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Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats?
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| Zeitschriftentitel: | Canadian Journal of Physiology and Pharmacology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Canadian Journal of Physiology and Pharmacology, 96, 2018, 1, S. 51-59 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Canadian Science Publishing
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| Schlagwörter: |
| author_facet |
Hassan, Sherif Sabry Razzaque, Ahmer Ahmad, Zulfiqar Pazdernik, Vanessa Amin, Shaimaa Nasr Hassan, Sherif Sabry Razzaque, Ahmer Ahmad, Zulfiqar Pazdernik, Vanessa Amin, Shaimaa Nasr |
|---|---|
| author |
Hassan, Sherif Sabry Razzaque, Ahmer Ahmad, Zulfiqar Pazdernik, Vanessa Amin, Shaimaa Nasr |
| spellingShingle |
Hassan, Sherif Sabry Razzaque, Ahmer Ahmad, Zulfiqar Pazdernik, Vanessa Amin, Shaimaa Nasr Canadian Journal of Physiology and Pharmacology Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? Physiology (medical) Pharmacology General Medicine Physiology |
| author_sort |
hassan, sherif sabry |
| spelling |
Hassan, Sherif Sabry Razzaque, Ahmer Ahmad, Zulfiqar Pazdernik, Vanessa Amin, Shaimaa Nasr 0008-4212 1205-7541 Canadian Science Publishing Physiology (medical) Pharmacology General Medicine Physiology http://dx.doi.org/10.1139/cjpp-2017-0599 <jats:p> Atorvastatin (ATO) was commonly used to lower blood cholesterol, but it caused harmful effects to organs, including the liver. Thymoquinone (TQ), a prominent constituent of Nigella sativa, has antioxidant, antiinflammatory, antiapoptotic, antimicrobial, and anticancer activity. The current study investigated the mechanism of ATO-induced hepatotoxicity, whether posttreatment TQ could reverse ATO-induced hepatic injury, and the mechanism of action of TQ as a hepatoprotective agent. Forty adult male Sprague Dawley rats were divided into four equal groups: control, TQ-treated, ATO-treated, and combined ATO/TQ-treated. Rats were treated for 8 weeks and 10 days and euthanized by cervical dislocation 3 days after the last treatment. Blood samples and livers were tested for liver enzymes, oxidative stress, and apoptosis markers and used for histopathological and ultrastructural examination. The ATO-treated group showed an increase in liver enzymes, decreases in reduced glutathione and catalase, and increases in the malondialdehyde lipid peroxidation marker, protein carbonylation, and caspase 3 activity. Posttreatment TQ in the ATO/TQ-treated group seemed to reverse these changes. Histopathological and ultrastructural examination supported these data. Results from the current study suggested that posttreatment TQ may reverse oxidative stress injury in rat liver produced by ATO, suggesting a potential clinical application of using TQ to prevent ATO-induced hepatic injury. </jats:p> Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? Canadian Journal of Physiology and Pharmacology |
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| title |
Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_unstemmed |
Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_full |
Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_fullStr |
Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_full_unstemmed |
Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_short |
Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_sort |
does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| topic |
Physiology (medical) Pharmacology General Medicine Physiology |
| url |
http://dx.doi.org/10.1139/cjpp-2017-0599 |
| publishDate |
2018 |
| physical |
51-59 |
| description |
<jats:p> Atorvastatin (ATO) was commonly used to lower blood cholesterol, but it caused harmful effects to organs, including the liver. Thymoquinone (TQ), a prominent constituent of Nigella sativa, has antioxidant, antiinflammatory, antiapoptotic, antimicrobial, and anticancer activity. The current study investigated the mechanism of ATO-induced hepatotoxicity, whether posttreatment TQ could reverse ATO-induced hepatic injury, and the mechanism of action of TQ as a hepatoprotective agent. Forty adult male Sprague Dawley rats were divided into four equal groups: control, TQ-treated, ATO-treated, and combined ATO/TQ-treated. Rats were treated for 8 weeks and 10 days and euthanized by cervical dislocation 3 days after the last treatment. Blood samples and livers were tested for liver enzymes, oxidative stress, and apoptosis markers and used for histopathological and ultrastructural examination. The ATO-treated group showed an increase in liver enzymes, decreases in reduced glutathione and catalase, and increases in the malondialdehyde lipid peroxidation marker, protein carbonylation, and caspase 3 activity. Posttreatment TQ in the ATO/TQ-treated group seemed to reverse these changes. Histopathological and ultrastructural examination supported these data. Results from the current study suggested that posttreatment TQ may reverse oxidative stress injury in rat liver produced by ATO, suggesting a potential clinical application of using TQ to prevent ATO-induced hepatic injury. </jats:p> |
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| author | Hassan, Sherif Sabry, Razzaque, Ahmer, Ahmad, Zulfiqar, Pazdernik, Vanessa, Amin, Shaimaa Nasr |
| author_facet | Hassan, Sherif Sabry, Razzaque, Ahmer, Ahmad, Zulfiqar, Pazdernik, Vanessa, Amin, Shaimaa Nasr, Hassan, Sherif Sabry, Razzaque, Ahmer, Ahmad, Zulfiqar, Pazdernik, Vanessa, Amin, Shaimaa Nasr |
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| description | <jats:p> Atorvastatin (ATO) was commonly used to lower blood cholesterol, but it caused harmful effects to organs, including the liver. Thymoquinone (TQ), a prominent constituent of Nigella sativa, has antioxidant, antiinflammatory, antiapoptotic, antimicrobial, and anticancer activity. The current study investigated the mechanism of ATO-induced hepatotoxicity, whether posttreatment TQ could reverse ATO-induced hepatic injury, and the mechanism of action of TQ as a hepatoprotective agent. Forty adult male Sprague Dawley rats were divided into four equal groups: control, TQ-treated, ATO-treated, and combined ATO/TQ-treated. Rats were treated for 8 weeks and 10 days and euthanized by cervical dislocation 3 days after the last treatment. Blood samples and livers were tested for liver enzymes, oxidative stress, and apoptosis markers and used for histopathological and ultrastructural examination. The ATO-treated group showed an increase in liver enzymes, decreases in reduced glutathione and catalase, and increases in the malondialdehyde lipid peroxidation marker, protein carbonylation, and caspase 3 activity. Posttreatment TQ in the ATO/TQ-treated group seemed to reverse these changes. Histopathological and ultrastructural examination supported these data. Results from the current study suggested that posttreatment TQ may reverse oxidative stress injury in rat liver produced by ATO, suggesting a potential clinical application of using TQ to prevent ATO-induced hepatic injury. </jats:p> |
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| spelling | Hassan, Sherif Sabry Razzaque, Ahmer Ahmad, Zulfiqar Pazdernik, Vanessa Amin, Shaimaa Nasr 0008-4212 1205-7541 Canadian Science Publishing Physiology (medical) Pharmacology General Medicine Physiology http://dx.doi.org/10.1139/cjpp-2017-0599 <jats:p> Atorvastatin (ATO) was commonly used to lower blood cholesterol, but it caused harmful effects to organs, including the liver. Thymoquinone (TQ), a prominent constituent of Nigella sativa, has antioxidant, antiinflammatory, antiapoptotic, antimicrobial, and anticancer activity. The current study investigated the mechanism of ATO-induced hepatotoxicity, whether posttreatment TQ could reverse ATO-induced hepatic injury, and the mechanism of action of TQ as a hepatoprotective agent. Forty adult male Sprague Dawley rats were divided into four equal groups: control, TQ-treated, ATO-treated, and combined ATO/TQ-treated. Rats were treated for 8 weeks and 10 days and euthanized by cervical dislocation 3 days after the last treatment. Blood samples and livers were tested for liver enzymes, oxidative stress, and apoptosis markers and used for histopathological and ultrastructural examination. The ATO-treated group showed an increase in liver enzymes, decreases in reduced glutathione and catalase, and increases in the malondialdehyde lipid peroxidation marker, protein carbonylation, and caspase 3 activity. Posttreatment TQ in the ATO/TQ-treated group seemed to reverse these changes. Histopathological and ultrastructural examination supported these data. Results from the current study suggested that posttreatment TQ may reverse oxidative stress injury in rat liver produced by ATO, suggesting a potential clinical application of using TQ to prevent ATO-induced hepatic injury. </jats:p> Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? Canadian Journal of Physiology and Pharmacology |
| spellingShingle | Hassan, Sherif Sabry, Razzaque, Ahmer, Ahmad, Zulfiqar, Pazdernik, Vanessa, Amin, Shaimaa Nasr, Canadian Journal of Physiology and Pharmacology, Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats?, Physiology (medical), Pharmacology, General Medicine, Physiology |
| title | Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_full | Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_fullStr | Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_full_unstemmed | Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_short | Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_sort | does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| title_unstemmed | Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? |
| topic | Physiology (medical), Pharmacology, General Medicine, Physiology |
| url | http://dx.doi.org/10.1139/cjpp-2017-0599 |