Eintrag weiter verarbeiten
Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage
Gespeichert in:
| Zeitschriftentitel: | Stroke and Vascular Neurology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Stroke and Vascular Neurology, 4, 2019, 2, S. 93-95 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
BMJ
|
| Schlagwörter: |
| author_facet |
Wan, Jieru Ren, Honglei Wang, Jian Wan, Jieru Ren, Honglei Wang, Jian |
|---|---|
| author |
Wan, Jieru Ren, Honglei Wang, Jian |
| spellingShingle |
Wan, Jieru Ren, Honglei Wang, Jian Stroke and Vascular Neurology Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage Cardiology and Cardiovascular Medicine Neurology (clinical) |
| author_sort |
wan, jieru |
| spelling |
Wan, Jieru Ren, Honglei Wang, Jian 2059-8688 2059-8696 BMJ Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1136/svn-2018-000205 <jats:p>Intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity. However, we have few options for ICH therapy and limited knowledge about post-ICH neuronal death and related mechanisms. In the aftermath of ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production and lipid peroxidation, which contribute to secondary brain injury. Indeed, iron chelation therapy has shown efficacy in preclinical ICH studies. Recently, an iron-dependent form of non-apoptotic cell death known as ferroptosis was identified. It is characterised by an accumulation of iron-induced lipid ROS, which leads to intracellular oxidative stress. The ROS cause damage to nucleic acids, proteins and lipid membranes, and eventually cell death. Recently, we and others discovered that ferroptosis does occur after haemorrhagic stroke in vitro and in vivo and contributes to neuronal death. Inhibition of ferroptosis is beneficial in several in vivo and in vitro ICH conditions. This minireview summarises current research on iron toxicity, lipid peroxidation and ferroptosis in the pathomechanisms of ICH, the underlying molecular mechanisms of ferroptosis and the potential for combined therapeutic strategies. Understanding the role of ferroptosis after ICH will provide a vital foundation for cell death-based ICH treatment and prevention.</jats:p> Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage Stroke and Vascular Neurology |
| doi_str_mv |
10.1136/svn-2018-000205 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9zdm4tMjAxOC0wMDAyMDU |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9zdm4tMjAxOC0wMDAyMDU |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
BMJ, 2019 |
| imprint_str_mv |
BMJ, 2019 |
| issn |
2059-8688 2059-8696 |
| issn_str_mv |
2059-8688 2059-8696 |
| language |
English |
| mega_collection |
BMJ (CrossRef) |
| match_str |
wan2019irontoxicitylipidperoxidationandferroptosisafterintracerebralhaemorrhage |
| publishDateSort |
2019 |
| publisher |
BMJ |
| recordtype |
ai |
| record_format |
ai |
| series |
Stroke and Vascular Neurology |
| source_id |
49 |
| title |
Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_unstemmed |
Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_full |
Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_fullStr |
Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_full_unstemmed |
Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_short |
Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_sort |
iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| topic |
Cardiology and Cardiovascular Medicine Neurology (clinical) |
| url |
http://dx.doi.org/10.1136/svn-2018-000205 |
| publishDate |
2019 |
| physical |
93-95 |
| description |
<jats:p>Intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity. However, we have few options for ICH therapy and limited knowledge about post-ICH neuronal death and related mechanisms. In the aftermath of ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production and lipid peroxidation, which contribute to secondary brain injury. Indeed, iron chelation therapy has shown efficacy in preclinical ICH studies. Recently, an iron-dependent form of non-apoptotic cell death known as ferroptosis was identified. It is characterised by an accumulation of iron-induced lipid ROS, which leads to intracellular oxidative stress. The ROS cause damage to nucleic acids, proteins and lipid membranes, and eventually cell death. Recently, we and others discovered that ferroptosis does occur after haemorrhagic stroke in vitro and in vivo and contributes to neuronal death. Inhibition of ferroptosis is beneficial in several in vivo and in vitro ICH conditions. This minireview summarises current research on iron toxicity, lipid peroxidation and ferroptosis in the pathomechanisms of ICH, the underlying molecular mechanisms of ferroptosis and the potential for combined therapeutic strategies. Understanding the role of ferroptosis after ICH will provide a vital foundation for cell death-based ICH treatment and prevention.</jats:p> |
| container_issue |
2 |
| container_start_page |
93 |
| container_title |
Stroke and Vascular Neurology |
| container_volume |
4 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792346843412168708 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:45:39.427Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Iron+toxicity%2C+lipid+peroxidation+and+ferroptosis+after+intracerebral+haemorrhage&rft.date=2019-06-01&genre=article&issn=2059-8696&volume=4&issue=2&spage=93&epage=95&pages=93-95&jtitle=Stroke+and+Vascular+Neurology&atitle=Iron+toxicity%2C+lipid+peroxidation+and+ferroptosis+after+intracerebral+haemorrhage&aulast=Wang&aufirst=Jian&rft_id=info%3Adoi%2F10.1136%2Fsvn-2018-000205&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792346843412168708 |
| author | Wan, Jieru, Ren, Honglei, Wang, Jian |
| author_facet | Wan, Jieru, Ren, Honglei, Wang, Jian, Wan, Jieru, Ren, Honglei, Wang, Jian |
| author_sort | wan, jieru |
| container_issue | 2 |
| container_start_page | 93 |
| container_title | Stroke and Vascular Neurology |
| container_volume | 4 |
| description | <jats:p>Intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity. However, we have few options for ICH therapy and limited knowledge about post-ICH neuronal death and related mechanisms. In the aftermath of ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production and lipid peroxidation, which contribute to secondary brain injury. Indeed, iron chelation therapy has shown efficacy in preclinical ICH studies. Recently, an iron-dependent form of non-apoptotic cell death known as ferroptosis was identified. It is characterised by an accumulation of iron-induced lipid ROS, which leads to intracellular oxidative stress. The ROS cause damage to nucleic acids, proteins and lipid membranes, and eventually cell death. Recently, we and others discovered that ferroptosis does occur after haemorrhagic stroke in vitro and in vivo and contributes to neuronal death. Inhibition of ferroptosis is beneficial in several in vivo and in vitro ICH conditions. This minireview summarises current research on iron toxicity, lipid peroxidation and ferroptosis in the pathomechanisms of ICH, the underlying molecular mechanisms of ferroptosis and the potential for combined therapeutic strategies. Understanding the role of ferroptosis after ICH will provide a vital foundation for cell death-based ICH treatment and prevention.</jats:p> |
| doi_str_mv | 10.1136/svn-2018-000205 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9zdm4tMjAxOC0wMDAyMDU |
| imprint | BMJ, 2019 |
| imprint_str_mv | BMJ, 2019 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 2059-8688, 2059-8696 |
| issn_str_mv | 2059-8688, 2059-8696 |
| language | English |
| last_indexed | 2024-03-01T17:45:39.427Z |
| match_str | wan2019irontoxicitylipidperoxidationandferroptosisafterintracerebralhaemorrhage |
| mega_collection | BMJ (CrossRef) |
| physical | 93-95 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | BMJ |
| record_format | ai |
| recordtype | ai |
| series | Stroke and Vascular Neurology |
| source_id | 49 |
| spelling | Wan, Jieru Ren, Honglei Wang, Jian 2059-8688 2059-8696 BMJ Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1136/svn-2018-000205 <jats:p>Intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity. However, we have few options for ICH therapy and limited knowledge about post-ICH neuronal death and related mechanisms. In the aftermath of ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production and lipid peroxidation, which contribute to secondary brain injury. Indeed, iron chelation therapy has shown efficacy in preclinical ICH studies. Recently, an iron-dependent form of non-apoptotic cell death known as ferroptosis was identified. It is characterised by an accumulation of iron-induced lipid ROS, which leads to intracellular oxidative stress. The ROS cause damage to nucleic acids, proteins and lipid membranes, and eventually cell death. Recently, we and others discovered that ferroptosis does occur after haemorrhagic stroke in vitro and in vivo and contributes to neuronal death. Inhibition of ferroptosis is beneficial in several in vivo and in vitro ICH conditions. This minireview summarises current research on iron toxicity, lipid peroxidation and ferroptosis in the pathomechanisms of ICH, the underlying molecular mechanisms of ferroptosis and the potential for combined therapeutic strategies. Understanding the role of ferroptosis after ICH will provide a vital foundation for cell death-based ICH treatment and prevention.</jats:p> Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage Stroke and Vascular Neurology |
| spellingShingle | Wan, Jieru, Ren, Honglei, Wang, Jian, Stroke and Vascular Neurology, Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| title | Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_full | Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_fullStr | Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_full_unstemmed | Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_short | Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_sort | iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| title_unstemmed | Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage |
| topic | Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| url | http://dx.doi.org/10.1136/svn-2018-000205 |