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Modulation ofN-methyl-d-aspartate receptors in isolated rat heart
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| Zeitschriftentitel: | Canadian Journal of Physiology and Pharmacology |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Canadian Journal of Physiology and Pharmacology, 95, 2017, 11, S. 1327-1334 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Canadian Science Publishing
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| Schlagwörter: |
| author_facet |
Srejovic, Ivan Zivkovic, Vladimir Nikolic, Tamara Jeremic, Nevena Stojic, Isidora Jeremic, Jovana Djuric, Dragan Jakovljevic, Vladimir Srejovic, Ivan Zivkovic, Vladimir Nikolic, Tamara Jeremic, Nevena Stojic, Isidora Jeremic, Jovana Djuric, Dragan Jakovljevic, Vladimir |
|---|---|
| author |
Srejovic, Ivan Zivkovic, Vladimir Nikolic, Tamara Jeremic, Nevena Stojic, Isidora Jeremic, Jovana Djuric, Dragan Jakovljevic, Vladimir |
| spellingShingle |
Srejovic, Ivan Zivkovic, Vladimir Nikolic, Tamara Jeremic, Nevena Stojic, Isidora Jeremic, Jovana Djuric, Dragan Jakovljevic, Vladimir Canadian Journal of Physiology and Pharmacology Modulation ofN-methyl-d-aspartate receptors in isolated rat heart Physiology (medical) Pharmacology General Medicine Physiology |
| author_sort |
srejovic, ivan |
| spelling |
Srejovic, Ivan Zivkovic, Vladimir Nikolic, Tamara Jeremic, Nevena Stojic, Isidora Jeremic, Jovana Djuric, Dragan Jakovljevic, Vladimir 0008-4212 1205-7541 Canadian Science Publishing Physiology (medical) Pharmacology General Medicine Physiology http://dx.doi.org/10.1139/cjpp-2017-0056 <jats:p>Considering the limited data on the role of NMDA-Rs in the cardiovascular system, the aim of the present study was to examine the effects of NMDA and DL-Hcy TLHC, alone and in combination with glycine, memantine, and ifenprodil, in the isolated rat heart. The hearts of Wistar albino rats were retrogradely perfused according to the Langendorff technique at a constant perfusion pressure. The experimental protocol for all experimental groups included the stabilization period, application of estimated substance for 5 min, followed by a washout period of 10 min. Using a sensor placed in the left ventricle, we registered the following parameters of myocardial function: dp/dt<jats:sub>max</jats:sub>, dp/dt<jats:sub>min</jats:sub>, SLVP, DVLP, HR; CF was measured using flowmetry). We estimated the following oxidative stress biomarkers in the coronary venous effluent using spectrophotometry: TBARS, NO<jats:sub>2</jats:sub><jats:sup>−</jats:sup>, O<jats:sub>2</jats:sub><jats:sup>−</jats:sup>, and H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>. NMDA alone did not induce any change in any of the observed parameters, while DL-Hcy TLHC alone, as well as a combined application of NMDA and DL-Hcy TLHC with glycine, induced a reduction of most cardiodynamic parameters. Memantine and ifenprodil induced a reduction of cardiodynamic parameters and CF, as well as some oxidative stress biomarkers.</jats:p> Modulation of<i>N</i>-methyl-<scp>d</scp>-aspartate receptors in isolated rat heart Canadian Journal of Physiology and Pharmacology |
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| title |
Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_unstemmed |
Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_full |
Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_fullStr |
Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_full_unstemmed |
Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_short |
Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_sort |
modulation of<i>n</i>-methyl-<scp>d</scp>-aspartate receptors in isolated rat heart |
| topic |
Physiology (medical) Pharmacology General Medicine Physiology |
| url |
http://dx.doi.org/10.1139/cjpp-2017-0056 |
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2017 |
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1327-1334 |
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<jats:p>Considering the limited data on the role of NMDA-Rs in the cardiovascular system, the aim of the present study was to examine the effects of NMDA and DL-Hcy TLHC, alone and in combination with glycine, memantine, and ifenprodil, in the isolated rat heart. The hearts of Wistar albino rats were retrogradely perfused according to the Langendorff technique at a constant perfusion pressure. The experimental protocol for all experimental groups included the stabilization period, application of estimated substance for 5 min, followed by a washout period of 10 min. Using a sensor placed in the left ventricle, we registered the following parameters of myocardial function: dp/dt<jats:sub>max</jats:sub>, dp/dt<jats:sub>min</jats:sub>, SLVP, DVLP, HR; CF was measured using flowmetry). We estimated the following oxidative stress biomarkers in the coronary venous effluent using spectrophotometry: TBARS, NO<jats:sub>2</jats:sub><jats:sup>−</jats:sup>, O<jats:sub>2</jats:sub><jats:sup>−</jats:sup>, and H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>. NMDA alone did not induce any change in any of the observed parameters, while DL-Hcy TLHC alone, as well as a combined application of NMDA and DL-Hcy TLHC with glycine, induced a reduction of most cardiodynamic parameters. Memantine and ifenprodil induced a reduction of cardiodynamic parameters and CF, as well as some oxidative stress biomarkers.</jats:p> |
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| author | Srejovic, Ivan, Zivkovic, Vladimir, Nikolic, Tamara, Jeremic, Nevena, Stojic, Isidora, Jeremic, Jovana, Djuric, Dragan, Jakovljevic, Vladimir |
| author_facet | Srejovic, Ivan, Zivkovic, Vladimir, Nikolic, Tamara, Jeremic, Nevena, Stojic, Isidora, Jeremic, Jovana, Djuric, Dragan, Jakovljevic, Vladimir, Srejovic, Ivan, Zivkovic, Vladimir, Nikolic, Tamara, Jeremic, Nevena, Stojic, Isidora, Jeremic, Jovana, Djuric, Dragan, Jakovljevic, Vladimir |
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| description | <jats:p>Considering the limited data on the role of NMDA-Rs in the cardiovascular system, the aim of the present study was to examine the effects of NMDA and DL-Hcy TLHC, alone and in combination with glycine, memantine, and ifenprodil, in the isolated rat heart. The hearts of Wistar albino rats were retrogradely perfused according to the Langendorff technique at a constant perfusion pressure. The experimental protocol for all experimental groups included the stabilization period, application of estimated substance for 5 min, followed by a washout period of 10 min. Using a sensor placed in the left ventricle, we registered the following parameters of myocardial function: dp/dt<jats:sub>max</jats:sub>, dp/dt<jats:sub>min</jats:sub>, SLVP, DVLP, HR; CF was measured using flowmetry). We estimated the following oxidative stress biomarkers in the coronary venous effluent using spectrophotometry: TBARS, NO<jats:sub>2</jats:sub><jats:sup>−</jats:sup>, O<jats:sub>2</jats:sub><jats:sup>−</jats:sup>, and H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>. NMDA alone did not induce any change in any of the observed parameters, while DL-Hcy TLHC alone, as well as a combined application of NMDA and DL-Hcy TLHC with glycine, induced a reduction of most cardiodynamic parameters. Memantine and ifenprodil induced a reduction of cardiodynamic parameters and CF, as well as some oxidative stress biomarkers.</jats:p> |
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| spelling | Srejovic, Ivan Zivkovic, Vladimir Nikolic, Tamara Jeremic, Nevena Stojic, Isidora Jeremic, Jovana Djuric, Dragan Jakovljevic, Vladimir 0008-4212 1205-7541 Canadian Science Publishing Physiology (medical) Pharmacology General Medicine Physiology http://dx.doi.org/10.1139/cjpp-2017-0056 <jats:p>Considering the limited data on the role of NMDA-Rs in the cardiovascular system, the aim of the present study was to examine the effects of NMDA and DL-Hcy TLHC, alone and in combination with glycine, memantine, and ifenprodil, in the isolated rat heart. The hearts of Wistar albino rats were retrogradely perfused according to the Langendorff technique at a constant perfusion pressure. The experimental protocol for all experimental groups included the stabilization period, application of estimated substance for 5 min, followed by a washout period of 10 min. Using a sensor placed in the left ventricle, we registered the following parameters of myocardial function: dp/dt<jats:sub>max</jats:sub>, dp/dt<jats:sub>min</jats:sub>, SLVP, DVLP, HR; CF was measured using flowmetry). We estimated the following oxidative stress biomarkers in the coronary venous effluent using spectrophotometry: TBARS, NO<jats:sub>2</jats:sub><jats:sup>−</jats:sup>, O<jats:sub>2</jats:sub><jats:sup>−</jats:sup>, and H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>. NMDA alone did not induce any change in any of the observed parameters, while DL-Hcy TLHC alone, as well as a combined application of NMDA and DL-Hcy TLHC with glycine, induced a reduction of most cardiodynamic parameters. Memantine and ifenprodil induced a reduction of cardiodynamic parameters and CF, as well as some oxidative stress biomarkers.</jats:p> Modulation of<i>N</i>-methyl-<scp>d</scp>-aspartate receptors in isolated rat heart Canadian Journal of Physiology and Pharmacology |
| spellingShingle | Srejovic, Ivan, Zivkovic, Vladimir, Nikolic, Tamara, Jeremic, Nevena, Stojic, Isidora, Jeremic, Jovana, Djuric, Dragan, Jakovljevic, Vladimir, Canadian Journal of Physiology and Pharmacology, Modulation ofN-methyl-d-aspartate receptors in isolated rat heart, Physiology (medical), Pharmacology, General Medicine, Physiology |
| title | Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_full | Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_fullStr | Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_full_unstemmed | Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_short | Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| title_sort | modulation of<i>n</i>-methyl-<scp>d</scp>-aspartate receptors in isolated rat heart |
| title_unstemmed | Modulation ofN-methyl-d-aspartate receptors in isolated rat heart |
| topic | Physiology (medical), Pharmacology, General Medicine, Physiology |
| url | http://dx.doi.org/10.1139/cjpp-2017-0056 |