |
1040-1049 |
| description |
<jats:p>The aim of this study was to assess the impact of atorvastatin and simvastatin on myocardial contractility during the different degrees of hyperhomocysteinemia (HHcy) in rats. Study was conducted on adult male Wistar albino rats (n = 90; 4 weeks old; 100 ± 15 g body mass) in which HHcy was achieved by dietary manipulation. Animals were exposed to pharmacology treatment with atorvastatin in dose of 3 mg/kg per day i.p. or simvastatin in dose of 5 mg/kg per day i.p. at the same time every day, according to equivalent therapeutic doses of these statins (10 mg atorvastatin = 20 mg simvastatin). After the dietary manipulation and pharmacological treatment and confirmation of HHcy, all animals were sacrificed, hearts were isolated, and cardiac function was tested according to the Langendorff technique. Size of recovery of maximum rate of left ventricular development (dp/dt<jats:sub>max</jats:sub>), minimum rate of left ventricular development (dp/dt<jats:sub>min</jats:sub>), systolic left ventricular development, diastolic left ventricular development, heart rate, and coronary flow at the 40, 60, 80, 100, and 120 cmH<jats:sub>2</jats:sub>O coronary perfusion pressure were measured in state of physiological condition (homocysteine less than 15 μmol/L), mild HHcy, and moderate HHcy. Atorvastatin treatment significantly attenuated homocysteine-induced impairment of myocyte contractility and dominantly decreased dp/dt<jats:sub>max</jats:sub>, dp/dt<jats:sub>min</jats:sub>, and heart rate and induced greater changes in systolic left ventricular development compared with simvastatin. Treatment with atorvastatin seems able to revert systolic abnormalities and improve contractility during the different degrees of HHcy.</jats:p> |
| container_issue |
10 |
| container_start_page |
1040 |
| container_title |
Canadian Journal of Physiology and Pharmacology |
| container_volume |
96 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792331432062877707 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T13:40:35.423Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Efficiency+of+atorvastatin+and+simvastatin+in+improving+cardiac+function+during+the+different+degrees+of+hyperhomocysteinemia&rft.date=2018-10-01&genre=article&issn=1205-7541&volume=96&issue=10&spage=1040&epage=1049&pages=1040-1049&jtitle=Canadian+Journal+of+Physiology+and+Pharmacology&atitle=Efficiency+of+atorvastatin+and+simvastatin+in+improving+cardiac+function+during+the+different+degrees+of+hyperhomocysteinemia&aulast=Zivkovic&aufirst=Vladimir+I.&rft_id=info%3Adoi%2F10.1139%2Fcjpp-2018-0102&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792331432062877707 |
| author | Nikolic Turnic, Tamara R., Jakovljevic, Vladimir Lj., Djuric, Dragan M., Jeremic, Nevena S., Jeremic, Jovana N., Milosavljevic, Isidora M., Srejovic, Ivan M., Selakovic, Dragica V., Zivkovic, Vladimir I. |
| author_facet | Nikolic Turnic, Tamara R., Jakovljevic, Vladimir Lj., Djuric, Dragan M., Jeremic, Nevena S., Jeremic, Jovana N., Milosavljevic, Isidora M., Srejovic, Ivan M., Selakovic, Dragica V., Zivkovic, Vladimir I., Nikolic Turnic, Tamara R., Jakovljevic, Vladimir Lj., Djuric, Dragan M., Jeremic, Nevena S., Jeremic, Jovana N., Milosavljevic, Isidora M., Srejovic, Ivan M., Selakovic, Dragica V., Zivkovic, Vladimir I. |
| author_sort | nikolic turnic, tamara r. |
| container_issue | 10 |
| container_start_page | 1040 |
| container_title | Canadian Journal of Physiology and Pharmacology |
| container_volume | 96 |
| description | <jats:p>The aim of this study was to assess the impact of atorvastatin and simvastatin on myocardial contractility during the different degrees of hyperhomocysteinemia (HHcy) in rats. Study was conducted on adult male Wistar albino rats (n = 90; 4 weeks old; 100 ± 15 g body mass) in which HHcy was achieved by dietary manipulation. Animals were exposed to pharmacology treatment with atorvastatin in dose of 3 mg/kg per day i.p. or simvastatin in dose of 5 mg/kg per day i.p. at the same time every day, according to equivalent therapeutic doses of these statins (10 mg atorvastatin = 20 mg simvastatin). After the dietary manipulation and pharmacological treatment and confirmation of HHcy, all animals were sacrificed, hearts were isolated, and cardiac function was tested according to the Langendorff technique. Size of recovery of maximum rate of left ventricular development (dp/dt<jats:sub>max</jats:sub>), minimum rate of left ventricular development (dp/dt<jats:sub>min</jats:sub>), systolic left ventricular development, diastolic left ventricular development, heart rate, and coronary flow at the 40, 60, 80, 100, and 120 cmH<jats:sub>2</jats:sub>O coronary perfusion pressure were measured in state of physiological condition (homocysteine less than 15 μmol/L), mild HHcy, and moderate HHcy. Atorvastatin treatment significantly attenuated homocysteine-induced impairment of myocyte contractility and dominantly decreased dp/dt<jats:sub>max</jats:sub>, dp/dt<jats:sub>min</jats:sub>, and heart rate and induced greater changes in systolic left ventricular development compared with simvastatin. Treatment with atorvastatin seems able to revert systolic abnormalities and improve contractility during the different degrees of HHcy.</jats:p> |
| doi_str_mv | 10.1139/cjpp-2018-0102 |
| facet_avail | Online |
| finc_class_facet | Biologie, Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzOS9janBwLTIwMTgtMDEwMg |
| imprint | Canadian Science Publishing, 2018 |
| imprint_str_mv | Canadian Science Publishing, 2018 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161 |
| issn | 0008-4212, 1205-7541 |
| issn_str_mv | 0008-4212, 1205-7541 |
| language | English |
| last_indexed | 2024-03-01T13:40:35.423Z |
| match_str | nikolicturnic2018efficiencyofatorvastatinandsimvastatininimprovingcardiacfunctionduringthedifferentdegreesofhyperhomocysteinemia |
| mega_collection | Canadian Science Publishing (CrossRef) |
| physical | 1040-1049 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | Canadian Science Publishing |
| record_format | ai |
| recordtype | ai |
| series | Canadian Journal of Physiology and Pharmacology |
| source_id | 49 |
| spelling | Nikolic Turnic, Tamara R. Jakovljevic, Vladimir Lj. Djuric, Dragan M. Jeremic, Nevena S. Jeremic, Jovana N. Milosavljevic, Isidora M. Srejovic, Ivan M. Selakovic, Dragica V. Zivkovic, Vladimir I. 0008-4212 1205-7541 Canadian Science Publishing Physiology (medical) Pharmacology General Medicine Physiology http://dx.doi.org/10.1139/cjpp-2018-0102 <jats:p>The aim of this study was to assess the impact of atorvastatin and simvastatin on myocardial contractility during the different degrees of hyperhomocysteinemia (HHcy) in rats. Study was conducted on adult male Wistar albino rats (n = 90; 4 weeks old; 100 ± 15 g body mass) in which HHcy was achieved by dietary manipulation. Animals were exposed to pharmacology treatment with atorvastatin in dose of 3 mg/kg per day i.p. or simvastatin in dose of 5 mg/kg per day i.p. at the same time every day, according to equivalent therapeutic doses of these statins (10 mg atorvastatin = 20 mg simvastatin). After the dietary manipulation and pharmacological treatment and confirmation of HHcy, all animals were sacrificed, hearts were isolated, and cardiac function was tested according to the Langendorff technique. Size of recovery of maximum rate of left ventricular development (dp/dt<jats:sub>max</jats:sub>), minimum rate of left ventricular development (dp/dt<jats:sub>min</jats:sub>), systolic left ventricular development, diastolic left ventricular development, heart rate, and coronary flow at the 40, 60, 80, 100, and 120 cmH<jats:sub>2</jats:sub>O coronary perfusion pressure were measured in state of physiological condition (homocysteine less than 15 μmol/L), mild HHcy, and moderate HHcy. Atorvastatin treatment significantly attenuated homocysteine-induced impairment of myocyte contractility and dominantly decreased dp/dt<jats:sub>max</jats:sub>, dp/dt<jats:sub>min</jats:sub>, and heart rate and induced greater changes in systolic left ventricular development compared with simvastatin. Treatment with atorvastatin seems able to revert systolic abnormalities and improve contractility during the different degrees of HHcy.</jats:p> Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia Canadian Journal of Physiology and Pharmacology |
| spellingShingle | Nikolic Turnic, Tamara R., Jakovljevic, Vladimir Lj., Djuric, Dragan M., Jeremic, Nevena S., Jeremic, Jovana N., Milosavljevic, Isidora M., Srejovic, Ivan M., Selakovic, Dragica V., Zivkovic, Vladimir I., Canadian Journal of Physiology and Pharmacology, Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia, Physiology (medical), Pharmacology, General Medicine, Physiology |
| title | Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_full | Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_fullStr | Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_full_unstemmed | Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_short | Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_sort | efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| title_unstemmed | Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia |
| topic | Physiology (medical), Pharmacology, General Medicine, Physiology |
| url | http://dx.doi.org/10.1139/cjpp-2018-0102 |